FMR LLC in group FMR LLC More: the full row for FMR LLC 15,167,808 $413M 0.03% new 13F-HR Timeline Group Alphabet Inc. in group Alphabet Inc. More: the full row for Alphabet Inc. 4,961,744 $135M 8.56% new 13F-HR Timeline Group MIC Capital Management UK LLP More: the full row for MIC Capital Management UK LLP 4,539,540 $124M 25.18% new 13F-HR Timeline Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 3,750,662 $102M 8.69% new 13F-HR Timeline JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 2,905,462 $81.3M 0.04% new 13F-HR Timeline Group T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 2,893,009 $78.7M 0.05% new 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 2,401,991 $65.4M 0.01% new 13F-HR Timeline Group Alpha Wave Global, LP More: the full row for Alpha Wave Global, LP 2,384,050 $64.9M 28.91% new 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,814,353 $49.4M <0.01% new 13F-HR Timeline Group VIKING GLOBAL INVESTORS LP in group VIKING GLOBAL INVESTORS LP More: the full row for VIKING GLOBAL INVESTORS LP 1,616,612 $44M 0.14% new 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 1,557,487 $42.4M 0.01% new 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 1,467,011 $39.9M <0.01% new 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 1,202,952 $32.7M 0.01% new 13F-HR Timeline Paradigm Biocapital Advisors LP in group Paradigm Biocapital Advisors … More: the full row for Paradigm Biocapital Advisors LP 1,191,462 $32.4M 1.49% new 13F-HR Timeline Group Deep Track Capital, LP More: the full row for Deep Track Capital, LP 1,094,408 $29.8M 0.96% new 13F-HR Timeline RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 675,525 $18.4M 0.31% new 13F-HR Timeline Group DEERFIELD MANAGEMENT COMPANY, L.P. in group DEERFIELD MANAGEMENT COMPANY,… More: the full row for DEERFIELD MANAGEMENT COMPANY, L.P. 500,000 $13.6M 0.27% new 13F-HR Timeline Group MASSACHUSETTS FINANCIAL SERVICES CO /MA/ in group MASSACHUSETTS FINANCIAL SERVI… More: the full row for MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 481,679 $13.1M <0.01% new 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 434,647 $11.8M <0.01% new 13F-HR Timeline Group Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 400,000 $10.9M 0.82% new 13F-HR Timeline JENNISON ASSOCIATES LLC More: the full row for JENNISON ASSOCIATES LLC 355,567 $9.68M 0.01% new 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 300,217 $8.17M 0.05% new 13F-HR Timeline AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 286,207 $7.79M <0.01% new 13F-HR Timeline Group EVENTIDE ASSET MANAGEMENT, LLC More: the full row for EVENTIDE ASSET MANAGEMENT, LLC 250,000 $6.8M 0.14% new 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 248,648 $6.77M <0.01% new 13F-HR Timeline Group BRAIDWELL LP More: the full row for BRAIDWELL LP 175,000 $4.76M 0.17% new 13F-HR Timeline Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 150,000 $4.08M 1.33% new 13F-HR Timeline Group Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 150,000 $4.08M 0.23% new 13F-HR/A Timeline Group NORGES BANK More: the full row for NORGES BANK 127,442 $3.47M <0.01% new 13F-HR/A Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 125,282 $3.41M <0.01% new 13F-HR/A Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 122,319 $3.33M <0.01% new 13F-HR Timeline Group SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 112,759 $3.07M 0.64% new 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 105,275 $2.87M <0.01% new 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 76,824 $2.09M <0.01% new 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 73,698 $2.01M <0.01% new 13F-HR Timeline Group EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 50,000 $1.36M 0.08% new 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 48,495 $1.32M <0.01% new 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 48,105 $1.31M 0.05% new 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 45,468 $1.24M <0.01% new 13F-HR Timeline Group Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 36,800 $1M 0.08% new 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 32,494 $884K <0.01% new 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 21,395 $582K <0.01% new 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 20,856 $568K <0.01% new 13F-HR/A Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 20,317 $553K <0.01% 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 19,888 $541K <0.01% new 13F-HR/A Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 19,112 $520K <0.01% new 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 19,105 $520K <0.01% new 13F-HR/A Timeline PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 14,900 $406K <0.01% new 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 13,740 $374K <0.01% new 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 10,851 $295K <0.01% new 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 10,606 $289K <0.01% new 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 10,022 $273K <0.01% new 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 9,974 $271K <0.01% new 13F-HR Timeline Group SummitTX Capital, L.P. More: the full row for SummitTX Capital, L.P. 9,523 $259K 0.01% 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 9,342 $254K <0.01% new 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 9,126 $248K <0.01% new 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 8,193 $223K <0.01% new 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 8,154 $222K <0.01% new 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 7,835 $213K <0.01% new 13F-HR/A Timeline Group Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 7,556 $206K <0.01% new 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 7,295 $199K <0.01% new 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 4,800 $131K <0.01% new 13F-HR/A Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 4,647 $126K <0.01% new 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 3,237 $88.1K <0.01% new 13F-HR Timeline STRS OHIO More: the full row for STRS OHIO 2,800 $76.2K <0.01% new 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,573 $42.8K <0.01% new 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 1,560 $42.5K <0.01% new 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 1,533 $41.7K <0.01% new 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 1,139 $31K <0.01% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 800 $21.8K <0.01% new 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 650 $17.7K <0.01% new 13F-HR Timeline Group AMALGAMATED BANK More: the full row for AMALGAMATED BANK 532 $14K <0.01% new 13F-HR Timeline SALEM INVESTMENT COUNSELORS INC More: the full row for SALEM INVESTMENT COUNSELORS INC 200 $5.44K <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 152 $4.14K <0.01% new 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 126 $3.43K <0.01% new 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 71 $2K <0.01% new 13F-HR/A Timeline Group Arax Advisory Partners More: the full row for Arax Advisory Partners 30 $817 <0.01% new 13F-HR Timeline JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 25 $700 <0.01% new 13F-HR/A Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 17 $463 <0.01% new 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 9 $245 <0.01% new 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 new 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.