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Disclosery

PLRX PLIANT THERAPEUTICS INC

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COM (common), issuer CIK 1746473

96 managers (98 13F filers) reported a position in PLRX shares at 2025-12-31, 46,739,657 shares in all. 10 filers opened a position and 13 filers sold out during the quarter.

Managers
96
13F filers
98
New
10
Added
30
Reduced
34
Sold out
13
Shares held by filers
46,739,657

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
TANG CAPITAL MANAGEMENT LLCin group TANG CAPITAL MANAGEMENT LLC6,143,132$7.49M0.37%+139,68613F-HRTimelineGroup
Blue Owl Capital Holdings LP2,969,199$3.62M1.12%013F-HR/ATimeline
VANGUARD GROUP INCgroup of 2 filers holding2,844,478$3.47M+33,797Timeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC2,583,332$3.15M<0.01%+243,86413F-HRTimelineGroup
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC2,364,669$2.88M<0.01%-4,87313F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding2,198,893$2.68M+343,138Timeline
Woodline Partners LP2,026,191$2.47M0.01%-2,478,62613F-HRTimeline
Monaco Asset Management SAM1,938,747$2.37M0.7%+1,116,05413F-HRTimeline
Redmile Group, LLCin group Redmile Group, LLC1,616,228$1.97M0.15%+24,53313F-HRTimelineGroup
Prosight Management, LP1,555,744$1.9M0.39%+1,535,25713F-HRTimeline
BML Capital Management, LLC1,546,137$1.89M1.67%new13F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO1,212,875$1.48M<0.01%-917,61413F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP1,080,128$1.32M<0.01%+780,66713F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.1,073,272$1.31M<0.01%-347,59113F-HRTimelineGroup
UBS Group AGin group UBS Group AG1,062,615$1.3M<0.01%-259,40213F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC1,045,818$1.28M<0.01%+34,01613F-HRTimeline
Centiva Capital, LP1,000,000$1.22M0.07%new13F-HRTimeline
Peapod Lane Capital LLC886,374$1.08M0.92%-210,65413F-HRTimeline
Eversept Partners, LP842,023$1.03M0.06%+17,42913F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/711,777$868K<0.01%+3,72113F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC653,774$798K<0.01%+273,44713F-HRTimelineGroup
GSA CAPITAL PARTNERS LLP623,698$761K0.07%+462,81413F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC592,696$723K<0.01%+5,28713F-HRTimelineGroup
JACOBS LEVY EQUITY MANAGEMENT, INC556,938$679K<0.01%+189,82513F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY548,962$670K<0.01%-2,958,32613F-HR/ATimelineGroup
XTX Topco Ltdin group XTX Topco Ltd545,016$665K0.02%+78,03213F-HRTimelineGroup
BESSEMER GROUP INCin group BESSEMER GROUP INC532,079$649K<0.01%013F-HRTimelineGroup
DekaBank Deutsche Girozentrale40,000$633K<0.01%013F-HRTimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC408,831$499K<0.01%-128,50613F-HRTimelineGroup
Connor, Clark & Lunn Investment Managem…371,951$454K<0.01%+347,61113F-HRTimeline
BRIDGEWAY CAPITAL MANAGEMENT, LLC321,530$392K0.01%+239,23013F-HRTimeline
TORNO CAPITAL, LLC320,000$390K0.17%+189,08413F-HR/ATimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO297,291$363K<0.01%013F-HRTimelineGroup
ArrowMark Colorado Holdings LLC281,189$343K0.01%013F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC276,866$338K<0.01%-278,21013F-HR/ATimelineGroup
Seven Fleet Capital Management LP276,500$337K0.23%13F-HR/ATimeline
Laurion Capital Management LP257,400$314K0.02%new13F-HR/ATimeline
STATE STREET CORPin group STATE STREET CORP253,418$309K<0.01%-41613F-HRTimelineGroup
NANO CAP NEW MILLENNIUM GROWTH FUND L P235,000$287K0.24%13F-HRTimeline
Stonepine Capital Management, LLC230,050$281K0.22%-59,18713F-HRTimeline
Rangeley Capital, LLC225,000$274K0.24%+164,78013F-HRTimeline
HighMark Wealth Management LLC170,924$209K0.08%-48,07613F-HRTimeline
RICE HALL JAMES & ASSOCIATES, LLC147,705$180K0.01%+2,86213F-HRTimeline
DIADEMA PARTNERS LP144,914$177K0.11%new13F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP123,273$150K<0.01%-13,22713F-HRTimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP121,756$149K<0.01%-29,91713F-HRTimelineGroup
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.114,971$140K<0.01%-10,40513F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.113,934$139K<0.01%+6,83813F-HRTimelineGroup
Hennion & Walsh Asset Management, Inc.113,383$138K<0.01%+15,34913F-HRTimeline
Bond & Devick Financial Network, Inc.100,160$122K0.03%013F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC99,018$121K<0.01%+65,17613F-HRTimelineGroup
Quadrature Capital Ltdin group Quadrature Capital Ltd97,891$119K<0.01%+60,29613F-HRTimelineGroup
KOTLER KEVIN93,000$113K0.08%13F-HRTimeline
ALGERT GLOBAL LLC84,452$103K<0.01%-19,93013F-HR/ATimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC73,819$90.1K0.01%new13F-HR/ATimelineGroup
CANADA PENSION PLAN INVESTMENT BOARD61,400$74.9K<0.01%new13F-HRTimeline
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.59,495$72.6K<0.01%+4,19913F-HRTimelineGroup
Deeter Investments LLP48,025$58.6K0.01%13F-HRTimeline
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.46,537$56.8K<0.01%-4,291,85713F-HRTimelineGroup
SIMPLEX TRADING, LLC45,912$56K<0.01%+32,92313F-HRTimeline
Persistent Asset Partners Ltd38,831$47.4K0.02%new13F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…34,201$41.7K<0.01%-39,75313F-HRTimelineGroup
HRT FINANCIAL LP32,205$39K<0.01%new13F-HRTimeline
Engineers Gate Manager LP30,544$37.3K<0.01%+7,05613F-HRTimeline
TUDOR INVESTMENT CORP ET AL29,729$36.3K<0.01%013F-HRTimeline
Blackstone Inc.in group Blackstone Inc.22,206$27.1K<0.01%013F-HRTimelineGroupThe filing omitted confidential holdings, a later amendment may add them.
Bronte Capital Management Pty Ltd.18,613$22.7K<0.01%new13F-HRTimeline
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …18,065$22K<0.01%013F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp15,824$19.3K<0.01%-10913F-HRTimelineGroup
GROUP ONE TRADING LLC15,790$19.3K<0.01%+12,66913F-HRTimeline
Qube Research & Technologies Ltd15,425$18.8K<0.01%-34,09013F-HRTimeline
SG Americas Securities, LLC12,261$15K<0.01%-4,52213F-HRTimeline
AlphaQuest LLC11,716$14.3K<0.01%013F-HRTimeline
Fiduciary Trust Coin group Fiduciary Trust Co11,620$14.2K<0.01%013F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC10,584$12.9K<0.01%-358,97213F-HRTimelineGroup
RHUMBLINE ADVISERS2,379$2.9K<0.01%013F-HRTimeline
FMR LLCin group FMR LLC1,934$2.36K<0.01%-3,04013F-HRTimelineGroup
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA1,185$2K<0.01%-14,99013F-HRTimelineGroup
Fortitude Family Office, LLC1,278$1.56K<0.01%013F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…978$1.19K<0.01%-613F-HRTimelineGroup
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…660$805<0.01%-42513F-HR/ATimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS657$802<0.01%-181,69913F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…542$661<0.01%-86413F-HRTimelineGroup
Bare Financial Services, Inc413$504<0.01%new13F-HRTimeline
MAI Capital Management400$488<0.01%013F-HRTimeline
SBI Securities Co., Ltd.320$390<0.01%013F-HRTimeline
Cornerstone Financial Management LLC319$389<0.01%13F-HR/ATimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN50$61<0.01%013F-HRTimelineGroup
Truvestments Capital LLC50$61<0.01%013F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…36$44<0.01%-57013F-HRTimeline
COMERICA BANK6$7<0.01%-813F-HRTimeline
Farther Finance Advisors, LLC5$6<0.01%013F-HRTimeline
Global Retirement Partners, LLC4$5<0.01%013F-HRTimeline
Caitong International Asset Management …1$1<0.01%-2,04613F-HR/ATimeline
CWM, LLCin group CWM, LLC391$00%-26613F-HRTimelineGroupValue filed as zero, left out of ratios.
Covestor Ltd45$00%-113F-HRTimelineValue filed as zero, left out of ratios.