Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 6,703,985 $77.4M 6.58% +454,254 13F-HR Timeline TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 4,941,798 $57M 3.15% +47,951 13F-HR Timeline Group MONTANOVA CAPITAL, LLC More: the full row for MONTANOVA CAPITAL, LLC 4,913,012 $56.7M 2.29% 0 13F-HR Timeline Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 4,887,867 $56.4M 2.58% 0 13F-HR Timeline Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 4,751,292 $54.8M 3.92% -18,708 13F-HR Timeline Capital World Investors More: the full row for Capital World Investors 3,177,587 $36.7M 0.01% -196,477 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 3,151,735 $36.4M <0.01% +287,739 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 2,298,598 $26.5M <0.01% +43,355 13F-HR Timeline Group SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 1,698,984 $19.6M 4.1% +1,086,811 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 1,617,469 $18.7M 0.12% +329,068 13F-HR Timeline EMERALD ADVISERS, LLC group of 2 filers holding More: the full row for EMERALD ADVISERS, LLC 1,506,403 $17.4M +120,665 Timeline Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 1,370,000 $15.8M 3.11% 0 13F-HR/A Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,093,643 $12.6M <0.01% -297,220 13F-HR Timeline Group GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 1,014,367 $11.7M 6.36% -772,636 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 915,241 $10.6M <0.01% +92,889 13F-HR Timeline Group SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 868,011 $10.4M 0.01% +62,566 13F-HR Timeline Parkman Healthcare Partners LLC More: the full row for Parkman Healthcare Partners LLC 753,752 $8.7M 1.03% new 13F-HR Timeline DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 752,359 $8.68M 2.46% -59,319 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 645,993 $7.46M <0.01% -50,044 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 581,746 $6.71M 0.05% new 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 507,703 $5.86M <0.01% +133,072 13F-HR Timeline Group Allostery Investments LP More: the full row for Allostery Investments LP 458,302 $5.29M 7.63% -20,798 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 37,321 $4.93M <0.01% 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 402,504 $4.64M <0.01% +381,244 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 387,562 $4.47M <0.01% +21,392 13F-HR Timeline Group STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 386,837 $4.46M 1.43% -605,966 13F-HR Timeline Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 375,000 $4.33M 0.07% 0 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 339,936 $3.92M <0.01% +12,263 13F-HR/A Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 308,247 $3.56M <0.01% +198,197 13F-HR Timeline Group Rosalind Advisors, Inc. More: the full row for Rosalind Advisors, Inc. 303,864 $3.51M 1.71% 0 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 276,000 $3.19M 0.01% -24,000 13F-HR Timeline Group Saturn V Capital Management LP More: the full row for Saturn V Capital Management LP 255,060 $2.94M 1.49% -301,429 13F-HR Timeline Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 249,161 $2.88M 0.03% -18,582 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 223,789 $2.58M <0.01% -65,726 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 198,205 $2.29M <0.01% new 13F-HR Timeline Group OCONNOR, A Distinct Business Unit of UB… More: the full row for OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 169,692 $1.96M 0.05% -3,001 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. EARNED WEALTH ADVISORS, LLC More: the full row for EARNED WEALTH ADVISORS, LLC 3,845 $1.8M 0.4% new 13F-HR Timeline Nan Fung Group Holdings Ltd More: the full row for Nan Fung Group Holdings Ltd 154,522 $1.78M 1.45% 0 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 148,227 $1.71M <0.01% -179,069 13F-HR Timeline Group DIADEMA PARTNERS LP More: the full row for DIADEMA PARTNERS LP 135,509 $1.56M 1.25% new 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 126,268 $1.46M <0.01% +3,405 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 113,124 $1.31M <0.01% +12,776 13F-HR/A Timeline Group Hennion & Walsh Asset Management, Inc. More: the full row for Hennion & Walsh Asset Management, Inc. 111,106 $1.28M 0.06% +36,279 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 103,530 $1.19M <0.01% +4,983 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 95,311 $1.1M -14,186 Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 82,896 $957K <0.01% +891 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 80,965 $934K <0.01% -37,013 13F-HR Timeline Group PANAGORA ASSET MANAGEMENT INC More: the full row for PANAGORA ASSET MANAGEMENT INC 71,896 $830K <0.01% 0 13F-HR Timeline Birchview Capital, LP More: the full row for Birchview Capital, LP 67,002 $773K 0.67% +2 13F-HR Timeline STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 61,043 $704K <0.01% -4,705 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 55,975 $646K <0.01% new 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 55,227 $637K <0.01% -12,835 13F-HR/A Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 53,028 $612K <0.01% -80,544 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 52,918 $611K <0.01% +1,762 13F-HR/A Timeline F/m Investments LLC More: the full row for F/m Investments LLC 50,097 $578K 0.02% new 13F-HR Timeline Skandinaviska Enskilda Banken AB (publ) More: the full row for Skandinaviska Enskilda Banken AB (publ) 40,863 $471K <0.01% 0 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 40,072 $462K <0.01% -13,310 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 40,020 $462K <0.01% 0 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 39,804 $459K <0.01% +24,164 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 35,743 $412K 0.08% -100 13F-HR Timeline Group Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 34,098 $393K 0.35% -7,854 13F-HR Timeline HighVista Strategies LLC More: the full row for HighVista Strategies LLC 33,305 $384K 0.15% 0 13F-HR Timeline EVOKE WEALTH, LLC More: the full row for EVOKE WEALTH, LLC 32,446 $374K 0.01% +83 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 32,126 $371K <0.01% -3,715 13F-HR Timeline Group Creative Planning in group Creative Planning More: the full row for Creative Planning 27,807 $321K <0.01% +27,694 13F-HR Timeline Group Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 26,269 $303K <0.01% -28,197 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 25,965 $301K +2,956 Timeline Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 25,842 $298K 0.01% new 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 25,720 $297K <0.01% -47,566 13F-HR Timeline Group PDT Partners, LLC More: the full row for PDT Partners, LLC 23,654 $273K 0.02% -11,547 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 22,862 $264K <0.01% +2,697 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 21,688 $250K <0.01% +2,536 13F-HR Timeline Group Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 21,550 $249K 0.24% new 13F-HR Timeline Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 19,094 $220K <0.01% +2,149 13F-HR Timeline Group Rathbones Group PLC More: the full row for Rathbones Group PLC 19,022 $220K <0.01% 0 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 17,888 $206K <0.01% +684 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 16,823 $195K <0.01% +2,984 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 13,808 $159K <0.01% -385 13F-HR Timeline Group IRONWOOD INVESTMENT MANAGEMENT LLC More: the full row for IRONWOOD INVESTMENT MANAGEMENT LLC 11,488 $133K 0.07% 0 13F-HR Timeline IEQ CAPITAL, LLC More: the full row for IEQ CAPITAL, LLC 10,915 $126K <0.01% new 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 10,666 $123K <0.01% -1,240 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 10,239 $118K <0.01% -2,151 13F-HR/A Timeline Group Martin Worley Group More: the full row for Martin Worley Group 10,168 $117K 0.07% 0 13F-HR Timeline Choate Investment Advisors More: the full row for Choate Investment Advisors 10,000 $115K <0.01% 0 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 9,964 $115K <0.01% 0 13F-HR/A Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 9,912 $114K 0.01% -417 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 8,540 $98.6K <0.01% +396 13F-HR Timeline Group Quarry LP More: the full row for Quarry LP 8,400 $96.9K 0.02% new 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 7,695 $88.8K <0.01% 0 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 4,585 $53K <0.01% +4,549 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 4,557 $52.6K <0.01% +218 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 3,731 $43.1K <0.01% 0 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 2,749 $31.7K <0.01% -3,503 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 2,511 $29K <0.01% 0 13F-HR Timeline 1620 INVESTMENT ADVISORS, INC. More: the full row for 1620 INVESTMENT ADVISORS, INC. 1,590 $18.3K 0.01% 0 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 1,343 $15K <0.01% +278 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 1,287 $14.9K <0.01% +1,184 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,247 $14.4K <0.01% +224 13F-HR Timeline Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 979 $11.3K <0.01% +813 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 879 $10.1K <0.01% -5,448 13F-HR Timeline Group COMERICA BANK More: the full row for COMERICA BANK 711 $8.21K <0.01% +192 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 570 $6.58K <0.01% new 13F-HR Timeline Group Wilmington Savings Fund Society, FSB More: the full row for Wilmington Savings Fund Society, FSB 415 $4.79K <0.01% 0 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 384 $4.43K <0.01% -280 13F-HR/A Timeline Brooklyn Investment Group More: the full row for Brooklyn Investment Group 347 $4K <0.01% new 13F-HR Timeline QUADRANT CAPITAL GROUP LLC More: the full row for QUADRANT CAPITAL GROUP LLC 337 $3.89K <0.01% new 13F-HR Timeline Smartleaf Asset Management LLC More: the full row for Smartleaf Asset Management LLC 279 $3.33K <0.01% -27 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 268 $3.09K <0.01% +187 13F-HR Timeline Lindbrook Capital, LLC More: the full row for Lindbrook Capital, LLC 265 $3.06K <0.01% new 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 196 $2.19K <0.01% new 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 154 $2K <0.01% 0 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 151 $2K <0.01% -548 13F-HR/A Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 157 $1.81K <0.01% 0 13F-HR Timeline Larson Financial Group LLC More: the full row for Larson Financial Group LLC 144 $1.66K <0.01% new 13F-HR Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 144 $1.66K <0.01% new 13F-HR Timeline CIBC Private Wealth Group LLC in group CIBC Bancorp USA Inc. More: the full row for CIBC Private Wealth Group LLC 160 $1.65K <0.01% new 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 137 $1.58K <0.01% +118 13F-HR Timeline Group ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 105 $1.21K <0.01% +90 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 102 $1.18K <0.01% +81 13F-HR Timeline Group SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 94 $1.08K <0.01% 0 13F-HR Timeline COLDSTREAM CAPITAL MANAGEMENT INC More: the full row for COLDSTREAM CAPITAL MANAGEMENT INC 69 $797 <0.01% new 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 41 $473 <0.01% 0 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 31 $400 <0.01% new 13F-HR Timeline Stephens Consulting, LLC More: the full row for Stephens Consulting, LLC 30 $347 <0.01% new 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 4 $46 <0.01% 0 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.