TANG CAPITAL MANAGEMENT LLC

13F filer, CIK 1232621, SAN DIEGO, CA

TANG CAPITAL MANAGEMENT LLC reported $1,399,857,815 across 154 holdings for the quarter ended 2024-09-30, in a 13F-HR filed 2024-11-14. Its ten largest share positions make up 35.88% of the portfolio.

Filed 2024-11-14 (acceptance time not in the bulk data set), ingested 2026-10-07 18:26:56 UTC13F-HR 0001214659-24-019100

Period: 2024-09-30
Reported value: $1.4B
Holdings: 154
Top 10 weight: 35.88%
New: 35
Sold out: 9

Part of the filer group TANG CAPITAL MANAGEMENT LLC

TANG KEVINTANG CAPITAL PARTNERS III, INC +3 others

TANG KEVIN
TANG CAPITAL PARTNERS III, INC
TANG CAPITAL PARTNERS INTERNATIONAL, LP
TANG CAPITAL PARTNERS IV, INC
TANG CAPITAL PARTNERS, LP

How groups are built

Largest buys vs the previous quarter

Security	Shares change	Approx. value
AUPHadded	+4,450,000	$32.6M
BNTXnew	+270,000	$32.1M
RLAYnew	+3,568,058	$25.3M
ITEOS THERAPEUTICS INCnew	+2,407,800	$24.6M
IMCRadded	+700,000	$21.8M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

Security	Shares change	Approx. value
LLYexited	-27,000	-$24.4M
DVAXreduced	-600,000	-$6.68M
BEAMreduced	-100,000	-$2.45M
INBXexited	-167,500	-$2.37M
CRSPreduced	-50,000	-$2.35M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q3 2024

Share positions as resolved from 13F-HR 0001214659-24-019100, largest first. % of portfolio is the value over $1,399,857,815, the sum of the share positions whose value is usable for ratios (method).

Security	Shares	Value	% of portfolio	Change	Latest event	Timeline
EOLSEVOLUS INC	4,847,399	$78.5M	5.61%	0		Timeline
TARSTARSUS PHARMACEUTICALS INC	2,254,797	$74.2M	5.3%	0		Timeline
AUPHAURINIA PHARMACEUTICALS INC	7,229,500	$53M	3.79%	+4,450,000		Timeline
VRDNVIRIDIAN THERAPEUTICS INC	2,242,925	$51M	3.65%	+850,000		Timeline
MIRMMIRUM PHARMACEUTICALS INC	1,287,107	$50.2M	3.59%	0		Timeline
KALVKALVISTA PHARMACEUTICALS INC	4,321,547	$50M	3.57%	+102,718		Timeline
ANABANAPTYSBIO INC	1,330,879	$44.6M	3.18%	0		Timeline
IMCRIMMUNOCORE HLDGS PLC	1,105,600	$34.4M	2.46%	+700,000		Timeline
PCVXVAXCYTE INC	300,000	$34.3M	2.45%	0		Timeline
BNTXBIONTECH SE	270,000	$32.1M	2.29%	new		Timeline
ANIPANI PHARMACEUTICALS INC	450,000	$26.8M	1.92%	0		Timeline
PTCTPTC THERAPEUTICS INC	700,000	$26M	1.86%	0		Timeline
RLAYRELAY THERAPEUTICS INC	3,568,058	$25.3M	1.8%	new		Timeline
ITEOS THERAPEUTICS INCITEOS THERAPEUTICS INC	2,407,800	$24.6M	1.76%	new
Applied Therapeutics IncApplied Therapeutics Inc	2,730,000	$23.2M	1.66%	+400,000
ACADACADIA PHARMACEUTICALS INC	1,500,000	$23.1M	1.65%	0		Timeline
INTRA-CELLULAR THERAPIES INCINTRA-CELLULAR THERAPIES INC	300,000	$22M	1.57%	0
DVAXDYNAVAX TECHNOLOGIES CORP	1,900,000	$21.2M	1.51%	-600,000		Timeline
LKFTLAKEFRONT BIOTHERAPEUTICS NV	700,000	$20.2M	1.44%	+644,391		Timeline
GSKGSK PLC	450,000	$18.4M	1.31%	+50,000		Timeline
LENZLENZ THERAPEUTICS INC	766,940	$18.2M	1.3%	+19,324		Timeline
NVDANVIDIA CORPORATION	147,732	$17.9M	1.28%	+32,713		Timeline
NBIXNEUROCRINE BIOSCIENCES INC	150,000	$17.3M	1.23%	new		Timeline
ALTALTIMMUNE INC	2,750,000	$16.9M	1.21%	0		Timeline
AVADEL PHARMACEUTICALSAVADEL PHARMACEUTICALS	1,230,000	$16.1M	1.15%	0
KNSAKINIKSA PHARMACEUTICALS INTL	628,609	$15.7M	1.12%	+3,300		Timeline
JAZZJAZZ PHARMACEUTICALS PLC	140,000	$15.6M	1.11%	0		Timeline
AVIRATEA PHARMACEUTICALS INC	4,607,060	$15.4M	1.1%	+130,319	2026-10-06, 13G: 4,814,700 shares, 6% of the class, 13G filed 2026-10-06	Timeline
CGEMCULLINAN THERAPEUTICS INC	921,138	$15.4M	1.1%	0		Timeline
METAMETA PLATFORMS INC	25,855	$14.8M	1.06%	+14,459		Timeline
RCKTROCKET PHARMACEUTICALS INC	750,000	$13.9M	0.99%	0		Timeline
ZYMEZYMEWORKS INC	1,100,000	$13.8M	0.99%	0		Timeline
REPLREPLIMUNE GROUP INC	1,200,000	$13.2M	0.94%	+394,560		Timeline
REVANCE THERAPEUTICS INCREVANCE THERAPEUTICS INC	2,500,000	$13M	0.93%	+2,100,000
CARGO THERAPEUTICS INC COMCARGO THERAPEUTICS INC COM	700,749	$12.9M	0.92%	+128,052
TDOCTELADOC HEALTH INC	1,400,000	$12.9M	0.92%	+400,000		Timeline
NVAXNOVAVAX INC	1,000,000	$12.6M	0.9%	new		Timeline
CRSPCRISPR THERAPEUTICS AG	266,500	$12.5M	0.89%	-50,000		Timeline
CRBPCORBUS PHARMACEUTICALS HLDGS	600,000	$12.4M	0.88%	new		Timeline
ADICET BIO INCADICET BIO INC	8,216,960	$11.8M	0.85%	0
AZNASTRAZENECA PLC-SPONS ADR	150,000	$11.7M	0.83%	0		Timeline
HRMYHARMONY BIOSCIENCES HLDGS IN	281,200	$11.2M	0.8%	0		Timeline
VNDAVANDA PHARMACEUTICALS INC	2,353,307	$11M	0.79%	+200,000		Timeline
IMNMIMMUNOME INC	720,000	$10.5M	0.75%	0		Timeline
CTMXCYTOMX THERAPEUTICS INC.	7,811,760	$9.22M	0.66%	+19,824		Timeline
NUVBNUVATION BIO INC	3,900,000	$8.93M	0.64%	+148,136		Timeline
ELANELANCO ANIMAL HEALTH INC	600,000	$8.81M	0.63%	new		Timeline
HILLEVAX INCHILLEVAX INC	4,920,000	$8.66M	0.62%	new
OTLKOUTLOOK THERAPEUTICS INC	1,559,560	$8.33M	0.59%	-59,852		Timeline
ONCBEONE MEDICINES LTD	37,000	$8.31M	0.59%	0		Timeline
MARINUS PHARMACEUTICALS INCMARINUS PHARMACEUTICALS INC	4,700,000	$8.27M	0.59%	-100,000
LQDALIQUIDIA CORPORATION	800,000	$8M	0.57%	+450,000		Timeline
DSGNDESIGN THERAPEUTICS INC	1,480,975	$7.97M	0.57%	0		Timeline
ALXOALX ONCOLOGY HLDGS INC	4,204,735	$7.65M	0.55%	new		Timeline
VKTXVIKING THERAPEUTICS INC	120,000	$7.6M	0.54%	0		Timeline
INSMINSMED INC	100,000	$7.3M	0.52%	0		Timeline
DNTHDIANTHUS THERAPEUTICS INC	264,692	$7.25M	0.52%	0		Timeline
BHVNBIOHAVEN LTD	140,000	$7M	0.5%	0		Timeline
BIIBBIOGEN INC	35,000	$6.78M	0.48%	0		Timeline
VTYXVENTYX BIOSCIENCES INC	3,100,000	$6.76M	0.48%	0		Timeline
BLCOBAUSCH PLUS LOMB CORP	350,000	$6.75M	0.48%	new		Timeline
CNTACENTESSA PHARMACEUTICALS PLC	400,000	$6.4M	0.46%	new		Timeline
GPCRSTRUCTURE THERAPEUTICS INC	144,500	$6.34M	0.45%	0		Timeline
BCRXBIOCRYST PHARMACEUTICALS INC	800,000	$6.08M	0.43%	0		Timeline
IONSIONIS PHARMACEUTICALS INC	150,000	$6.01M	0.43%	0		Timeline
ABCLABCELLERA BIOLOGICS INC	2,300,000	$5.98M	0.43%	+1,838,301		Timeline
BDTXBLACK DIAMOND THERAPEUTICS I	1,370,209	$5.96M	0.43%	-232,991		Timeline
APGEAPOGEE THERAPEUTICS INC	100,000	$5.87M	0.42%	0		Timeline
SINGULAR GENOMICS SYSTEMS INSINGULAR GENOMICS SYSTEMS IN	372,000	$5.83M	0.42%	new
DTILPRECISION BIOSCIENCES INC	623,332	$5.59M	0.4%	0		Timeline
LNTHLANTHEUS HLDGS INC	50,000	$5.49M	0.39%	0		Timeline
CYTKCYTOKINETICS INC	100,000	$5.28M	0.38%	0		Timeline
NUVLNUVALENT INC	50,000	$5.12M	0.37%	new		Timeline
RENEO PHARMACEUTICALS INCRENEO PHARMACEUTICALS INC	2,946,260	$5.01M	0.36%	-50,000
MERUS N VMERUS N V	100,000	$5M	0.36%	0
AREALEXANDRIA REAL ESTATE EQ IN	40,000	$4.75M	0.34%	0		Timeline
IOVAIOVANCE BIOTHERAPEUTICS INC	500,000	$4.7M	0.34%	0		Timeline
ALMSALUMIS INC	426,594	$4.56M	0.33%	new		Timeline
SEERSEER INC	2,300,000	$4.53M	0.32%	0		Timeline
ARVNARVINAS INC	180,000	$4.43M	0.32%	0		Timeline
BEAMBEAM THERAPEUTICS INC	170,000	$4.17M	0.3%	-100,000		Timeline
SNYSANOFI SA	70,000	$4.03M	0.29%	new		Timeline
CCCCC4 THERAPEUTICS INC	700,000	$3.99M	0.29%	+500,000		Timeline
HRTXHERON THERAPEUTICS INC	1,850,000	$3.68M	0.26%	0		Timeline
HELPCYBIN INC	400,000	$3.56M	0.25%	new		Timeline
TYRATYRA BIOSCIENCES INC	150,000	$3.53M	0.25%	+107,777		Timeline
CMPXCOMPASS THERAPEUTICS INC	1,812,995	$3.34M	0.24%	new		Timeline
NKTXNKARTA INC	650,000	$2.94M	0.21%	+100,000		Timeline
ELEVATION ONCOLOGY INC COMELEVATION ONCOLOGY INC COM	4,760,000	$2.86M	0.2%	+1,700,000
KEZAR LIFE SCIENCES INCKEZAR LIFE SCIENCES INC	3,640,300	$2.81M	0.2%	new
BOLT BIOTHERAPEUTICS INCBOLT BIOTHERAPEUTICS INC	3,812,773	$2.47M	0.18%	0
FATEFATE THERAPEUTICS INC	700,000	$2.45M	0.18%	0		Timeline
CHRSCOHERUS ONCOLOGY INC	2,350,000	$2.44M	0.17%	+1,300,000		Timeline
GMABGENMAB A/S	100,000	$2.44M	0.17%	0		Timeline
TECXTECTONIC THERAPEUTIC INC	79,166	$2.4M	0.17%	0		Timeline
SPRINGWORKS THERAPEUTICS INCSPRINGWORKS THERAPEUTICS INC	74,265	$2.38M	0.17%	new
TGTXTG THERAPEUTICS INC	100,000	$2.34M	0.17%	0		Timeline
TBPHTHERAVANCE BIOPHARMA INC	262,896	$2.12M	0.15%	new		Timeline
KURAKURA ONCOLOGY INC	100,000	$1.95M	0.14%	0		Timeline
IPSCCENTURY THERAPEUTICS INC	900,000	$1.54M	0.11%	0		Timeline
BCABBIOATLA INC	874,076	$1.54M	0.11%	-500,000		Timeline
ERASERASCA INC	502,915	$1.37M	0.1%	-47,085		Timeline
ENTAENANTA PHARMACEUTICALS INC	126,655	$1.31M	0.09%	-173,345		Timeline
OABIOMNIAB INC	300,000	$1.27M	0.09%	0		Timeline
ATYRATYR PHARMA INC	671,134	$1.18M	0.08%	0		Timeline
ASTRIA THERAPEUTICS INCASTRIA THERAPEUTICS INC	100,000	$1.1M	0.08%	0
PASSAGE BIO INCPASSAGE BIO INC	1,500,000	$1.05M	0.08%	0
WMTWALMART INC	12,725	$1.03M	0.07%	+8,265		Timeline
JPMJPMORGAN CHASE & CO	4,673	$985K	0.07%	+2,862		Timeline
MSFTMICROSOFT CORP	2,250	$968K	0.07%	+1,436		Timeline
BRK-BBERKSHIRE HATHAWAY INC DEL	2,079	$957K	0.07%	+1,368		Timeline
HDHOME DEPOT INC	2,354	$954K	0.07%	+1,675		Timeline
PCRXPACIRA BIOSCIENCES INC	61,226	$921K	0.07%	new		Timeline
VZVERIZON COMMUNICATIONS INC	20,401	$916K	0.07%	+15,093		Timeline
VVISA INC	3,318	$912K	0.07%	+2,269		Timeline
NEXTCURE INCNEXTCURE INC	652,386	$894K	0.06%	+49,392
PGPROCTER & GAMBLE CO	5,145	$891K	0.06%	+3,602		Timeline
KOCOCA COLA CO	12,373	$889K	0.06%	+8,812		Timeline
TXNTEXAS INSTRS INC	4,202	$868K	0.06%	+2,998		Timeline
PYPLPAYPAL HLDGS INC	11,099	$866K	0.06%	new		Timeline
INTCINTEL CORP	36,572	$858K	0.06%	+29,218		Timeline
VTRSVIATRIS INC	73,881	$858K	0.06%	+51,801		Timeline
DISDISNEY WALT CO	8,834	$850K	0.06%	+6,805		Timeline
NKENIKE INC	9,539	$843K	0.06%	new		Timeline
UNHUNITEDHEALTH GROUP INC	1,422	$831K	0.06%	new		Timeline
XOMEXXON MOBIL CORP	7,004	$821K	0.06%	+5,096		Timeline
JNJJOHNSON & JOHNSON	5,015	$813K	0.06%	new		Timeline
VSTMVERASTEM INC	270,000	$807K	0.06%	-271,514		Timeline
LABSTANDARD BIOTOOLS INC	407,755	$787K	0.06%	new		Timeline
PFEPFIZER INC	25,738	$745K	0.05%	new		Timeline
MGNXMACROGENICS INC	218,856	$720K	0.05%	0		Timeline
ATRAATARA BIOTHERAPEUTICS INC	75,196	$611K	0.04%	0		Timeline
PBYIPUMA BIOTECHNOLOGY INC	200,000	$510K	0.04%	0		Timeline
AFMDQAFFIMED N V ORDINARY SHARES NE	148,315	$498K	0.04%	new		Timeline
PGENPRECIGEN INC	500,000	$474K	0.03%	new		Timeline
EAGLE PHARMACEUTICALS INCEAGLE PHARMACEUTICALS INC	118,857	$443K	0.03%	0
IVVDINVIVYD INC	330,172	$337K	0.02%	+130,172		Timeline
AMLXAMYLYX PHARMACEUTICALS INC	100,000	$324K	0.02%	0		Timeline
NFLXNETFLIX INC.	427	$303K	0.02%	0		Timeline
AXPAMERICAN EXPRESS CO	1,001	$271K	0.02%	0		Timeline
ATHIRA PHARMA INCATHIRA PHARMA INC	600,000	$268K	0.02%	-452,715
GEGE AEROSPACE	1,383	$261K	0.02%	0		Timeline
ALLALLSTATE CORP	1,260	$239K	0.02%	0		Timeline
SHWSHERWIN WILLIAMS CO	612	$234K	0.02%	new		Timeline
TMUST-MOBILE US INC	1,071	$221K	0.02%	new		Timeline
UALUNITED AIRLS HLDGS INC	3,872	$221K	0.02%	new		Timeline
AMZNAMAZON COM INC	1,164	$217K	0.02%	0		Timeline
CLXCLOROX CO DEL	1,236	$201K	0.01%	new		Timeline
SERES THERAPEUTICS INCSERES THERAPEUTICS INC	200,000	$189K	0.01%	-2,207,112
RLMDRELMADA THERAPEUTICS INC	50,825	$165K	0.01%	-187,049		Timeline
LXRXLEXICON PHARMACEUTICALS INC	100,000	$157K	0.01%	new		Timeline
FFORD MTR CO	12,773	$135K	0.01%	0		Timeline
LAVA THERAPEUTICS NVLAVA THERAPEUTICS NV	53,101	$88.1K	0.01%	+47,992
ALLAKOS INCALLAKOS INC	45,262	$29.6K	<0.01%	new

Sold out in Q3 2024

Positions in the previous quarter's report that this quarter's report no longer lists.

Security	Shares before	Value before	Type
LLYELI LILLY & CO	27,000	$24.4M	shares
MIRUM PHARMACEUTICALS INCMIRUM PHARMACEUTICALS INC	2,120,000	$2.83M	principal
INBXINHIBRX BIOSCIENCES INC	167,500	$2.37M	shares
DEIDOUGLAS EMMETT INC	171,138	$2.28M	shares
ADAPYADAPTIMMUNE THERAPEUTICS PLC S	1,743,619	$1.7M	shares
QNCXQUINCE THERAPEUTICS INC	1,500,000	$1.12M	shares
DERMJOURNEY MED CORP	148,322	$837K	shares
ALIGOS THERAPEUTICS INC COM…ALIGOS THERAPEUTICS INC COM NEW	1,650,000	$578K	shares
MOLNMOLECULAR PARTNERS AG	2,500	$18.1K	shares

How Q3 2024 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

Filing	Role	Amendment	Filed	Accepted	Ingested
13F-HR 0001214659-24-019100	base		2024-11-14	acceptance time not in the bulk data set	2026-10-07 18:26:56 UTC