Catalys Pacific, LLC More: the full row for Catalys Pacific, LLC 8,644,579 $106M 91.82% 0 13F-HR Timeline SAMSARA BIOCAPITAL, LLC More: the full row for SAMSARA BIOCAPITAL, LLC 5,074,916 $62.5M 8.57% 0 13F-HR Timeline RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 4,850,984 $59.7M 0.79% 0 13F-HR Timeline Group TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 2,470,265 $30.4M 2.97% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 2,138,522 $26.3M <0.01% -5,646 13F-HR Timeline Group SR One Capital Management, LP More: the full row for SR One Capital Management, LP 2,016,822 $24.8M 6.05% 0 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 1,745,597 $21.5M 0.01% +84 13F-HR Timeline Group ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 1,611,637 $19.8M 0.41% -391,302 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 1,432,042 $17.6M <0.01% +68,811 13F-HR Timeline Group Laurion Capital Management LP More: the full row for Laurion Capital Management LP 1,412,389 $17.4M 1.08% 0 13F-HR Timeline ADAMS STREET PARTNERS LLC More: the full row for ADAMS STREET PARTNERS LLC 1,129,807 $13.9M 12.33% -402,847 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 1,101,674 $13.6M 0.01% +1,002,941 13F-HR Timeline Group JENNISON ASSOCIATES LLC More: the full row for JENNISON ASSOCIATES LLC 1,082,006 $13.3M 0.01% +385,726 13F-HR Timeline Caligan Partners LP More: the full row for Caligan Partners LP 1,011,155 $12.4M 3.15% +30,000 13F-HR Timeline Integral Health Asset Management, LLC More: the full row for Integral Health Asset Management, LLC 875,000 $10.8M 0.95% +519,000 13F-HR Timeline AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 848,630 $10.4M 0.01% -83,020 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 841,541 $10.4M 2.14% +112,140 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 650,023 $8M 0.25% +44,067 13F-HR Timeline Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 632,506 $7.79M 0.54% 0 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 620,033 $7.63M <0.01% -820 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 589,444 $7.26M <0.01% +73,631 13F-HR/A Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 504,533 $6.21M <0.01% +20,767 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 503,590 $6.2M <0.01% +482,174 13F-HR Timeline Group STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 400,101 $4.93M 1.24% new 13F-HR Timeline SECTORAL ASSET MANAGEMENT INC More: the full row for SECTORAL ASSET MANAGEMENT INC 380,883 $4.69M 3.13% +51,370 13F-HR Timeline Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 350,000 $4.31M 0.67% 0 13F-HR Timeline Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 332,390 $4.09M 1.17% +152,390 13F-HR Timeline Group Candriam S.C.A. More: the full row for Candriam S.C.A. 305,272 $3.76M 0.02% new 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 304,184 $3.74M <0.01% +426 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 246,113 $3.03M <0.01% +1,688 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 214,906 $2.65M <0.01% +1,307 13F-HR Timeline Group SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 190,672 $2.35M 0.43% -81,800 13F-HR Timeline Group DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 146,500 $1.8M 0.46% 0 13F-HR Timeline Pale Fire Capital SE in group Pale Fire Capital More: the full row for Pale Fire Capital SE 136,897 $1.69M 0.39% 0 13F-HR Timeline Group PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 125,650 $1.55M <0.01% +58,000 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 119,500 $1.47M <0.01% +15,700 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 111,915 $1.38M <0.01% +22,464 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 107,703 $1.33M <0.01% +11,549 13F-HR Timeline Group Polar Asset Management Partners Inc. More: the full row for Polar Asset Management Partners Inc. 99,100 $1.22M 0.02% +58,600 13F-HR/A Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 91,529 $1.13M <0.01% +27,531 13F-HR Timeline Group NEOS Investment Management LLC More: the full row for NEOS Investment Management LLC 89,529 $1.1M 0.03% -33,969 13F-HR Timeline Tema ETFs LLC More: the full row for Tema ETFs LLC 89,529 $1.1M 0.46% 13F-HR Timeline Lion Point Capital, LP More: the full row for Lion Point Capital, LP 79,000 $972K 5.09% 0 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Nuveen Asset Management, LLC in group TIAA More: the full row for Nuveen Asset Management, LLC 67,877 $836K <0.01% 0 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 65,318 $804K <0.01% +1,711 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 48,885 $602K <0.01% +32,785 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 46,396 $571K <0.01% +8,178 13F-HR/A Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 40,556 $499K <0.01% +695 13F-HR/A Timeline ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 40,248 $495K <0.01% +1,984 13F-HR Timeline Group OCONNOR, A Distinct Business Unit of UB… More: the full row for OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 28,068 $346K 0.01% -3,000 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. STRS OHIO More: the full row for STRS OHIO 26,900 $331K <0.01% 0 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 26,732 $329K <0.01% +10,264 13F-HR/A Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 23,714 $292K <0.01% +3,802 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 23,364 $288K <0.01% +1,391 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 23,024 $283K <0.01% +64 13F-HR Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 19,961 $246K <0.01% +10,845 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 18,041 $223K +543 Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 17,786 $219K <0.01% new 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 17,124 $211K <0.01% 0 13F-HR Timeline Group LETKO, BROSSEAU & ASSOCIATES INC More: the full row for LETKO, BROSSEAU & ASSOCIATES INC 16,500 $203K <0.01% +5,100 13F-HR Timeline Bellevue Group AG in group Bellevue Group AG More: the full row for Bellevue Group AG 16,499 $203K <0.01% 0 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 16,412 $202K <0.01% new 13F-HR Timeline Group FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 15,516 $191K <0.01% -1,332 13F-HR Timeline Group AlphaQuest LLC More: the full row for AlphaQuest LLC 15,222 $187K 0.02% +14,666 13F-HR Timeline MARTINGALE ASSET MANAGEMENT L P More: the full row for MARTINGALE ASSET MANAGEMENT L P 14,965 $184K <0.01% 0 13F-HR Timeline Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 14,197 $175K <0.01% -1,071 13F-HR Timeline Group EntryPoint Capital, LLC More: the full row for EntryPoint Capital, LLC 12,487 $154K 0.06% new 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 12,346 $152K <0.01% new 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 11,797 $145K <0.01% -347 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 11,715 $145K <0.01% new 13F-HR Timeline CreativeOne Wealth, LLC in group CreativeOne Wealth, LLC More: the full row for CreativeOne Wealth, LLC 10,750 $132K <0.01% 0 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 10,553 $130K 0.01% +989 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 10,405 $128K <0.01% new 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 7,764 $95.6K <0.01% 0 13F-HR/A Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 7,136 $87.8K <0.01% 13F-HR Timeline VIRTUS ADVISERS, LLC in group Virtus Investment Advisers, L… More: the full row for VIRTUS ADVISERS, LLC 5,842 $71.9K 0.03% -1,425 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 5,237 $64K <0.01% +14 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 3,895 $47.9K <0.01% new 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 3,535 $43K <0.01% +661 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 2,798 $34.4K <0.01% 0 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 2,582 $31.8K <0.01% 0 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 2,185 $26.9K <0.01% -26 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 2,069 $25.5K <0.01% 0 13F-HR/A Timeline Smartleaf Asset Management LLC More: the full row for Smartleaf Asset Management LLC 1,905 $23.9K <0.01% +368 13F-HR Timeline GeoWealth Management, LLC More: the full row for GeoWealth Management, LLC 1,439 $17.7K <0.01% 0 13F-HR Timeline MEEDER ASSET MANAGEMENT INC in group Meeder Advisory Services, Inc. More: the full row for MEEDER ASSET MANAGEMENT INC 1,338 $16.5K <0.01% new 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,045 $12.9K <0.01% 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,005 $12.4K <0.01% -1,669 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 723 $8.9K <0.01% +646 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 682 $8K <0.01% 0 13F-HR Timeline COMERICA BANK More: the full row for COMERICA BANK 644 $7.93K <0.01% 0 13F-HR/A Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 400 $4.92K <0.01% 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 337 $4K <0.01% +33 13F-HR Timeline MassMutual Private Wealth & Trust, FSB More: the full row for MassMutual Private Wealth & Trust, FSB 319 $3.93K <0.01% 0 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 152 $2K <0.01% 0 13F-HR Timeline Group QUADRANT CAPITAL GROUP LLC More: the full row for QUADRANT CAPITAL GROUP LLC 129 $1.59K <0.01% 0 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 108 $1.33K <0.01% 0 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 105 $1.29K <0.01% +75 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 103 $1.27K <0.01% +98 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 91 $1.12K <0.01% +16 13F-HR Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 77 $948 <0.01% new 13F-HR Timeline Group Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 53 $652 <0.01% -10 13F-HR Timeline Private Wealth Management Group, LLC More: the full row for Private Wealth Management Group, LLC 50 $616 <0.01% 0 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 28 $286 <0.01% -105 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 22 $271 <0.01% 0 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 18 $222 <0.01% new 13F-HR Timeline Group Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 17 $209 <0.01% 0 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 0 $25 <0.01% new 13F-HR Timeline Amount filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.