Artisan Partners Limited Partnership More: the full row for Artisan Partners Limited Partnership 3,309,055 $63.4M 0.1% +3,257,135 13F-HR Timeline Vivo Capital, LLC More: the full row for Vivo Capital, LLC 2,461,626 $47.2M 3.05% +1,407,120 13F-HR Timeline Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 1,857,362 $35.6M 1.06% new 13F-HR Timeline Group BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 1,461,425 $28M 0.16% 0 13F-HR Timeline Group MPM BIOIMPACT LLC More: the full row for MPM BIOIMPACT LLC 996,825 $19.1M 2.19% -57,679 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 640,885 $12.3M 0.01% +303,022 13F-HR Timeline Group Yiheng Capital Management, L.P. More: the full row for Yiheng Capital Management, L.P. 639,769 $12.3M 5.35% -16,540 13F-HR Timeline Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 574,200 $11M 1.38% -443,821 13F-HR Timeline Redmile Group, LLC in group Redmile Group, LLC More: the full row for Redmile Group, LLC 549,840 $10.5M 0.78% new 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 454,343 $8.71M 0.04% new 13F-HR Timeline Patient Square Capital LP More: the full row for Patient Square Capital LP 359,050 $6.88M 1.47% new 13F-HR Timeline Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 300,000 $5.75M 0.21% new 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 244,862 $4.69M <0.01% +244,714 13F-HR Timeline Group Squadron Capital Management LLC More: the full row for Squadron Capital Management LLC 240,000 $4.6M 2.05% 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 235,023 $4.51M 0.01% new 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 223,186 $4.28M 0.01% +219,766 13F-HR Timeline Atika Capital Management LLC in group Atika Capital Management LLC More: the full row for Atika Capital Management LLC 206,881 $3.97M 0.55% new 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 163,401 $3.13M 0.08% new 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 145,129 $2.78M <0.01% +123,080 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 122,495 $2.35M <0.01% +114,031 13F-HR/A Timeline Group Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 525,000 $2.08M 0.27% new 13F-HR Timeline Group SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 66,341 $1.27M <0.01% new 13F-HR Timeline Group Polymer Capital Management (HK) LTD More: the full row for Polymer Capital Management (HK) LTD 64,500 $1.24M 0.19% new 13F-HR Timeline Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 47,728 $915K 0.02% +39,381 13F-HR Timeline Group NAN FUNG TRINITY (HK) LTD More: the full row for NAN FUNG TRINITY (HK) LTD 37,095 $711K 0.06% 0 13F-HR Timeline TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 33,947 $651K <0.01% +17,265 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 28,379 $544K <0.01% +28,359 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 27,211 $522K 0.01% new 13F-HR Timeline Logos Global Management LP More: the full row for Logos Global Management LP 25,000 $479K 0.03% new 13F-HR Timeline Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 24,984 $479K 0.01% new 13F-HR Timeline ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 22,392 $429K <0.01% new 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 20,961 $402K <0.01% new 13F-HR Timeline Group HighVista Strategies LLC More: the full row for HighVista Strategies LLC 15,877 $304K 0.08% new 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 13,736 $263K <0.01% new 13F-HR Timeline Cetera Investment Advisers More: the full row for Cetera Investment Advisers 13,115 $251K <0.01% new 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 6,433 $123K <0.01% +2,822 13F-HR Timeline Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 6,019 $115K 0.06% new 13F-HR Timeline Truvestments Capital LLC More: the full row for Truvestments Capital LLC 3,892 $74.6K 0.01% +1,620 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 2,680 $51.4K <0.01% +744 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 1,752 $34K <0.01% new 13F-HR Timeline Group Allworth Financial LP More: the full row for Allworth Financial LP 1,683 $32.3K <0.01% new 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 479 $9.18K <0.01% +456 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 343 $6.57K <0.01% +261 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 300 $5.75K <0.01% new 13F-HR Timeline Group MARK SHEPTOFF FINANCIAL PLANNING, LLC More: the full row for MARK SHEPTOFF FINANCIAL PLANNING, LLC 300 $5.75K <0.01% 0 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 257 $4.93K <0.01% new 13F-HR Timeline Group Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 145 $2.78K <0.01% -5 13F-HR Timeline NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO in group NORTHWESTERN MUTUAL INVESTMEN… More: the full row for NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 111 $2.13K <0.01% 0 13F-HR/A Timeline Group Pinnacle Wealth Planning Services, Inc. More: the full row for Pinnacle Wealth Planning Services, Inc. 40 $767 <0.01% new 13F-HR Timeline CURIO WEALTH, LLC More: the full row for CURIO WEALTH, LLC 27 $514 <0.01% 0 13F-HR Timeline TRUST CO OF TOLEDO NA /OH/ More: the full row for TRUST CO OF TOLEDO NA /OH/ 10 $192 <0.01% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 2 $38 <0.01% 0 13F-HR Timeline Group