Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 6,249,731 $52.9M 3.63% 0 13F-HR Timeline MONTANOVA CAPITAL, LLC More: the full row for MONTANOVA CAPITAL, LLC 4,913,012 $41.6M 1.54% +701,007 13F-HR Timeline TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 4,893,847 $41.5M 2.74% +572,300 13F-HR Timeline Group Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 4,887,867 $41.4M 1.72% +1,200,000 13F-HR Timeline Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 4,770,000 $40.4M 2.4% +770,000 13F-HR Timeline Capital World Investors More: the full row for Capital World Investors 3,374,064 $28.6M <0.01% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 2,863,996 $24.3M <0.01% -198,323 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 2,255,243 $19.1M <0.01% +104,716 13F-HR Timeline Group GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 1,787,003 $15.1M 7.13% +487,500 13F-HR Timeline Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 1,590,000 $13.5M 1.15% 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,390,863 $11.8M <0.01% +119,254 13F-HR Timeline Group EMERALD ADVISERS, LLC group of 2 filers holding More: the full row for EMERALD ADVISERS, LLC 1,385,738 $11.7M -101,230 Timeline Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 1,370,000 $11.6M 1.97% new 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 1,288,401 $10.9M 0.07% +680,148 13F-HR Timeline STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 992,803 $8.41M 2.11% new 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 822,352 $6.97M <0.01% -8,632 13F-HR Timeline Group DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 811,678 $6.87M 1.75% +88,000 13F-HR Timeline SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 805,445 $6.76M 0.01% +374,213 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 696,037 $5.9M <0.01% +89,001 13F-HR Timeline Group SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 612,173 $5.19M 1.16% +37,615 13F-HR Timeline Group Saturn V Capital Management LP More: the full row for Saturn V Capital Management LP 556,489 $4.71M 1.85% 0 13F-HR Timeline Allostery Investments LP More: the full row for Allostery Investments LP 479,100 $4.06M 7.97% 13F-HR Timeline Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 375,000 $3.18M 0.04% 0 13F-HR/A Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 374,631 $3.17M <0.01% +331,202 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 366,170 $3.1M <0.01% -13,205 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 327,673 $2.78M <0.01% +193,632 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 327,296 $2.77M <0.01% +21,792 13F-HR Timeline Group READYSTATE ASSET MANAGEMENT LP More: the full row for READYSTATE ASSET MANAGEMENT LP 315,700 $2.67M 0.11% +135,700 13F-HR Timeline Rosalind Advisors, Inc. More: the full row for Rosalind Advisors, Inc. 303,864 $2.57M 1.39% 0 13F-HR/A Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 300,000 $2.54M <0.01% -1,119,792 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 289,515 $2.45M <0.01% -7,887 13F-HR/A Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 267,743 $2.27M 0.02% new 13F-HR Timeline Group OCONNOR, A Distinct Business Unit of UB… More: the full row for OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 172,693 $1.46M 0.04% +37,141 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Nan Fung Group Holdings Ltd More: the full row for Nan Fung Group Holdings Ltd 154,522 $1.31M 1.12% 0 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 136,493 $1.16M <0.01% +9,244 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 133,572 $1.13M <0.01% +17,580 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 126,132 $1.07M <0.01% -52,476 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 122,863 $1.04M <0.01% +4,940 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 117,978 $999K <0.01% +103,072 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 110,050 $932K <0.01% +57,356 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 3 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 109,497 $927K +73,338 Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 100,348 $850K <0.01% -10,372 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 98,547 $835K <0.01% -7,064 13F-HR Timeline Group Zimmer Partners, LP More: the full row for Zimmer Partners, LP 95,704 $811K 0.01% 0 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 82,005 $695K <0.01% +15,582 13F-HR Timeline Group Nuveen Asset Management, LLC in group TIAA More: the full row for Nuveen Asset Management, LLC 80,443 $681K <0.01% 0 13F-HR Timeline Group Hennion & Walsh Asset Management, Inc. More: the full row for Hennion & Walsh Asset Management, Inc. 74,827 $634K 0.03% new 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 73,286 $621K <0.01% -16,643 13F-HR Timeline Group PANAGORA ASSET MANAGEMENT INC More: the full row for PANAGORA ASSET MANAGEMENT INC 71,896 $609K <0.01% new 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 69,397 $588K <0.01% +48,889 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 68,062 $576K <0.01% +840 13F-HR/A Timeline Group Birchview Capital, LP More: the full row for Birchview Capital, LP 67,000 $567K 0.46% -15,000 13F-HR/A Timeline STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 65,748 $557K <0.01% +11,280 13F-HR Timeline Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 54,466 $461K <0.01% +10,636 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 53,382 $452K <0.01% new 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 51,156 $433K <0.01% +877 13F-HR/A Timeline Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 41,952 $374K 0.32% 13F-HR Timeline Skandinaviska Enskilda Banken AB (publ) More: the full row for Skandinaviska Enskilda Banken AB (publ) 40,863 $343K <0.01% 0 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 40,020 $339K <0.01% 0 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 36,285 $307K -28,987 Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 35,843 $304K 0.06% +21,700 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 35,841 $304K <0.01% +13,923 13F-HR/A Timeline Group PDT Partners, LLC More: the full row for PDT Partners, LLC 35,201 $298K 0.03% +12,747 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 35,125 $297K 0.01% +33,041 13F-HR Timeline HighVista Strategies LLC More: the full row for HighVista Strategies LLC 33,305 $282K 0.1% 0 13F-HR Timeline EVOKE WEALTH, LLC More: the full row for EVOKE WEALTH, LLC 32,363 $274K 0.01% 0 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 31,573 $267K 0.02% new 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 23,009 $195K -1,139 Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 21,260 $180K <0.01% -1,350 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 20,804 $176K <0.01% +144 13F-HR/A Timeline Group GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 20,227 $171K 0.01% +16,727 13F-HR/A Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 20,165 $171K <0.01% +4,543 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 19,152 $162K <0.01% -3,137 13F-HR Timeline Group Rathbones Group PLC More: the full row for Rathbones Group PLC 19,022 $161K <0.01% 0 13F-HR Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 17,700 $150K 0.02% +2,588 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 17,204 $146K <0.01% +6,349 13F-HR Timeline Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 16,945 $144K <0.01% -3,682 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 15,640 $132K <0.01% +1,083 13F-HR Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 14,508 $123K <0.01% +1,319 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 14,193 $120K <0.01% -709 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 13,839 $118K <0.01% +722 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 12,390 $105K <0.01% -931 13F-HR/A Timeline Group ProShare Advisors LLC More: the full row for ProShare Advisors LLC 11,906 $101K <0.01% new 13F-HR Timeline Nebula Research & Development LLC More: the full row for Nebula Research & Development LLC 11,579 $98.1K 0.01% new 13F-HR Timeline EntryPoint Capital, LLC More: the full row for EntryPoint Capital, LLC 11,509 $97.5K 0.04% -12,813 13F-HR Timeline IRONWOOD INVESTMENT MANAGEMENT LLC More: the full row for IRONWOOD INVESTMENT MANAGEMENT LLC 11,488 $97.3K 0.05% 0 13F-HR Timeline SYON CAPITAL LLC More: the full row for SYON CAPITAL LLC 10,993 $93.1K 0.01% new 13F-HR Timeline PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 10,762 $91.2K <0.01% new 13F-HR Timeline Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 10,479 $88.8K <0.01% new 13F-HR Timeline ALGERT GLOBAL LLC More: the full row for ALGERT GLOBAL LLC 10,360 $87.7K <0.01% new 13F-HR/A Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 10,329 $87.5K 0.01% +2,043 13F-HR Timeline Martin Worley Group More: the full row for Martin Worley Group 10,168 $86.1K 0.05% 13F-HR Timeline AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 10,072 $85.3K <0.01% -24,651 13F-HR Timeline Group Choate Investment Advisors More: the full row for Choate Investment Advisors 10,000 $84.7K <0.01% 0 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 9,964 $84.4K <0.01% 0 13F-HR/A Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 8,144 $69K <0.01% +1,494 13F-HR Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 7,695 $65.2K <0.01% 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 6,327 $53.6K <0.01% +5,502 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 6,252 $53K <0.01% -37,044 13F-HR Timeline Group Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 5,188 $43.9K <0.01% new 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 4,339 $36.8K <0.01% -26 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 3,731 $31.6K <0.01% 0 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 2,511 $21.3K <0.01% -342 13F-HR/A Timeline 1620 INVESTMENT ADVISORS, INC. More: the full row for 1620 INVESTMENT ADVISORS, INC. 1,590 $13.5K 0.01% 0 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 1,164 $9.86K <0.01% -247 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 1,065 $9K <0.01% 0 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,023 $8.66K <0.01% 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 699 $6K <0.01% -3,294 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 664 $5.62K <0.01% +605 13F-HR Timeline COMERICA BANK More: the full row for COMERICA BANK 519 $4.4K <0.01% -133 13F-HR/A Timeline Wilmington Savings Fund Society, FSB More: the full row for Wilmington Savings Fund Society, FSB 415 $3.52K <0.01% new 13F-HR Timeline Smartleaf Asset Management LLC More: the full row for Smartleaf Asset Management LLC 306 $2.57K <0.01% 0 13F-HR Timeline Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 166 $1.41K <0.01% new 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 157 $1.33K <0.01% 13F-HR/A Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 154 $1K <0.01% 0 13F-HR Timeline Group Creative Planning in group Creative Planning More: the full row for Creative Planning 113 $957 <0.01% new 13F-HR Timeline Group R Squared Ltd More: the full row for R Squared Ltd 110 $932 <0.01% 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 103 $872 <0.01% +35 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 94 $796 <0.01% 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 81 $686 <0.01% -242 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 41 $347 <0.01% +2 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 21 $178 <0.01% new 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 19 $161 <0.01% 0 13F-HR Timeline Group ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 15 $127 <0.01% -25 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 4 $34 <0.01% new 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 36 $0 0% +15 13F-HR Timeline Group Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.