Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 6,728,985 $76.1M 5.7% +25,000 13F-HR Timeline MONTANOVA CAPITAL, LLC More: the full row for MONTANOVA CAPITAL, LLC 4,955,000 $56M 2.11% +41,988 13F-HR Timeline TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 4,941,798 $55.9M 2.82% 0 13F-HR Timeline Group Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 4,887,867 $55.3M 2.21% 0 13F-HR Timeline Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 4,675,000 $52.9M 2.78% -76,292 13F-HR Timeline Capital World Investors More: the full row for Capital World Investors 3,177,587 $35.9M 0.01% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 3,129,494 $35.4M <0.01% -22,241 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 2,412,399 $27.3M <0.01% +113,801 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 1,920,664 $21.7M 0.11% +303,195 13F-HR Timeline SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 1,832,171 $20.7M 4.24% +133,187 13F-HR Timeline Group EMERALD ADVISERS, LLC group of 2 filers holding More: the full row for EMERALD ADVISERS, LLC 1,807,021 $20.4M +300,618 Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,349,539 $15.3M <0.01% +255,896 13F-HR Timeline Group Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 1,273,333 $14.4M 3.16% -96,667 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 945,125 $10.7M <0.01% +905,053 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 941,212 $10.6M <0.01% +25,971 13F-HR Timeline Group Parkman Healthcare Partners LLC More: the full row for Parkman Healthcare Partners LLC 679,063 $7.68M 0.89% -74,689 13F-HR Timeline DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 581,757 $6.58M 1.82% -170,602 13F-HR Timeline SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 554,958 $6.27M 0.01% -313,053 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 3 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 415,341 $4.7M +320,030 Timeline STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 386,790 $4.37M 1.41% -47 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 366,966 $4.15M <0.01% +58,719 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 352,152 $3.98M <0.01% -35,410 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 340,629 $3.85M <0.01% +142,424 13F-HR Timeline Group GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 323,170 $3.65M 2.38% -691,197 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 299,194 $3.38M <0.01% +150,967 13F-HR Timeline Group PANAGORA ASSET MANAGEMENT INC More: the full row for PANAGORA ASSET MANAGEMENT INC 292,593 $3.31M 0.01% +220,697 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 272,861 $3.08M <0.01% -234,842 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 239,629 $2.71M <0.01% +15,840 13F-HR Timeline Group First Turn Management, LLC More: the full row for First Turn Management, LLC 214,138 $2.42M 0.45% new 13F-HR Timeline Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 198,528 $2.24M 0.74% new 13F-HR Timeline Group F/m Investments LLC More: the full row for F/m Investments LLC 182,262 $2.06M 0.07% +132,165 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 173,209 $1.96M <0.01% -472,784 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 168,923 $1.91M <0.01% +113,696 13F-HR/A Timeline Group Rosalind Advisors, Inc. More: the full row for Rosalind Advisors, Inc. 157,725 $1.78M 0.86% -146,139 13F-HR Timeline Hennion & Walsh Asset Management, Inc. More: the full row for Hennion & Walsh Asset Management, Inc. 155,961 $1.76M 0.07% +44,855 13F-HR Timeline NAN FUNG TRINITY (HK) LTD More: the full row for NAN FUNG TRINITY (HK) LTD 154,522 $1.75M 0.21% new 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 148,927 $1.68M 0.05% new 13F-HR Timeline Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 145,282 $1.64M 0.01% -436,464 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 134,398 $1.52M <0.01% -205,538 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 133,566 $1.51M <0.01% +50,670 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 132,900 $1.5M <0.01% +6,632 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 119,622 $1.35M <0.01% +38,657 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 113,496 $1.28M <0.01% +372 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 107,635 $1.22M <0.01% +4,105 13F-HR Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 101,035 $1.14M <0.01% new 13F-HR Timeline Group Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 100,000 $1.13M 1.11% +78,450 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 97,248 $1.1M <0.01% new 13F-HR Timeline Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 93,400 $1.06M 0.53% new 13F-HR/A Timeline Group OCONNOR, A Distinct Business Unit of UB… More: the full row for OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 79,460 $898K 0.02% -90,232 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 73,343 $829K <0.01% +12,300 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 68,539 $775K <0.01% +31,218 13F-HR Timeline Group Birchview Capital, LP More: the full row for Birchview Capital, LP 67,000 $757K 0.75% -2 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 64,294 $727K <0.01% +64,143 13F-HR/A Timeline Group Saturn V Capital Management LP More: the full row for Saturn V Capital Management LP 62,793 $710K 0.29% -192,267 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 54,910 $621K <0.01% new 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 54,376 $615K <0.01% +1,458 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 53,069 $600K <0.01% +41 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 50,761 $574K <0.01% +10,957 13F-HR Timeline Group AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 47,413 $536K <0.01% -8,562 13F-HR Timeline Group Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 46,901 $530K <0.01% +20,632 13F-HR Timeline Skandinaviska Enskilda Banken AB (publ) More: the full row for Skandinaviska Enskilda Banken AB (publ) 40,863 $462K <0.01% 0 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 40,020 $452K <0.01% 0 13F-HR Timeline Allostery Investments LP More: the full row for Allostery Investments LP 40,000 $452K 5.76% -418,302 13F-HR Timeline OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 33,900 $383K <0.01% new 13F-HR Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 33,380 $377K <0.01% +5,573 13F-HR Timeline Group EVOKE WEALTH, LLC More: the full row for EVOKE WEALTH, LLC 32,181 $364K 0.01% -265 13F-HR Timeline Virtu Financial LLC in group Virtu Financial LLC More: the full row for Virtu Financial LLC 30,739 $347K 0.02% new 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 28,474 $322K <0.01% -3,652 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 26,386 $298K <0.01% new 13F-HR/A Timeline Group Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 26,257 $297K <0.01% +415 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 25,720 $291K <0.01% 0 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 25,324 $286K <0.01% +2,462 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 24,885 $282K -1,080 Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 23,218 $262K <0.01% -379,286 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 21,915 $248K <0.01% new 13F-HR/A Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 21,688 $245K <0.01% 0 13F-HR Timeline Group Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 19,973 $226K <0.01% new 13F-HR Timeline Group Rathbones Group PLC More: the full row for Rathbones Group PLC 19,022 $215K <0.01% 0 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 17,864 $202K <0.01% +1,041 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 17,671 $200K <0.01% -217 13F-HR Timeline Quarry LP More: the full row for Quarry LP 16,796 $190K 0.04% +8,396 13F-HR Timeline IRONWOOD INVESTMENT MANAGEMENT LLC More: the full row for IRONWOOD INVESTMENT MANAGEMENT LLC 16,711 $189K 0.09% +5,223 13F-HR Timeline Atom Investors LP More: the full row for Atom Investors LP 16,312 $184K 0.02% new 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 15,841 $179K <0.01% new 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 14,626 $165K <0.01% +818 13F-HR Timeline Group Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 13,333 $151K <0.01% new 13F-HR Timeline Group Trexquant Investment LP More: the full row for Trexquant Investment LP 12,781 $144K <0.01% new 13F-HR Timeline Whalen Wealth Management Inc. More: the full row for Whalen Wealth Management Inc. 10,938 $124K 0.08% new 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 10,714 $121K <0.01% +475 13F-HR Timeline Group Martin Worley Group More: the full row for Martin Worley Group 10,168 $115K 0.06% 0 13F-HR Timeline PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 10,020 $113K <0.01% new 13F-HR Timeline Choate Investment Advisors More: the full row for Choate Investment Advisors 10,000 $113K <0.01% 0 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 10,000 $113K 0.02% -25,743 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 9,985 $113K 0.01% +73 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 9,964 $113K <0.01% 0 13F-HR/A Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 9,756 $110K <0.01% +2,061 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 8,059 $91.1K <0.01% +7,180 13F-HR Timeline Group Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 7,184 $81.2K 0.03% new 13F-HR Timeline Group GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 4,963 $56.1K <0.01% new 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 4,557 $51.5K <0.01% 0 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 4,202 $47.5K <0.01% -4,338 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 4,041 $45.7K <0.01% +1,292 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 3,731 $42.2K <0.01% 0 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 3,627 $41K <0.01% -958 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 3,543 $40K <0.01% new 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 2,511 $28.4K <0.01% 0 13F-HR Timeline 1620 INVESTMENT ADVISORS, INC. More: the full row for 1620 INVESTMENT ADVISORS, INC. 1,590 $18K 0.01% 0 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 1,423 $16.1K <0.01% +136 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 1,392 $15.7K <0.01% +1,124 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 1,343 $15K <0.01% 0 13F-HR Timeline Truvestments Capital LLC More: the full row for Truvestments Capital LLC 1,324 $15K <0.01% new 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,247 $14.1K <0.01% 0 13F-HR Timeline Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 1,024 $11.6K <0.01% +45 13F-HR Timeline COMERICA BANK More: the full row for COMERICA BANK 711 $8.04K <0.01% 0 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 533 $6.03K <0.01% -37 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 524 $5.92K <0.01% +387 13F-HR Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 449 $5.08K <0.01% +347 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 441 $4.99K <0.01% +57 13F-HR Timeline Wilmington Savings Fund Society, FSB More: the full row for Wilmington Savings Fund Society, FSB 415 $4.69K <0.01% 0 13F-HR Timeline Brooklyn Investment Group More: the full row for Brooklyn Investment Group 244 $2.76K <0.01% -103 13F-HR/A Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 196 $2.22K <0.01% 0 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 154 $2K <0.01% 0 13F-HR Timeline Group Larson Financial Group LLC More: the full row for Larson Financial Group LLC 166 $1.88K <0.01% +22 13F-HR Timeline CIBC Private Wealth Group LLC in group CIBC Bancorp USA Inc. More: the full row for CIBC Private Wealth Group LLC 160 $1.81K <0.01% 0 13F-HR Timeline Group ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 140 $1.58K <0.01% +35 13F-HR Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 131 $1.48K <0.01% new 13F-HR Timeline TOTH FINANCIAL ADVISORY CORP More: the full row for TOTH FINANCIAL ADVISORY CORP 100 $1.13K <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 94 $1.06K <0.01% 0 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 91 $1.03K <0.01% +50 13F-HR/A Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 58 $656 <0.01% -86 13F-HR Timeline Physician Wealth Advisors, Inc. More: the full row for Physician Wealth Advisors, Inc. 51 $577 <0.01% new 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 45 $509 <0.01% +14 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 0 $498 <0.01% -4 13F-HR Timeline Amount filed as zero, left out of ratios. Parkside Financial Bank & Trust More: the full row for Parkside Financial Bank & Trust 40 $453 <0.01% new 13F-HR Timeline Essential Partners LLC More: the full row for Essential Partners LLC 38 $430 <0.01% 13F-HR Timeline Parkworth Wealth Management, Inc. More: the full row for Parkworth Wealth Management, Inc. 22 $249 <0.01% new 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.