T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 5,499,954 $58.4M 0.04% -262,059 13F-HR Timeline Redmile Group, LLC in group Redmile Group, LLC More: the full row for Redmile Group, LLC 4,828,026 $51.3M 3.57% -61,528 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 4,124,988 $43.8M <0.01% +143,206 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 3,919,216 $41.6M <0.01% -305,484 13F-HR Timeline Group EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 3,879,415 $41.2M 1.65% 0 13F-HR Timeline ENAVATE SCIENCES GP, LLC More: the full row for ENAVATE SCIENCES GP, LLC 3,478,261 $36.9M 26.53% 13F-HR Timeline JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 3,455,939 $36.7M 0.02% -32,182 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 3,003,438 $31.9M <0.01% -128,130 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 2,282,754 $24.2M <0.01% +246,447 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 2,126,835 $22.6M <0.01% -60,631 13F-HR Timeline Group Opaleye Management Inc. More: the full row for Opaleye Management Inc. 2,040,000 $21.7M 3.79% +802,500 13F-HR Timeline Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 2,000,000 $21.2M 0.24% +124,108 13F-HR/A Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,228,851 $13.1M <0.01% +21,396 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 1,216,182 $12.9M 0.02% -251,228 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 980,925 $10.4M 0.07% +56,533 13F-HR Timeline Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 746,824 $7.93M 0.58% +70,058 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 688,790 $7.31M 0.02% +218,143 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 648,610 $6.89M <0.01% +624,045 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 516,491 $5.49M <0.01% +43,146 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 500,000 $5.31M 0.01% +280,000 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 457,252 $4.86M <0.01% +14,775 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 423,302 $4.5M <0.01% +28,684 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 398,867 $4.24M <0.01% +109,789 13F-HR/A Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 316,000 $3.36M <0.01% +304,700 13F-HR Timeline Granahan Investment Management, LLC More: the full row for Granahan Investment Management, LLC 314,239 $3.34M 0.14% new 13F-HR Timeline PRIMECAP MANAGEMENT CO/CA/ More: the full row for PRIMECAP MANAGEMENT CO/CA/ 280,800 $2.98M <0.01% 0 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 273,761 $2.91M <0.01% -294,747 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 246,390 $2.62M +123,285 Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 202,667 $2.15M new Timeline Handelsbanken Fonder AB More: the full row for Handelsbanken Fonder AB 200,000 $2.12M 0.01% -30,000 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 189,060 $2.01M <0.01% +23,569 13F-HR Timeline Group Nuveen Asset Management, LLC in group TIAA More: the full row for Nuveen Asset Management, LLC 186,087 $1.98M <0.01% -2,931 13F-HR Timeline Group AXA S.A. in group AXA S.A. More: the full row for AXA S.A. 179,458 $1.91M 0.01% -283 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 158,428 $1.68M <0.01% new 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 145,564 $1.55M <0.01% +4,874 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 123,203 $1.31M <0.01% -1,736 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 107,794 $1.14M <0.01% -51,016 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 104,314 $1.11M <0.01% -1,572 13F-HR/A Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 95,866 $1.02M <0.01% new 13F-HR Timeline Group Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 84,930 $902K 0.01% new 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 82,595 $877K <0.01% +30,964 13F-HR Timeline Group Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 81,391 $864K <0.01% -5,698 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 77,236 $820K <0.01% +39,667 13F-HR Timeline Group Swiss National Bank More: the full row for Swiss National Bank 76,400 $811K <0.01% 0 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 68,167 $724K <0.01% -852 13F-HR/A Timeline Cerity Partners LLC in group Cerity Partners LLC More: the full row for Cerity Partners LLC 52,678 $663K <0.01% -425 13F-HR Timeline Group Prosight Management, LP More: the full row for Prosight Management, LP 54,342 $577K 0.16% +15,207 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 53,790 $571K <0.01% 0 13F-HR Timeline Magnus Financial Group LLC More: the full row for Magnus Financial Group LLC 53,536 $569K 0.05% +27,777 13F-HR Timeline ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 50,470 $536K <0.01% new 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 46,075 $489K <0.01% +15,514 13F-HR/A Timeline Group Virtu Financial LLC in group Virtu Financial LLC More: the full row for Virtu Financial LLC 45,743 $486K 0.03% new 13F-HR Timeline Group Scharf Investments, LLC More: the full row for Scharf Investments, LLC 44,389 $471K 0.01% new 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 43,917 $466K <0.01% -44,020 13F-HR Timeline Group Northeast Financial Consultants Inc More: the full row for Northeast Financial Consultants Inc 42,953 $456K 0.02% -30,000 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 41,993 $446K <0.01% -90 13F-HR Timeline Group WEALTH ENHANCEMENT ADVISORY SERVICES, L… More: the full row for WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 41,505 $441K <0.01% +2,005 13F-HR/A Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 37,368 $397K <0.01% -385 13F-HR/A Timeline LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 35,721 $379K <0.01% new 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 35,619 $378K <0.01% +5,354 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 32,423 $343K <0.01% +692 13F-HR Timeline Group Three Bridge Wealth Advisors, LLC More: the full row for Three Bridge Wealth Advisors, LLC 27,615 $293K 0.1% new 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 26,661 $283K <0.01% -406,059 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 26,207 $278K <0.01% +8,190 13F-HR Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 25,817 $274K <0.01% 13F-HR/A Timeline Group Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 25,556 $271K <0.01% -1,929 13F-HR Timeline Group Baldwin Investment Management, LLC More: the full row for Baldwin Investment Management, LLC 25,394 $270K 0.04% 0 13F-HR Timeline Crestline Management, L.P. More: the full row for Crestline Management, L.P. 24,744 $263K 0.01% new 13F-HR Timeline Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 22,960 $244K <0.01% +11,327 13F-HR Timeline Johnson Financial Group, LLC More: the full row for Johnson Financial Group, LLC 20,000 $212K 0.02% new 13F-HR Timeline Sequoia Financial Advisors, LLC More: the full row for Sequoia Financial Advisors, LLC 19,065 $202K <0.01% +2,000 13F-HR/A Timeline COMMONWEALTH EQUITY SERVICES, LLC More: the full row for COMMONWEALTH EQUITY SERVICES, LLC 19,017 $202K <0.01% new 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 18,961 $201K <0.01% +3,974 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 18,153 $193K <0.01% -15,098 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 17,914 $190K <0.01% -13,772 13F-HR Timeline Group PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 16,094 $171K 0.01% -1,453 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 15,600 $166K <0.01% -1,439 13F-HR/A Timeline Group KENNEDY CAPITAL MANAGEMENT LLC More: the full row for KENNEDY CAPITAL MANAGEMENT LLC 14,521 $154K <0.01% new 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 14,477 $154K <0.01% new 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 12,700 $135K <0.01% 0 13F-HR/A Timeline Corient Private Wealth LP in group Corient Private Wealth LP More: the full row for Corient Private Wealth LP 12,085 $128K <0.01% -12,149 13F-HR Timeline Group TEACHER RETIREMENT SYSTEM OF TEXAS More: the full row for TEACHER RETIREMENT SYSTEM OF TEXAS 11,648 $124K <0.01% new 13F-HR Timeline STONERIDGE INVESTMENT PARTNERS LLC More: the full row for STONERIDGE INVESTMENT PARTNERS LLC 11,554 $123K 0.04% new 13F-HR Timeline ARIZONA STATE RETIREMENT SYSTEM More: the full row for ARIZONA STATE RETIREMENT SYSTEM 11,288 $120K <0.01% +63 13F-HR Timeline Verition Fund Management LLC More: the full row for Verition Fund Management LLC 11,175 $119K <0.01% new 13F-HR Timeline Sterling Investment Advisors, Ltd. More: the full row for Sterling Investment Advisors, Ltd. 11,065 $118K 0.03% 0 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 10,335 $110K <0.01% 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 10,276 $109K <0.01% -11,703 13F-HR Timeline Group Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 8,935 $94.9K <0.01% new 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 8,608 $91.4K <0.01% +7,129 13F-HR Timeline Group Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 8,011 $85.1K <0.01% 0 13F-HR Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 7,868 $83.6K 0.01% +7,867 13F-HR Timeline Point72 (DIFC) Ltd More: the full row for Point72 (DIFC) Ltd 7,275 $77.3K 0.01% new 13F-HR Timeline KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 7,100 $75.4K <0.01% 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 6,584 $69.9K <0.01% new 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 6,280 $66K <0.01% +4,954 13F-HR Timeline VIRTUS ADVISERS, LLC in group Virtus Investment Advisers, L… More: the full row for VIRTUS ADVISERS, LLC 5,440 $57.8K 0.02% -303 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 5,036 $53.5K <0.01% 0 13F-HR Timeline Group MB, LEVIS & ASSOCIATES, LLC More: the full row for MB, LEVIS & ASSOCIATES, LLC 2,373 $25.2K 0.01% 0 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 1,778 $19K <0.01% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 1,714 $18K <0.01% -31,822 13F-HR Timeline Group R Squared Ltd More: the full row for R Squared Ltd 1,410 $15K 0.01% 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 602 $6.39K <0.01% -19 13F-HR/A Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 353 $3.75K <0.01% 0 13F-HR Timeline Group Aster Capital Management (DIFC) Ltd More: the full row for Aster Capital Management (DIFC) Ltd 327 $3.47K <0.01% new 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 307 $3.26K <0.01% +108 13F-HR Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 233 $2.47K <0.01% new 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 210 $2.23K <0.01% +81 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 106 $1.13K <0.01% 13F-HR/A Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 100 $1.06K <0.01% 0 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 93 $988 <0.01% +65 13F-HR Timeline Amundi in group Amundi More: the full row for Amundi 78 $831 <0.01% new 13F-HR Timeline Group ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 60 $637 <0.01% -15 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 53 $563 <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 24 $255 <0.01% 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 0 $244 <0.01% new 13F-HR Timeline Amount filed as zero, left out of ratios. Bear Mountain Capital, Inc. More: the full row for Bear Mountain Capital, Inc. 20 $204 <0.01% new 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 13 $138 <0.01% -71 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 17 $0 0% -5 13F-HR Timeline Group Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.