Opaleye Management Inc. More: the full row for Opaleye Management Inc. 2,852,070 $37M 8.24% 0 13F-HR Timeline EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 1,939,288 $25.2M 1.5% +109,685 13F-HR Timeline Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 1,175,951 $15.3M 1.26% +57,468 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 1,100,963 $14.3M <0.01% +37,256 13F-HR Timeline Group CANNELL CAPITAL LLC More: the full row for CANNELL CAPITAL LLC 691,367 $8.97M 3.03% +310,044 13F-HR Timeline Westside Investment Management, Inc. More: the full row for Westside Investment Management, Inc. 493,650 $6.41M 1.36% -81,572 13F-HR Timeline National Philanthropic Trust More: the full row for National Philanthropic Trust 492,112 $6.39M 0.1% 0 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 448,804 $5.83M 0.01% +256,478 13F-HR Timeline Group ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 402,428 $5.22M 0.01% +153,923 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 355,929 $4.62M <0.01% +217,042 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 345,360 $4.48M <0.01% +27,735 13F-HR Timeline Group STIFEL FINANCIAL CORP in group STIFEL FINANCIAL CORP More: the full row for STIFEL FINANCIAL CORP 319,990 $4.15M <0.01% new 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 298,248 $3.87M <0.01% +29,602 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 274,000 $3.56M 0.01% +80,900 13F-HR Timeline Aristides Capital LLC More: the full row for Aristides Capital LLC 241,587 $3.14M 1.16% 0 13F-HR Timeline Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 232,532 $3.02M 0.01% +17,654 13F-HR Timeline THOMPSON SIEGEL & WALMSLEY LLC More: the full row for THOMPSON SIEGEL & WALMSLEY LLC 189,863 $2.46M 0.04% +61,824 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 175,220 $2.27M <0.01% +45,341 13F-HR/A Timeline Group PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 169,436 $2.2M 0.22% +145,194 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 147,332 $1.91M <0.01% +134,139 13F-HR Timeline Group Mink Brook Asset Management LLC in group Mink Brook Asset Management L… More: the full row for Mink Brook Asset Management LLC 141,488 $1.84M 1.93% -314,317 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 135,455 $1.76M -26,703 Timeline BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 135,270 $1.76M 0.04% -103,692 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 114,236 $1.48M <0.01% +8,900 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 113,113 $1.47M <0.01% +61,152 13F-HR Timeline Group Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 103,200 $1.34M 0.02% +59,961 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 95,919 $1.25M <0.01% +31,596 13F-HR/A Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 95,748 $1.24M <0.01% -39,604 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 86,848 $1.13M <0.01% -7,333 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 84,450 $1.1M <0.01% -2,507 13F-HR Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 78,213 $1.02M <0.01% +67,170 13F-HR Timeline Group Informed Momentum Co LLC More: the full row for Informed Momentum Co LLC 77,833 $1.01M 0.17% -17,186 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 74,246 $964K <0.01% 0 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 64,795 $841K <0.01% new 13F-HR/A Timeline Group ANCHOR CAPITAL ADVISORS LLC More: the full row for ANCHOR CAPITAL ADVISORS LLC 60,179 $781K 0.02% -253 13F-HR Timeline HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 57,235 $742K <0.01% new 13F-HR Timeline JACOBS LEVY EQUITY MANAGEMENT, INC More: the full row for JACOBS LEVY EQUITY MANAGEMENT, INC 54,275 $704K <0.01% new 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 50,205 $652K <0.01% +38,355 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 44,661 $580K <0.01% -10,225 13F-HR/A Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 39,317 $510K <0.01% +38,967 13F-HR Timeline Group OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 35,300 $458K <0.01% -2,600 13F-HR Timeline BLAIR WILLIAM & CO/IL More: the full row for BLAIR WILLIAM & CO/IL 34,900 $453K <0.01% 0 13F-HR Timeline State of Wyoming More: the full row for State of Wyoming 26,443 $343K 0.05% new 13F-HR Timeline PDT Partners, LLC More: the full row for PDT Partners, LLC 25,755 $334K 0.02% new 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 25,283 $328K <0.01% new 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 24,492 $318K <0.01% new 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 24,213 $314K <0.01% -65,451 13F-HR Timeline Man Group plc in group Man Group plc More: the full row for Man Group plc 22,404 $291K <0.01% new 13F-HR Timeline Group Jain Global LLC More: the full row for Jain Global LLC 22,401 $291K 0.01% new 13F-HR Timeline ESSEX INVESTMENT MANAGEMENT CO LLC More: the full row for ESSEX INVESTMENT MANAGEMENT CO LLC 20,419 $265K 0.06% -4,023 13F-HR Timeline Diametric Capital, LP More: the full row for Diametric Capital, LP 19,597 $254K 0.3% new 13F-HR Timeline Hillsdale Investment Management Inc. More: the full row for Hillsdale Investment Management Inc. 18,983 $246K 0.01% +1,980 13F-HR Timeline ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 17,316 $225K <0.01% -424 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 17,102 $222K <0.01% new 13F-HR Timeline CHICAGO TRUST Co NA More: the full row for CHICAGO TRUST Co NA 16,700 $217K 0.04% 0 13F-HR Timeline Quantessence Capital LLC More: the full row for Quantessence Capital LLC 16,590 $215K 0.05% new 13F-HR Timeline Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 16,303 $212K <0.01% -8,407 13F-HR/A Timeline Group State of Tennessee, Department of Treas… More: the full row for State of Tennessee, Department of Treasury 13,950 $181K <0.01% new 13F-HR Timeline LMR Partners LLP in group LMR Partners LLP More: the full row for LMR Partners LLP 13,574 $176K <0.01% new 13F-HR Timeline Group Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 13,400 $174K 0.01% new 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 13,247 $172K <0.01% +8 13F-HR/A Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 12,440 $161K <0.01% +1,340 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 11,797 $153K 0.01% -2,858 13F-HR Timeline Group Quantum Private Wealth, LLC More: the full row for Quantum Private Wealth, LLC 11,500 $149K 0.06% 0 13F-HR Timeline Cannon Global Investment Management, LLC More: the full row for Cannon Global Investment Management, LLC 11,400 $148K 0.41% new 13F-HR Timeline Point72 Asia (Singapore) Pte. Ltd. More: the full row for Point72 Asia (Singapore) Pte. Ltd. 10,795 $140K 0.04% +234 13F-HR Timeline Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 10,693 $139K <0.01% new 13F-HR Timeline Group Verition Fund Management LLC More: the full row for Verition Fund Management LLC 10,189 $132K <0.01% new 13F-HR Timeline Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 10,000 $130K <0.01% 0 13F-HR Timeline Group Quantbot Technologies LP More: the full row for Quantbot Technologies LP 7,794 $101K <0.01% new 13F-HR Timeline Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 7,499 $97.3K <0.01% new 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 4,472 $58K <0.01% -31,904 13F-HR Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 4,118 $53.5K 0.01% new 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 2,971 $38.6K <0.01% -3,462 13F-HR Timeline Group Point72 (DIFC) Ltd More: the full row for Point72 (DIFC) Ltd 1,800 $23.4K <0.01% +359 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 1,629 $22K <0.01% +877 13F-HR/A Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 1,500 $19.5K <0.01% new 13F-HR/A Timeline Group Truvestments Capital LLC More: the full row for Truvestments Capital LLC 1,183 $15.4K <0.01% 0 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 750 $9.73K <0.01% -250 13F-HR Timeline Group FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 686 $8.9K <0.01% -706 13F-HR Timeline Group GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 634 $8.23K <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 100 $1.3K <0.01% -41 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 77 $999 <0.01% new 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 10 $130 <0.01% new 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 1 $13 <0.01% -21,976 13F-HR Timeline Group CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.