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Redmile Group, LLC

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13F filer, CIK 1425738, LARKSPUR, CA

Redmile Group, LLC reported $1,357,911,173 across 34 holdings for the quarter ended 2025-12-31, in a 13F-HR filed 2026-02-17. Its ten largest share positions make up 77.83% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001104659-26-016433

Period
2025-12-31
Reported value
$1.36B
Holdings
34
Top 10 weight
77.83%
New
3
Sold out
9

Part of the filer group Redmile Group, LLC

  • Jeremy C. Green
  • Redmile Biopharma Investments II, L.P.
How groups are built

Stakes and trades reported after 2025-12-31

13D, 13G and Form 4 filings by this filer's group, dated after the 13F period, on securities the quarter does not hold as shares.

  • ELECTRA THERAPEUTICS INC: 13G 5,462,881 shares, 8.7% of the class, 13G filed 2026-09-28, 0001104659-26-111478
    Accepted , ingested

Largest buys vs the previous quarter

SecurityShares changeApprox. value
NRIXadded+4,415,514$83.8M
SRRKadded+1,316,390$58M
ANNXadded+3,750,000$18.8M
IMNMadded+695,000$14.9M
RAPTadded+333,333$11.3M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
ZYMEreduced-3,214,096-$84.6M
LIVNreduced-808,745-$49.8M
AKROexited-747,818-$35.5M
COGTreduced-771,200-$27.4M
89BIO INCexited-1,473,136-$21.7M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q4 2025

Share positions as resolved from 13F-HR 0001104659-26-016433, largest first. % of portfolio is the value over $1,357,911,173, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
SRRKSCHOLAR ROCK HLDG CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,238,837 shares; 2024Q4: 4,549,881 shares; 2025Q1: 4,398,281 shares; 2025Q2: 3,929,039 shares; 2025Q3: 3,904,456 shares; 2025Q4: 5,220,846 shares 5,220,846$230M16.94%+1,316,390Timeline
KRYSKRYSTAL BIOTECH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 810,245 shares; 2024Q4: 753,175 shares; 2025Q1: 737,675 shares; 2025Q2: 663,471 shares; 2025Q3: 661,388 shares; 2025Q4: 677,705 shares 677,705$167M12.3%+16,317Timeline
NRIXNURIX THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,280,981 shares; 2024Q4: 4,192,627 shares; 2025Q1: 4,051,927 shares; 2025Q2: 3,732,888 shares; 2025Q3: 3,678,394 shares; 2025Q4: 8,093,908 shares 8,093,908$154M11.31%+4,415,514Timeline
STOKSTOKE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,713,509 shares; 2024Q4: 4,593,629 shares; 2025Q1: 4,485,981 shares; 2025Q2: 4,375,931 shares; 2025Q3: 4,175,542 shares; 2025Q4: 4,034,070 shares 4,034,070$128M9.43%-141,472Timeline
IMNMIMMUNOME INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,889,554 shares; 2024Q4: 4,828,026 shares; 2025Q1: 5,361,187 shares; 2025Q2: 4,872,225 shares; 2025Q3: 5,023,385 shares; 2025Q4: 5,718,385 shares 5,718,385$123M9.05%+695,000Timeline
RGNXREGENXBIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,892,902 shares; 2024Q4: 4,794,780 shares; 2025Q1: 4,794,780 shares; 2025Q2: 4,775,717 shares; 2025Q3: 4,693,389 shares; 2025Q4: 4,368,804 shares 4,368,804$62.9M4.63%-324,585Timeline
ADCTADC THERAPEUTICS SAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 15,669,217 shares; 2024Q4: 15,666,731 shares; 2025Q1: 15,666,731 shares; 2025Q2: 15,666,731 shares; 2025Q3: 15,666,731 shares; 2025Q4: 15,666,731 shares 15,666,731$55.3M4.07%0Timeline
COGTCOGENT BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,484,380 shares; 2024Q4: 3,554,836 shares; 2025Q1: 3,216,026 shares; 2025Q2: 1,448,040 shares; 2025Q3: 2,209,118 shares; 2025Q4: 1,437,918 shares 1,437,918$51.1M3.76%-771,200Timeline
ANNXANNEXON INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 6,427,462 shares; 2024Q4: 6,300,644 shares; 2025Q1: 6,300,644 shares; 2025Q2: 6,300,644 shares; 2025Q3: 6,300,644 shares; 2025Q4: 10,050,644 shares 10,050,644$50.5M3.72%+3,750,000Timeline
BEAMBEAM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,611,013 shares; 2024Q4: 1,528,567 shares; 2025Q1: 1,610,329 shares; 2025Q2: 1,423,411 shares; 2025Q3: 1,387,559 shares; 2025Q4: 1,285,859 shares 1,285,859$35.6M2.62%-101,700Timeline
NGNENEUROGENE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 964,347 shares; 2024Q4: 1,319,763 shares; 2025Q1: 1,308,063 shares; 2025Q2: 1,276,676 shares; 2025Q3: 1,299,022 shares; 2025Q4: 1,459,599 shares 1,459,599$30.1M2.21%+160,577Timeline
RAPTRAPT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 630,686 shares; 2025Q3: 552,594 shares; 2025Q4: 885,927 shares 885,927$30M2.21%+333,333Timeline
ABSIABSCI CORPORATIONQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 8,253,316 shares; 2024Q4: 8,253,316 shares; 2025Q1: 8,253,316 shares; 2025Q2: 8,253,316 shares; 2025Q3: 8,253,316 shares; 2025Q4: 8,253,316 shares 8,253,316$28.8M2.12%0Timeline
NUVBNUVATION BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,031,009 shares; 2024Q4: 3,031,009 shares; 2025Q1: 3,031,009 shares; 2025Q2: 3,031,009 shares; 2025Q3: 3,031,009 shares; 2025Q4: 3,163,256 shares 3,163,256$28.3M2.09%+132,247Timeline
IDYAIDEAYA BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 681,150 shares; 2024Q4: 619,300 shares; 2025Q1: 534,600 shares; 2025Q2: 432,494 shares; 2025Q3: 742,017 shares; 2025Q4: 742,017 shares 742,017$25.7M1.89%0Timeline
STTKSHATTUCK LABS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,615,489 shares; 2024Q4: 5,539,724 shares; 2025Q1: 5,539,724 shares; 2025Q2: 5,539,724 shares; 2025Q3: 5,539,724 shares; 2025Q4: 5,539,724 shares 5,539,724$20.2M1.49%0Timeline
SLNSILENCE THERAPEUTICS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,899,317 shares; 2024Q4: 2,399,317 shares; 2025Q1: 2,214,947 shares; 2025Q2: 2,164,777 shares; 2025Q3: 2,164,777 shares; 2025Q4: 2,164,777 shares 2,164,777$13.2M0.97%0Timeline
ZYMEZYMEWORKS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,101,911 shares; 2024Q4: 4,840,463 shares; 2025Q1: 4,788,945 shares; 2025Q2: 4,150,627 shares; 2025Q3: 3,705,750 shares; 2025Q4: 491,654 shares 491,654$12.9M0.95%-3,214,096Timeline
FATEFATE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 13,169,057 shares; 2024Q4: 12,872,946 shares; 2025Q1: 12,872,946 shares; 2025Q2: 12,872,946 shares; 2025Q3: 12,872,946 shares; 2025Q4: 12,872,946 shares 12,872,946$12.6M0.93%0Timeline
REPLREPLIMUNE GROUP INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,781,183 shares; 2024Q4: 4,905,527 shares; 2025Q1: 4,898,527 shares; 2025Q2: 4,664,791 shares; 2025Q3: 535,818 shares; 2025Q4: 1,099,756 shares 1,099,756$10.7M0.79%+563,938Timeline
DBVTDBV TECHNOLOGIES S AQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 549,840 shares 549,840$10.5M0.78%newTimeline
SLDBSOLID BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 615,246 shares; 2025Q1: 2,019,171 shares; 2025Q2: 1,915,926 shares; 2025Q3: 1,899,342 shares; 2025Q4: 1,860,542 shares 1,860,542$10.5M0.77%-38,800Timeline
CBLLCERIBELL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 435,239 shares; 2025Q1: 435,239 shares; 2025Q2: 435,239 shares; 2025Q3: 435,239 shares; 2025Q4: 435,239 shares 435,239$9.54M0.7%0Timeline
ESTAESTABLISHMENT LABS HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 261,803 shares; 2024Q4: 320,149 shares; 2025Q1: 335,366 shares; 2025Q2: 136,495 shares; 2025Q3: 129,364 shares; 2025Q4: 112,664 shares 112,664$8.21M0.6%-16,700Timeline
ATRAATARA BIOTHERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 452,270 shares; 2024Q4: 441,701 shares; 2025Q1: 441,701 shares; 2025Q2: 441,701 shares; 2025Q3: 441,701 shares; 2025Q4: 441,701 shares 441,701$7.99M0.59%0Timeline
CLDXCELLDEX THERAPEUTICS INC NEWQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 657,175 shares; 2024Q4: 615,775 shares; 2025Q1: 590,175 shares; 2025Q2: 343,026 shares; 2025Q3: 327,008 shares; 2025Q4: 283,308 shares 283,308$7.69M0.57%-43,700Timeline
LIVNLIVANOVA PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 875,039 shares; 2024Q4: 1,043,539 shares; 2025Q1: 1,014,139 shares; 2025Q2: 934,271 shares; 2025Q3: 926,799 shares; 2025Q4: 118,054 shares 118,054$7.26M0.53%-808,745Timeline
IVVDINVIVYD INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,065,714 shares; 2024Q4: 3,012,254 shares; 2025Q1: 2,285,320 shares; 2025Q2: 2,285,320 shares; 2025Q3: 2,285,320 shares; 2025Q4: 2,681,159 shares 2,681,159$6.62M0.49%+395,839Timeline
XENEXENON PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 133,882 shares 133,882$6M0.44%newTimeline
REPARE THERAPEUTICS INCREPARE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,942,555 shares; 2024Q4: 1,916,089 shares; 2025Q1: 1,884,389 shares; 2025Q2: 1,586,174 shares; 2025Q3: 1,586,174 shares; 2025Q4: 1,586,174 shares 1,586,174$4.12M0.3%0
ALXOALX ONCOLOGY HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,836,576 shares; 2024Q4: 3,689,611 shares; 2025Q1: 3,640,834 shares; 2025Q2: 3,391,455 shares; 2025Q3: 3,332,983 shares; 2025Q4: 3,264,718 shares 3,264,718$3.69M0.27%-68,265Timeline
ORICORIC PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 448,110 shares 448,110$3.67M0.27%newTimeline
PLRXPLIANT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,197,491 shares; 2024Q4: 2,895,478 shares; 2025Q1: 2,053,559 shares; 2025Q2: 1,632,577 shares; 2025Q3: 1,591,695 shares; 2025Q4: 1,616,228 shares 1,616,228$1.97M0.15%+24,533Timeline
KLRSKALARIS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 82,955 shares; 2025Q2: 82,955 shares; 2025Q3: 82,955 shares; 2025Q4: 82,955 shares 82,955$700K0.05%0Timeline

Sold out in Q4 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
AKROAKERO THERAPEUTICS INC747,818$35.5Mshares
89BIO INC89BIO INC1,473,136$21.7Mshares
KROSKEROS THERAPEUTICS INC552,506$8.74Mshares
FOLDAMICUS THERAPEUTIC777,178$6.12Mshares
XERSXERIS BIOPHARMA HOLDINGS INC451,099$3.67Mshares
VTYXVENTYX BIOSCIENCES INC1,073,386$3.34Mshares
LAVA THERAPEUTICS NVLAVA THERAPEUTICS NV2,074,372$3.24Mshares
PRMEPRIME MEDICINE INC87,118$483Kshares
BOLDBOUNDLESS BIO INC245,458$302Kshares

How Q4 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001104659-26-016433 base2026-02-17acceptance time not in the bulk data set