MPM BIOIMPACT LLC More: the full row for MPM BIOIMPACT LLC 5,213,361 $109M 8.41% +4,216,536 13F-HR Timeline Vivo Capital, LLC More: the full row for Vivo Capital, LLC 2,667,569 $55.7M 4.63% +205,943 13F-HR/A Timeline Artisan Partners Limited Partnership More: the full row for Artisan Partners Limited Partnership 2,219,386 $46.4M 0.08% -1,089,669 13F-HR Timeline Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 1,857,362 $38.8M 1.08% 0 13F-HR Timeline Group BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 1,461,425 $30.5M 0.18% 0 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 1,012,866 $21.2M 1.27% new 13F-HR Timeline Group PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 964,391 $20.1M 0.4% new 13F-HR/A Timeline Group Patient Square Capital LP More: the full row for Patient Square Capital LP 693,534 $14.5M 2.57% +334,484 13F-HR Timeline Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 574,200 $12M 1.33% 0 13F-HR Timeline Redmile Group, LLC in group Redmile Group, LLC More: the full row for Redmile Group, LLC 491,340 $10.3M 0.68% -58,500 13F-HR Timeline Group Duquesne Family Office LLC More: the full row for Duquesne Family Office LLC 383,363 $8.01M 0.27% new 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 318,959 $6.66M <0.01% -321,926 13F-HR Timeline Group Atika Capital Management LLC in group Atika Capital Management LLC More: the full row for Atika Capital Management LLC 271,300 $5.67M 0.89% +64,419 13F-HR Timeline Group Elmind Capital, LP More: the full row for Elmind Capital, LP 265,000 $5.54M 1.57% new 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 233,429 $4.88M 0.01% -1,594 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 231,417 $4.83M <0.01% new 13F-HR/A Timeline Group Yiheng Capital Management, L.P. More: the full row for Yiheng Capital Management, L.P. 170,142 $3.55M 1.54% -469,627 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 168,180 $3.51M <0.01% -55,006 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 163,401 $3.41M 0.08% 0 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 146,116 $3.05M <0.01% +23,621 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 128,560 $2.69M <0.01% new 13F-HR Timeline Group Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 525,000 $2.2M 0.31% 0 13F-HR Timeline Group Dorsey Wright & Associates More: the full row for Dorsey Wright & Associates 102,550 $2.14M 0.27% new 13F-HR Timeline Ishara Investments LP More: the full row for Ishara Investments LP 102,500 $2.14M 2.16% new 13F-HR Timeline ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 95,714 $2M <0.01% +73,322 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 79,537 $1.66M <0.01% -165,325 13F-HR Timeline Group Polymer Capital Management (HK) LTD More: the full row for Polymer Capital Management (HK) LTD 64,500 $1.35M 0.19% 0 13F-HR Timeline DIVERSIFY WEALTH MANAGEMENT, LLC in group Diversify Advisory Services, … More: the full row for DIVERSIFY WEALTH MANAGEMENT, LLC 63,672 $1.29M 0.02% new 13F-HR Timeline Group LPL Financial LLC More: the full row for LPL Financial LLC 55,871 $1.17M <0.01% new 13F-HR Timeline AdvisorShares Investments LLC More: the full row for AdvisorShares Investments LLC 50,340 $1.05M 0.19% new 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 42,055 $879K 0.02% new 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 37,427 $782K <0.01% +23,691 13F-HR Timeline NAN FUNG TRINITY (HK) LTD More: the full row for NAN FUNG TRINITY (HK) LTD 37,095 $775K 0.09% 0 13F-HR Timeline Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 33,040 $690K 0.01% +8,056 13F-HR Timeline STIFEL FINANCIAL CORP in group STIFEL FINANCIAL CORP More: the full row for STIFEL FINANCIAL CORP 30,736 $642K <0.01% new 13F-HR Timeline Group Cetera Investment Advisers More: the full row for Cetera Investment Advisers 25,358 $530K <0.01% +12,243 13F-HR Timeline HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 24,085 $503K <0.01% new 13F-HR Timeline Burns Matteson Capital Management, LLC More: the full row for Burns Matteson Capital Management, LLC 22,631 $473K 0.18% new 13F-HR Timeline Atria Investments, Inc More: the full row for Atria Investments, Inc 21,135 $442K <0.01% new 13F-HR Timeline Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 19,047 $398K 0.02% -28,681 13F-HR/A Timeline Group SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 16,764 $350K <0.01% -49,577 13F-HR Timeline Group PERSONAL CFO SOLUTIONS, LLC More: the full row for PERSONAL CFO SOLUTIONS, LLC 12,643 $264K 0.04% new 13F-HR Timeline ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 11,538 $241K <0.01% -15,673 13F-HR Timeline Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 11,392 $238K 0.09% +5,373 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 11,285 $236K <0.01% new 13F-HR Timeline Group Integrated Wealth Concepts LLC More: the full row for Integrated Wealth Concepts LLC 10,582 $221K <0.01% new 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 8,079 $169K <0.01% new 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 6,099 $127K <0.01% -334 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 5,000 $104K 0.01% new 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 4,680 $98K <0.01% +2,928 13F-HR Timeline Group Truvestments Capital LLC More: the full row for Truvestments Capital LLC 3,892 $81.3K 0.01% 0 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 2,899 $60.6K <0.01% +219 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 1,683 $35.2K <0.01% 0 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 1,121 $23.4K <0.01% +778 13F-HR Timeline Group HM PAYSON & CO More: the full row for HM PAYSON & CO 420 $8.77K <0.01% new 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 300 $6.27K <0.01% 0 13F-HR/A Timeline Group HARBOUR INVESTMENTS, INC. More: the full row for HARBOUR INVESTMENTS, INC. 259 $5.42K <0.01% new 13F-HR Timeline Ascentis Wealth Management, LLC in group Ascentis Wealth Management, L… More: the full row for Ascentis Wealth Management, LLC 259 $5.41K <0.01% new 13F-HR Timeline Group Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 164 $3.36K <0.01% new 13F-HR Timeline Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 145 $3.03K <0.01% 0 13F-HR Timeline NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO in group NORTHWESTERN MUTUAL INVESTMEN… More: the full row for NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 111 $2.32K <0.01% 0 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 67 $1.4K <0.01% new 13F-HR Timeline Pinnacle Wealth Planning Services, Inc. More: the full row for Pinnacle Wealth Planning Services, Inc. 40 $836 <0.01% 0 13F-HR Timeline Advisory Services Network, LLC More: the full row for Advisory Services Network, LLC 30 $627 <0.01% new 13F-HR Timeline CURIO WEALTH, LLC More: the full row for CURIO WEALTH, LLC 27 $564 <0.01% 0 13F-HR Timeline Bell Investment Advisors, Inc More: the full row for Bell Investment Advisors, Inc 21 $439 <0.01% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 20 $391 <0.01% -28,359 13F-HR/A Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 14 $292 <0.01% -465 13F-HR/A Timeline Group TRUST CO OF TOLEDO NA /OH/ More: the full row for TRUST CO OF TOLEDO NA /OH/ 10 $209 <0.01% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 2 $42 <0.01% 0 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1 $21 <0.01% new 13F-HR Timeline Group