Opaleye Management Inc. More: the full row for Opaleye Management Inc. 2,860,000 $48.4M 6.38% 0 13F-HR/A Timeline EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 2,030,544 $34.3M 1.57% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,738,907 $29.4M <0.01% +34,546 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 1,348,668 $22.8M <0.01% +4,553 13F-HR Timeline Group Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 1,175,951 $19.9M 1.19% 0 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 565,051 $9.56M <0.01% -8,979 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 501,925 $8.49M <0.01% +63,480 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 493,914 $8.35M <0.01% -92,132 13F-HR/A Timeline Group National Philanthropic Trust More: the full row for National Philanthropic Trust 492,112 $8.32M 0.08% 0 13F-HR Timeline Westside Investment Management, Inc. More: the full row for Westside Investment Management, Inc. 470,940 $7.96M 1.27% -1,600 13F-HR Timeline OBERWEIS ASSET MANAGEMENT INC/ More: the full row for OBERWEIS ASSET MANAGEMENT INC/ 431,300 $7.29M 0.27% +238,940 13F-HR Timeline THOMPSON SIEGEL & WALMSLEY LLC More: the full row for THOMPSON SIEGEL & WALMSLEY LLC 408,541 $6.91M 0.12% -10,025 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 277,458 $4.69M <0.01% +47,668 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 231,849 $3.92M <0.01% -13,202 13F-HR Timeline Group CANNELL CAPITAL LLC More: the full row for CANNELL CAPITAL LLC 216,917 $3.67M 2.34% -238,488 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 205,700 $3.48M 0.01% -118,921 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 196,263 $3.32M <0.01% +6,099 13F-HR/A Timeline Group Diametric Capital, LP More: the full row for Diametric Capital, LP 193,155 $3.27M 0.88% +93,846 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 185,439 $3.14M <0.01% -165,978 13F-HR Timeline Group Lumbard & Kellner, LLC More: the full row for Lumbard & Kellner, LLC 174,944 $2.96M 1.04% -1,356 13F-HR Timeline Aristides Capital LLC More: the full row for Aristides Capital LLC 161,436 $2.73M 0.94% -6,151 13F-HR/A Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 127,700 $2.16M <0.01% -1,482 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 126,674 $2.14M <0.01% -93,687 13F-HR Timeline Group Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 118,300 $2M 0.02% +29,860 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 104,796 $1.77M <0.01% +30,139 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 95,487 $1.61M 0.01% new 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 91,302 $1.54M -364,019 Timeline BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 84,020 $1.42M 0.03% -25,000 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 81,201 $1.37M <0.01% -7,018 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 79,331 $1.34M <0.01% +63,469 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 77,212 $1.31M <0.01% -62 13F-HR Timeline Group Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 76,586 $1.3M <0.01% -67,225 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 74,144 $1.25M <0.01% new 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 58,917 $996K <0.01% 0 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 58,056 $982K <0.01% -12,888 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 51,448 $870K <0.01% +14,642 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 49,694 $840K <0.01% -5,171 13F-HR Timeline Group PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 45,325 $766K 0.06% +3,452 13F-HR Timeline ANCHOR CAPITAL ADVISORS LLC More: the full row for ANCHOR CAPITAL ADVISORS LLC 40,668 $688K 0.02% +3,890 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 32,527 $550K 0.01% +8,128 13F-HR Timeline Group BLAIR WILLIAM & CO/IL More: the full row for BLAIR WILLIAM & CO/IL 32,400 $548K <0.01% 0 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 30,436 $515K <0.01% -5,688 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 28,293 $478K <0.01% +11,584 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 24,615 $416K <0.01% new 13F-HR Timeline Guilbault Capital LLC More: the full row for Guilbault Capital LLC 23,225 $393K 0.44% 13F-HR Timeline Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 22,802 $386K 0.01% -13,530 13F-HR Timeline ESSEX INVESTMENT MANAGEMENT CO LLC More: the full row for ESSEX INVESTMENT MANAGEMENT CO LLC 20,182 $341K 0.05% 0 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 19,691 $333K <0.01% +6,213 13F-HR Timeline Group JUNCTURE WEALTH STRATEGIES, LLC More: the full row for JUNCTURE WEALTH STRATEGIES, LLC 18,996 $321K 0.11% +2,028 13F-HR Timeline Bridge City Capital, LLC More: the full row for Bridge City Capital, LLC 18,600 $315K 0.09% +1,927 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 18,249 $309K <0.01% +850 13F-HR Timeline Group CHICAGO TRUST Co NA More: the full row for CHICAGO TRUST Co NA 16,700 $282K 0.04% 0 13F-HR Timeline LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 14,631 $267K <0.01% new 13F-HR Timeline Voleon Capital Management LP More: the full row for Voleon Capital Management LP 15,582 $263K 0.01% +4,632 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 15,537 $263K <0.01% 0 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 15,369 $260K <0.01% +1,845 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 15,331 $259K <0.01% new 13F-HR Timeline Group PDT Partners, LLC More: the full row for PDT Partners, LLC 14,891 $252K 0.02% 0 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 13,482 $228K <0.01% -46,163 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 13,167 $223K +1,160 Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 12,925 $219K <0.01% new 13F-HR Timeline Group CANADA PENSION PLAN INVESTMENT BOARD More: the full row for CANADA PENSION PLAN INVESTMENT BOARD 12,500 $211K <0.01% new 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 12,421 $210K <0.01% +1,244 13F-HR Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 12,250 $207K <0.01% -74,832 13F-HR Timeline Group Quantum Private Wealth, LLC More: the full row for Quantum Private Wealth, LLC 11,500 $194K 0.06% 0 13F-HR Timeline ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 10,944 $185K <0.01% -433 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 10,551 $178K <0.01% new 13F-HR Timeline Group Man Group plc in group Man Group plc More: the full row for Man Group plc 10,473 $177K <0.01% -2,176 13F-HR Timeline Group NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO in group NORTHWESTERN MUTUAL INVESTMEN… More: the full row for NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 10,000 $169K <0.01% 0 13F-HR/A Timeline Group Quantbot Technologies LP More: the full row for Quantbot Technologies LP 9,357 $158K 0.01% -2,175 13F-HR Timeline State of Wyoming More: the full row for State of Wyoming 8,161 $138K 0.02% +2,721 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 8,100 $137K <0.01% 0 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 7,209 $122K <0.01% 0 13F-HR Timeline State of Alaska, Department of Revenue More: the full row for State of Alaska, Department of Revenue 6,943 $117K <0.01% +5,522 13F-HR Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 6,471 $109K <0.01% new 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 4,370 $73.9K 0.01% new 13F-HR Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 4,149 $70.2K <0.01% -1 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 3,076 $52K <0.01% -2,618 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 2,994 $50.6K <0.01% +2,023 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 2,939 $49.7K 0.01% new 13F-HR/A Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 2,731 $46.2K <0.01% -121 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 2,167 $36.6K <0.01% 0 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 1,578 $26.7K <0.01% -23 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 1,451 $24.5K <0.01% +240 13F-HR Timeline Group Truvestments Capital LLC More: the full row for Truvestments Capital LLC 1,183 $20K <0.01% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 1,018 $17K <0.01% -478,175 13F-HR Timeline Group AMALGAMATED BANK More: the full row for AMALGAMATED BANK 805 $14K <0.01% -71 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 527 $8.91K <0.01% new 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 500 $8.46K <0.01% -262 13F-HR Timeline JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 221 $3.74K <0.01% new 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 200 $3.38K <0.01% 0 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 167 $2.82K <0.01% +105 13F-HR Timeline Vermillion & White Wealth Management Gr… More: the full row for Vermillion & White Wealth Management Group, LLC 150 $2.54K <0.01% 0 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 146 $2.47K <0.01% new 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 89 $2K <0.01% new 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 54 $913 <0.01% new 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 51 $862 <0.01% +34 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 23 $389 <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 10 $169 <0.01% -118 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 7 $119 <0.01% new 13F-HR Timeline Hughes Financial Services, LLC More: the full row for Hughes Financial Services, LLC 1 $17 <0.01% new 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 26 $0 0% -5 13F-HR Timeline Group Value filed as zero, left out of ratios.