T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 21,652,162 $213M 0.15% +193,006 13F-HR Timeline RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 12,869,340 $127M 1.26% +1,435,986 13F-HR Timeline MONTANOVA CAPITAL, LLC More: the full row for MONTANOVA CAPITAL, LLC 11,190,129 $110M 2.99% 0 13F-HR Timeline BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 10,916,693 $107M 0.62% -1,177,401 13F-HR Timeline Group PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 10,383,456 $102M 2.02% 0 13F-HR/A Timeline Group TORONTO DOMINION BANK in group TORONTO DOMINION BANK More: the full row for TORONTO DOMINION BANK 7,436,342 $73.2M 0.14% new 13F-HR Timeline Group Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 6,175,000 $60.8M 1.7% +50,000 13F-HR Timeline Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 5,059,551 $49.8M 0.61% 0 13F-HR Timeline Group Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 3,630,454 $35.7M 1.79% +194,912 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 2,149,082 $21.1M <0.01% +59,286 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,851,963 $18.2M 0.01% +137,002 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 1,561,892 $15.4M <0.01% -73,339 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 1,493,800 $14.7M 0.03% -260,381 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 1,000,597 $9.85M 0.04% 0 13F-HR/A Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 982,864 $9.67M 0.02% +390,436 13F-HR Timeline Group Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 820,717 $8.08M 0.01% +106,148 13F-HR Timeline Group Longaeva Partners L.P. More: the full row for Longaeva Partners L.P. 780,967 $7.68M 0.37% +736,366 13F-HR Timeline UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT… More: the full row for UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO 697,431 $6.86M 1% 0 13F-HR Timeline SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 696,105 $6.85M 1.18% -165,000 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 652,170 $6.42M <0.01% -95,865 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 470,444 $4.63M <0.01% -30,280 13F-HR Timeline WASATCH ADVISORS LP More: the full row for WASATCH ADVISORS LP 464,823 $4.57M 0.03% -50,305 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 456,998 $4.5M <0.01% +12,340 13F-HR Timeline Group SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 402,352 $3.74M <0.01% 0 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 366,772 $3.61M 0.01% +219,444 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 261,007 $2.57M <0.01% -302,456 13F-HR Timeline Group Atom Investors LP More: the full row for Atom Investors LP 254,140 $2.5M 0.18% new 13F-HR Timeline Troluce Capital Advisors LLC More: the full row for Troluce Capital Advisors LLC 250,000 $2.46M 0.26% new 13F-HR Timeline DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 225,860 $2.22M 0.51% -35,278 13F-HR Timeline Lynx1 Capital Management LP in group Lynx1 Capital Management LP More: the full row for Lynx1 Capital Management LP 216,973 $2.14M 0.34% -704,977 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 215,978 $2.13M <0.01% -107,045 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 215,721 $2.12M <0.01% +132,599 13F-HR Timeline Group Tidal Investments LLC in group Tidal Investments LLC More: the full row for Tidal Investments LLC 170,389 $1.68M 0.01% new 13F-HR Timeline Group Ishara Investments LP More: the full row for Ishara Investments LP 153,750 $1.51M 1.53% +73,750 13F-HR Timeline SummitTX Capital, L.P. More: the full row for SummitTX Capital, L.P. 151,112 $1.49M 0.05% +54,328 13F-HR Timeline Burkehill Global Management, LP More: the full row for Burkehill Global Management, LP 150,000 $1.48M 0.07% 0 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 134,277 $1.32M <0.01% -486 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 140,465 $1.31M <0.01% -6,507 13F-HR/A Timeline Group MYDA Advisors LLC More: the full row for MYDA Advisors LLC 120,000 $1.18M 0.28% 0 13F-HR Timeline ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 109,138 $1.07M 0.01% -944 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 104,023 $1.02M <0.01% -12,623 13F-HR Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 99,441 $978K <0.01% -109,015 13F-HR Timeline Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 75,427 $742K 0.01% new 13F-HR Timeline SECTORAL ASSET MANAGEMENT INC More: the full row for SECTORAL ASSET MANAGEMENT INC 66,830 $693K 0.57% +3,815 13F-HR Timeline TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 67,048 $660K <0.01% +12,328 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 64,654 $636K <0.01% +36,469 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 60,914 $599K <0.01% +4,547 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 55,300 $544K <0.01% 0 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 50,165 $494K <0.01% new 13F-HR Timeline Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 48,569 $478K 0.07% 0 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 48,339 $476K 0.01% -2,529 13F-HR Timeline Group Vanguard Personalized Indexing Manageme… in group VANGUARD GROUP INC More: the full row for Vanguard Personalized Indexing Management, LLC 44,890 $442K <0.01% -4,484 13F-HR Timeline Group Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 40,248 $396K <0.01% new 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 36,442 $359K <0.01% -167,007 13F-HR Timeline Group Prime Capital Investment Advisors, LLC More: the full row for Prime Capital Investment Advisors, LLC 30,000 $295K <0.01% new 13F-HR Timeline MERCER GLOBAL ADVISORS INC /ADV More: the full row for MERCER GLOBAL ADVISORS INC /ADV 29,987 $295K <0.01% 0 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 27,159 $267K 0.07% +662 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 26,600 $262K <0.01% +1,046 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 25,394 $250K <0.01% +11,848 13F-HR Timeline Group Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 25,169 $248K 0.01% +5,539 13F-HR Timeline Robeco Institutional Asset Management B… in group Robeco Institutional Asset Ma… More: the full row for Robeco Institutional Asset Management B.V. 24,034 $236K <0.01% new 13F-HR Timeline Group J. Goldman & Co LP More: the full row for J. Goldman & Co LP 22,788 $224K 0.01% 0 13F-HR Timeline Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 21,173 $208K 0.01% +953 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 21,094 $208K <0.01% new 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 18,943 $186K <0.01% -85,986 13F-HR Timeline Group Quarry LP More: the full row for Quarry LP 18,750 $184K 0.04% +10,749 13F-HR Timeline GUGGENHEIM CAPITAL LLC in group GUGGENHEIM CAPITAL LLC More: the full row for GUGGENHEIM CAPITAL LLC 16,583 $163K <0.01% +181 13F-HR Timeline Group Mitsubishi UFJ Asset Management Co., Lt… in group Mitsubishi UFJ Trust & Bankin… More: the full row for Mitsubishi UFJ Asset Management Co., Ltd. 16,546 $163K <0.01% -409 13F-HR Timeline Group Pale Fire Capital SE in group Pale Fire Capital More: the full row for Pale Fire Capital SE 16,272 $160K 0.01% 0 13F-HR Timeline Group FOX RUN MANAGEMENT, L.L.C. More: the full row for FOX RUN MANAGEMENT, L.L.C. 16,957 $158K 0.03% +4,650 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 14,293 $141K <0.01% +3,059 13F-HR Timeline Group Mariner, LLC in group Mariner, LLC More: the full row for Mariner, LLC 13,453 $132K <0.01% +48 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 5,175 $50.9K <0.01% 0 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 4,891 $48.1K <0.01% new 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 2,232 $22K <0.01% new 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 866 $8.52K <0.01% new 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 464 $4.57K <0.01% -187 13F-HR/A Timeline Group Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 335 $3.35K <0.01% -193 13F-HR Timeline Quantbot Technologies LP More: the full row for Quantbot Technologies LP 191 $1.88K <0.01% new 13F-HR Timeline NewEdge Advisors, LLC More: the full row for NewEdge Advisors, LLC 100 $984 <0.01% 0 13F-HR/A Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 52 $512 <0.01% new 13F-HR/A Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 25 $246 <0.01% 0 13F-HR Timeline Clearstead Advisors, LLC More: the full row for Clearstead Advisors, LLC 25 $244 <0.01% 0 13F-HR Timeline HUNTINGTON NATIONAL BANK in group HUNTINGTON NATIONAL BANK More: the full row for HUNTINGTON NATIONAL BANK 1 $10 <0.01% 0 13F-HR Timeline Group