RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 10,714,000 $23.8M 0.25% 0 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 10,714,000 $23.7M 0.01% new 13F-HR/A Timeline Group Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 10,636,318 $23.6M 1.38% +3,486,318 13F-HR Timeline EVENTIDE ASSET MANAGEMENT, LLC More: the full row for EVENTIDE ASSET MANAGEMENT, LLC 9,916,911 $22M 0.36% +5,631,911 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 6,163,781 $13.7M 0.02% +2,671,781 13F-HR Timeline Group VANGUARD GROUP INC group of 3 filers holding More: the full row for VANGUARD GROUP INC 5,975,241 $13.3M new Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 5,533,073 $12.3M 0.02% +5,208,073 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 4,544,113 $10.1M 0.61% +259,113 13F-HR Timeline Group Saturn V Capital Management LP More: the full row for Saturn V Capital Management LP 4,166,666 $9.25M 1.68% +1,666,666 13F-HR Timeline FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 3,571,000 $7.93M 0.01% 0 13F-HR Timeline Group Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 2,894,704 $6.43M 0.92% +2,647,146 13F-HR Timeline Group Ally Bridge Group (NY) LLC More: the full row for Ally Bridge Group (NY) LLC 2,818,459 $6.26M 6.22% +1,033,459 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 1,947,594 $4.32M 0.01% +1,605,854 13F-HR Timeline Group Blue Owl Capital Holdings LP More: the full row for Blue Owl Capital Holdings LP 1,904,666 $4.23M 1.14% new 13F-HR Timeline SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 1,622,828 $3.6M 0.62% new 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,533,283 $3.4M <0.01% +919,808 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 1,496,518 $3.32M <0.01% +157,053 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 1,320,610 $2.93M 0.01% -2,230,519 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,318,091 $2.93M <0.01% +646,087 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 1,256,869 $2.79M <0.01% +658,000 13F-HR Timeline Group Sio Capital Management, LLC More: the full row for Sio Capital Management, LLC 1,252,381 $2.78M 0.4% -175,114 13F-HR Timeline Rosalind Advisors, Inc. More: the full row for Rosalind Advisors, Inc. 1,107,994 $2.46M 1.01% new 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 1,104,300 $2.45M <0.01% -380,178 13F-HR Timeline SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 1,000,000 $2.22M 0.26% new 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 927,913 $2.06M 0.05% +772,172 13F-HR Timeline Propel Bio Management, LLC More: the full row for Propel Bio Management, LLC 921,457 $2.04M 1.28% new 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 917,733 $2.04M <0.01% -353,754 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 735,429 $1.63M <0.01% -148,438 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 713,625 $1.58M <0.01% -7,223 13F-HR/A Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 520,283 $1.16M <0.01% +243,750 13F-HR Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 443,362 $984K 0.01% -86,658 13F-HR/A Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 367,902 $817K <0.01% -429,922 13F-HR Timeline Group SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 328,924 $730K <0.01% new 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 290,432 $645K <0.01% +95,532 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 277,656 $616K <0.01% +84,671 13F-HR Timeline Group Informed Momentum Co LLC More: the full row for Informed Momentum Co LLC 270,298 $600K 0.07% new 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 254,804 $566K <0.01% +88,173 13F-HR Timeline Group CIBC WORLD MARKET INC. More: the full row for CIBC WORLD MARKET INC. 249,351 $554K <0.01% new 13F-HR Timeline Assenagon Asset Management S.A. More: the full row for Assenagon Asset Management S.A. 227,742 $506K <0.01% -390,277 13F-HR Timeline Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 212,211 $471K <0.01% +19,715 13F-HR Timeline Parkman Healthcare Partners LLC More: the full row for Parkman Healthcare Partners LLC 208,205 $462K 0.05% +7,169 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 197,971 $439K <0.01% +158,937 13F-HR Timeline Group Velan Capital Investment Management LP More: the full row for Velan Capital Investment Management LP 160,000 $355K 0.22% 0 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 152,847 $339K <0.01% -17,610 13F-HR Timeline Group Verdad Advisers, LP More: the full row for Verdad Advisers, LP 151,919 $337K 0.38% new 13F-HR Timeline Simplify Asset Management Inc. More: the full row for Simplify Asset Management Inc. 130,813 $290K <0.01% new 13F-HR Timeline GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 123,969 $275K 0.02% +15,635 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 114,242 $254K <0.01% +109,521 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 113,393 $252K <0.01% -75,063 13F-HR Timeline Group Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 111,804 $248K <0.01% +23,930 13F-HR Timeline Group Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 101,759 $226K <0.01% new 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 101,581 $226K <0.01% +68,273 13F-HR Timeline Group OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 100,100 $222K <0.01% -25,200 13F-HR Timeline BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 95,434 $212K <0.01% 0 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 94,301 $209K <0.01% +40,350 13F-HR Timeline Empowered Funds, LLC More: the full row for Empowered Funds, LLC 91,234 $203K <0.01% new 13F-HR/A Timeline AXQ CAPITAL, LP More: the full row for AXQ CAPITAL, LP 85,411 $190K 0.02% new 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 72,000 $160K <0.01% new 13F-HR Timeline Group LPL Financial LLC More: the full row for LPL Financial LLC 69,548 $154K <0.01% +39,548 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 55,038 $122K <0.01% -2,660 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 49,555 $110K <0.01% +12,603 13F-HR Timeline Group Diametric Capital, LP More: the full row for Diametric Capital, LP 43,262 $96K 0.03% new 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 42,138 $93.5K <0.01% -1,836 13F-HR Timeline Group Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 40,000 $88.8K 0.08% -62,367 13F-HR Timeline Abel Hall, LLC More: the full row for Abel Hall, LLC 31,189 $69.2K 0.01% -238 13F-HR Timeline Sovereign Financial Group, Inc. More: the full row for Sovereign Financial Group, Inc. 30,000 $66.6K 0.01% +20,000 13F-HR Timeline BLAIR WILLIAM & CO/IL More: the full row for BLAIR WILLIAM & CO/IL 28,839 $64K <0.01% +2,500 13F-HR Timeline MANGROVE PARTNERS IM, LLC More: the full row for MANGROVE PARTNERS IM, LLC 27,294 $60.6K <0.01% new 13F-HR Timeline FIRST MANHATTAN CO. LLC. More: the full row for FIRST MANHATTAN CO. LLC. 26,000 $57.7K <0.01% 0 13F-HR Timeline TWO SIGMA SECURITIES, LLC More: the full row for TWO SIGMA SECURITIES, LLC 25,324 $56.2K 0.01% new 13F-HR Timeline State of Wyoming More: the full row for State of Wyoming 22,171 $49.2K 0.01% new 13F-HR Timeline Total Clarity Wealth Management, Inc. More: the full row for Total Clarity Wealth Management, Inc. 20,975 $46.6K 0.01% -7,625 13F-HR Timeline Focus Partners Advisor Solutions, LLC in group Focus Partners Wealth More: the full row for Focus Partners Advisor Solutions, LLC 20,000 $44.4K <0.01% new 13F-HR Timeline Group Benin Management CORP More: the full row for Benin Management CORP 19,000 $42.2K 0.01% 0 13F-HR Timeline TLS Advisors LLC More: the full row for TLS Advisors LLC 18,858 $41K 0.1% +5,258 13F-HR Timeline Cetera Investment Advisers More: the full row for Cetera Investment Advisers 17,000 $37.7K <0.01% -1 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 13,246 $29.4K <0.01% new 13F-HR Timeline VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 13,166 $29.2K <0.01% new 13F-HR Timeline Aaron Wealth Advisors LLC More: the full row for Aaron Wealth Advisors LLC 11,234 $24.9K <0.01% 0 13F-HR Timeline Quadcap Wealth Management, LLC More: the full row for Quadcap Wealth Management, LLC 11,111 $24.7K <0.01% 0 13F-HR Timeline PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 10,951 $24.3K <0.01% new 13F-HR Timeline Allspring Global Investments Holdings, … in group Allspring Global Investments … More: the full row for Allspring Global Investments Holdings, LLC 11,262 $23.8K <0.01% 0 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 4,384 $9.73K <0.01% new 13F-HR Timeline Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 4,000 $8.88K <0.01% 0 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 3,674 $8.16K <0.01% -27,929 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 3,310 $7K <0.01% +2,235 13F-HR Timeline Group JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 2,925 $6.73K <0.01% new 13F-HR Timeline Group Clearstead Advisors, LLC More: the full row for Clearstead Advisors, LLC 2,734 $6.07K <0.01% 0 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 2,351 $5.22K <0.01% 0 13F-HR Timeline Atlantic Union Bankshares Corp in group Atlantic Union Bankshares Corp More: the full row for Atlantic Union Bankshares Corp 2,300 $5.11K <0.01% 0 13F-HR Timeline Group TFC Financial Management, Inc. More: the full row for TFC Financial Management, Inc. 1,000 $2.22K <0.01% 0 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 992 $2.2K <0.01% +12 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 903 $2K <0.01% 0 13F-HR Timeline Group Fortitude Family Office, LLC More: the full row for Fortitude Family Office, LLC 312 $693 <0.01% new 13F-HR Timeline Advisory Services Network, LLC More: the full row for Advisory Services Network, LLC 219 $486 <0.01% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 147 $310 <0.01% 0 13F-HR/A Timeline Group SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 107 $238 <0.01% -82 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 57 $127 <0.01% 0 13F-HR Timeline TD Waterhouse Canada Inc. More: the full row for TD Waterhouse Canada Inc. 30 $65 <0.01% 0 13F-HR Timeline Sound Income Strategies, LLC More: the full row for Sound Income Strategies, LLC 6 $13 <0.01% 0 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 1 $2 <0.01% 0 13F-HR Timeline Group