T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 8,275,257 $77M 0.05% +720,663 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 6,167,666 $57.4M <0.01% +2,275,348 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 5,770,692 $53.7M <0.01% +107,993 13F-HR Timeline Group Redmile Group, LLC in group Redmile Group, LLC More: the full row for Redmile Group, LLC 4,872,225 $45.3M 4.82% -488,962 13F-HR Timeline Group ENAVATE SCIENCES GP, LLC More: the full row for ENAVATE SCIENCES GP, LLC 4,768,583 $44.3M 25.12% 0 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 4,685,803 $43.6M 0.1% +325,128 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 4,524,952 $42.1M <0.01% +217,761 13F-HR Timeline Group EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 4,079,415 $37.9M 2.25% 0 13F-HR Timeline Opaleye Management Inc. More: the full row for Opaleye Management Inc. 3,529,581 $32.8M 6.64% -20,419 13F-HR/A Timeline PRIMECAP MANAGEMENT CO/CA/ More: the full row for PRIMECAP MANAGEMENT CO/CA/ 3,020,210 $28.1M 0.02% -393,490 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 2,982,080 $27.7M <0.01% -87,527 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 2,520,916 $23.4M <0.01% -119,527 13F-HR Timeline Group TORONTO DOMINION BANK in group TORONTO DOMINION BANK More: the full row for TORONTO DOMINION BANK 2,085,700 $19.4M 0.04% new 13F-HR Timeline Group Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 2,085,660 $19.4M 0.32% -202,340 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,860,580 $17.3M <0.01% +117,523 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 1,658,663 $15.4M 0.08% +934 13F-HR Timeline READYSTATE ASSET MANAGEMENT LP More: the full row for READYSTATE ASSET MANAGEMENT LP 1,353,586 $12.6M 0.52% +1,129,346 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 1,297,752 $12.1M 0.01% -312,956 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 1,040,414 $9.68M <0.01% -1,048,081 13F-HR Timeline Group Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 1,000,000 $9.3M 0.05% new 13F-HR Timeline Group Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 778,476 $7.24M 0.49% -10,190 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 691,557 $6.43M <0.01% -6,844 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 640,249 $5.95M <0.01% +25,862 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 612,613 $5.7M +190,218 Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 605,530 $5.63M <0.01% -1,232 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 576,130 $5.36M <0.01% -43,408 13F-HR Timeline Group NAN FUNG TRINITY (HK) LTD More: the full row for NAN FUNG TRINITY (HK) LTD 548,850 $5.1M 0.61% new 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 478,618 $4.45M <0.01% +285,316 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 404,357 $3.76M <0.01% -459,866 13F-HR Timeline Group Granahan Investment Management, LLC More: the full row for Granahan Investment Management, LLC 392,751 $3.65M 0.15% -26,520 13F-HR Timeline PRINCIPAL FINANCIAL GROUP INC in group PRINCIPAL FINANCIAL GROUP INC More: the full row for PRINCIPAL FINANCIAL GROUP INC 342,791 $3.19M <0.01% new 13F-HR Timeline Group Candriam S.C.A. More: the full row for Candriam S.C.A. 318,086 $2.96M 0.02% new 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 280,816 $2.61M <0.01% +9,686 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 241,410 $2.25M <0.01% +1,470 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 229,873 $2.14M <0.01% +103,294 13F-HR/A Timeline Group NATIXIS in group Natixis Investment Managers More: the full row for NATIXIS 229,305 $2.13M 0.01% new 13F-HR Timeline Group Driehaus Capital Management LLC More: the full row for Driehaus Capital Management LLC 221,000 $2.06M 0.02% -389,551 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 211,829 $1.97M <0.01% +58,818 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 205,257 $1.91M <0.01% +12,110 13F-HR Timeline Group Handelsbanken Fonder AB More: the full row for Handelsbanken Fonder AB 200,000 $1.86M 0.01% 0 13F-HR Timeline Private Capital Advisors, Inc. More: the full row for Private Capital Advisors, Inc. 189,844 $1.77M 0.22% +151,343 13F-HR Timeline AXA S.A. in group AXA S.A. More: the full row for AXA S.A. 179,519 $1.67M <0.01% +287 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 135,162 $1.26M <0.01% -1,241,891 13F-HR Timeline Group Swiss National Bank More: the full row for Swiss National Bank 132,800 $1.24M <0.01% +4,800 13F-HR Timeline NEOS Investment Management LLC More: the full row for NEOS Investment Management LLC 115,431 $1.07M 0.01% new 13F-HR Timeline Tema ETFs LLC More: the full row for Tema ETFs LLC 115,431 $1.07M 0.29% new 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 113,552 $1.06M <0.01% -347,507 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 109,754 $1.02M <0.01% new 13F-HR Timeline Group KENNEDY CAPITAL MANAGEMENT LLC More: the full row for KENNEDY CAPITAL MANAGEMENT LLC 109,352 $1.02M 0.02% +94,627 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 108,414 $1.01M <0.01% +19,526 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 104,784 $974K <0.01% new 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 99,676 $927K <0.01% -244,715 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 99,372 $924K <0.01% -16,628 13F-HR Timeline Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 85,227 $793K 0.02% new 13F-HR Timeline ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 81,873 $761K 0.01% -20,280 13F-HR Timeline Main Management ETF Advisors, LLC in group Main Management ETF Advisors,… More: the full row for Main Management ETF Advisors, LLC 76,944 $716K 0.03% +1,248 13F-HR Timeline Group Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 76,402 $711K <0.01% -26,073 13F-HR Timeline GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 76,046 $707K 0.05% new 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 63,029 $586K <0.01% +526 13F-HR Timeline Group Freestone Capital Holdings, LLC in group Freestone Capital Holdings, L… More: the full row for Freestone Capital Holdings, LLC 61,599 $573K 0.02% -82 13F-HR Timeline Group Birchview Capital, LP More: the full row for Birchview Capital, LP 60,000 $558K 0.55% new 13F-HR Timeline Lido Advisors, LLC in group Lido Advisors, LLC More: the full row for Lido Advisors, LLC 59,085 $549K <0.01% +6,085 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 55,260 $514K <0.01% +6,750 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 53,742 $500K <0.01% -9,940 13F-HR Timeline Group Magnus Financial Group LLC More: the full row for Magnus Financial Group LLC 53,536 $498K 0.04% 0 13F-HR Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 51,139 $476K 0.05% -2,649 13F-HR Timeline WEALTH ENHANCEMENT ADVISORY SERVICES, L… More: the full row for WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 53,187 $470K <0.01% +1,643 13F-HR Timeline ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 46,935 $436K <0.01% -15,609 13F-HR Timeline Group Cerity Partners LLC in group Cerity Partners LLC More: the full row for Cerity Partners LLC 46,532 $433K <0.01% -5,527 13F-HR Timeline Group VIRGINIA RETIREMENT SYSTEMS ET Al More: the full row for VIRGINIA RETIREMENT SYSTEMS ET Al 46,000 $428K <0.01% +26,100 13F-HR Timeline Scharf Investments, LLC More: the full row for Scharf Investments, LLC 44,389 $413K 0.01% 0 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 43,883 $408K <0.01% -101,133 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 44,093 $408K <0.01% -2,728 13F-HR Timeline Group Northeast Financial Consultants Inc More: the full row for Northeast Financial Consultants Inc 42,953 $399K 0.02% 0 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 42,411 $394K <0.01% 0 13F-HR Timeline Group LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 41,857 $389K <0.01% +6,009 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 41,761 $388K <0.01% +5,661 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 40,565 $377K <0.01% +6,141 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 38,240 $356K <0.01% +872 13F-HR Timeline Three Bridge Wealth Advisors, LLC More: the full row for Three Bridge Wealth Advisors, LLC 37,615 $350K 0.09% 0 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 28,792 $268K <0.01% +413 13F-HR Timeline Group DRW Securities, LLC More: the full row for DRW Securities, LLC 28,099 $261K 0.02% new 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 27,599 $256K 0.01% +15,445 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 26,654 $248K -74,470 Timeline Baldwin Investment Management, LLC More: the full row for Baldwin Investment Management, LLC 25,394 $236K 0.03% 0 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 21,154 $197K <0.01% +13,143 13F-HR Timeline CANTOR FITZGERALD, L. P. in group CANTOR FITZGERALD, L. P. More: the full row for CANTOR FITZGERALD, L. P. 21,000 $195K <0.01% new 13F-HR Timeline Group COMMONWEALTH EQUITY SERVICES, LLC More: the full row for COMMONWEALTH EQUITY SERVICES, LLC 20,917 $195K <0.01% +372 13F-HR Timeline Man Group plc in group Man Group plc More: the full row for Man Group plc 20,614 $192K <0.01% -1,931 13F-HR Timeline Group ARIZONA STATE RETIREMENT SYSTEM More: the full row for ARIZONA STATE RETIREMENT SYSTEM 20,266 $188K <0.01% +1,502 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 20,213 $188K <0.01% +1,308 13F-HR Timeline Group CITIZENS FINANCIAL GROUP INC/RI in group CITIZENS FINANCIAL GROUP INC/… More: the full row for CITIZENS FINANCIAL GROUP INC/RI 20,000 $186K <0.01% 0 13F-HR Timeline Group Sequoia Financial Advisors, LLC More: the full row for Sequoia Financial Advisors, LLC 19,065 $177K <0.01% 0 13F-HR Timeline TEACHER RETIREMENT SYSTEM OF TEXAS More: the full row for TEACHER RETIREMENT SYSTEM OF TEXAS 18,548 $172K <0.01% +1,188 13F-HR Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 17,954 $167K <0.01% new 13F-HR Timeline Group PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 16,537 $154K 0.01% -5,064 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 15,387 $143K <0.01% 0 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 15,107 $140K <0.01% -241 13F-HR Timeline Whalen Wealth Management Inc. More: the full row for Whalen Wealth Management Inc. 13,722 $128K 0.08% new 13F-HR Timeline KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 13,200 $123K <0.01% -3,900 13F-HR Timeline Verition Fund Management LLC More: the full row for Verition Fund Management LLC 12,875 $120K <0.01% new 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 12,700 $118K <0.01% 0 13F-HR/A Timeline HighTower Advisors, LLC More: the full row for HighTower Advisors, LLC 12,658 $118K <0.01% new 13F-HR Timeline STONERIDGE INVESTMENT PARTNERS LLC More: the full row for STONERIDGE INVESTMENT PARTNERS LLC 11,554 $107K 0.08% 0 13F-HR Timeline Sterling Investment Advisors, Ltd. More: the full row for Sterling Investment Advisors, Ltd. 11,065 $103K 0.02% 0 13F-HR Timeline SummitTX Capital, L.P. More: the full row for SummitTX Capital, L.P. 10,695 $99.5K <0.01% -10,181 13F-HR Timeline BRIGHTON JONES LLC More: the full row for BRIGHTON JONES LLC 10,491 $97.6K <0.01% new 13F-HR Timeline ANTIPODES PARTNERS Ltd More: the full row for ANTIPODES PARTNERS Ltd 10,261 $95.4K <0.01% -3,903 13F-HR Timeline Gotham Asset Management, LLC More: the full row for Gotham Asset Management, LLC 10,200 $94.9K <0.01% 0 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 9,605 $89.3K 0.03% -2,956 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 7,173 $66.7K <0.01% 0 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 6,938 $64.5K <0.01% +3,802 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 6,464 $60.1K <0.01% +2,909 13F-HR Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 3,841 $35.7K <0.01% -8,209 13F-HR Timeline Group GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 3,046 $28.3K <0.01% +1,346 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 2,444 $23K <0.01% 0 13F-HR Timeline MB, LEVIS & ASSOCIATES, LLC More: the full row for MB, LEVIS & ASSOCIATES, LLC 2,373 $22.1K 0.01% 0 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 2,226 $20.7K <0.01% +269 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 1,513 $14K <0.01% +127 13F-HR/A Timeline Group Allworth Financial LP More: the full row for Allworth Financial LP 1,120 $10.4K <0.01% +1,000 13F-HR Timeline JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 1,120 $9.82K <0.01% +1,000 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 931 $8.66K <0.01% +19 13F-HR Timeline BNP PARIBAS ASSET MANAGEMENT Holding S.… in group BNP PARIBAS ASSET MANAGEMENT … More: the full row for BNP PARIBAS ASSET MANAGEMENT Holding S.A. 637 $6K <0.01% new 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 625 $5.81K <0.01% +23 13F-HR/A Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 610 $5.67K <0.01% +419 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 353 $3.28K <0.01% 0 13F-HR Timeline Group Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 352 $3.27K <0.01% +211 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 280 $3K <0.01% +258 13F-HR Timeline Group ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 250 $2.33K <0.01% +150 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 204 $1.9K <0.01% new 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 180 $1.67K <0.01% +106 13F-HR/A Timeline Parkside Financial Bank & Trust More: the full row for Parkside Financial Bank & Trust 75 $698 <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 70 $651 <0.01% +20 13F-HR Timeline Larson Financial Group LLC More: the full row for Larson Financial Group LLC 67 $623 <0.01% new 13F-HR Timeline Fortitude Family Office, LLC More: the full row for Fortitude Family Office, LLC 60 $558 <0.01% new 13F-HR Timeline CIBC Private Wealth Group LLC in group CIBC Bancorp USA Inc. More: the full row for CIBC Private Wealth Group LLC 32 $298 <0.01% new 13F-HR Timeline Group True Wealth Design, LLC More: the full row for True Wealth Design, LLC 26 $242 <0.01% +18 13F-HR Timeline Bear Mountain Capital, Inc. More: the full row for Bear Mountain Capital, Inc. 20 $212 <0.01% 0 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 21 $195 <0.01% 0 13F-HR Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 8 $74 <0.01% -61 13F-HR Timeline Group IFP Advisors, Inc More: the full row for IFP Advisors, Inc 6 $56 <0.01% +6 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.