RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 11,293,828 $77.7M 0.8% -20,125,439 13F-HR Timeline Group MPM BIOIMPACT LLC More: the full row for MPM BIOIMPACT LLC 2,671,480 $10.7M 1.22% new 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 1,923,639 $7.7M <0.01% +1,396,722 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 1,432,475 $5.73M 0.43% +1,298,945 13F-HR/A Timeline Group VANGUARD GROUP INC group of 2 filers holding More: the full row for VANGUARD GROUP INC 1,351,631 $5.41M +21,274 Timeline Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 1,300,000 $5.2M 0.37% 0 13F-HR Timeline Kynam Capital Management, LP More: the full row for Kynam Capital Management, LP 1,028,341 $4.11M 0.27% 0 13F-HR Timeline GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 979,534 $3.92M 1.27% new 13F-HR Timeline SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 932,247 $3.73M 0.78% +497,410 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 716,680 $2.87M <0.01% new 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 691,412 $2.77M +497,831 Timeline Driehaus Capital Management LLC More: the full row for Driehaus Capital Management LLC 600,946 $2.4M 0.02% new 13F-HR Timeline Peapod Lane Capital LLC More: the full row for Peapod Lane Capital LLC 565,992 $2.26M 1.93% +4,126 13F-HR Timeline NAN FUNG TRINITY (HK) LTD More: the full row for NAN FUNG TRINITY (HK) LTD 463,654 $1.85M 0.15% 0 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 445,342 $1.78M +284,620 Timeline KOTLER KEVIN More: the full row for KOTLER KEVIN 400,000 $1.6M 1.18% 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 389,309 $1.56M <0.01% -346,194 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 320,600 $1.28M <0.01% -216,500 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 310,756 $1.24M <0.01% -965 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 304,015 $1.22M <0.01% +74,126 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 296,314 $1.19M <0.01% -175,390 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 246,200 $985K <0.01% +156,800 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 239,043 $956K <0.01% new 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 224,883 $900K <0.01% +151,168 13F-HR/A Timeline Group 683 Capital Management, LLC in group 683 Capital Management, LLC More: the full row for 683 Capital Management, LLC 201,652 $807K 0.07% new 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 187,403 $750K <0.01% +107,749 13F-HR Timeline Group BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 159,300 $637K 0.01% +50,000 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 148,538 $594K <0.01% +62,204 13F-HR/A Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 140,617 $567K <0.01% +101,717 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 139,529 $558K <0.01% new 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 128,900 $516K <0.01% +25,800 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 124,670 $499K <0.01% -753 13F-HR Timeline Group ArchPoint Investors More: the full row for ArchPoint Investors 121,400 $486K 0.12% new 13F-HR Timeline Squadron Capital Management LLC More: the full row for Squadron Capital Management LLC 100,000 $400K 0.18% 13F-HR Timeline OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 85,466 $342K <0.01% new 13F-HR Timeline Seven Fleet Capital Management LP More: the full row for Seven Fleet Capital Management LP 76,400 $306K 0.21% 13F-HR/A Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 71,323 $285K <0.01% -334,081 13F-HR Timeline Group LPL Financial LLC More: the full row for LPL Financial LLC 62,000 $248K <0.01% +1,000 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 61,853 $247K <0.01% +37,100 13F-HR Timeline Group Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 48,736 $195K <0.01% new 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 34,852 $139K <0.01% +5,668 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 34,596 $138K <0.01% -2,006 13F-HR Timeline CITIZENS FINANCIAL GROUP INC/RI in group CITIZENS FINANCIAL GROUP INC/… More: the full row for CITIZENS FINANCIAL GROUP INC/RI 28,168 $113K <0.01% -17,832 13F-HR Timeline Group HSBC HOLDINGS PLC in group HSBC HOLDINGS PLC More: the full row for HSBC HOLDINGS PLC 24,744 $99.2K <0.01% +12,800 13F-HR/A Timeline Group PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 19,918 $79.7K 0.01% -20,800 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 14,236 $56.9K <0.01% new 13F-HR Timeline Group Chicago Partners Investment Group LLC More: the full row for Chicago Partners Investment Group LLC 10,962 $55K <0.01% +630 13F-HR Timeline BLAIR WILLIAM & CO/IL More: the full row for BLAIR WILLIAM & CO/IL 11,000 $44K <0.01% new 13F-HR Timeline Virtu Financial LLC in group Virtu Financial LLC More: the full row for Virtu Financial LLC 10,655 $43K <0.01% new 13F-HR Timeline Group Scientech Research LLC More: the full row for Scientech Research LLC 10,428 $41.7K 0.03% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 10,331 $41.3K <0.01% -319,217 13F-HR Timeline Group Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 9,228 $36.9K 0.02% -18,993 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 6,349 $25.4K <0.01% -793 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 5,063 $20.3K <0.01% -690 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 3,357 $13.4K <0.01% -9,887 13F-HR Timeline Group HARBOUR INVESTMENTS, INC. More: the full row for HARBOUR INVESTMENTS, INC. 2,000 $8K <0.01% 0 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 600 $2.4K <0.01% -22,000 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 573 $2.29K <0.01% 0 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 513 $2.05K <0.01% -1,341 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 408 $1K <0.01% -283 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 46 $184 <0.01% -21,966 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 1 $4 <0.01% 0 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 29 $0 0% -78 13F-HR Timeline Group Value filed as zero, left out of ratios.