T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 7,554,594 $50.8M 0.03% +2,054,640 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 5,662,699 $38.1M <0.01% +1,537,711 13F-HR Timeline Group Redmile Group, LLC in group Redmile Group, LLC More: the full row for Redmile Group, LLC 5,361,187 $36.1M 3.41% +533,161 13F-HR Timeline Group ENAVATE SCIENCES GP, LLC More: the full row for ENAVATE SCIENCES GP, LLC 4,768,583 $32.1M 24.18% +1,290,322 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 4,360,675 $29.3M 0.08% +3,671,885 13F-HR/A Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 4,307,191 $29M <0.01% +1,303,753 13F-HR Timeline Group EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 4,079,415 $27.5M 1.63% +200,000 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 3,892,318 $26.2M <0.01% -26,898 13F-HR Timeline Group Opaleye Management Inc. More: the full row for Opaleye Management Inc. 3,550,000 $23.9M 5.32% +1,510,000 13F-HR Timeline PRIMECAP MANAGEMENT CO/CA/ More: the full row for PRIMECAP MANAGEMENT CO/CA/ 3,413,700 $23M 0.02% +3,132,900 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 3,069,607 $20.7M <0.01% +786,853 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 2,640,443 $17.8M <0.01% +513,608 13F-HR Timeline Group Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 2,288,000 $15.4M 0.27% +288,000 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 2,088,495 $14.6M 0.01% -1,367,444 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,743,057 $11.7M <0.01% +514,206 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 1,657,729 $11.2M 0.07% +676,804 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 1,610,708 $10.8M 0.01% +394,526 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 1,377,053 $9.27M 0.02% +1,294,458 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 864,223 $5.82M <0.01% +465,356 13F-HR Timeline Group Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 788,666 $5.31M 0.4% +41,842 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 775,000 $5.22M 0.01% +275,000 13F-HR Timeline Group Caption Management, LLC More: the full row for Caption Management, LLC 750,000 $5.05M 0.23% new 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 698,401 $4.7M <0.01% +181,910 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 619,538 $4.17M <0.01% -29,072 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 614,387 $4.13M <0.01% +157,135 13F-HR/A Timeline Group Driehaus Capital Management LLC More: the full row for Driehaus Capital Management LLC 610,551 $4.11M 0.04% new 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 606,762 $4.08M <0.01% +183,460 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 461,059 $3.1M <0.01% +302,631 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 422,395 $2.84M +176,005 Timeline Granahan Investment Management, LLC More: the full row for Granahan Investment Management, LLC 419,271 $2.82M 0.14% +105,032 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 344,391 $2.32M <0.01% +300,474 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 340,103 $2.29M <0.01% +244,237 13F-HR Timeline Group SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 263,867 $1.84M <0.01% new 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 271,130 $1.82M <0.01% +82,070 13F-HR Timeline Group Exome Asset Management LLC More: the full row for Exome Asset Management LLC 263,841 $1.78M 1.59% new 13F-HR/A Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 239,940 $1.61M <0.01% 13F-HR Timeline Group READYSTATE ASSET MANAGEMENT LP More: the full row for READYSTATE ASSET MANAGEMENT LP 224,240 $1.51M 0.08% new 13F-HR Timeline Handelsbanken Fonder AB More: the full row for Handelsbanken Fonder AB 200,000 $1.35M 0.01% 0 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 193,302 $1.3M <0.01% -80,459 13F-HR/A Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 193,147 $1.3M <0.01% +69,944 13F-HR Timeline Group AXA S.A. in group AXA S.A. More: the full row for AXA S.A. 179,232 $1.21M <0.01% -226 13F-HR Timeline Group Velan Capital Investment Management LP More: the full row for Velan Capital Investment Management LP 153,500 $1.03M 1.06% new 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 153,011 $1.03M <0.01% +7,447 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 145,016 $976K <0.01% +67,780 13F-HR Timeline Group Swiss National Bank More: the full row for Swiss National Bank 128,000 $861K <0.01% +51,600 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 126,579 $852K <0.01% +22,265 13F-HR/A Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 116,000 $781K <0.01% -200,000 13F-HR Timeline Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 102,475 $690K <0.01% +21,084 13F-HR Timeline ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 102,153 $687K 0.01% new 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 101,124 $681K -101,543 Timeline Zimmer Partners, LP More: the full row for Zimmer Partners, LP 100,000 $673K 0.01% new 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 88,888 $598K <0.01% +20,721 13F-HR/A Timeline PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 80,742 $543K 0.05% new 13F-HR Timeline Main Management ETF Advisors, LLC in group Main Management ETF Advisors,… More: the full row for Main Management ETF Advisors, LLC 75,696 $509K 0.02% new 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 63,682 $429K <0.01% +17,607 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 62,544 $421K <0.01% +12,074 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 62,503 $421K <0.01% +20,510 13F-HR Timeline Group Freestone Capital Holdings, LLC in group Freestone Capital Holdings, L… More: the full row for Freestone Capital Holdings, LLC 61,681 $415K 0.02% new 13F-HR Timeline Group AlphaQuest LLC More: the full row for AlphaQuest LLC 53,788 $362K 0.04% +45,920 13F-HR Timeline Magnus Financial Group LLC More: the full row for Magnus Financial Group LLC 53,536 $360K 0.03% 0 13F-HR Timeline Lido Advisors, LLC in group Lido Advisors, LLC More: the full row for Lido Advisors, LLC 53,000 $357K <0.01% new 13F-HR Timeline Group Cerity Partners LLC in group Cerity Partners LLC More: the full row for Cerity Partners LLC 52,059 $350K <0.01% -619 13F-HR Timeline Group WEALTH ENHANCEMENT ADVISORY SERVICES, L… More: the full row for WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 51,544 $347K <0.01% +10,039 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 48,510 $326K <0.01% -5,280 13F-HR Timeline Johnson Financial Group, LLC More: the full row for Johnson Financial Group, LLC 48,000 $323K 0.03% +28,000 13F-HR Timeline MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 46,821 $316K <0.01% +14,398 13F-HR Timeline Group DARK FOREST CAPITAL MANAGEMENT LP More: the full row for DARK FOREST CAPITAL MANAGEMENT LP 46,044 $310K 0.01% new 13F-HR Timeline Scharf Investments, LLC More: the full row for Scharf Investments, LLC 44,389 $299K 0.01% 0 13F-HR Timeline Northeast Financial Consultants Inc More: the full row for Northeast Financial Consultants Inc 42,953 $289K 0.01% 0 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 42,411 $285K <0.01% +6,792 13F-HR Timeline Group Private Capital Advisors, Inc. More: the full row for Private Capital Advisors, Inc. 38,501 $259K 0.03% new 13F-HR Timeline Three Bridge Wealth Advisors, LLC More: the full row for Three Bridge Wealth Advisors, LLC 37,615 $253K 0.09% +10,000 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 37,368 $251K <0.01% 0 13F-HR Timeline Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 37,114 $250K <0.01% new 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 36,100 $243K <0.01% +9,893 13F-HR Timeline Group LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 35,848 $241K <0.01% +127 13F-HR Timeline Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 34,735 $234K <0.01% +9,179 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 34,424 $232K <0.01% +15,463 13F-HR Timeline FOX RUN MANAGEMENT, L.L.C. More: the full row for FOX RUN MANAGEMENT, L.L.C. 30,220 $203K 0.03% new 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 28,379 $191K <0.01% +1,718 13F-HR Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 26,599 $179K <0.01% new 13F-HR Timeline Baldwin Investment Management, LLC More: the full row for Baldwin Investment Management, LLC 25,394 $171K 0.02% 0 13F-HR Timeline Prosight Management, LP More: the full row for Prosight Management, LP 23,618 $159K 0.05% -30,724 13F-HR Timeline Man Group plc in group Man Group plc More: the full row for Man Group plc 22,545 $152K <0.01% new 13F-HR Timeline Group PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 21,601 $145K 0.01% +5,507 13F-HR Timeline SummitTX Capital, L.P. More: the full row for SummitTX Capital, L.P. 20,876 $140K 0.01% 13F-HR Timeline COMMONWEALTH EQUITY SERVICES, LLC More: the full row for COMMONWEALTH EQUITY SERVICES, LLC 20,545 $138K <0.01% +1,528 13F-HR Timeline CITIZENS FINANCIAL GROUP INC/RI in group CITIZENS FINANCIAL GROUP INC/… More: the full row for CITIZENS FINANCIAL GROUP INC/RI 20,000 $135K <0.01% new 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 20,000 $135K 0.03% new 13F-HR Timeline Group VIRGINIA RETIREMENT SYSTEMS ET Al More: the full row for VIRGINIA RETIREMENT SYSTEMS ET Al 19,900 $134K <0.01% 13F-HR Timeline Sequoia Financial Advisors, LLC More: the full row for Sequoia Financial Advisors, LLC 19,065 $128K <0.01% 0 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 18,905 $127K <0.01% +3,305 13F-HR/A Timeline Group ARIZONA STATE RETIREMENT SYSTEM More: the full row for ARIZONA STATE RETIREMENT SYSTEM 18,764 $126K <0.01% +7,476 13F-HR Timeline TEACHER RETIREMENT SYSTEM OF TEXAS More: the full row for TEACHER RETIREMENT SYSTEM OF TEXAS 17,360 $117K <0.01% +5,712 13F-HR Timeline KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 17,100 $115K <0.01% +10,000 13F-HR Timeline CIBC WORLD MARKETS CORP More: the full row for CIBC WORLD MARKETS CORP 15,733 $106K <0.01% new 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 15,387 $104K <0.01% +5,052 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 15,348 $103K <0.01% +871 13F-HR Timeline KENNEDY CAPITAL MANAGEMENT LLC More: the full row for KENNEDY CAPITAL MANAGEMENT LLC 14,725 $99.1K <0.01% +204 13F-HR Timeline ANTIPODES PARTNERS Ltd More: the full row for ANTIPODES PARTNERS Ltd 14,164 $95.3K <0.01% new 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 12,700 $85.5K <0.01% 0 13F-HR/A Timeline Virtus Investment Advisers, LLC group of 2 filers holding More: the full row for Virtus Investment Advisers, LLC 12,561 $84.5K +7,121 Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 12,050 $81.1K <0.01% -13,767 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 12,154 $81K <0.01% +5,874 13F-HR Timeline STONERIDGE INVESTMENT PARTNERS LLC More: the full row for STONERIDGE INVESTMENT PARTNERS LLC 11,554 $78K 0.07% 0 13F-HR Timeline Sterling Investment Advisors, Ltd. More: the full row for Sterling Investment Advisors, Ltd. 11,065 $74.5K 0.02% 0 13F-HR Timeline Gotham Asset Management, LLC More: the full row for Gotham Asset Management, LLC 10,200 $68.6K <0.01% new 13F-HR Timeline Pictet Asset Management Holding SA in group Pictet Asset Management Holdi… More: the full row for Pictet Asset Management Holding SA 10,181 $68.5K <0.01% new 13F-HR Timeline Group Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 8,011 $53.9K <0.01% 0 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 7,173 $48.3K <0.01% +2,137 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 3,555 $23.9K <0.01% -3,029 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 3,136 $21.1K <0.01% -5,472 13F-HR Timeline Group AMALGAMATED BANK More: the full row for AMALGAMATED BANK 2,444 $16K <0.01% +666 13F-HR Timeline MB, LEVIS & ASSOCIATES, LLC More: the full row for MB, LEVIS & ASSOCIATES, LLC 2,373 $16K 0.01% 0 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 1,957 $13.2K <0.01% +1,650 13F-HR Timeline COLDSTREAM CAPITAL MANAGEMENT INC More: the full row for COLDSTREAM CAPITAL MANAGEMENT INC 1,950 $13.1K <0.01% new 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 1,700 $11.4K <0.01% new 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 1,386 $10K <0.01% -328 13F-HR/A Timeline Group Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 1,170 $7.87K <0.01% new 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 912 $6.14K <0.01% +702 13F-HR/A Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 602 $4.05K <0.01% 0 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 353 $2.38K <0.01% 0 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 191 $1.28K <0.01% +85 13F-HR Timeline Aster Capital Management (DIFC) Ltd More: the full row for Aster Capital Management (DIFC) Ltd 114 $1.07K <0.01% -213 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 120 $1.02K <0.01% new 13F-HR Timeline Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 141 $949 <0.01% new 13F-HR Timeline JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 120 $839 <0.01% new 13F-HR/A Timeline Group Lindbrook Capital, LLC More: the full row for Lindbrook Capital, LLC 102 $686 <0.01% new 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 100 $673 <0.01% +40 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 100 $626 <0.01% 0 13F-HR Timeline Amundi in group Amundi More: the full row for Amundi 92 $574 <0.01% +14 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 74 $498 <0.01% +21 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 69 $465 <0.01% new 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 69 $464 <0.01% new 13F-HR Timeline Group SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 50 $337 <0.01% +26 13F-HR Timeline Stephens Consulting, LLC More: the full row for Stephens Consulting, LLC 50 $337 <0.01% new 13F-HR Timeline Bear Mountain Capital, Inc. More: the full row for Bear Mountain Capital, Inc. 20 $171 <0.01% 0 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 0 $155 <0.01% 0 13F-HR Timeline Amount filed as zero, left out of ratios. US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 21 $141 <0.01% new 13F-HR Timeline Group True Wealth Design, LLC More: the full row for True Wealth Design, LLC 8 $54 <0.01% new 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 22 $0 0% +5 13F-HR Timeline Group Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.