T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 21,459,156 $225M 0.14% +2,075,987 13F-HR/A Timeline BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 12,094,094 $127M 0.74% 0 13F-HR Timeline Group RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 11,433,354 $120M 1.2% +2,617,737 13F-HR Timeline MONTANOVA CAPITAL, LLC More: the full row for MONTANOVA CAPITAL, LLC 11,190,129 $117M 2.93% -840,000 13F-HR Timeline PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 10,383,456 $109M 2% +1,000,000 13F-HR Timeline Group Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 6,125,000 $64.3M 2.36% -225,000 13F-HR Timeline Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 5,059,551 $53.1M 0.44% +3,864,636 13F-HR Timeline Group Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 3,435,542 $36.1M 1.56% +1,207,705 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 2,089,796 $21.9M <0.01% -115,525 13F-HR/A Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 1,754,181 $18.4M 0.03% +1,635,992 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,714,961 $18M 0.01% +1,111,806 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 1,635,231 $17.2M <0.01% +122,990 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 1,000,597 $10.5M 0.04% -841,005 13F-HR Timeline Lynx1 Capital Management LP in group Lynx1 Capital Management LP More: the full row for Lynx1 Capital Management LP 921,950 $9.68M 1.96% new 13F-HR Timeline Group SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 861,105 $9.04M 1.89% +278,000 13F-HR Timeline Group Alyeska Investment Group, L.P. in group Alyeska Investment Group, L.P. More: the full row for Alyeska Investment Group, L.P. 789,163 $8.29M 0.02% +489,163 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 748,035 $7.86M <0.01% +23,228 13F-HR Timeline Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 714,569 $7.5M 0.01% -74,877 13F-HR Timeline Group UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT… More: the full row for UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO 697,431 $7.32M 1.04% 0 13F-HR Timeline STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 610,308 $6.41M 1.1% new 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 592,428 $6.22M 0.01% new 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 563,463 $5.92M <0.01% +214,084 13F-HR Timeline Group Caption Management, LLC More: the full row for Caption Management, LLC 550,891 $5.78M 0.26% new 13F-HR Timeline WASATCH ADVISORS LP More: the full row for WASATCH ADVISORS LP 515,128 $5.41M 0.03% -203,769 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 500,724 $5.26M <0.01% +116,920 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 444,658 $4.67M <0.01% +226,157 13F-HR Timeline Group SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 402,352 $4.05M <0.01% -25,642 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 323,023 $3.39M <0.01% +132,264 13F-HR/A Timeline Group DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 261,138 $2.74M 0.64% +26,138 13F-HR Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 208,456 $2.19M <0.01% new 13F-HR Timeline Verition Fund Management LLC More: the full row for Verition Fund Management LLC 206,568 $2.17M 0.01% +161,366 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 203,449 $2.14M <0.01% -11,112 13F-HR Timeline Group Monashee Investment Management LLC More: the full row for Monashee Investment Management LLC 160,336 $1.68M 0.95% new 13F-HR Timeline Burkehill Global Management, LP More: the full row for Burkehill Global Management, LP 150,000 $1.57M 0.1% new 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 147,328 $1.55M <0.01% -7,425 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 146,972 $1.54M <0.01% +11,015 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 134,763 $1.42M <0.01% +66,031 13F-HR Timeline Group MYDA Advisors LLC More: the full row for MYDA Advisors LLC 120,000 $1.26M 0.35% 0 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 116,646 $1.22M <0.01% -5,864 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 110,082 $1.16M 0.01% new 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 104,929 $1.1M <0.01% new 13F-HR Timeline Group SummitTX Capital, L.P. More: the full row for SummitTX Capital, L.P. 96,784 $1.02M 0.03% +52,318 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 83,122 $873K <0.01% -638,744 13F-HR Timeline Group Ishara Investments LP More: the full row for Ishara Investments LP 80,000 $840K 0.98% 13F-HR Timeline SECTORAL ASSET MANAGEMENT INC More: the full row for SECTORAL ASSET MANAGEMENT INC 63,015 $662K 0.53% -497,479 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 56,367 $592K <0.01% new 13F-HR Timeline Group TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 54,720 $575K <0.01% new 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 55,300 $557K <0.01% +8,500 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 50,868 $534K 0.01% new 13F-HR Timeline Group Vanguard Personalized Indexing Manageme… in group VANGUARD GROUP INC More: the full row for Vanguard Personalized Indexing Management, LLC 49,374 $518K 0.01% +1,739 13F-HR Timeline Group Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 48,569 $510K 0.07% -827 13F-HR Timeline Group Longaeva Partners L.P. More: the full row for Longaeva Partners L.P. 44,601 $468K 0.06% new 13F-HR Timeline MERCER GLOBAL ADVISORS INC /ADV More: the full row for MERCER GLOBAL ADVISORS INC /ADV 29,987 $315K <0.01% 0 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 28,185 $296K <0.01% +2,874 13F-HR Timeline Group Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 26,497 $278K 0.08% +7,965 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 25,554 $268K <0.01% -210,969 13F-HR Timeline Group J. Goldman & Co LP More: the full row for J. Goldman & Co LP 22,788 $239K 0.01% 0 13F-HR Timeline Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 20,220 $212K 0.01% new 13F-HR Timeline Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 19,630 $206K 0.01% new 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 17,024 $179K <0.01% -430 13F-HR Timeline Group Mitsubishi UFJ Asset Management Co., Lt… in group Mitsubishi UFJ Trust & Bankin… More: the full row for Mitsubishi UFJ Asset Management Co., Ltd. 16,955 $177K <0.01% -15,003 13F-HR Timeline Group GUGGENHEIM CAPITAL LLC in group GUGGENHEIM CAPITAL LLC More: the full row for GUGGENHEIM CAPITAL LLC 16,402 $172K <0.01% +124 13F-HR Timeline Group Pale Fire Capital SE in group Pale Fire Capital More: the full row for Pale Fire Capital SE 16,272 $171K 0.02% -17,998 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 13,546 $142K <0.01% +5,524 13F-HR Timeline Group Mariner, LLC in group Mariner, LLC More: the full row for Mariner, LLC 13,405 $141K <0.01% -145 13F-HR Timeline Group FOX RUN MANAGEMENT, L.L.C. More: the full row for FOX RUN MANAGEMENT, L.L.C. 12,307 $129K 0.02% new 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 11,234 $118K <0.01% -208 13F-HR Timeline Group Quarry LP More: the full row for Quarry LP 8,001 $84K 0.01% new 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 5,175 $54.3K <0.01% -162 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 651 $6.84K <0.01% +637 13F-HR Timeline Group Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 528 $5.54K <0.01% +193 13F-HR Timeline NewEdge Advisors, LLC More: the full row for NewEdge Advisors, LLC 100 $1.05K <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 25 $263 <0.01% 0 13F-HR Timeline Clearstead Advisors, LLC More: the full row for Clearstead Advisors, LLC 25 $261 <0.01% new 13F-HR Timeline HUNTINGTON NATIONAL BANK in group HUNTINGTON NATIONAL BANK More: the full row for HUNTINGTON NATIONAL BANK 1 $11 <0.01% 0 13F-HR Timeline Group