Opaleye Management Inc. More: the full row for Opaleye Management Inc. 2,860,000 $40.8M 8.25% +7,930 13F-HR/A Timeline EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 2,030,544 $28.9M 1.72% +91,256 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,531,711 $21.8M <0.01% +1,186,351 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 1,312,173 $18.7M <0.01% +211,210 13F-HR Timeline Group Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 1,175,951 $16.8M 1.19% 0 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 592,865 $8.45M <0.01% +294,617 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 509,568 $7.26M <0.01% +362,236 13F-HR Timeline Group Divisadero Street Capital Management, LP in group Divisadero Street Capital Man… More: the full row for Divisadero Street Capital Management, LP 497,716 $7.09M 0.47% new 13F-HR Timeline Group National Philanthropic Trust More: the full row for National Philanthropic Trust 492,112 $7.01M 0.09% 0 13F-HR Timeline Westside Investment Management, Inc. More: the full row for Westside Investment Management, Inc. 472,790 $6.74M 1.25% -20,860 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 405,900 $5.78M 0.01% +131,900 13F-HR Timeline ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 392,715 $5.59M 0.01% -9,713 13F-HR Timeline Group CANNELL CAPITAL LLC More: the full row for CANNELL CAPITAL LLC 388,175 $5.53M 1.73% -303,192 13F-HR Timeline THOMPSON SIEGEL & WALMSLEY LLC More: the full row for THOMPSON SIEGEL & WALMSLEY LLC 381,265 $5.43M 0.09% +191,402 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 323,194 $4.61M <0.01% +208,958 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 315,452 $4.5M +179,997 Timeline Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 285,000 $4.06M 0.28% new 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 262,211 $3.74M <0.01% +177,761 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 242,580 $3.46M <0.01% +129,467 13F-HR Timeline Group Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 222,083 $3.16M 0.01% -10,449 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 212,484 $3.03M <0.01% +116,736 13F-HR Timeline Group Aristides Capital LLC More: the full row for Aristides Capital LLC 167,587 $2.39M 0.76% -74,000 13F-HR Timeline BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 135,270 $1.93M 0.05% 0 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 127,344 $1.81M <0.01% +53,098 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 109,379 $1.56M <0.01% -65,841 13F-HR Timeline Group STIFEL FINANCIAL CORP in group STIFEL FINANCIAL CORP More: the full row for STIFEL FINANCIAL CORP 108,168 $1.54M <0.01% -211,822 13F-HR Timeline Group Apis Capital Advisors, LLC More: the full row for Apis Capital Advisors, LLC 106,000 $1.51M 0.54% new 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 93,796 $1.34M <0.01% +29,001 13F-HR/A Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 90,415 $1.29M <0.01% +12,202 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 87,696 $1.25M <0.01% +48,379 13F-HR Timeline Group ANCHOR CAPITAL ADVISORS LLC More: the full row for ANCHOR CAPITAL ADVISORS LLC 87,661 $1.25M 0.04% +27,482 13F-HR Timeline Diametric Capital, LP More: the full row for Diametric Capital, LP 84,858 $1.21M 0.65% +65,261 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 77,848 $1.11M <0.01% +64,601 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 58,917 $840K <0.01% new 13F-HR Timeline Group JACOBS LEVY EQUITY MANAGEMENT, INC More: the full row for JACOBS LEVY EQUITY MANAGEMENT, INC 54,275 $773K <0.01% 0 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 45,790 $653K <0.01% +1,129 13F-HR/A Timeline Group PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 43,600 $621K 0.06% -125,836 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 36,921 $526K <0.01% +24,481 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 36,594 $521K <0.01% new 13F-HR Timeline Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 35,850 $511K 0.01% new 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 34,557 $492K <0.01% -52,291 13F-HR Timeline BLAIR WILLIAM & CO/IL More: the full row for BLAIR WILLIAM & CO/IL 32,400 $462K <0.01% -2,500 13F-HR Timeline BRC Group Holdings, Inc. More: the full row for BRC Group Holdings, Inc. 31,504 $449K 0.5% new 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 30,598 $436K <0.01% -418,206 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 29,213 $416K <0.01% +3,930 13F-HR Timeline Group Quantbot Technologies LP More: the full row for Quantbot Technologies LP 25,233 $360K 0.01% +17,439 13F-HR Timeline Man Group plc in group Man Group plc More: the full row for Man Group plc 23,754 $338K <0.01% +1,350 13F-HR Timeline Group ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 23,050 $328K <0.01% +5,734 13F-HR Timeline Group ESSEX INVESTMENT MANAGEMENT CO LLC More: the full row for ESSEX INVESTMENT MANAGEMENT CO LLC 20,182 $288K 0.05% -237 13F-HR Timeline Hillsdale Investment Management Inc. More: the full row for Hillsdale Investment Management Inc. 18,903 $269K 0.01% -80 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 18,112 $258K <0.01% new 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 17,399 $248K <0.01% new 13F-HR Timeline Group CHICAGO TRUST Co NA More: the full row for CHICAGO TRUST Co NA 16,700 $238K 0.03% 0 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 15,537 $221K <0.01% new 13F-HR Timeline Group Mink Brook Asset Management LLC in group Mink Brook Asset Management L… More: the full row for Mink Brook Asset Management LLC 15,139 $216K 0.19% -126,349 13F-HR Timeline Group PDT Partners, LLC More: the full row for PDT Partners, LLC 14,891 $212K 0.01% -10,864 13F-HR Timeline Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 14,064 $200K <0.01% +6,565 13F-HR Timeline MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 14,038 $200K <0.01% new 13F-HR Timeline Group Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 13,889 $198K <0.01% new 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 13,750 $196K <0.01% +13,000 13F-HR Timeline Group Magnetar Financial LLC in group Magnetar Financial LLC More: the full row for Magnetar Financial LLC 13,731 $196K <0.01% new 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 13,478 $192K <0.01% new 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 12,840 $183K <0.01% new 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 12,068 $172K <0.01% new 13F-HR Timeline State of Tennessee, Department of Treas… More: the full row for State of Tennessee, Department of Treasury 12,000 $171K <0.01% -1,950 13F-HR Timeline State of Wyoming More: the full row for State of Wyoming 11,503 $164K 0.02% -14,940 13F-HR Timeline Quantum Private Wealth, LLC More: the full row for Quantum Private Wealth, LLC 11,500 $164K 0.05% 0 13F-HR Timeline Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 10,991 $157K <0.01% -2,409 13F-HR Timeline NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO in group NORTHWESTERN MUTUAL INVESTMEN… More: the full row for NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 10,000 $142K <0.01% new 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 9,103 $130K <0.01% +9,102 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 8,100 $115K <0.01% new 13F-HR/A Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 6,137 $87.5K <0.01% new 13F-HR Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 5,948 $84.8K 0.01% +1,830 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 5,065 $72K <0.01% +3,436 13F-HR/A Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 2,852 $40.6K <0.01% new 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 2,617 $37.3K <0.01% new 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 2,558 $36.5K <0.01% -413 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 1,600 $22.8K <0.01% new 13F-HR Timeline Truvestments Capital LLC More: the full row for Truvestments Capital LLC 1,183 $16.9K <0.01% 0 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 876 $12K <0.01% new 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 455 $6.48K <0.01% +445 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 433 $6.17K <0.01% +356 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 200 $2.85K <0.01% new 13F-HR/A Timeline Group Vermillion & White Wealth Management Gr… More: the full row for Vermillion & White Wealth Management Group, LLC 150 $2.14K <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 102 $1.45K <0.01% +2 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 62 $884 <0.01% new 13F-HR/A Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.