EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 3,400,000 $60M 2.4% new 13F-HR Timeline Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 3,025,000 $53.4M 3.17% -1,725,000 13F-HR Timeline Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 2,453,364 $43.3M 3.03% -327,649 13F-HR Timeline Group Avoro Capital Advisors LLC More: the full row for Avoro Capital Advisors LLC 2,175,000 $38.4M 0.54% new 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 1,987,688 $35.1M 0.01% +494,726 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 1,771,352 $31.3M 0.09% +794,459 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 1,635,784 $28.9M +84,388 Timeline 683 Capital Management, LLC in group 683 Capital Management, LLC More: the full row for 683 Capital Management, LLC 1,525,000 $26.9M 2.65% -325,000 13F-HR Timeline Group Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 1,509,335 $26.7M 0.05% -419,726 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,415,558 $25M <0.01% -147,002 13F-HR Timeline Group VANGUARD GROUP INC group of 2 filers holding More: the full row for VANGUARD GROUP INC 1,120,553 $19.8M -127,529 Timeline Integral Health Asset Management, LLC More: the full row for Integral Health Asset Management, LLC 1,100,000 $19.4M 1.72% +700,000 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 966,650 $17.1M <0.01% +616,078 13F-HR Timeline Group RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 903,625 $16M 0.24% +893,625 13F-HR Timeline Catalio Capital Management, LP in group Catalio Capital Management, LP More: the full row for Catalio Capital Management, LP 901,973 $15.9M 3.48% 13F-HR Timeline Group SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 834,075 $14.4M 0.01% -634,571 13F-HR Timeline Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 750,000 $13.2M 1.13% 13F-HR Timeline Group Privium Fund Management B.V. More: the full row for Privium Fund Management B.V. 742,162 $13.1M 2.97% -2,754 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 729,417 $12.9M 0.02% -396,239 13F-HR Timeline Group MACQUARIE GROUP LTD in group MACQUARIE GROUP LTD More: the full row for MACQUARIE GROUP LTD 706,166 $12.5M 0.02% 0 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 697,324 $12.3M <0.01% -3,380 13F-HR/A Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 613,601 $10.8M <0.01% +502,684 13F-HR Timeline Group Pale Fire Capital SE in group Pale Fire Capital More: the full row for Pale Fire Capital SE 580,708 $10.3M 2.4% +244,240 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 536,422 $9.47M 0.06% new 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 531,830 $9.39M <0.01% -333,968 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 525,343 $9.28M +365,249 Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 520,553 $9.2M <0.01% +11,951 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 468,357 $8.27M 0.01% +41,166 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 464,535 $8.2M 0.01% -1,725,446 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 453,784 $8.01M <0.01% +58,246 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 359,173 $6.34M 0.01% +125,682 13F-HR Timeline Group LORD, ABBETT & CO. LLC More: the full row for LORD, ABBETT & CO. LLC 314,413 $5.55M 0.02% new 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 299,771 $5.29M 0.01% -443,727 13F-HR Timeline Group PFM Health Sciences, LP More: the full row for PFM Health Sciences, LP 283,158 $5M 0.38% +161,530 13F-HR Timeline Parkman Healthcare Partners LLC More: the full row for Parkman Healthcare Partners LLC 275,000 $4.86M 0.65% new 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 269,980 $4.77M <0.01% -7,295 13F-HR Timeline Group ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 257,821 $4.55M 0.01% -184,311 13F-HR Timeline Group Avidity Partners Management LP More: the full row for Avidity Partners Management LP 222,000 $3.92M 0.39% -451,618 13F-HR Timeline Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 211,776 $3.74M 0.08% +139,624 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 203,919 $3.6M <0.01% +25,319 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 192,533 $3.4M <0.01% +17,631 13F-HR Timeline Group OCONNOR, A Distinct Business Unit of UB… More: the full row for OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 192,223 $3.39M 0.08% -6,000 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. VOLORIDGE INVESTMENT MANAGEMENT, LLC More: the full row for VOLORIDGE INVESTMENT MANAGEMENT, LLC 177,179 $3.13M 0.01% new 13F-HR Timeline Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 175,000 $3.09M 0.02% -460,500 13F-HR Timeline Group MOORE CAPITAL MANAGEMENT, LP More: the full row for MOORE CAPITAL MANAGEMENT, LP 150,000 $2.65M 0.05% +50,000 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 143,826 $2.54M <0.01% +138,860 13F-HR Timeline Group Trexquant Investment LP More: the full row for Trexquant Investment LP 143,080 $2.53M 0.03% new 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 140,631 $2.48M 0.02% new 13F-HR Timeline Monaco Asset Management SAM More: the full row for Monaco Asset Management SAM 136,708 $2.41M 1.07% new 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 130,849 $2.31M 0.08% -23,132 13F-HR/A Timeline Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 130,423 $2.3M 0.02% +40,281 13F-HR Timeline Group Campbell & CO Investment Adviser LLC More: the full row for Campbell & CO Investment Adviser LLC 123,210 $2.18M 0.17% new 13F-HR Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 110,460 $1.95M <0.01% 13F-HR/A Timeline Group SANDERS MORRIS HARRIS LLC More: the full row for SANDERS MORRIS HARRIS LLC 102,104 $1.8M 0.27% +34,034 13F-HR Timeline SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 100,000 $1.77M 0.39% new 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 95,591 $1.69M <0.01% +1,923 13F-HR Timeline Group STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 90,000 $1.59M 0.4% new 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 82,267 $1.45M <0.01% -1,312 13F-HR Timeline Group Marex Group Ltd in group Marex Group Ltd More: the full row for Marex Group Ltd 80,000 $1.41M 0.02% 0 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 79,324 $1.4M <0.01% -243,840 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 77,639 $1.37M 0.04% +36,647 13F-HR Timeline Assenagon Asset Management S.A. More: the full row for Assenagon Asset Management S.A. 73,571 $1.3M <0.01% -197,775 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 72,602 $1.28M +3,859 Timeline SECTORAL ASSET MANAGEMENT INC More: the full row for SECTORAL ASSET MANAGEMENT INC 71,500 $1.26M 0.84% -81,500 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 69,064 $1.22M <0.01% -182,421 13F-HR Timeline Group Quinn Opportunity Partners LLC More: the full row for Quinn Opportunity Partners LLC 69,000 $1.22M 0.09% +45,000 13F-HR Timeline Diamond Hill Capital Management, LLC (I… More: the full row for Diamond Hill Capital Management, LLC (Investment Advisor) 67,320 $1.19M 0.01% -9,310 13F-HR Timeline Shay Capital LLC More: the full row for Shay Capital LLC 56,824 $1M 0.25% -18,392 13F-HR Timeline STIFEL FINANCIAL CORP in group STIFEL FINANCIAL CORP More: the full row for STIFEL FINANCIAL CORP 56,168 $992K <0.01% -4,828 13F-HR Timeline Group J. Goldman & Co LP More: the full row for J. Goldman & Co LP 51,110 $903K 0.03% -182,256 13F-HR Timeline Sonic GP LLC More: the full row for Sonic GP LLC 50,000 $883K 1.95% 0 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 49,055 $866K <0.01% -68,970 13F-HR/A Timeline Group Sigma Planning Corp More: the full row for Sigma Planning Corp 46,745 $826K 0.03% -1,500 13F-HR Timeline AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 41,410 $731K <0.01% -41,149 13F-HR Timeline Group PDT Partners, LLC More: the full row for PDT Partners, LLC 31,098 $549K 0.05% -26,101 13F-HR Timeline WOLVERINE TRADING, LLC More: the full row for WOLVERINE TRADING, LLC 30,724 $529K 0.01% +20,383 13F-HR Timeline Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 28,319 $500K 0.03% -29,014 13F-HR Timeline TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 24,784 $438K <0.01% +1,371 13F-HR Timeline Palumbo Wealth Management LLC More: the full row for Palumbo Wealth Management LLC 24,749 $437K 0.16% new 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 23,659 $418K 0.01% -50,756 13F-HR Timeline Lighthouse Investment Partners, LLC in group Lighthouse Investment Partner… More: the full row for Lighthouse Investment Partners, LLC 22,500 $397K 0.02% new 13F-HR Timeline Group Bellevue Group AG in group Bellevue Group AG More: the full row for Bellevue Group AG 22,500 $397K 0.01% new 13F-HR Timeline Group DNB Asset Management AS in group DNB Asset Management AS More: the full row for DNB Asset Management AS 22,028 $389K <0.01% -5,625 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 21,669 $383K <0.01% -62,701 13F-HR Timeline Group Birchview Capital, LP More: the full row for Birchview Capital, LP 20,000 $353K 0.29% 0 13F-HR/A Timeline Headlands Technologies LLC More: the full row for Headlands Technologies LLC 18,450 $326K 0.03% new 13F-HR Timeline PEAK6 LLC in group PEAK6 LLC More: the full row for PEAK6 LLC 18,187 $321K 0.01% 13F-HR Timeline Group OPPENHEIMER & CO INC in group OPPENHEIMER ASSET MANAGEMENT … More: the full row for OPPENHEIMER & CO INC 18,100 $320K <0.01% new 13F-HR Timeline Group Clear Harbor Asset Management, LLC More: the full row for Clear Harbor Asset Management, LLC 17,000 $300K 0.02% -2,500 13F-HR Timeline Rangeley Capital, LLC More: the full row for Rangeley Capital, LLC 16,700 $295K 0.28% 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 16,279 $287K 0.02% new 13F-HR Timeline Group Total Clarity Wealth Management, Inc. More: the full row for Total Clarity Wealth Management, Inc. 15,350 $271K 0.09% -1,100 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 14,587 $258K <0.01% -9,442 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 12,294 $217K <0.01% +1,503 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 12,006 $212K <0.01% -104,454 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 11,062 $195K 0.02% +969 13F-HR Timeline Corient Private Wealth LP in group Corient Private Wealth LP More: the full row for Corient Private Wealth LP 10,630 $188K <0.01% 0 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 10,000 $177K 0.04% new 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 8,722 $154K <0.01% +4,427 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 7,243 $128K <0.01% +4,574 13F-HR/A Timeline Group Activest Wealth Management More: the full row for Activest Wealth Management 5,000 $88.3K 0.02% 0 13F-HR Timeline FNY Investment Advisers, LLC More: the full row for FNY Investment Advisers, LLC 5,004 $88K 0.05% new 13F-HR Timeline VIRTUS ADVISERS, LLC in group Virtus Investment Advisers, L… More: the full row for VIRTUS ADVISERS, LLC 4,721 $83.4K 0.03% -12,835 13F-HR Timeline Group Twin Tree Management, LP More: the full row for Twin Tree Management, LP 4,387 $77.5K <0.01% new 13F-HR Timeline Future Financial Wealth Managment LLC More: the full row for Future Financial Wealth Managment LLC 4,000 $70.6K 0.05% 0 13F-HR Timeline Coppell Advisory Solutions LLC More: the full row for Coppell Advisory Solutions LLC 4,000 $61.2K 0.01% 0 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 2,096 $37K <0.01% -280 13F-HR Timeline NATIONAL BANK OF CANADA /FI/ in group NATIONAL BANK OF CANADA /FI/ More: the full row for NATIONAL BANK OF CANADA /FI/ 1,438 $25.4K <0.01% +233 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,023 $18.1K <0.01% 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 849 $15K <0.01% -1,220 13F-HR Timeline Group SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 727 $12.8K <0.01% 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 676 $11.9K <0.01% +251 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 475 $8.39K 0.01% 13F-HR/A Timeline Wilmington Savings Fund Society, FSB More: the full row for Wilmington Savings Fund Society, FSB 352 $6.22K <0.01% 0 13F-HR Timeline Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 328 $5.79K <0.01% +30 13F-HR Timeline SALEM INVESTMENT COUNSELORS INC More: the full row for SALEM INVESTMENT COUNSELORS INC 300 $5.3K <0.01% 0 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. BFSG, LLC More: the full row for BFSG, LLC 300 $5.3K <0.01% new 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 234 $4K <0.01% new 13F-HR Timeline Group Brooklyn Investment Group More: the full row for Brooklyn Investment Group 199 $3.52K <0.01% new 13F-HR Timeline QUADRANT CAPITAL GROUP LLC More: the full row for QUADRANT CAPITAL GROUP LLC 187 $3.3K <0.01% new 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 158 $3K <0.01% 0 13F-HR Timeline Group TOTH FINANCIAL ADVISORY CORP More: the full row for TOTH FINANCIAL ADVISORY CORP 165 $2.91K <0.01% 0 13F-HR Timeline Accent Capital Management, LLC More: the full row for Accent Capital Management, LLC 160 $2.83K <0.01% new 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 152 $2.68K <0.01% -56 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 164 $2.51K <0.01% 0 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 115 $2.03K <0.01% 0 13F-HR/A Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 109 $1.93K <0.01% 0 13F-HR Timeline Group JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 100 $1.77K <0.01% new 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 60 $1.06K <0.01% 0 13F-HR Timeline Point72 (DIFC) Ltd More: the full row for Point72 (DIFC) Ltd 52 $926 <0.01% -1 13F-HR Timeline Pineridge Advisors LLC More: the full row for Pineridge Advisors LLC 38 $671 <0.01% 0 13F-HR Timeline First Horizon Advisors, Inc. More: the full row for First Horizon Advisors, Inc. 11 $194 <0.01% 0 13F-HR Timeline HUNTINGTON NATIONAL BANK in group HUNTINGTON NATIONAL BANK More: the full row for HUNTINGTON NATIONAL BANK 2 $35 <0.01% 0 13F-HR Timeline Group LAZARD ASSET MANAGEMENT LLC in group LAZARD ASSET MANAGEMENT LLC More: the full row for LAZARD ASSET MANAGEMENT LLC 47 $0 0% -13,483 13F-HR Timeline Group Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.