JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 7,099,328 $238M 0.11% -79,026 13F-HR/A Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 5,788,410 $194M 0.01% -2,290,894 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 4,426,781 $148M 0.03% +1,103,982 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 3,742,774 $125M <0.01% -128,865 13F-HR Timeline Group VANGUARD GROUP INC group of 6 filers holding More: the full row for VANGUARD GROUP INC 3,033,974 $102M new Timeline VANGUARD CAPITAL MANAGEMENT LLC : 2,153,218 (<0.01%) 13F-HR/A VANGUARD PORTFOLIO MANAGEMENT LLC : 477,321 (<0.01%) 13F-HR VANGUARD FIDUCIARY TRUST CO : 342,758 (<0.01%) 13F-HR VANGUARD ASSET MANAGEMENT, Ltd : 29,905 (<0.01%) 13F-HR Vanguard Global Advisers, LLC : 19,264 (<0.01%) 13F-HR Vanguard Investments Australia, L… : 11,508 (<0.01%) 13F-HR STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 2,680,802 $89.8M <0.01% +31,176 13F-HR Timeline Group Avoro Capital Advisors LLC More: the full row for Avoro Capital Advisors LLC 2,300,000 $77M 0.76% -600,000 13F-HR Timeline Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 1,744,124 $58.4M 3.64% +430,122 13F-HR Timeline Group Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 1,698,855 $56.9M 0.25% +561,926 13F-HR Timeline Group Khrom Capital Management LLC More: the full row for Khrom Capital Management LLC 1,511,481 $50.6M 4.63% new 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,237,550 $41.4M <0.01% +74,212 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 1,112,104 $37.2M 0.14% +326 13F-HR/A Timeline Deep Track Capital, LP More: the full row for Deep Track Capital, LP 1,078,710 $36.1M 0.75% +78,710 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 1,025,937 $34.4M <0.01% -2,292,761 13F-HR Timeline BRAIDWELL LP More: the full row for BRAIDWELL LP 959,259 $32.1M 1.07% -228,600 13F-HR Timeline READYSTATE ASSET MANAGEMENT LP More: the full row for READYSTATE ASSET MANAGEMENT LP 952,165 $31.9M 1.86% +77,718 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 835,178 $28M 0.01% +11,220 13F-HR Timeline Group Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 730,000 $24.4M 0.68% new 13F-HR Timeline Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 652,432 $21.8M 1.26% -547,568 13F-HR Timeline Group Hood River Capital Management LLC More: the full row for Hood River Capital Management LLC 623,421 $20.9M 0.21% +5,416 13F-HR Timeline Pictet Asset Management Holding SA in group Pictet Asset Management Holdi… More: the full row for Pictet Asset Management Holding SA 616,217 $20.6M 0.02% -7,911 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 606,513 $20.3M 0.02% -629,808 13F-HR Timeline Group SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 648,827 $19.8M 0.02% +198,979 13F-HR Timeline Catalio Capital Management, LP More: the full row for Catalio Capital Management, LP 577,808 $19.3M 4.04% +217,468 13F-HR Timeline KINGDON CAPITAL MANAGEMENT, L.L.C. More: the full row for KINGDON CAPITAL MANAGEMENT, L.L.C. 575,000 $19.3M 3.22% +175,100 13F-HR Timeline Kynam Capital Management, LP More: the full row for Kynam Capital Management, LP 560,000 $18.7M 1.19% new 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 549,877 $18.4M 0.02% +305,519 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 483,884 $16.2M 0.02% +196,591 13F-HR Timeline EMERALD ADVISERS, LLC group of 2 filers holding More: the full row for EMERALD ADVISERS, LLC 474,865 $15.9M -170,271 Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 447,300 $15M 0.02% new 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 439,902 $14.7M <0.01% +231,307 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 432,535 $14.5M 0.01% +219,717 13F-HR Timeline Group Caption Management, LLC More: the full row for Caption Management, LLC 420,143 $14.1M 0.67% +378,043 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 405,910 $13.6M <0.01% +4,724 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 393,523 $13.2M <0.01% +28,105 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 386,545 $12.9M 0.01% +77,715 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 385,798 $12.9M <0.01% -527,252 13F-HR Timeline Group Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 344,123 $11.5M 1.65% +275,300 13F-HR Timeline Group Integral Health Asset Management, LLC More: the full row for Integral Health Asset Management, LLC 325,000 $10.9M 0.58% 0 13F-HR Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 297,133 $9.95M +55,267 Timeline Vivo Capital, LLC More: the full row for Vivo Capital, LLC 294,909 $9.87M 0.82% -600,000 13F-HR/A Timeline Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 287,456 $9.62M 0.02% 0 13F-HR Timeline Group Candriam S.C.A. More: the full row for Candriam S.C.A. 281,620 $9.43M 0.05% new 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 277,851 $9.3M <0.01% -343,960 13F-HR Timeline Group Penn Capital Management Company, LLC More: the full row for Penn Capital Management Company, LLC 268,785 $9.02M 0.7% -6,997 13F-HR Timeline Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 257,253 $8.61M 0.51% +10,200 13F-HR Timeline Logos Global Management LP More: the full row for Logos Global Management LP 250,000 $8.37M 0.43% -50,000 13F-HR Timeline PFM Health Sciences, LP More: the full row for PFM Health Sciences, LP 248,180 $8.31M 0.87% +287 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 242,262 $8.11M <0.01% -45,377 13F-HR Timeline Group Trexquant Investment LP More: the full row for Trexquant Investment LP 221,928 $7.43M 0.05% +89,016 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 221,214 $7.41M 0.01% +214,619 13F-HR Timeline Group Alyeska Investment Group, L.P. in group Alyeska Investment Group, L.P. More: the full row for Alyeska Investment Group, L.P. 217,500 $7.28M 0.02% 0 13F-HR Timeline Group SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 216,281 $7.24M 1.25% +79,967 13F-HR Timeline Group RICE HALL JAMES & ASSOCIATES, LLC More: the full row for RICE HALL JAMES & ASSOCIATES, LLC 206,147 $6.9M 0.38% new 13F-HR Timeline Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 203,291 $6.81M 0.04% +202,952 13F-HR Timeline Group National Philanthropic Trust More: the full row for National Philanthropic Trust 200,000 $6.7M 0.07% +130,455 13F-HR Timeline Ally Bridge Group (NY) LLC More: the full row for Ally Bridge Group (NY) LLC 200,000 $6.7M 6.65% +31,971 13F-HR Timeline Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 200,000 $6.7M 0.88% new 13F-HR Timeline Group SEB Asset Management AB More: the full row for SEB Asset Management AB 187,475 $6.28M 0.03% 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 185,337 $6.21M 0.01% -283,317 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 185,317 $6.2M 0.01% 0 13F-HR Timeline Buckley Capital Advisors, LLC More: the full row for Buckley Capital Advisors, LLC 181,750 $6.08M 5.15% +32,600 13F-HR Timeline HSBC HOLDINGS PLC in group HSBC HOLDINGS PLC More: the full row for HSBC HOLDINGS PLC 174,204 $5.83M <0.01% new 13F-HR Timeline Group HighVista Strategies LLC More: the full row for HighVista Strategies LLC 165,227 $5.53M 1.53% +30,158 13F-HR Timeline NICOLET BANKSHARES INC in group NICOLET BANKSHARES INC More: the full row for NICOLET BANKSHARES INC 156,766 $5.25M 0.19% new 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 148,374 $4.97M <0.01% +6,392 13F-HR Timeline Group Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 135,621 $4.54M 0.05% -12,179 13F-HR Timeline Group Deeter Investments LLP More: the full row for Deeter Investments LLP 129,500 $4.34M 0.76% new 13F-HR Timeline NAN FUNG TRINITY (HK) LTD More: the full row for NAN FUNG TRINITY (HK) LTD 126,050 $4.22M 0.46% +2,200 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 124,519 $4.17M 0.1% +80,657 13F-HR Timeline Seven Fleet Capital Management LP More: the full row for Seven Fleet Capital Management LP 115,770 $3.88M 1.22% -14,309 13F-HR/A Timeline Granahan Investment Management, LLC More: the full row for Granahan Investment Management, LLC 114,825 $3.84M 0.19% -22,767 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 104,738 $3.51M <0.01% +4,116 13F-HR Timeline Group Tetragon Partners GP Ltd in group Tetragon Partners GP Ltd More: the full row for Tetragon Partners GP Ltd 102,125 $3.42M 0.67% new 13F-HR Timeline Group Centiva Capital, LP More: the full row for Centiva Capital, LP 101,234 $3.39M 0.16% -17,570 13F-HR Timeline STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 90,907 $3.04M 0.01% +18,425 13F-HR Timeline Swiss National Bank More: the full row for Swiss National Bank 90,300 $3.02M <0.01% +1,200 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 85,680 $2.87M 0.05% +49,386 13F-HR Timeline Group MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC in group MUTUAL OF AMERICA CAPITAL MAN… More: the full row for MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 82,834 $2.77M 0.03% -332 13F-HR Timeline Group Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 79,622 $2.67M 0.01% -15,975 13F-HR Timeline Artia Global Partners LP More: the full row for Artia Global Partners LP 68,490 $2.29M 0.52% -465,208 13F-HR Timeline Atle Fund Management AB More: the full row for Atle Fund Management AB 90,184 $2.21M 0.71% +27,449 13F-HR Timeline SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 62,946 $2.11M <0.01% -4,384 13F-HR Timeline Group Exome Asset Management LLC More: the full row for Exome Asset Management LLC 61,673 $2.06M 1.21% new 13F-HR Timeline KVP Capital Advisors, LP More: the full row for KVP Capital Advisors, LP 59,700 $2M 1.49% 0 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 43,090 $2M <0.01% +800 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 59,285 $1.98M <0.01% +4,217 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 58,692 $1.97M <0.01% +12,014 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 58,388 $1.95M <0.01% +17,671 13F-HR Timeline Diametric Capital, LP More: the full row for Diametric Capital, LP 57,832 $1.94M 0.51% +26,504 13F-HR Timeline BNP PARIBAS ASSET MANAGEMENT Holding S.… in group BNP PARIBAS ASSET MANAGEMENT … More: the full row for BNP PARIBAS ASSET MANAGEMENT Holding S.A. 57,828 $1.94M <0.01% +18,870 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 56,656 $1.9M <0.01% +21,993 13F-HR Timeline Group SummitTX Capital, L.P. More: the full row for SummitTX Capital, L.P. 56,585 $1.89M 0.06% -155,142 13F-HR Timeline TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 56,118 $1.88M 0.01% new 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 54,219 $1.82M <0.01% -103,466 13F-HR Timeline Group DV Trading LLC More: the full row for DV Trading LLC 54,000 $1.81M 0.16% 0 13F-HR Timeline Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 49,145 $1.65M 0.02% -118,860 13F-HR Timeline Moody Aldrich Partners LLC More: the full row for Moody Aldrich Partners LLC 48,261 $1.62M 0.29% +1,955 13F-HR Timeline TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 48,092 $1.61M <0.01% new 13F-HR Timeline Group Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 47,731 $1.6M 0.03% +21,046 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 46,830 $1.57M 0.09% +5,000 13F-HR Timeline Group Ruffer LLP More: the full row for Ruffer LLP 46,673 $1.57M 0.06% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 51,480 $1.57M <0.01% -64,037 13F-HR/A Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 44,814 $1.5M <0.01% -830,205 13F-HR Timeline Group Anson Funds Management LP in group Anson Funds Management LP More: the full row for Anson Funds Management LP 44,231 $1.48M 0.19% new 13F-HR/A Timeline Group BANQUE PICTET & CIE SA More: the full row for BANQUE PICTET & CIE SA 38,730 $1.3M 0.02% -5,066 13F-HR Timeline PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 35,607 $1.19M 0.04% +236 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 35,144 $1.18M <0.01% -6,644 13F-HR Timeline Group LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 33,372 $1.12M <0.01% +13,703 13F-HR Timeline LAZARD ASSET MANAGEMENT LLC in group LAZARD ASSET MANAGEMENT LLC More: the full row for LAZARD ASSET MANAGEMENT LLC 32,664 $1.09M <0.01% -15,781 13F-HR Timeline Group D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 30,247 $1.01M <0.01% +24,480 13F-HR Timeline Group CANTOR FITZGERALD, L. P. in group CANTOR FITZGERALD, L. P. More: the full row for CANTOR FITZGERALD, L. P. 30,000 $1M 0.04% new 13F-HR Timeline Group F/m Investments LLC More: the full row for F/m Investments LLC 29,351 $983K 0.07% -520 13F-HR Timeline MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 29,288 $963K <0.01% +2,045 13F-HR Timeline Group FRED ALGER MANAGEMENT, LLC in group FRED ALGER MANAGEMENT, LLC More: the full row for FRED ALGER MANAGEMENT, LLC 28,215 $945K <0.01% -264 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 27,501 $921K <0.01% +1,740 13F-HR Timeline Group CAPITAL FUND MANAGEMENT S.A. More: the full row for CAPITAL FUND MANAGEMENT S.A. 26,511 $888K 0.01% new 13F-HR Timeline TWINBEECH CAPITAL LP More: the full row for TWINBEECH CAPITAL LP 26,200 $877K 0.09% new 13F-HR Timeline Alberta Investment Management Corp More: the full row for Alberta Investment Management Corp 25,000 $837K 0.01% new 13F-HR Timeline GUGGENHEIM CAPITAL LLC in group GUGGENHEIM CAPITAL LLC More: the full row for GUGGENHEIM CAPITAL LLC 24,326 $814K 0.01% +6,145 13F-HR Timeline Group Erste Asset Management GmbH in group Erste Asset Management GmbH More: the full row for Erste Asset Management GmbH 25,600 $779K 0.01% 0 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 23,240 $778K 0.01% new 13F-HR Timeline Weiss Asset Management LP in group Weiss Asset Management LP More: the full row for Weiss Asset Management LP 23,000 $770K 0.01% new 13F-HR Timeline Group The filing omitted confidential holdings, a later amendment may add them. MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 22,878 $766K <0.01% -18,308 13F-HR Timeline Group PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 22,845 $765K <0.01% -2,010 13F-HR Timeline Group AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 21,152 $708K <0.01% -37,600 13F-HR Timeline Group PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 21,140 $708K 0.05% +15,762 13F-HR Timeline TEACHERS RETIREMENT SYSTEM OF THE STATE… More: the full row for TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 20,941 $701K 0.01% 0 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 20,751 $695K <0.01% -31,892 13F-HR/A Timeline Group Man Group plc in group Man Group plc More: the full row for Man Group plc 20,678 $692K <0.01% +5,631 13F-HR Timeline Group GC Wealth Management RIA, LLC More: the full row for GC Wealth Management RIA, LLC 20,027 $671K 0.03% new 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 19,953 $668K 0.02% -2,577 13F-HR Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 19,139 $641K <0.01% -21,059 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 18,166 $608K 0.02% -30,942 13F-HR Timeline FOX RUN MANAGEMENT, L.L.C. More: the full row for FOX RUN MANAGEMENT, L.L.C. 19,934 $607K 0.11% -1,851 13F-HR Timeline FORA Capital, LLC More: the full row for FORA Capital, LLC 17,964 $601K 0.04% +985 13F-HR Timeline CREDIT AGRICOLE S A in group CREDIT AGRICOLE S A More: the full row for CREDIT AGRICOLE S A 17,500 $586K <0.01% new 13F-HR Timeline Group Universal- Beteiligungs- und Serviceges… in group Universal- Beteiligungs- und … More: the full row for Universal- Beteiligungs- und Servicegesellschaft mbH 17,048 $571K <0.01% +274 13F-HR Timeline Group OXFORD ASSET MANAGEMENT LLP More: the full row for OXFORD ASSET MANAGEMENT LLP 15,664 $524K 0.21% +643 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. State of New Jersey Common Pension Fund… in group State of New Jersey Common Pe… More: the full row for State of New Jersey Common Pension Fund D 15,602 $522K <0.01% +184 13F-HR Timeline Group Handelsbanken Fonder AB More: the full row for Handelsbanken Fonder AB 15,400 $516K <0.01% 0 13F-HR Timeline Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 14,689 $492K 0.02% +2,275 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 14,109 $472K <0.01% -4,237 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 13,714 $459K <0.01% +1,142 13F-HR Timeline Gotham Asset Management, LLC More: the full row for Gotham Asset Management, LLC 13,702 $459K <0.01% +1,572 13F-HR Timeline DNB Asset Management AS in group DNB Asset Management AS More: the full row for DNB Asset Management AS 13,366 $447K <0.01% -705 13F-HR Timeline Group ARIZONA STATE RETIREMENT SYSTEM More: the full row for ARIZONA STATE RETIREMENT SYSTEM 12,540 $420K <0.01% -89 13F-HR Timeline ASPIRIANT, LLC More: the full row for ASPIRIANT, LLC 12,128 $406K 0.01% 0 13F-HR Timeline CANADA PENSION PLAN INVESTMENT BOARD More: the full row for CANADA PENSION PLAN INVESTMENT BOARD 11,300 $378K <0.01% +1,800 13F-HR Timeline HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 11,247 $376K <0.01% +6,463 13F-HR Timeline OPTIMIZE FINANCIAL INC. More: the full row for OPTIMIZE FINANCIAL INC. 11,169 $374K 0.18% new 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 11,002 $368K <0.01% -130,738 13F-HR Timeline Group Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 10,829 $363K <0.01% -10,246 13F-HR Timeline KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 10,600 $355K <0.01% +600 13F-HR Timeline Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 10,507 $352K 0.01% +3,877 13F-HR Timeline E Fund Management Co., Ltd. More: the full row for E Fund Management Co., Ltd. 10,009 $335K 0.01% 13F-HR Timeline STATE BOARD OF ADMINISTRATION OF FLORID… More: the full row for STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 9,041 $303K <0.01% 0 13F-HR Timeline OPPENHEIMER & CO INC in group OPPENHEIMER ASSET MANAGEMENT … More: the full row for OPPENHEIMER & CO INC 8,661 $290K <0.01% -86 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 8,586 $287K 0.05% +7,764 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 8,471 $284K <0.01% -254 13F-HR/A Timeline Group Pale Fire Capital SE in group Pale Fire Capital More: the full row for Pale Fire Capital SE 8,450 $283K 0.02% new 13F-HR Timeline Group VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 8,351 $280K <0.01% +245 13F-HR Timeline Group Virtu Financial LLC in group Virtu Financial LLC More: the full row for Virtu Financial LLC 8,244 $276K 0.01% -14,634 13F-HR Timeline Group GLENMEDE TRUST CO NA in group GLENMEDE TRUST CO NA More: the full row for GLENMEDE TRUST CO NA 8,229 $276K <0.01% +440 13F-HR Timeline Group WINTON GROUP Ltd in group WINTON GROUP Ltd More: the full row for WINTON GROUP Ltd 7,832 $262K 0.01% -36,368 13F-HR Timeline Group ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 7,693 $258K <0.01% -11,282 13F-HR Timeline Group B Group, Inc. More: the full row for B Group, Inc. 7,500 $251K 0.19% new 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 7,303 $245K <0.01% -1,219 13F-HR Timeline GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 6,465 $216K 0.01% new 13F-HR Timeline VIRGINIA RETIREMENT SYSTEMS ET Al More: the full row for VIRGINIA RETIREMENT SYSTEMS ET Al 6,100 $204K <0.01% -10,000 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 5,243 $176K 0.05% +127 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 4,900 $164K <0.01% +4,569 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 4,659 $155K <0.01% -4,997 13F-HR Timeline Group PUBLIC EMPLOYEES RETIREMENT ASSOCIATION… More: the full row for PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO 4,435 $148K <0.01% 0 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 4,124 $138K <0.01% +334 13F-HR Timeline Group FNY Investment Advisers, LLC More: the full row for FNY Investment Advisers, LLC 3,500 $117K 0.05% 0 13F-HR Timeline Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 3,351 $112K <0.01% 0 13F-HR/A Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 1,626 $54.4K <0.01% -283 13F-HR Timeline Group KBC Group NV in group KBC Group NV More: the full row for KBC Group NV 1,367 $46K <0.01% 0 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 1,339 $44.8K <0.01% -4 13F-HR Timeline Group NATIXIS in group Natixis Investment Managers More: the full row for NATIXIS 692 $23.2K <0.01% -13,148 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 419 $14K <0.01% -89 13F-HR Timeline Kemnay Advisory Services Inc. More: the full row for Kemnay Advisory Services Inc. 412 $13.8K <0.01% new 13F-HR Timeline Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 344 $11.5K <0.01% +333 13F-HR Timeline Group FIFTH THIRD BANCORP in group FIFTH THIRD BANK, NATIONAL AS… More: the full row for FIFTH THIRD BANCORP 331 $11.1K <0.01% new 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 327 $10.9K <0.01% +22 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 301 $10.1K <0.01% +192 13F-HR/A Timeline Group Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 284 $9.51K <0.01% +74 13F-HR/A Timeline Group Larson Financial Group LLC More: the full row for Larson Financial Group LLC 230 $7.7K <0.01% +60 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 164 $6.07K <0.01% -1 13F-HR Timeline NewEdge Advisors, LLC More: the full row for NewEdge Advisors, LLC 175 $5.86K <0.01% 0 13F-HR/A Timeline J.Safra Asset Management Corp More: the full row for J.Safra Asset Management Corp 174 $5.83K <0.01% +122 13F-HR Timeline SMA Capital LLC More: the full row for SMA Capital LLC 153 $5.12K <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 149 $4.99K <0.01% +66 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 131 $4.39K <0.01% +120 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 116 $3.88K <0.01% -11 13F-HR Timeline QUADRANT CAPITAL GROUP LLC More: the full row for QUADRANT CAPITAL GROUP LLC 111 $3.72K <0.01% new 13F-HR/A Timeline Smartleaf Asset Management LLC More: the full row for Smartleaf Asset Management LLC 112 $3.41K <0.01% -59 13F-HR Timeline HARBOUR INVESTMENTS, INC. More: the full row for HARBOUR INVESTMENTS, INC. 74 $2.48K <0.01% new 13F-HR Timeline JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 82 $2.46K <0.01% +54 13F-HR Timeline Group