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Redmile Group, LLC

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13F filer, CIK 1425738, LARKSPUR, CA

Redmile Group, LLC reported $1,027,815,748 across 40 holdings for the quarter ended 2025-09-30, in a 13F-HR filed 2025-11-14. Its ten largest share positions make up 68.92% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001104659-25-112572

Period
2025-09-30
Reported value
$1.03B
Holdings
40
Top 10 weight
68.92%
New
0
Sold out
8

Part of the filer group Redmile Group, LLC

  • Jeremy C. Green
  • Redmile Biopharma Investments II, L.P.
How groups are built

Stakes and trades reported after 2025-09-30

13D, 13G and Form 4 filings by this filer's group, dated after the 13F period, on securities the quarter does not hold as shares.

  • ELECTRA THERAPEUTICS INC: 13G 5,462,881 shares, 8.7% of the class, 13G filed 2026-09-28, 0001104659-26-111478
    Accepted , ingested

Largest buys vs the previous quarter

SecurityShares changeApprox. value
COGTadded+761,078$10.9M
IDYAadded+309,523$8.42M
IMNMadded+151,160$1.77M
NGNEadded+22,346$387K

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
KYMRexited-803,289-$35.1M
REPLreduced-4,128,973-$17.3M
HNGEexited-300,000-$15.5M
PRMEreduced-1,987,232-$11M
BHVNexited-729,515-$10.3M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q3 2025

Share positions as resolved from 13F-HR 0001104659-25-112572, largest first. % of portfolio is the value over $1,027,815,748, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
SRRKSCHOLAR ROCK HLDG CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,238,837 shares; 2024Q4: 4,549,881 shares; 2025Q1: 4,398,281 shares; 2025Q2: 3,929,039 shares; 2025Q3: 3,904,456 shares 3,904,456$145M14.15%-24,583Timeline
KRYSKRYSTAL BIOTECH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 810,245 shares; 2024Q4: 753,175 shares; 2025Q1: 737,675 shares; 2025Q2: 663,471 shares; 2025Q3: 661,388 shares 661,388$117M11.36%-2,083Timeline
STOKSTOKE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,713,509 shares; 2024Q4: 4,593,629 shares; 2025Q1: 4,485,981 shares; 2025Q2: 4,375,931 shares; 2025Q3: 4,175,542 shares 4,175,542$98.1M9.55%-200,389Timeline
ZYMEZYMEWORKS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,101,911 shares; 2024Q4: 4,840,463 shares; 2025Q1: 4,788,945 shares; 2025Q2: 4,150,627 shares; 2025Q3: 3,705,750 shares 3,705,750$63.3M6.16%-444,877Timeline
ADCTADC THERAPEUTICS SAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 15,669,217 shares; 2024Q4: 15,666,731 shares; 2025Q1: 15,666,731 shares; 2025Q2: 15,666,731 shares; 2025Q3: 15,666,731 shares 15,666,731$62.7M6.1%0Timeline
IMNMIMMUNOME INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,889,554 shares; 2024Q4: 4,828,026 shares; 2025Q1: 5,361,187 shares; 2025Q2: 4,872,225 shares; 2025Q3: 5,023,385 shares 5,023,385$58.8M5.72%+151,160Timeline
LIVNLIVANOVA PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 875,039 shares; 2024Q4: 1,043,539 shares; 2025Q1: 1,014,139 shares; 2025Q2: 934,271 shares; 2025Q3: 926,799 shares 926,799$48.5M4.72%-7,472Timeline
RGNXREGENXBIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,892,902 shares; 2024Q4: 4,794,780 shares; 2025Q1: 4,794,780 shares; 2025Q2: 4,775,717 shares; 2025Q3: 4,693,389 shares 4,693,389$45.3M4.41%-82,328Timeline
AKROAKERO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,387,479 shares; 2024Q4: 1,235,209 shares; 2025Q1: 939,277 shares; 2025Q2: 774,311 shares; 2025Q3: 747,818 shares 747,818$35.5M3.45%-26,493Timeline
NRIXNURIX THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,280,981 shares; 2024Q4: 4,192,627 shares; 2025Q1: 4,051,927 shares; 2025Q2: 3,732,888 shares; 2025Q3: 3,678,394 shares 3,678,394$34M3.31%-54,494Timeline
BEAMBEAM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,611,013 shares; 2024Q4: 1,528,567 shares; 2025Q1: 1,610,329 shares; 2025Q2: 1,423,411 shares; 2025Q3: 1,387,559 shares 1,387,559$33.7M3.28%-35,852Timeline
COGTCOGENT BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,484,380 shares; 2024Q4: 3,554,836 shares; 2025Q1: 3,216,026 shares; 2025Q2: 1,448,040 shares; 2025Q3: 2,209,118 shares 2,209,118$31.7M3.09%+761,078Timeline
ABSIABSCI CORPORATIONQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 8,253,316 shares; 2024Q4: 8,253,316 shares; 2025Q1: 8,253,316 shares; 2025Q2: 8,253,316 shares; 2025Q3: 8,253,316 shares 8,253,316$25.1M2.44%0Timeline
NGNENEUROGENE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 964,347 shares; 2024Q4: 1,319,763 shares; 2025Q1: 1,308,063 shares; 2025Q2: 1,276,676 shares; 2025Q3: 1,299,022 shares 1,299,022$22.5M2.19%+22,346Timeline
89BIO INC89BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,569,850 shares; 2024Q4: 2,167,176 shares; 2025Q1: 1,886,444 shares; 2025Q2: 1,545,208 shares; 2025Q3: 1,473,136 shares 1,473,136$21.7M2.11%-72,072
IDYAIDEAYA BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 681,150 shares; 2024Q4: 619,300 shares; 2025Q1: 534,600 shares; 2025Q2: 432,494 shares; 2025Q3: 742,017 shares 742,017$20.2M1.96%+309,523Timeline
ANNXANNEXON INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 6,427,462 shares; 2024Q4: 6,300,644 shares; 2025Q1: 6,300,644 shares; 2025Q2: 6,300,644 shares; 2025Q3: 6,300,644 shares 6,300,644$19.2M1.87%0Timeline
FATEFATE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 13,169,057 shares; 2024Q4: 12,872,946 shares; 2025Q1: 12,872,946 shares; 2025Q2: 12,872,946 shares; 2025Q3: 12,872,946 shares 12,872,946$16.2M1.58%0Timeline
RAPTRAPT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 630,686 shares; 2025Q3: 552,594 shares 552,594$14.3M1.39%-78,092Timeline
STTKSHATTUCK LABS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,615,489 shares; 2024Q4: 5,539,724 shares; 2025Q1: 5,539,724 shares; 2025Q2: 5,539,724 shares; 2025Q3: 5,539,724 shares 5,539,724$13.2M1.29%0Timeline
SLDBSOLID BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 615,246 shares; 2025Q1: 2,019,171 shares; 2025Q2: 1,915,926 shares; 2025Q3: 1,899,342 shares 1,899,342$11.7M1.14%-16,584Timeline
SLNSILENCE THERAPEUTICS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,899,317 shares; 2024Q4: 2,399,317 shares; 2025Q1: 2,214,947 shares; 2025Q2: 2,164,777 shares; 2025Q3: 2,164,777 shares 2,164,777$11.2M1.09%0Timeline
NUVBNUVATION BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,031,009 shares; 2024Q4: 3,031,009 shares; 2025Q1: 3,031,009 shares; 2025Q2: 3,031,009 shares; 2025Q3: 3,031,009 shares 3,031,009$11.2M1.09%0Timeline
KROSKEROS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 552,506 shares; 2024Q4: 552,506 shares; 2025Q1: 552,506 shares; 2025Q2: 552,506 shares; 2025Q3: 552,506 shares 552,506$8.74M0.85%0Timeline
CLDXCELLDEX THERAPEUTICS INC NEWQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 657,175 shares; 2024Q4: 615,775 shares; 2025Q1: 590,175 shares; 2025Q2: 343,026 shares; 2025Q3: 327,008 shares 327,008$8.46M0.82%-16,018Timeline
ATRAATARA BIOTHERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 452,270 shares; 2024Q4: 441,701 shares; 2025Q1: 441,701 shares; 2025Q2: 441,701 shares; 2025Q3: 441,701 shares 441,701$6.33M0.62%0Timeline
FOLDAMICUS THERAPEUTICQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 8,246,592 shares; 2024Q4: 7,054,890 shares; 2025Q1: 9,533,669 shares; 2025Q2: 1,188,998 shares; 2025Q3: 777,178 shares 777,178$6.12M0.6%-411,820Timeline
ALXOALX ONCOLOGY HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,836,576 shares; 2024Q4: 3,689,611 shares; 2025Q1: 3,640,834 shares; 2025Q2: 3,391,455 shares; 2025Q3: 3,332,983 shares 3,332,983$6.1M0.59%-58,472Timeline
ESTAESTABLISHMENT LABS HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 261,803 shares; 2024Q4: 320,149 shares; 2025Q1: 335,366 shares; 2025Q2: 136,495 shares; 2025Q3: 129,364 shares 129,364$5.3M0.52%-7,131Timeline
CBLLCERIBELL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 435,239 shares; 2025Q1: 435,239 shares; 2025Q2: 435,239 shares; 2025Q3: 435,239 shares 435,239$5M0.49%0Timeline
XERSXERIS BIOPHARMA HOLDINGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,046,587 shares; 2024Q4: 451,099 shares; 2025Q1: 451,099 shares; 2025Q2: 451,099 shares; 2025Q3: 451,099 shares 451,099$3.67M0.36%0Timeline
VTYXVENTYX BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,107,215 shares; 2024Q4: 124,178 shares; 2025Q1: 1,569,793 shares; 2025Q2: 1,114,529 shares; 2025Q3: 1,073,386 shares 1,073,386$3.34M0.32%-41,143Timeline
LAVA THERAPEUTICS NVLAVA THERAPEUTICS NVQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,074,372 shares; 2024Q4: 2,074,372 shares; 2025Q1: 2,074,372 shares; 2025Q2: 2,074,372 shares; 2025Q3: 2,074,372 shares 2,074,372$3.24M0.31%0
REPARE THERAPEUTICS INCREPARE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,942,555 shares; 2024Q4: 1,916,089 shares; 2025Q1: 1,884,389 shares; 2025Q2: 1,586,174 shares; 2025Q3: 1,586,174 shares 1,586,174$2.79M0.27%0
IVVDINVIVYD INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,065,714 shares; 2024Q4: 3,012,254 shares; 2025Q1: 2,285,320 shares; 2025Q2: 2,285,320 shares; 2025Q3: 2,285,320 shares 2,285,320$2.51M0.24%0Timeline
PLRXPLIANT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,197,491 shares; 2024Q4: 2,895,478 shares; 2025Q1: 2,053,559 shares; 2025Q2: 1,632,577 shares; 2025Q3: 1,591,695 shares 1,591,695$2.36M0.23%-40,882Timeline
REPLREPLIMUNE GROUP INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,781,183 shares; 2024Q4: 4,905,527 shares; 2025Q1: 4,898,527 shares; 2025Q2: 4,664,791 shares; 2025Q3: 535,818 shares 535,818$2.25M0.22%-4,128,973Timeline
PRMEPRIME MEDICINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,074,350 shares; 2024Q4: 2,074,350 shares; 2025Q1: 2,074,350 shares; 2025Q2: 2,074,350 shares; 2025Q3: 87,118 shares 87,118$483K0.05%-1,987,232Timeline
KLRSKALARIS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 82,955 shares; 2025Q2: 82,955 shares; 2025Q3: 82,955 shares 82,955$479K0.05%0Timeline
BOLDBOUNDLESS BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,023,548 shares; 2024Q4: 740,204 shares; 2025Q1: 725,204 shares; 2025Q2: 589,034 shares; 2025Q3: 245,458 shares 245,458$302K0.03%-343,576Timeline

Sold out in Q3 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
KYMRKYMERA THERAPEUTICS INC803,289$35.1Mshares
HNGEHINGE HEALTH INC300,000$15.5Mshares
BHVNBIOHAVEN LTD729,515$10.3Mshares
BSXBOSTON SCIENTIFIC CORP85,301$9.16Mshares
VERVE THERAPEUTICS INCVERVE THERAPEUTICS INC740,261$8.31Mshares
PENPENUMBRA INC18,818$4.83Mshares
IGM BIOSCIENCES INCIGM BIOSCIENCES INC2,952,131$3.31Mshares
FDMT4D MOLECULAR THERAPEUTICS IN112,168$416Kshares

How Q3 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001104659-25-112572 base2025-11-14acceptance time not in the bulk data set