Opaleye Management Inc. More: the full row for Opaleye Management Inc. 2,860,000 $70.6M 9.3% 0 13F-HR Timeline EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 2,171,938 $53.6M 2.29% +141,394 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,717,286 $42.4M <0.01% -21,621 13F-HR Timeline Group VANGUARD GROUP INC group of 4 filers holding More: the full row for VANGUARD GROUP INC 1,319,543 $32.6M new Timeline Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 1,175,951 $29M 1.81% 0 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 577,666 $14.3M <0.01% +12,615 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 530,215 $13.1M <0.01% +28,290 13F-HR Timeline Group National Philanthropic Trust More: the full row for National Philanthropic Trust 492,112 $12.1M 0.13% 0 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 477,957 $11.8M <0.01% -15,957 13F-HR Timeline Group Westside Investment Management, Inc. More: the full row for Westside Investment Management, Inc. 467,915 $11.5M 1.77% -3,025 13F-HR Timeline OBERWEIS ASSET MANAGEMENT INC/ More: the full row for OBERWEIS ASSET MANAGEMENT INC/ 439,300 $10.8M 0.32% +8,000 13F-HR Timeline THOMPSON SIEGEL & WALMSLEY LLC More: the full row for THOMPSON SIEGEL & WALMSLEY LLC 406,089 $10M 0.18% -2,452 13F-HR Timeline Pillsbury Lake Capital LLC More: the full row for Pillsbury Lake Capital LLC 364,954 $9.01M 4.08% new 13F-HR Timeline CANNELL CAPITAL LLC More: the full row for CANNELL CAPITAL LLC 341,985 $8.44M 5.48% +125,068 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 302,108 $7.46M <0.01% +24,650 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 237,832 $5.87M <0.01% +5,983 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 217,446 $5.37M <0.01% +21,183 13F-HR Timeline Group PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 188,802 $4.66M 0.36% +143,477 13F-HR Timeline Aristides Capital LLC More: the full row for Aristides Capital LLC 186,041 $4.59M 1.52% +24,605 13F-HR Timeline Panoramic Capital, LLC More: the full row for Panoramic Capital, LLC 185,000 $4.57M 3.21% new 13F-HR Timeline Lumbard & Kellner, LLC More: the full row for Lumbard & Kellner, LLC 175,911 $4.34M 1.5% +967 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 170,699 $4.21M 0.02% +75,212 13F-HR/A Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 169,326 $4.18M +42,652 Timeline Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 166,381 $4.11M 0.17% new 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 163,321 $4.03M 0.01% -42,379 13F-HR Timeline Diametric Capital, LP More: the full row for Diametric Capital, LP 156,926 $3.87M 1.01% -36,229 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 169,876 $3.84M <0.01% -15,563 13F-HR/A Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 144,367 $3.56M <0.01% +39,571 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 111,255 $2.75M <0.01% -16,445 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 107,815 $2.66M <0.01% +33,671 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 106,393 $2.63M <0.01% +29,791 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 95,420 $2.35M <0.01% +37,364 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 82,721 $2.04M <0.01% new 13F-HR Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 81,963 $2.02M 0.01% new 13F-HR/A Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 70,124 $1.73M <0.01% -11,077 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 68,795 $1.7M <0.01% -8,417 13F-HR Timeline Group SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 58,034 $1.43M <0.01% new 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 57,950 $1.43M <0.01% -967 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 55,605 $1.37M 0.03% new 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 51,772 $1.28M 0.02% +19,245 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 49,374 $1.22M <0.01% -2,074 13F-HR Timeline Group Informed Momentum Co LLC More: the full row for Informed Momentum Co LLC 48,623 $1.2M 0.14% new 13F-HR Timeline Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 42,693 $1.05M <0.01% -33,893 13F-HR Timeline ANCHOR CAPITAL ADVISORS LLC More: the full row for ANCHOR CAPITAL ADVISORS LLC 40,858 $1.01M 0.03% +190 13F-HR Timeline Manatuck Hill Partners, LLC More: the full row for Manatuck Hill Partners, LLC 40,000 $987K 0.32% new 13F-HR Timeline Numerai GP LLC More: the full row for Numerai GP LLC 37,356 $922K 0.09% new 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 34,084 $841K <0.01% new 13F-HR Timeline Group BLAIR WILLIAM & CO/IL More: the full row for BLAIR WILLIAM & CO/IL 32,400 $800K <0.01% 0 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 30,726 $758K <0.01% +290 13F-HR Timeline POLEN CAPITAL MANAGEMENT LLC More: the full row for POLEN CAPITAL MANAGEMENT LLC 30,138 $744K 0.01% new 13F-HR Timeline Guilbault Capital LLC More: the full row for Guilbault Capital LLC 23,225 $573K 0.63% 0 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 22,874 $565K <0.01% +3,183 13F-HR Timeline Group Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 22,506 $555K 0.01% new 13F-HR Timeline Group Bridge City Capital, LLC More: the full row for Bridge City Capital, LLC 21,150 $522K 0.14% +2,550 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 21,136 $522K <0.01% +2,887 13F-HR Timeline Group ESSEX INVESTMENT MANAGEMENT CO LLC More: the full row for ESSEX INVESTMENT MANAGEMENT CO LLC 20,182 $498K 0.08% 0 13F-HR Timeline JUNCTURE WEALTH STRATEGIES, LLC More: the full row for JUNCTURE WEALTH STRATEGIES, LLC 19,181 $473K 0.16% +185 13F-HR Timeline STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 18,644 $460K <0.01% -5,971 13F-HR Timeline HighTower Advisors, LLC More: the full row for HighTower Advisors, LLC 18,423 $455K <0.01% new 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 17,652 $436K <0.01% +2,283 13F-HR Timeline CHICAGO TRUST Co NA More: the full row for CHICAGO TRUST Co NA 16,700 $412K 0.07% 0 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 15,537 $383K <0.01% 0 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 14,939 $369K <0.01% -64,392 13F-HR Timeline Group PDT Partners, LLC More: the full row for PDT Partners, LLC 14,891 $368K 0.02% 0 13F-HR Timeline BANK OF NOVA SCOTIA in group BANK OF NOVA SCOTIA More: the full row for BANK OF NOVA SCOTIA 15,000 $365K <0.01% new 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 13,437 $332K +270 Timeline Voleon Capital Management LP More: the full row for Voleon Capital Management LP 13,290 $328K 0.01% -2,292 13F-HR Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 12,250 $302K <0.01% 0 13F-HR Timeline Group Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 12,061 $298K 0.01% -10,741 13F-HR Timeline AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 11,926 $294K <0.01% new 13F-HR Timeline Group Quantum Private Wealth, LLC More: the full row for Quantum Private Wealth, LLC 11,500 $284K 0.09% 0 13F-HR Timeline ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 10,739 $265K <0.01% -205 13F-HR Timeline Group LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 10,269 $253K <0.01% -4,362 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 9,559 $236K <0.01% -18,734 13F-HR/A Timeline Group State of Wyoming More: the full row for State of Wyoming 9,498 $234K 0.03% +1,337 13F-HR Timeline Granite Investment Partners, LLC More: the full row for Granite Investment Partners, LLC 8,479 $209K 0.01% new 13F-HR Timeline Jain Global LLC More: the full row for Jain Global LLC 8,287 $205K <0.01% new 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 8,100 $200K <0.01% 0 13F-HR Timeline Quantbot Technologies LP More: the full row for Quantbot Technologies LP 7,787 $192K 0.01% -1,570 13F-HR Timeline NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO in group NORTHWESTERN MUTUAL INVESTMEN… More: the full row for NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 7,500 $185K <0.01% -2,500 13F-HR Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 7,209 $178K <0.01% 0 13F-HR Timeline State of Alaska, Department of Revenue More: the full row for State of Alaska, Department of Revenue 6,943 $171K <0.01% 0 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 4,759 $117K 0.01% +389 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 2,670 $65.9K <0.01% -47,024 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 2,548 $62.9K <0.01% +1,097 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 2,330 $57.5K <0.01% -401 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 2,167 $53.5K <0.01% 0 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 1,519 $37.5K <0.01% -1,557 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 1,388 $34.3K <0.01% -190 13F-HR Timeline Truvestments Capital LLC More: the full row for Truvestments Capital LLC 1,183 $29.2K 0.01% 0 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,156 $28.5K <0.01% -1,838 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 597 $14.7K <0.01% +70 13F-HR Timeline JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 350 $8.13K <0.01% +129 13F-HR Timeline Group Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 303 $7.48K <0.01% new 13F-HR/A Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 263 $6.49K <0.01% +253 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 200 $4.94K <0.01% 0 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 179 $4.42K <0.01% +128 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 167 $4.12K <0.01% 0 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 123 $3.12K <0.01% -23 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 107 $2.64K <0.01% +81 13F-HR Timeline Group Advisory Services Network, LLC More: the full row for Advisory Services Network, LLC 50 $1.23K <0.01% new 13F-HR Timeline Investors Portfolio Services LLC More: the full row for Investors Portfolio Services LLC 34 $1.04K <0.01% new 13F-HR Timeline Covestor Ltd More: the full row for Covestor Ltd 28 $1K <0.01% new 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 38 $938 <0.01% new 13F-HR/A Timeline Group TWIN PEAKS WEALTH ADVISORS, LLC More: the full row for TWIN PEAKS WEALTH ADVISORS, LLC 38 $938 <0.01% new 13F-HR Timeline Hughes Financial Services, LLC More: the full row for Hughes Financial Services, LLC 26 $642 <0.01% +25 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 24 $592 <0.01% -2,915 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 21 $518 <0.01% -2 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 19 $469 <0.01% -35 13F-HR Timeline Group Keating Financial Advisory Services, In… More: the full row for Keating Financial Advisory Services, Inc. 1 $25 <0.01% new 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 13 $0 0% -1,005 13F-HR Timeline Group Value filed as zero, left out of ratios.