Opaleye Management Inc. More: the full row for Opaleye Management Inc. 2,860,000 $62.1M 8.79% 0 13F-HR Timeline EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 2,030,544 $44.1M 2.12% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,704,361 $37M <0.01% +172,650 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 1,344,115 $29.2M <0.01% +31,942 13F-HR Timeline Group Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 1,175,951 $25.6M 1.58% 0 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 586,046 $12.7M <0.01% +76,478 13F-HR/A Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 574,030 $12.5M <0.01% -18,835 13F-HR Timeline Group National Philanthropic Trust More: the full row for National Philanthropic Trust 492,112 $10.7M 0.12% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 479,193 $10.4M <0.01% +474,128 13F-HR Timeline Group Westside Investment Management, Inc. More: the full row for Westside Investment Management, Inc. 472,540 $10.3M 1.64% -250 13F-HR Timeline CANNELL CAPITAL LLC More: the full row for CANNELL CAPITAL LLC 455,405 $9.9M 2.6% +67,230 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 455,321 $9.89M +139,869 Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 438,445 $9.53M <0.01% +115,251 13F-HR Timeline Group THOMPSON SIEGEL & WALMSLEY LLC More: the full row for THOMPSON SIEGEL & WALMSLEY LLC 418,566 $9.1M 0.15% +37,301 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 351,417 $7.64M <0.01% +108,837 13F-HR/A Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 324,621 $7.05M 0.01% -81,279 13F-HR Timeline Divisadero Street Capital Management, LP in group Divisadero Street Capital Man… More: the full row for Divisadero Street Capital Management, LP 298,000 $6.48M 0.3% -199,716 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 245,051 $5.32M <0.01% -17,160 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 229,790 $4.99M <0.01% +142,094 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 220,361 $4.79M <0.01% +7,877 13F-HR Timeline Group Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 200,000 $4.35M 0.23% -85,000 13F-HR Timeline OBERWEIS ASSET MANAGEMENT INC/ More: the full row for OBERWEIS ASSET MANAGEMENT INC/ 192,360 $4.18M 0.16% new 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 190,164 $4.13M <0.01% +80,785 13F-HR Timeline Group Lumbard & Kellner, LLC More: the full row for Lumbard & Kellner, LLC 176,300 $3.83M 1.41% new 13F-HR Timeline Aristides Capital LLC More: the full row for Aristides Capital LLC 167,587 $3.64M 1.07% 0 13F-HR Timeline SUMMIT WEALTH GROUP LLC / CO More: the full row for SUMMIT WEALTH GROUP LLC / CO 25,999 $3.33M 0.35% new 13F-HR Timeline Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 143,811 $3.13M 0.01% -78,272 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 129,182 $2.81M <0.01% +1,838 13F-HR Timeline Group Apis Capital Advisors, LLC More: the full row for Apis Capital Advisors, LLC 117,600 $2.56M 0.56% +11,600 13F-HR Timeline BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 109,020 $2.37M 0.05% -26,250 13F-HR Timeline Diametric Capital, LP More: the full row for Diametric Capital, LP 99,309 $2.16M 0.8% +14,451 13F-HR Timeline Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 88,440 $1.92M 0.02% new 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 88,219 $1.92M <0.01% +59,006 13F-HR Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 87,082 $1.89M <0.01% -3,333 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 77,274 $1.68M <0.01% -574 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 74,657 $1.62M <0.01% +37,736 13F-HR/A Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 70,944 $1.54M <0.01% new 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 59,645 $1.3M <0.01% -34,151 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 58,917 $1.28M <0.01% 0 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 54,865 $1.19M <0.01% +36,753 13F-HR Timeline Group Informed Momentum Co LLC More: the full row for Informed Momentum Co LLC 52,897 $1.15M 0.13% new 13F-HR Timeline PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 41,873 $910K 0.07% -1,727 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 36,806 $800K <0.01% -8,984 13F-HR/A Timeline Group ANCHOR CAPITAL ADVISORS LLC More: the full row for ANCHOR CAPITAL ADVISORS LLC 36,778 $799K 0.02% -50,883 13F-HR Timeline Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 36,332 $789K 0.01% +482 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 36,124 $785K <0.01% -470 13F-HR Timeline WINTON GROUP Ltd in group WINTON GROUP Ltd More: the full row for WINTON GROUP Ltd 35,304 $767K 0.03% new 13F-HR Timeline Group BLAIR WILLIAM & CO/IL More: the full row for BLAIR WILLIAM & CO/IL 32,400 $704K <0.01% 0 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 30,056 $653K <0.01% -542 13F-HR Timeline Group ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 26,410 $573K <0.01% -366,305 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 24,399 $530K 0.03% new 13F-HR Timeline Group Calamos Advisors LLC in group Calamos Advisors LLC More: the full row for Calamos Advisors LLC 23,634 $514K <0.01% new 13F-HR Timeline Group ESSEX INVESTMENT MANAGEMENT CO LLC More: the full row for ESSEX INVESTMENT MANAGEMENT CO LLC 20,182 $439K 0.07% 0 13F-HR Timeline Hillsdale Investment Management Inc. More: the full row for Hillsdale Investment Management Inc. 18,503 $402K 0.01% -400 13F-HR Timeline NAVELLIER & ASSOCIATES INC More: the full row for NAVELLIER & ASSOCIATES INC 17,494 $380K 0.04% new 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 17,399 $378K <0.01% 0 13F-HR Timeline Group JUNCTURE WEALTH STRATEGIES, LLC More: the full row for JUNCTURE WEALTH STRATEGIES, LLC 16,968 $369K 0.12% new 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 16,709 $363K <0.01% +2,959 13F-HR Timeline Group CHICAGO TRUST Co NA More: the full row for CHICAGO TRUST Co NA 16,700 $363K 0.05% 0 13F-HR Timeline Bridge City Capital, LLC More: the full row for Bridge City Capital, LLC 16,673 $362K 0.1% new 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 15,862 $345K <0.01% new 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 15,537 $338K <0.01% 0 13F-HR Timeline Group PDT Partners, LLC More: the full row for PDT Partners, LLC 14,891 $324K 0.02% 0 13F-HR Timeline Sheets Smith Investment Management More: the full row for Sheets Smith Investment Management 14,842 $323K 0.21% new 13F-HR Timeline GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 14,785 $321K 0.03% new 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 13,524 $294K <0.01% +684 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 13,478 $293K <0.01% 0 13F-HR Timeline Group Man Group plc in group Man Group plc More: the full row for Man Group plc 12,649 $275K <0.01% -11,105 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 12,007 $261K <0.01% -2,031 13F-HR Timeline Group Quantbot Technologies LP More: the full row for Quantbot Technologies LP 11,532 $251K 0.01% -13,701 13F-HR Timeline Quantum Private Wealth, LLC More: the full row for Quantum Private Wealth, LLC 11,500 $250K 0.07% 0 13F-HR Timeline ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 11,377 $247K <0.01% -11,673 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 11,177 $243K <0.01% -891 13F-HR Timeline Voleon Capital Management LP More: the full row for Voleon Capital Management LP 10,950 $238K 0.01% new 13F-HR Timeline PharVision Advisers, LLC More: the full row for PharVision Advisers, LLC 10,535 $229K 0.13% new 13F-HR Timeline NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO in group NORTHWESTERN MUTUAL INVESTMEN… More: the full row for NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 10,000 $217K <0.01% 0 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 9,600 $209K <0.01% new 13F-HR Timeline EntryPoint Capital, LLC More: the full row for EntryPoint Capital, LLC 9,365 $204K 0.08% new 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 8,100 $176K <0.01% 0 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 7,209 $157K <0.01% +1,072 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 5,694 $124K <0.01% +5,239 13F-HR Timeline Group State of Wyoming More: the full row for State of Wyoming 5,440 $118K 0.01% -6,063 13F-HR Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 4,150 $90.2K 0.01% -1,798 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 2,852 $62K <0.01% 0 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 2,167 $47.1K <0.01% -450 13F-HR Timeline Group Quarry LP More: the full row for Quarry LP 1,700 $36.9K 0.01% new 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 1,601 $34.8K <0.01% +1 13F-HR Timeline State of Alaska, Department of Revenue More: the full row for State of Alaska, Department of Revenue 1,421 $30K <0.01% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 1,211 $26.3K <0.01% -7,892 13F-HR Timeline Group Truvestments Capital LLC More: the full row for Truvestments Capital LLC 1,183 $25.7K <0.01% 0 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 971 $21.1K <0.01% -1,587 13F-HR Timeline Group AMALGAMATED BANK More: the full row for AMALGAMATED BANK 876 $19K <0.01% 0 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 762 $16.6K <0.01% new 13F-HR Timeline COMERICA BANK More: the full row for COMERICA BANK 219 $4.76K <0.01% new 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 200 $4.35K <0.01% 0 13F-HR Timeline Group Vermillion & White Wealth Management Gr… More: the full row for Vermillion & White Wealth Management Group, LLC 150 $3.26K <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 128 $2.78K <0.01% +26 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 62 $1.35K <0.01% 0 13F-HR Timeline Advisory Services Network, LLC More: the full row for Advisory Services Network, LLC 50 $1.09K <0.01% new 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 31 $1K <0.01% new 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 17 $369 <0.01% new 13F-HR Timeline Group Arax Advisory Partners More: the full row for Arax Advisory Partners 6 $131 <0.01% new 13F-HR Timeline