HighVista Strategies LLC

13F filer, CIK 1335325, BOSTON, MA

HighVista Strategies LLC reported $289,961,060 across 142 holdings for the quarter ended 2024-09-30, in a 13F-HR filed 2024-11-14. Its ten largest share positions make up 25.51% of the portfolio.

Filed 2024-11-14 (acceptance time not in the bulk data set), ingested 2026-10-07 18:26:56 UTC13F-HR 0001172661-24-004811

Period: 2024-09-30
Reported value: $290M
Holdings: 142
Top 10 weight: 25.51%
New: 37
Sold out: 32

Largest buys vs the previous quarter

Security	Shares change	Approx. value
GEVnew	+14,700	$3.75M
AMGNnew	+10,101	$3.25M
PTGXadded	+68,279	$3.07M
AMZNadded	+14,200	$2.65M
EWTXnew	+88,838	$2.37M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

Security	Shares change	Approx. value
INSMreduced	-81,333	-$5.94M
EQUITRANS MIDSTREAM CORP NPVexited	-310,000	-$4.02M
CEREVEL THERAPEUTICS HLDNG Iexited	-97,200	-$3.97M
MERUS N Vreduced	-42,738	-$2.14M
METAexited	-4,090	-$2.06M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q3 2024

Share positions as resolved from 13F-HR 0001172661-24-004811, largest first. % of portfolio is the value over $289,961,060, the sum of the share positions whose value is usable for ratios (method).

Security	Shares	Value	% of portfolio	Change	Timeline
DBCINVESCO DB COMMDY INDX TRCK	1,436,136	$32M	11.03%	0	Timeline
AMZNAMAZON COM INC	32,193	$6M	2.07%	+14,200	Timeline
PCVXVAXCYTE INC	44,661	$5.1M	1.76%	+12,348	Timeline
ACLXARCELLX INC	55,139	$4.6M	1.59%	+4,099	Timeline
CATALENT INC USD 0.01CATALENT INC USD 0.01	75,600	$4.58M	1.58%	0
CRMSALESFORCE INC	16,585	$4.54M	1.57%	-4,600	Timeline
JUNIPER NETWORKS INCJUNIPER NETWORKS INC	114,700	$4.47M	1.54%	0
HASHICORP INCHASHICORP INC	130,200	$4.41M	1.52%	0
VRDNVIRIDIAN THERAPEUTICS INC	185,240	$4.21M	1.45%	-13,244	Timeline
ANSYS INCANSYS INC	12,800	$4.08M	1.41%	0
XPOXPO INC	37,680	$4.05M	1.4%	+12,200	Timeline
PTGXPROTAGONIST THERAPEUTICS INC	89,508	$4.03M	1.39%	+68,279	Timeline
HESS CORPHESS CORP	28,900	$3.92M	1.35%	0
ARGXARGENX SE	7,154	$3.88M	1.34%	+550	Timeline
AMEDISYS INCAMEDISYS INC	39,250	$3.79M	1.31%	0
GEVGE VERNOVA INC	14,700	$3.75M	1.29%	new	Timeline
AXSMAXSOME THERAPEUTICS INC.	41,542	$3.73M	1.29%	-20,650	Timeline
MERUS N VMERUS N V	73,980	$3.7M	1.27%	-42,738
APGEAPOGEE THERAPEUTICS INC	61,788	$3.63M	1.25%	-17,154	Timeline
ACIALBERTSONS COMPANIES INC	188,753	$3.49M	1.2%	0	Timeline
INSMINSMED INC	45,447	$3.32M	1.14%	-81,333	Timeline
CPRICAPRI HOLDINGS LIMITED	77,700	$3.3M	1.14%	0	Timeline
AMGNAMGEN INC	10,101	$3.25M	1.12%	new	Timeline
CARTMAPLEBEAR INC	78,500	$3.2M	1.1%	-14,488	Timeline
BCYCBICYCLE THERAPEUTICS PLC	139,544	$3.16M	1.09%	+12,289	Timeline
MSFTMICROSOFT CORP	7,258	$3.12M	1.08%	-1,900	Timeline
SYRESPYRE THERAPEUTICS INC	105,351	$3.1M	1.07%	-8,199	Timeline
XOMAXOMA ROYALTY CORPORATION	114,548	$3.03M	1.05%	-4,351	Timeline
KROSKEROS THERAPEUTICS INC	52,107	$3.03M	1.04%	+12,899	Timeline
NUVLNUVALENT INC	29,018	$2.97M	1.02%	+320	Timeline
XENEXENON PHARMACEUTICALS INC	73,762	$2.9M	1%	+1,047	Timeline
ELVNENLIVEN THERAPEUTICS INC	112,459	$2.87M	0.99%	-7,330	Timeline
OLMAOLEMA PHARMACEUTICALS INC	212,185	$2.53M	0.87%	-35,695	Timeline
RVMDREVOLUTION MEDICINES INC	55,562	$2.52M	0.87%	+15,479	Timeline
COGTCOGENT BIOSCIENCES INC	225,633	$2.44M	0.84%	-55,460	Timeline
EWTXEDGEWISE THERAPEUTICS INC	88,838	$2.37M	0.82%	new	Timeline
DYNDYNE THERAPEUTICS INC	65,482	$2.35M	0.81%	new	Timeline
PFSIPENNYMAC FINL SVCS INC NEW	19,337	$2.2M	0.76%	+6,100	Timeline
MLTXMOONLAKE IMMUNOTHERAPEUTICS	43,541	$2.2M	0.76%	+1,292	Timeline
BABAALIBABA GROUP HLDG LTD	20,357	$2.16M	0.75%	+4,300	Timeline
GOOGALPHABET INC	12,536	$2.1M	0.72%	+1,100	Timeline
ADSKAUTODESK INC	7,500	$2.07M	0.71%	new	Timeline
TVTXTRAVERE THERAPEUTICS INC	147,233	$2.06M	0.71%	-72,183	Timeline
PTCPTC INC	11,181	$2.02M	0.7%	+600	Timeline
LAURLAUREATE ED INC	121,607	$2.02M	0.7%	+9,500	Timeline
RYTMRHYTHM PHARMACEUTICALS INC	37,426	$1.96M	0.68%	+23,064	Timeline
AUTLAUTOLUS THERAPEUTICS LTD	533,024	$1.93M	0.67%	+14,204	Timeline
MRC GLOBAL INCMRC GLOBAL INC	149,800	$1.91M	0.66%	+15,200
LADLITHIA MTRS INC	6,000	$1.91M	0.66%	new	Timeline
DALDELTA AIR LINES INC	37,200	$1.89M	0.65%	new	Timeline
SESEA LTD	19,941	$1.88M	0.65%	+600	Timeline
RTXRTX CORPORATION	15,400	$1.87M	0.64%	-2,100	Timeline
KNSAKINIKSA PHARMACEUTICALS INTL	74,639	$1.87M	0.64%	-14,049	Timeline
VVISA INC	6,727	$1.85M	0.64%	-2,200	Timeline
CATXPERSPECTIVE THERAPEUTICS INC	138,350	$1.85M	0.64%	+24,800	Timeline
HPEHEWLETT PACKARD ENTERPRISE C	88,900	$1.82M	0.63%	new	Timeline
DVAXDYNAVAX TECHNOLOGIES CORP	162,708	$1.81M	0.63%	+6,547	Timeline
LQDALIQUIDIA CORPORATION	180,947	$1.81M	0.62%	+59,193	Timeline
FISVFISERV INC	10,053	$1.81M	0.62%	-5,500	Timeline
TSMTAIWAN SEMICONDUCTOR MANUFAC	10,300	$1.79M	0.62%	new	Timeline
INTUINTUIT	2,863	$1.78M	0.61%	-2,000	Timeline
BBIOBRIDGEBIO PHARMA INC	69,054	$1.76M	0.61%	+24,482	Timeline
HDBHDFC BANK LTD	27,441	$1.72M	0.59%	+2,400	Timeline
IBNICICI BK LTD	57,447	$1.71M	0.59%	+5,300	Timeline
STXSEAGATE TECHNOLOGY HLDNGS PL	15,600	$1.71M	0.59%	-2,200	Timeline
WDCWESTERN DIGITAL CORP	25,000	$1.71M	0.59%	+1,400	Timeline
CSCOCISCO SYS INC	31,900	$1.7M	0.59%	new	Timeline
OFIXORTHOFIX MED INC	108,100	$1.69M	0.58%	new	Timeline
GDXVANECK ETF TRUST	42,000	$1.67M	0.58%	-4,200	Timeline
AERAERCAP HOLDINGS NV	17,000	$1.61M	0.56%	+1,400	Timeline
STNESTONECO LTD	141,930	$1.6M	0.55%	+46,800	Timeline
NUNU HLDGS LTD	116,761	$1.59M	0.55%	-4,300	Timeline
LYVLIVE NATION ENTERTAINMENT IN	14,400	$1.58M	0.54%	-200	Timeline
CORZCORE SCIENTIFIC INC NEW	132,800	$1.58M	0.54%	new	Timeline
BBDBANCO BRADESCO S A	585,400	$1.56M	0.54%	+48,300	Timeline
CRBPCORBUS PHARMACEUTICALS HLDGS	75,292	$1.55M	0.54%	+36,499	Timeline
AVGOBROADCOM INC	8,900	$1.54M	0.53%	new	Timeline
TEVATEVA PHARMACEUTICAL INDS LTD	85,100	$1.53M	0.53%	-51,400	Timeline
RCLROYAL CARIBBEAN GROUP	8,600	$1.53M	0.53%	new	Timeline
NOWSERVICENOW INC	1,700	$1.52M	0.52%	new	Timeline
BKNGBOOKING HOLDINGS INC	357	$1.5M	0.52%	-400	Timeline
CRNXCRINETICS PHARMACEUTICALS IN	28,911	$1.48M	0.51%	-6,326	Timeline
TKOTKO GROUP HOLDINGS INC	11,700	$1.45M	0.5%	new	Timeline
LENLENNAR CORP	7,700	$1.44M	0.5%	new	Timeline
ARVNARVINAS INC	58,001	$1.43M	0.49%	+6,879	Timeline
NFLXNETFLIX INC.	2,000	$1.42M	0.49%	+200	Timeline
INDIVIOR PLCINDIVIOR PLC	142,634	$1.4M	0.48%	-36,202
GPCRSTRUCTURE THERAPEUTICS INC	31,718	$1.39M	0.48%	-3,410	Timeline
ROIVROIVANT SCIENCES LTD	115,326	$1.33M	0.46%	-11,415	Timeline
LLYELI LILLY & CO	1,500	$1.33M	0.46%	0	Timeline
PMPHILIP MORRIS INTL INC	10,900	$1.32M	0.46%	-600	Timeline
UBERUBER TECHNOLOGIES INC	17,600	$1.32M	0.46%	new	Timeline
TMUST-MOBILE US INC	6,400	$1.32M	0.46%	-5,500	Timeline
ELVELEVANCE HEALTH INC FORMERLY	2,500	$1.3M	0.45%	new	Timeline
RXORXO INC	46,000	$1.29M	0.44%	new	Timeline
GEHCGE HEALTHCARE TECHNOLOGIES I	13,200	$1.24M	0.43%	-2,900	Timeline
SPRINGWORKS THERAPEUTICS INCSPRINGWORKS THERAPEUTICS INC	35,852	$1.15M	0.4%	-15,135
TERNTERNS PHARMACEUTICALS INC	130,966	$1.09M	0.38%	-17,234	Timeline
PDDPDD HOLDINGS INC	8,078	$1.09M	0.38%	+5,500	Timeline
JANXJANUX THERAPEUTICS INC	23,472	$1.07M	0.37%	+140	Timeline
APLSAPELLIS PHARMACEUTICALS INC	35,975	$1.04M	0.36%	+28,409	Timeline
CRHCRH PLC	11,100	$1.03M	0.36%	+1,000	Timeline
PGRPROGRESSIVE CORP	4,000	$1.02M	0.35%	new	Timeline
VERAVERA THERAPEUTICS INC	22,010	$973K	0.34%	+12,848	Timeline
ADBEADOBE INC	1,800	$932K	0.32%	-1,300	Timeline
FCNCAFIRST CTZNS BANCSHARES INC D	500	$920K	0.32%	new	Timeline
CNTACENTESSA PHARMACEUTICALS PLC	46,116	$737K	0.25%	new	Timeline
VERONA PHARMA PLCVERONA PHARMA PLC	23,739	$683K	0.24%	-8,710
ALVAUTOLIV INC	7,200	$672K	0.23%	new	Timeline
PRAXPRAXIS PRECISION MEDICINES I	10,951	$630K	0.22%	new	Timeline
BEKEKE HLDGS INC	30,507	$607K	0.21%	+6,800	Timeline
KYMRKYMERA THERAPEUTICS INC	12,743	$603K	0.21%	new	Timeline
CGONCG ONCOLOGY INC	15,734	$594K	0.2%	new	Timeline
GERNGERON CORP	127,284	$578K	0.2%	-52,515	Timeline
RNAMAVIDITY BIOSCIENCES INC	12,504	$574K	0.2%	new	Timeline
JDJD.COM INC	14,283	$571K	0.2%	-4,900	Timeline
TCOMTRIP COM GROUP LTD	9,556	$568K	0.2%	-2,200	Timeline
BIDUBAIDU INC	5,386	$567K	0.2%	+1,200	Timeline
OCULOCULAR THERAPEUTIX INC	65,027	$566K	0.2%	+3,168	Timeline
ABVXABIVAX SA	49,064	$565K	0.19%	-445	Timeline
LILI AUTO INC	21,900	$562K	0.19%	new	Timeline
SLNOSOLENO THERAPEUTICS INC	11,085	$560K	0.19%	new	Timeline
INTRA-CELLULAR THERAPIES INCINTRA-CELLULAR THERAPIES INC	7,496	$548K	0.19%	-16,841
DNTHDIANTHUS THERAPEUTICS INC	19,808	$542K	0.19%	new	Timeline
CGEMCULLINAN THERAPEUTICS INC	31,893	$534K	0.18%	new	Timeline
CYTKCYTOKINETICS INC	10,055	$531K	0.18%	new	Timeline
MIRMMIRUM PHARMACEUTICALS INC	13,571	$529K	0.18%	-6,637	Timeline
ANABANAPTYSBIO INC	15,574	$522K	0.18%	new	Timeline
IMTXIMMATICS N.V	45,544	$520K	0.18%	-32,277	Timeline
89BIO INC89BIO INC	66,787	$494K	0.17%	new
URGNUROGEN PHARMA LTD	38,566	$490K	0.17%	new	Timeline
IRONDISC MEDICINE INC	9,565	$470K	0.16%	new	Timeline
MDGLMADRIGAL PHARMACEUTICALS INC	2,211	$469K	0.16%	-323	Timeline
2SEVENTY BIO INC COMMON STO…2SEVENTY BIO INC COMMON STOCK	95,454	$451K	0.16%	+1,954
NTRANATERA INC	3,440	$437K	0.15%	-128	Timeline
ALNYALNYLAM PHARMACEUTICALS INC	1,551	$427K	0.15%	-1,051	Timeline
PHVSPHARVARIS N V	22,768	$422K	0.15%	+6,018	Timeline
KURAKURA ONCOLOGY INC	21,161	$413K	0.14%	+4,397	Timeline
ACADACADIA PHARMACEUTICALS INC	25,287	$389K	0.13%	-591	Timeline
KALVKALVISTA PHARMACEUTICALS INC	33,305	$386K	0.13%	+1,432	Timeline
TYRATYRA BIOSCIENCES INC	16,078	$378K	0.13%	0	Timeline
CLDXCELLDEX THERAPEUTICS INC NEW	8,981	$305K	0.11%	-646	Timeline

Sold out in Q3 2024

Positions in the previous quarter's report that this quarter's report no longer lists.

Security	Shares before	Value before	Type
EQUITRANS MIDSTREAM CORP NPVEQUITRANS MIDSTREAM CORP NPV	310,000	$4.02M	shares
CEREVEL THERAPEUTICS HLDNG ICEREVEL THERAPEUTICS HLDNG I	97,200	$3.97M	shares
METAMETA PLATFORMS INC	4,090	$2.06M	shares
VMRKVIVMARK RESIDENTIAL	25,900	$1.8M	shares
PFEPFIZER INC	60,300	$1.69M	shares
WCCWESCO INTL INC	9,797	$1.55M	shares
DUOLDUOLINGO INC	7,400	$1.54M	shares
WMTWALMART INC	22,500	$1.52M	shares
NVDANVIDIA CORPORATION	12,000	$1.48M	shares
IDYAIDEAYA BIOSCIENCES INC	40,856	$1.43M	shares
ROPROPER TECHNOLOGIES INC	2,400	$1.35M	shares
FSVFIRSTSERVICE CORP NEW	8,700	$1.33M	shares
BFAMBRIGHT HORIZONS FAM SOL IN D	11,800	$1.3M	shares
JBHTHUNT J B TRANS SVCS INC	8,000	$1.28M	shares
TOSTTOAST INC	48,300	$1.24M	shares
HUBSHUBSPOT INC	2,100	$1.24M	shares
RIGTRANSOCEAN LTD	229,725	$1.23M	shares
CRWDCROWDSTRIKE HLDGS INC	3,200	$1.23M	shares
RBCRBC BEARINGS INC	4,400	$1.19M	shares
STZCONSTELLATION BRANDS INC	4,600	$1.18M	shares
MUMICRON TECHNOLOGY INC	8,900	$1.17M	shares
AMDADVANCED MICRO DEVICES INC	6,900	$1.12M	shares
Tourmaline Bio IncTourmaline Bio Inc	83,397	$1.07M	shares
BILIBILIBILI INC	46,857	$723K	shares
HTHTH WORLD GROUP LTD	19,029	$634K	shares
ASNDASCENDIS PHARMA A/S	4,527	$617K	shares
UTHRUNITED THERAPEUTICS CORP DEL	1,409	$449K	shares
SRPTSAREPTA THERAPEUTICS INC	2,364	$374K	shares
EDUNEW ORIENTAL ED & TECHNOLOGY	4,600	$358K	shares
FDMT4D MOLECULAR THERAPEUTICS IN	15,532	$326K	shares
TALTAL ED GROUP	29,900	$319K	shares
CABACABALETTA BIO INC	22,208	$166K	shares

How Q3 2024 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

Filing	Role	Amendment	Filed	Accepted	Ingested
13F-HR 0001172661-24-004811	base		2024-11-14	acceptance time not in the bulk data set	2026-10-07 18:26:56 UTC