Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 4,792,572 $50.8M 3.63% +1,767,572 13F-HR Timeline RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 4,265,428 $45.2M 0.69% +3,361,803 13F-HR Timeline EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 3,988,971 $42.3M 2.51% +588,971 13F-HR Timeline Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 2,755,962 $29.2M 2.42% +302,598 13F-HR Timeline Group Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 2,215,551 $23.5M 0.05% +706,216 13F-HR Timeline Group Avoro Capital Advisors LLC More: the full row for Avoro Capital Advisors LLC 2,175,000 $23.1M 0.36% 0 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 1,987,688 $21.1M 0.01% 0 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 1,584,993 $16.8M -50,791 Timeline 683 Capital Management, LLC in group 683 Capital Management, LLC More: the full row for 683 Capital Management, LLC 1,550,000 $16.4M 1.67% +25,000 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,436,981 $15.2M <0.01% +21,423 13F-HR Timeline Group SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 1,190,121 $14.8M 0.01% +356,046 13F-HR Timeline Integral Health Asset Management, LLC More: the full row for Integral Health Asset Management, LLC 1,250,000 $13.2M 1.47% +150,000 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,229,589 $13M <0.01% +1,037,056 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 1,200,944 $12.7M <0.01% +234,294 13F-HR Timeline Group VANGUARD GROUP INC group of 2 filers holding More: the full row for VANGUARD GROUP INC 959,112 $10.2M -161,441 Timeline Catalio Capital Management, LP in group Catalio Capital Management, LP More: the full row for Catalio Capital Management, LP 830,325 $8.8M 2.18% -71,648 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 785,320 $8.32M 0.01% +773,314 13F-HR Timeline Group Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 750,000 $7.95M 2.39% 0 13F-HR/A Timeline Group STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 731,039 $7.75M 2.48% +641,039 13F-HR Timeline MACQUARIE GROUP LTD in group MACQUARIE GROUP LTD More: the full row for MACQUARIE GROUP LTD 706,166 $7.49M 0.01% 0 13F-HR/A Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 610,971 $6.48M <0.01% +90,418 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 603,516 $6.4M <0.01% -93,808 13F-HR Timeline Group PFM Health Sciences, LP More: the full row for PFM Health Sciences, LP 599,967 $6.36M 0.49% +316,809 13F-HR Timeline Privium Fund Management B.V. More: the full row for Privium Fund Management B.V. 579,139 $6.14M 1.6% -163,023 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 549,730 $5.83M <0.01% +17,900 13F-HR Timeline Group Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 545,771 $5.79M 0.44% new 13F-HR Timeline VOLORIDGE INVESTMENT MANAGEMENT, LLC More: the full row for VOLORIDGE INVESTMENT MANAGEMENT, LLC 500,977 $5.31M 0.02% +323,798 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 485,305 $5.14M <0.01% -128,296 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 481,450 $5.1M <0.01% +13,093 13F-HR Timeline Group Pale Fire Capital SE in group Pale Fire Capital More: the full row for Pale Fire Capital SE 462,359 $4.9M 0.59% -118,349 13F-HR Timeline Group LORD, ABBETT & CO. LLC More: the full row for LORD, ABBETT & CO. LLC 400,785 $4.25M 0.02% +86,372 13F-HR Timeline Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 400,000 $4.24M 0.66% new 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 380,852 $4.04M <0.01% +311,788 13F-HR Timeline Group Avidity Partners Management LP More: the full row for Avidity Partners Management LP 336,200 $3.56M 0.74% +114,200 13F-HR Timeline Assenagon Asset Management S.A. More: the full row for Assenagon Asset Management S.A. 334,894 $3.55M 0.01% +261,323 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 316,199 $3.35M <0.01% -137,585 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 303,632 $3.22M <0.01% new 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 279,999 $2.97M <0.01% +10,019 13F-HR/A Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 266,726 $2.83M 0.03% +136,303 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 265,666 $2.82M <0.01% -198,869 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 259,637 $2.75M <0.01% +180,313 13F-HR/A Timeline Group ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 250,104 $2.65M 0.01% -7,717 13F-HR Timeline Group Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 241,684 $2.56M 0.03% new 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 226,896 $2.41M <0.01% +83,070 13F-HR Timeline Group Parkman Healthcare Partners LLC More: the full row for Parkman Healthcare Partners LLC 203,833 $2.16M 0.26% -71,167 13F-HR Timeline SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 203,400 $2.16M 0.45% +103,400 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 178,332 $1.89M <0.01% +163,745 13F-HR/A Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 175,806 $1.86M 0.01% +35,175 13F-HR Timeline ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 167,659 $1.78M 0.02% new 13F-HR Timeline Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 151,700 $1.61M 0.01% -23,300 13F-HR Timeline Group MOORE CAPITAL MANAGEMENT, LP More: the full row for MOORE CAPITAL MANAGEMENT, LP 150,000 $1.59M 0.05% 0 13F-HR/A Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 130,075 $1.38M <0.01% -1,641,277 13F-HR/A Timeline Group J. Goldman & Co LP More: the full row for J. Goldman & Co LP 128,026 $1.36M 0.05% +76,916 13F-HR Timeline OCONNOR, A Distinct Business Unit of UB… More: the full row for OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 114,889 $1.22M 0.03% -77,334 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. SANDERS MORRIS HARRIS LLC More: the full row for SANDERS MORRIS HARRIS LLC 114,887 $1.14M 0.18% +12,783 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 98,896 $1.05M <0.01% +3,305 13F-HR Timeline Group Verition Fund Management LLC More: the full row for Verition Fund Management LLC 96,534 $1.02M 0.01% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 94,197 $998K <0.01% +85,475 13F-HR Timeline Group Birchview Capital, LP More: the full row for Birchview Capital, LP 88,697 $940K 0.82% +68,697 13F-HR Timeline Diamond Hill Capital Management, LLC (I… More: the full row for Diamond Hill Capital Management, LLC (Investment Advisor) 82,653 $876K <0.01% +15,333 13F-HR Timeline Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 82,589 $875K <0.01% new 13F-HR Timeline Shay Capital LLC More: the full row for Shay Capital LLC 81,849 $868K 0.25% +25,025 13F-HR Timeline Marex Group Ltd in group Marex Group Ltd More: the full row for Marex Group Ltd 80,000 $848K 0.02% 0 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 79,881 $847K -445,462 Timeline Monaco Asset Management SAM More: the full row for Monaco Asset Management SAM 75,000 $795K 0.4% -61,708 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 72,836 $783K +234 Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 67,744 $718K <0.01% +60,501 13F-HR/A Timeline Group Quinn Opportunity Partners LLC More: the full row for Quinn Opportunity Partners LLC 64,000 $678K 0.05% -5,000 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 59,230 $628K <0.01% -670,187 13F-HR Timeline Group SECTORAL ASSET MANAGEMENT INC More: the full row for SECTORAL ASSET MANAGEMENT INC 57,550 $610K 0.47% -13,950 13F-HR Timeline STIFEL FINANCIAL CORP in group STIFEL FINANCIAL CORP More: the full row for STIFEL FINANCIAL CORP 55,768 $591K <0.01% -400 13F-HR Timeline Group Main Management ETF Advisors, LLC in group Main Management ETF Advisors,… More: the full row for Main Management ETF Advisors, LLC 55,508 $588K 0.03% new 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 49,331 $523K <0.01% -32,936 13F-HR/A Timeline Group VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 49,055 $520K <0.01% 0 13F-HR/A Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 47,524 $503K 0.02% -30,115 13F-HR Timeline Sigma Planning Corp More: the full row for Sigma Planning Corp 46,150 $489K 0.02% -595 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 42,499 $450K <0.01% -161,420 13F-HR Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 42,186 $447K <0.01% -68,274 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 42,147 $447K <0.01% -494,275 13F-HR Timeline CANTOR FITZGERALD, L. P. in group CANTOR FITZGERALD, L. P. More: the full row for CANTOR FITZGERALD, L. P. 40,300 $427K 0.02% new 13F-HR Timeline Group Massar Capital Management, LP More: the full row for Massar Capital Management, LP 40,000 $424K 0.51% new 13F-HR Timeline Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 38,200 $405K 0.01% -173,576 13F-HR/A Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 37,772 $400K 0.01% +14,113 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 37,396 $396K <0.01% +15,727 13F-HR/A Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 36,999 $392K 0.02% +20,720 13F-HR Timeline Group DIADEMA PARTNERS LP More: the full row for DIADEMA PARTNERS LP 36,500 $387K 0.31% new 13F-HR Timeline PDT Partners, LLC More: the full row for PDT Partners, LLC 31,047 $329K 0.02% -51 13F-HR Timeline GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 28,643 $304K 0.03% new 13F-HR Timeline Total Clarity Wealth Management, Inc. More: the full row for Total Clarity Wealth Management, Inc. 15,350 $271K 0.09% 0 13F-HR Timeline Palumbo Wealth Management LLC More: the full row for Palumbo Wealth Management LLC 25,400 $269K 0.09% +651 13F-HR Timeline DNB Asset Management AS in group DNB Asset Management AS More: the full row for DNB Asset Management AS 25,320 $268K <0.01% +3,292 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 24,928 $264K <0.01% -334,245 13F-HR Timeline Group NOMURA HOLDINGS INC in group NOMURA ASSET MANAGEMENT CO LTD More: the full row for NOMURA HOLDINGS INC 23,081 $245K <0.01% new 13F-HR Timeline Group Bellevue Group AG in group Bellevue Group AG More: the full row for Bellevue Group AG 22,500 $238K 0.01% 0 13F-HR Timeline Group PEAK6 LLC in group PEAK6 LLC More: the full row for PEAK6 LLC 22,057 $234K 0.01% +3,870 13F-HR Timeline Group Caption Management, LLC More: the full row for Caption Management, LLC 20,359 $216K 0.01% new 13F-HR Timeline PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 16,348 $173K 0.01% new 13F-HR Timeline OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 14,300 $152K <0.01% new 13F-HR Timeline FARALLON CAPITAL MANAGEMENT, L.L.C. More: the full row for FARALLON CAPITAL MANAGEMENT, L.L.C. 14,000 $148K <0.01% new 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Clear Harbor Asset Management, LLC More: the full row for Clear Harbor Asset Management, LLC 13,500 $143K 0.01% -3,500 13F-HR Timeline WOLVERINE TRADING, LLC More: the full row for WOLVERINE TRADING, LLC 10,835 $135K <0.01% -19,889 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 12,330 $131K <0.01% +36 13F-HR Timeline Group Mraz, Amerine & Associates, Inc. More: the full row for Mraz, Amerine & Associates, Inc. 10,019 $125K 0.02% new 13F-HR/A Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 11,574 $123K 0.01% +512 13F-HR Timeline Virtus Investment Advisers, LLC group of 2 filers holding More: the full row for Virtus Investment Advisers, LLC 10,906 $116K +6,185 Timeline Corient Private Wealth LP in group Corient Private Wealth LP More: the full row for Corient Private Wealth LP 10,630 $113K <0.01% 0 13F-HR Timeline Group Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 10,590 $112K <0.01% new 13F-HR Timeline Headlands Technologies LLC More: the full row for Headlands Technologies LLC 10,496 $111K 0.01% -7,954 13F-HR Timeline Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 8,386 $88.9K 0.08% new 13F-HR Timeline Activest Wealth Management More: the full row for Activest Wealth Management 5,000 $53K 0.01% 0 13F-HR Timeline Future Financial Wealth Managment LLC More: the full row for Future Financial Wealth Managment LLC 4,000 $42.4K 0.03% 0 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 3,545 $37.6K <0.01% -127,304 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 2,456 $26K <0.01% +360 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,547 $16.4K <0.01% +698 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,248 $13.2K <0.01% +225 13F-HR Timeline NATIONAL BANK OF CANADA /FI/ in group NATIONAL BANK OF CANADA /FI/ More: the full row for NATIONAL BANK OF CANADA /FI/ 967 $10.2K <0.01% -471 13F-HR Timeline Group SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 727 $7.71K <0.01% 0 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 676 $7.17K <0.01% 0 13F-HR Timeline Group SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 524 $5.55K <0.01% +372 13F-HR Timeline Wilmington Savings Fund Society, FSB More: the full row for Wilmington Savings Fund Society, FSB 352 $3.73K <0.01% 0 13F-HR Timeline SVB WEALTH LLC More: the full row for SVB WEALTH LLC 350 $3.71K <0.01% new 13F-HR Timeline Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 328 $3.48K <0.01% 0 13F-HR Timeline SALEM INVESTMENT COUNSELORS INC More: the full row for SALEM INVESTMENT COUNSELORS INC 300 $3.18K <0.01% 0 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 164 $2.34K <0.01% 0 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 234 $2K <0.01% 0 13F-HR Timeline Group Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 158 $2K <0.01% 0 13F-HR Timeline Group QUADRANT CAPITAL GROUP LLC More: the full row for QUADRANT CAPITAL GROUP LLC 187 $1.98K <0.01% 0 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 181 $1.92K <0.01% +66 13F-HR Timeline Group TOTH FINANCIAL ADVISORY CORP More: the full row for TOTH FINANCIAL ADVISORY CORP 165 $1.75K <0.01% 0 13F-HR Timeline JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 100 $1.25K <0.01% 0 13F-HR/A Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 109 $1.16K <0.01% 0 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 96 $1.02K <0.01% -379 13F-HR Timeline COLDSTREAM CAPITAL MANAGEMENT INC More: the full row for COLDSTREAM CAPITAL MANAGEMENT INC 63 $668 <0.01% new 13F-HR Timeline Physician Wealth Advisors, Inc. More: the full row for Physician Wealth Advisors, Inc. 47 $499 <0.01% new 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 20 $212 <0.01% -40 13F-HR/A Timeline First Horizon Advisors, Inc. More: the full row for First Horizon Advisors, Inc. 11 $117 <0.01% 0 13F-HR Timeline HUNTINGTON NATIONAL BANK in group HUNTINGTON NATIONAL BANK More: the full row for HUNTINGTON NATIONAL BANK 2 $21 <0.01% 0 13F-HR Timeline Group CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.