MONTANOVA CAPITAL, LLC More: the full row for MONTANOVA CAPITAL, LLC 9,067,001 $53.9M 1.46% +3,500,000 13F-HR Timeline Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 6,434,990 $38.3M 1.43% +1,089,875 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 4,458,851 $25.3M <0.01% -13,905 13F-HR/A Timeline Group GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 4,215,930 $25.1M 6.14% +400,000 13F-HR Timeline BRAIDWELL LP More: the full row for BRAIDWELL LP 3,988,989 $23.7M 0.79% +808,600 13F-HR Timeline Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 3,734,866 $22.2M 0.62% +2,434,866 13F-HR Timeline Group Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 3,250,000 $19.3M 1.12% new 13F-HR Timeline Group Pfizer Inc More: the full row for Pfizer Inc 2,838,913 $16.8M 7.05% -131,109 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 2,750,000 $16.4M 0.03% 0 13F-HR Timeline Group Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 2,564,303 $15.3M 0.89% +750,632 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 1,508,063 $8.97M 0.01% +475,383 13F-HR Timeline Group ARMISTICE CAPITAL, LLC More: the full row for ARMISTICE CAPITAL, LLC 1,507,000 $8.97M 0.3% -53,000 13F-HR Timeline Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 1,450,000 $8.63M 0.43% new 13F-HR Timeline QVT Financial LP More: the full row for QVT Financial LP 1,310,593 $7.8M 0.62% new 13F-HR Timeline Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 1,193,492 $7.1M 1.02% +391,170 13F-HR Timeline Group EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 1,179,715 $7.02M 0.3% new 13F-HR Timeline Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 900,000 $5.36M 0.7% +850,000 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 872,950 $5.19M <0.01% -636,461 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 872,662 $5.19M 0.01% +645,829 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 852,340 $5.07M 0.01% -25,423 13F-HR Timeline Group STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 753,520 $4.48M 0.86% new 13F-HR/A Timeline Saturn V Capital Management LP More: the full row for Saturn V Capital Management LP 739,960 $4.4M 0.8% new 13F-HR Timeline VANGUARD GROUP INC group of 3 filers holding More: the full row for VANGUARD GROUP INC 735,533 $4.38M new Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 630,403 $3.75M 0.23% +68,338 13F-HR Timeline Group SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 560,651 $3.34M 0.39% new 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 529,346 $3.15M <0.01% +42 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 527,691 $3.14M <0.01% +123,212 13F-HR Timeline Group Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 511,000 $3.04M 0.09% new 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 457,359 $2.72M <0.01% +87,994 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 450,311 $2.68M <0.01% +390,442 13F-HR Timeline Foresite Capital Management VI LLC in group Foresite Capital Management V… More: the full row for Foresite Capital Management VI LLC 450,000 $2.68M 0.58% new 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 374,506 $2.23M 0.05% +112,223 13F-HR Timeline KVP Capital Advisors, LP More: the full row for KVP Capital Advisors, LP 373,128 $2.22M 1.66% new 13F-HR Timeline TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 318,186 $1.89M <0.01% -94,237 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 313,300 $1.86M <0.01% +10,200 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 282,207 $1.68M <0.01% new 13F-HR/A Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 278,890 $1.66M <0.01% -378,964 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 241,027 $1.43M <0.01% -229,513 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 194,963 $1.16M <0.01% +38,600 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 169,833 $1.01M <0.01% +121,172 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 152,915 $910K <0.01% -63,895 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 136,523 $812K <0.01% +132,130 13F-HR Timeline Group Alberta Investment Management Corp More: the full row for Alberta Investment Management Corp 133,200 $793K <0.01% 0 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 119,712 $712K 0.01% +53,259 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 116,686 $694K <0.01% new 13F-HR Timeline Group 683 Capital Management, LLC in group 683 Capital Management, LLC More: the full row for 683 Capital Management, LLC 110,000 $654K 0.06% -149,165 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 104,130 $620K <0.01% +3,294 13F-HR Timeline Group Verdad Advisers, LP More: the full row for Verdad Advisers, LP 97,102 $578K 0.65% new 13F-HR Timeline Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 95,355 $567K <0.01% +32,271 13F-HR Timeline Group BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 85,348 $508K 0.01% -32,647 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 84,865 $505K 0.02% +84,665 13F-HR Timeline HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 77,505 $461K <0.01% new 13F-HR Timeline Burkehill Global Management, LP More: the full row for Burkehill Global Management, LP 75,000 $446K 0.02% new 13F-HR Timeline Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 72,038 $429K <0.01% new 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 70,192 $418K <0.01% +16,803 13F-HR Timeline Group RBF Capital, LLC More: the full row for RBF Capital, LLC 58,193 $346K 0.02% -10,000 13F-HR/A Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 47,886 $285K <0.01% -236,211 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 44,939 $267K <0.01% +11,138 13F-HR Timeline Group FOX RUN MANAGEMENT, L.L.C. More: the full row for FOX RUN MANAGEMENT, L.L.C. 46,062 $262K 0.05% new 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 43,135 $257K <0.01% +19,603 13F-HR Timeline Group AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 33,733 $201K <0.01% +12,350 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 31,096 $185K <0.01% new 13F-HR Timeline Group OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 29,800 $177K <0.01% -37,400 13F-HR Timeline Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 28,063 $167K <0.01% -49,637 13F-HR Timeline Group Brendel Financial Advisors LLC More: the full row for Brendel Financial Advisors LLC 28,052 $167K 0.08% new 13F-HR Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 26,892 $160K <0.01% +383 13F-HR Timeline Group INSIGNEO ADVISORY SERVICES, LLC More: the full row for INSIGNEO ADVISORY SERVICES, LLC 25,650 $153K 0.01% -30,000 13F-HR Timeline Ghisallo Capital Management LLC More: the full row for Ghisallo Capital Management LLC 25,000 $149K <0.01% new 13F-HR Timeline Mariner, LLC in group Mariner, LLC More: the full row for Mariner, LLC 24,734 $147K <0.01% -11,882 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 21,600 $129K 0.01% new 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 18,491 $110K <0.01% -12,670 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 17,898 $106K <0.01% -291,259 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 16,146 $96.1K <0.01% new 13F-HR Timeline Diametric Capital, LP More: the full row for Diametric Capital, LP 15,681 $93.3K 0.02% new 13F-HR Timeline Catalyst Funds Management Pty Ltd More: the full row for Catalyst Funds Management Pty Ltd 15,300 $91K 0.02% new 13F-HR Timeline Forefront Analytics, LLC More: the full row for Forefront Analytics, LLC 14,901 $88.7K 0.08% -4,676 13F-HR Timeline MANGROVE PARTNERS IM, LLC More: the full row for MANGROVE PARTNERS IM, LLC 14,791 $88K 0.01% new 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 13,316 $79.2K <0.01% +7,566 13F-HR Timeline Abel Hall, LLC More: the full row for Abel Hall, LLC 13,189 $78.5K 0.02% -1 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 9,409 $56K <0.01% -30,350 13F-HR Timeline Group Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 7,500 $44.6K <0.01% new 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 7,335 $43.6K <0.01% -11,423 13F-HR Timeline Group MAI Capital Management More: the full row for MAI Capital Management 4,000 $23.8K <0.01% 0 13F-HR Timeline Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 1,000 $5.95K <0.01% 0 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 702 $4.18K <0.01% 0 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 318 $1.89K <0.01% new 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 116 $690 <0.01% -26 13F-HR Timeline Group SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 106 $631 <0.01% -32 13F-HR Timeline State of Wyoming More: the full row for State of Wyoming 55 $327 <0.01% new 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 24 $143 <0.01% 0 13F-HR Timeline Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 16 $95 <0.01% 0 13F-HR/A Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 1 $6 <0.01% new 13F-HR Timeline