Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 22,729,436 $28.9M 1.15% +153,585 13F-HR Timeline T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 20,332,161 $25.8M 0.02% +3,039,997 13F-HR Timeline Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 17,857,083 $22.7M 1.7% +1,640,867 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 15,166,198 $19.3M <0.01% -432,610 13F-HR Timeline Group Logos Global Management LP More: the full row for Logos Global Management LP 15,000,000 $19.1M 2.54% +2,000,000 13F-HR Timeline MONTANOVA CAPITAL, LLC More: the full row for MONTANOVA CAPITAL, LLC 14,502,004 $18.4M 0.69% +2,187,000 13F-HR Timeline VANGUARD GROUP INC group of 2 filers holding More: the full row for VANGUARD GROUP INC 12,731,959 $16.2M -11,270 Timeline Paradigm Biocapital Advisors LP in group Paradigm Biocapital Advisors … More: the full row for Paradigm Biocapital Advisors LP 11,907,182 $15.1M 0.65% +1,104,828 13F-HR Timeline Group ARCH Venture Management, LLC More: the full row for ARCH Venture Management, LLC 11,055,554 $14.1M 4.71% 0 13F-HR Timeline Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 8,757,249 $11.1M 0.58% 0 13F-HR Timeline Group Vivo Capital, LLC More: the full row for Vivo Capital, LLC 6,756,756 $8.58M 0.88% 0 13F-HR Timeline 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 5,405,404 $6.86M 2.64% 0 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 4,835,642 $6.14M <0.01% +77,790 13F-HR Timeline Group Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 4,085,787 $5.19M 0.77% +744,268 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 4,002,110 $5.08M <0.01% -175,775 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 3,797,987 $4.82M <0.01% +573,469 13F-HR Timeline Group a16z Capital Management, L.L.C. in group a16z Capital Management, L.L.… More: the full row for a16z Capital Management, L.L.C. 2,862,500 $3.64M 1.16% 0 13F-HR Timeline Group SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 2,569,591 $3.26M 0.67% -4,798,405 13F-HR Timeline Group Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 2,162,162 $2.75M 0.19% 0 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 2,074,425 $2.63M <0.01% +47,398 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 2,074,390 $2.63M 0.01% -2,073,043 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 1,819,849 $2.31M <0.01% -116,408 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 1,696,593 $2.15M <0.01% +254,937 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 1,693,423 $2.15M <0.01% -144,705 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 1,571,325 $2M <0.01% -377,500 13F-HR Timeline Group TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 1,502,915 $1.91M 0.1% +312,903 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 1,411,022 $1.79M <0.01% -254,787 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 1,372,569 $1.74M <0.01% -42,675 13F-HR Timeline Group Sio Capital Management, LLC More: the full row for Sio Capital Management, LLC 1,369,748 $1.74M 0.7% +13,562 13F-HR Timeline PFM Health Sciences, LP More: the full row for PFM Health Sciences, LP 1,072,224 $1.36M 0.12% -2,417,335 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 885,651 $1.12M <0.01% +35,504 13F-HR Timeline Group Jain Global LLC More: the full row for Jain Global LLC 774,340 $983K 0.02% +743,094 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 742,500 $943K <0.01% -214,007 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 708,060 $899K <0.01% +311,858 13F-HR Timeline Group Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 700,000 $889K 0.2% -4,436,795 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 609,343 $774K <0.01% +31,105 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 606,803 $771K -327,934 Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 605,390 $769K <0.01% +593,591 13F-HR/A Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 555,194 $705K <0.01% +6,925 13F-HR Timeline Group Atom Investors LP More: the full row for Atom Investors LP 549,959 $698K 0.06% -260,496 13F-HR Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 495,647 $629K -88,366 Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 450,056 $572K <0.01% -33,527 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 376,976 $479K <0.01% +17,598 13F-HR Timeline Group DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 350,000 $444K 0.12% +10,000 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 3 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 345,937 $439K +62,202 Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 323,480 $411K <0.01% +73,886 13F-HR/A Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 256,032 $325K <0.01% 0 13F-HR Timeline IPG Investment Advisors LLC More: the full row for IPG Investment Advisors LLC 248,108 $315K 0.06% 0 13F-HR Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 244,332 $310K <0.01% +197,637 13F-HR Timeline Group Prosight Management, LP More: the full row for Prosight Management, LP 240,295 $305K 0.07% -706,815 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 233,430 $296K <0.01% +78,940 13F-HR Timeline Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 215,220 $273K <0.01% 0 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 201,516 $256K <0.01% -7,927 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 172,226 $219K <0.01% +58,643 13F-HR Timeline Group HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 156,160 $198K <0.01% new 13F-HR Timeline ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 152,827 $194K <0.01% -57,456 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 136,896 $174K <0.01% +1,080 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 132,269 $168K <0.01% new 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 132,174 $168K <0.01% +4,081 13F-HR Timeline GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 123,120 $156K 0.01% -115,585 13F-HR Timeline Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 122,671 $156K <0.01% new 13F-HR Timeline Group FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 122,128 $155K <0.01% +4,844 13F-HR Timeline Group Palumbo Wealth Management LLC More: the full row for Palumbo Wealth Management LLC 120,466 $153K 0.05% +77,135 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 112,348 $143K <0.01% +18,754 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 106,779 $136K 0.01% -16,722 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 105,929 $135K -12,319 Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 86,468 $110K <0.01% +10,195 13F-HR Timeline Cresset Asset Management, LLC More: the full row for Cresset Asset Management, LLC 79,913 $101K <0.01% -1,656 13F-HR/A Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 71,409 $90.7K <0.01% -80,820 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 67,901 $86.2K <0.01% -1,526 13F-HR Timeline Group Velan Capital Investment Management LP More: the full row for Velan Capital Investment Management LP 65,000 $82.5K 0.08% +15,000 13F-HR Timeline Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 63,824 $81.1K <0.01% +21,815 13F-HR Timeline IEQ CAPITAL, LLC More: the full row for IEQ CAPITAL, LLC 61,928 $78.6K <0.01% +21,606 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 61,459 $78.1K 0.03% -962 13F-HR Timeline Group Cerity Partners LLC in group Cerity Partners LLC More: the full row for Cerity Partners LLC 57,817 $73.4K <0.01% +22,313 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 56,897 $72.3K 0.01% +187 13F-HR Timeline CAPTRUST FINANCIAL ADVISORS More: the full row for CAPTRUST FINANCIAL ADVISORS 54,111 $68.7K <0.01% +6,486 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 52,338 $66.5K <0.01% 0 13F-HR Timeline Group PANAGORA ASSET MANAGEMENT INC More: the full row for PANAGORA ASSET MANAGEMENT INC 49,606 $63K <0.01% new 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 46,175 $58.6K <0.01% -6,366 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 41,091 $52K <0.01% +4,841 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 37,360 $47.4K <0.01% +10,501 13F-HR/A Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 36,797 $46.7K <0.01% 0 13F-HR Timeline LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 35,075 $44.5K <0.01% new 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 32,647 $41K <0.01% +32,389 13F-HR Timeline Dynamic Technology Lab Private Ltd More: the full row for Dynamic Technology Lab Private Ltd 29,177 $37K 0.01% +18,788 13F-HR Timeline WEALTH ENHANCEMENT ADVISORY SERVICES, L… More: the full row for WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 21,349 $30.7K <0.01% -6,790 13F-HR Timeline EP Wealth Advisors, LLC More: the full row for EP Wealth Advisors, LLC 23,000 $29.2K <0.01% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 21,579 $27.4K <0.01% +7,923 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 21,533 $27.3K <0.01% +7,351 13F-HR Timeline Group CIBC WORLD MARKETS CORP More: the full row for CIBC WORLD MARKETS CORP 21,388 $27.2K <0.01% -19,394 13F-HR Timeline VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 19,151 $24.3K <0.01% -559 13F-HR Timeline PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 18,161 $23.1K <0.01% +7,210 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 17,980 $22.8K <0.01% 0 13F-HR Timeline Group QUADRANT CAPITAL GROUP LLC More: the full row for QUADRANT CAPITAL GROUP LLC 17,546 $22.3K <0.01% +16,516 13F-HR Timeline SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 16,682 $21.2K <0.01% 0 13F-HR Timeline Group Ballentine Partners, LLC More: the full row for Ballentine Partners, LLC 15,769 $20K <0.01% new 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 15,428 $19.6K <0.01% -171,397 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 13,539 $17.2K <0.01% -158,282 13F-HR Timeline XPONANCE LLC More: the full row for XPONANCE LLC 13,490 $17.1K <0.01% +374 13F-HR Timeline NEUBERGER BERMAN GROUP LLC in group NEUBERGER BERMAN GROUP LLC More: the full row for NEUBERGER BERMAN GROUP LLC 13,158 $16.7K <0.01% 0 13F-HR/A Timeline Group Catalyst Funds Management Pty Ltd More: the full row for Catalyst Funds Management Pty Ltd 13,061 $16.6K <0.01% new 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 13,052 $16.6K <0.01% new 13F-HR Timeline Group PRINCIPAL FINANCIAL GROUP INC in group PRINCIPAL FINANCIAL GROUP INC More: the full row for PRINCIPAL FINANCIAL GROUP INC 12,496 $15.9K <0.01% -26 13F-HR Timeline Group Pallas Capital Advisors LLC More: the full row for Pallas Capital Advisors LLC 12,325 $15.7K <0.01% +815 13F-HR Timeline HSBC HOLDINGS PLC in group HSBC HOLDINGS PLC More: the full row for HSBC HOLDINGS PLC 11,090 $14.3K <0.01% -17,484 13F-HR Timeline Group MACKENZIE FINANCIAL CORP More: the full row for MACKENZIE FINANCIAL CORP 11,141 $14.1K <0.01% 0 13F-HR Timeline Qtron Investments LLC More: the full row for Qtron Investments LLC 10,501 $13.3K <0.01% new 13F-HR Timeline Mariner, LLC in group Mariner, LLC More: the full row for Mariner, LLC 10,092 $12.8K <0.01% new 13F-HR Timeline Group FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 10,070 $12.8K <0.01% -4,920 13F-HR Timeline Group AlphaCore Capital LLC More: the full row for AlphaCore Capital LLC 10,000 $12.7K <0.01% 0 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 7,879 $10K <0.01% +5,139 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 7,240 $9.2K <0.01% 0 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 6,343 $8K <0.01% 0 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 5,192 $6.59K <0.01% +2,021 13F-HR/A Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 4,227 $5.37K <0.01% new 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 2,442 $3.1K <0.01% +927 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 2,038 $2.59K <0.01% +934 13F-HR Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 2,000 $2.54K <0.01% new 13F-HR Timeline Group Allworth Financial LP More: the full row for Allworth Financial LP 1,817 $2.31K <0.01% +1,604 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 1,700 $2.16K <0.01% new 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 1,587 $2.02K <0.01% new 13F-HR Timeline Group Physician Wealth Advisors, Inc. More: the full row for Physician Wealth Advisors, Inc. 1,192 $1.51K <0.01% new 13F-HR Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 1,158 $1.47K <0.01% +64 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 1,074 $1K <0.01% 0 13F-HR Timeline Group Hughes Financial Services, LLC More: the full row for Hughes Financial Services, LLC 490 $701 <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 508 $645 <0.01% +120 13F-HR Timeline MAI Capital Management More: the full row for MAI Capital Management 467 $594 <0.01% new 13F-HR Timeline Rialto Wealth Management, LLC More: the full row for Rialto Wealth Management, LLC 413 $525 <0.01% new 13F-HR Timeline Brooklyn Investment Group More: the full row for Brooklyn Investment Group 408 $519 <0.01% new 13F-HR/A Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 385 $489 <0.01% +140 13F-HR Timeline Rise Advisors, LLC More: the full row for Rise Advisors, LLC 365 $464 <0.01% new 13F-HR Timeline Fortitude Family Office, LLC More: the full row for Fortitude Family Office, LLC 360 $457 <0.01% new 13F-HR Timeline Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 200 $254 <0.01% 0 13F-HR Timeline Essential Partners LLC More: the full row for Essential Partners LLC 157 $199 <0.01% 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 86 $109 <0.01% new 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 8 $10 <0.01% 0 13F-HR Timeline Group Covestor Ltd More: the full row for Covestor Ltd 40 $0 0% -3 13F-HR Timeline Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.