Decheng Capital LLC More: the full row for Decheng Capital LLC 6,371,669 $183M 39.2% +892,859 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 5,861,082 $168M <0.01% +779,730 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 4,061,130 $116M <0.01% +490,203 13F-HR Timeline Group TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 3,670,206 $105M 10.29% 0 13F-HR Timeline BRAIDWELL LP More: the full row for BRAIDWELL LP 3,283,317 $94.2M 2.79% +112,442 13F-HR Timeline Foresite Capital Management VI LLC group of 2 filers holding More: the full row for Foresite Capital Management VI LLC 2,914,024 $83.6M +2,221,474 Timeline Kynam Capital Management, LP More: the full row for Kynam Capital Management, LP 2,519,705 $72.3M 4.77% +748,900 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 2,433,593 $69.8M <0.01% +2,287,987 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,923,584 $55.2M <0.01% +222,931 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 1,910,470 $54.8M 0.01% +1,400,251 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 1,817,887 $52.1M 0.02% +692,982 13F-HR Timeline RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 1,701,216 $48.8M 0.74% +357,142 13F-HR Timeline JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 1,485,843 $42.6M 0.02% -40,691 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 1,458,072 $41.8M 0.05% +1,450,372 13F-HR Timeline Group ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 1,431,114 $41M 0.85% +740,000 13F-HR Timeline Group FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 1,275,891 $36.6M 0.01% +45,698 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,169,253 $33.5M 0.03% +847,890 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,156,670 $33.2M <0.01% +78,143 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 1,139,793 $32.7M +1,032,137 Timeline ACORN CAPITAL ADVISORS, LLC More: the full row for ACORN CAPITAL ADVISORS, LLC 1,131,501 $32.5M 17.46% 13F-HR/A Timeline Avidity Partners Management LP More: the full row for Avidity Partners Management LP 1,097,800 $31.5M 3.14% -558,200 13F-HR Timeline Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 967,055 $27.7M 0.16% 0 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 945,194 $27.1M <0.01% +353,787 13F-HR Timeline DEERFIELD MANAGEMENT COMPANY, L.P. in group DEERFIELD MANAGEMENT COMPANY,… More: the full row for DEERFIELD MANAGEMENT COMPANY, L.P. 851,593 $24.4M 0.46% +898 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 818,667 $23.5M <0.01% +169,093 13F-HR Timeline Group Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 775,000 $22.2M 1.22% -200,000 13F-HR Timeline Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 770,000 $22.1M 0.92% 0 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 725,227 $20.8M <0.01% +490,356 13F-HR/A Timeline Group Avoro Capital Advisors LLC More: the full row for Avoro Capital Advisors LLC 700,000 $20.1M 0.28% 0 13F-HR Timeline Pictet Asset Management Holding SA in group Pictet Asset Management Holdi… More: the full row for Pictet Asset Management Holding SA 674,607 $19.3M 0.02% new 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 628,885 $18M 0.12% +22,987 13F-HR Timeline Saturn V Capital Management LP More: the full row for Saturn V Capital Management LP 593,262 $17M 6.66% +73,143 13F-HR Timeline TimesSquare Capital Management, LLC More: the full row for TimesSquare Capital Management, LLC 546,904 $15.7M 0.23% +109,835 13F-HR Timeline ABG-WTT Global Life Science Capital Par… More: the full row for ABG-WTT Global Life Science Capital Partners GP Ltd 495,526 $14.2M 32.51% 0 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 433,860 $12.4M <0.01% +52,419 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 427,760 $12.3M <0.01% +48,096 13F-HR Timeline Group PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 419,450 $12M 0.34% -314,245 13F-HR Timeline Group Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 328,585 $9.42M 0.71% -12,000 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 308,259 $8.84M 0.02% -437,804 13F-HR Timeline Group MASSACHUSETTS FINANCIAL SERVICES CO /MA/ in group MASSACHUSETTS FINANCIAL SERVI… More: the full row for MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 257,157 $7.38M <0.01% -22,788 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 249,001 $7.14M 0.01% new 13F-HR Timeline Group CenterBook Partners LP More: the full row for CenterBook Partners LP 236,108 $6.77M 0.4% -73,188 13F-HR Timeline ArrowMark Colorado Holdings LLC More: the full row for ArrowMark Colorado Holdings LLC 224,582 $6.44M 0.09% -5,808 13F-HR Timeline Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 224,580 $6.44M 0.06% new 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 215,750 $6.19M 1.28% +72,646 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 209,518 $6.01M <0.01% +38,626 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 200,000 $5.74M 0.01% -200,000 13F-HR Timeline Group Driehaus Capital Management LLC More: the full row for Driehaus Capital Management LLC 197,937 $5.68M 0.05% -2,046 13F-HR Timeline Pamalican Asset Management Ltd More: the full row for Pamalican Asset Management Ltd 181,582 $5.21M 2.3% 13F-HR Timeline Ally Bridge Group (NY) LLC More: the full row for Ally Bridge Group (NY) LLC 174,048 $4.99M 4.28% -89,218 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 168,866 $4.84M <0.01% +137,795 13F-HR Timeline Group Maven Securities LTD in group Maven Securities LTD More: the full row for Maven Securities LTD 140,000 $4.02M 0.65% new 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 135,567 $3.89M <0.01% -9,359 13F-HR Timeline Group Nuveen Asset Management, LLC in group TIAA More: the full row for Nuveen Asset Management, LLC 111,716 $3.2M <0.01% -41,918 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 101,257 $2.9M <0.01% +10,737 13F-HR/A Timeline Group Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 100,000 $2.87M 0.45% new 13F-HR Timeline Crestline Management, L.P. More: the full row for Crestline Management, L.P. 95,439 $2.74M 0.1% +87,549 13F-HR Timeline Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 93,189 $2.67M 0.01% -42,440 13F-HR Timeline Group CANADA PENSION PLAN INVESTMENT BOARD More: the full row for CANADA PENSION PLAN INVESTMENT BOARD 83,000 $2.38M <0.01% 0 13F-HR Timeline Swiss National Bank More: the full row for Swiss National Bank 79,600 $2.28M <0.01% +47,000 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 79,184 $2.27M <0.01% +8,348 13F-HR Timeline Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 78,721 $2.26M 0.01% +126 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 76,522 $2.19M <0.01% +3,373 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 71,636 $2.05M <0.01% +36,430 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 69,016 $1.98M <0.01% +1,458 13F-HR/A Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 61,362 $1.76M <0.01% -134,589 13F-HR Timeline Group Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 60,565 $1.74M <0.01% 0 13F-HR Timeline ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 54,690 $1.57M 0.01% +831 13F-HR Timeline Group iA Global Asset Management Inc. More: the full row for iA Global Asset Management Inc. 45,890 $1.32M 0.02% new 13F-HR Timeline Alyeska Investment Group, L.P. in group Alyeska Investment Group, L.P. More: the full row for Alyeska Investment Group, L.P. 45,000 $1.29M <0.01% new 13F-HR Timeline Group Yu Fan More: the full row for Yu Fan 163,456 $1.28M 2.41% 0 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 38,978 $1.12M <0.01% +13,589 13F-HR/A Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 38,768 $1.11M <0.01% +20,763 13F-HR/A Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 37,669 $1.08M <0.01% +24,676 13F-HR Timeline Group Monashee Investment Management LLC More: the full row for Monashee Investment Management LLC 36,872 $1.06M 0.15% new 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 32,334 $930K +3,280 Timeline LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 30,197 $866K <0.01% +8,145 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 29,262 $839K <0.01% +4,865 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 29,026 $832K <0.01% +1,894 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 28,234 $810K <0.01% +8,803 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 27,069 $776K <0.01% +11,662 13F-HR Timeline Group Sicart Associates LLC More: the full row for Sicart Associates LLC 25,000 $717K 0.26% 0 13F-HR Timeline Cinctive Capital Management LP More: the full row for Cinctive Capital Management LP 22,608 $648K 0.03% new 13F-HR Timeline HighVista Strategies LLC More: the full row for HighVista Strategies LLC 22,305 $640K 0.24% +6,571 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 21,946 $629K <0.01% +9,051 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 19,996 $573K 0.05% new 13F-HR Timeline Group M&T Bank Corp in group M&T Bank Corp More: the full row for M&T Bank Corp 16,891 $485K <0.01% +133 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 16,787 $481K <0.01% new 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 16,561 $475K <0.01% +7,599 13F-HR Timeline PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 15,515 $445K 0.02% -342 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 14,340 $411K 0.04% new 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 14,163 $406K <0.01% -840 13F-HR/A Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 13,996 $401K <0.01% +2,000 13F-HR/A Timeline Handelsbanken Fonder AB More: the full row for Handelsbanken Fonder AB 13,300 $381K <0.01% new 13F-HR Timeline OCONNOR, A Distinct Business Unit of UB… More: the full row for OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 12,834 $368K 0.01% +1,810 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. TEACHER RETIREMENT SYSTEM OF TEXAS More: the full row for TEACHER RETIREMENT SYSTEM OF TEXAS 11,927 $342K <0.01% new 13F-HR Timeline ARIZONA STATE RETIREMENT SYSTEM More: the full row for ARIZONA STATE RETIREMENT SYSTEM 11,853 $340K <0.01% new 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 10,907 $313K <0.01% new 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 10,893 $312K <0.01% -678 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 10,342 $297K <0.01% 13F-HR Timeline Zimmer Partners, LP More: the full row for Zimmer Partners, LP 10,000 $287K <0.01% new 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 8,865 $254K 0.01% +8,541 13F-HR Timeline Group NEOS Investment Management LLC More: the full row for NEOS Investment Management LLC 8,329 $239K 0.01% +817 13F-HR Timeline Tema ETFs LLC More: the full row for Tema ETFs LLC 8,329 $239K 0.1% 13F-HR Timeline MEEDER ASSET MANAGEMENT INC in group Meeder Advisory Services, Inc. More: the full row for MEEDER ASSET MANAGEMENT INC 6,578 $189K 0.01% new 13F-HR Timeline Group FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 6,000 $172K <0.01% new 13F-HR Timeline Group Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 5,856 $168K <0.01% -543 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 5,636 $162K <0.01% -21,024 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 4,805 $138K <0.01% 0 13F-HR Timeline Group KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 3,500 $100K <0.01% 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 3,182 $91K <0.01% -2,434 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 2,692 $77.2K <0.01% -27 13F-HR Timeline Group VIRTUS ADVISERS, LLC in group Virtus Investment Advisers, L… More: the full row for VIRTUS ADVISERS, LLC 2,463 $70.6K 0.03% -185 13F-HR Timeline Group AMALGAMATED BANK More: the full row for AMALGAMATED BANK 1,621 $46K <0.01% 0 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,420 $40.7K <0.01% 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 632 $18.1K <0.01% +540 13F-HR Timeline Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 413 $11.8K <0.01% new 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 339 $9.72K 0.01% 13F-HR/A Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 223 $6K <0.01% new 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 200 $5.74K <0.01% +94 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 100 $2.87K <0.01% 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 90 $2.58K <0.01% -14 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 72 $2.06K <0.01% -15 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 69 $1.98K <0.01% +1 13F-HR Timeline COMERICA BANK More: the full row for COMERICA BANK 55 $1.58K <0.01% 0 13F-HR/A Timeline Washington Trust Advisors, Inc. More: the full row for Washington Trust Advisors, Inc. 49 $1.41K <0.01% 0 13F-HR Timeline MRP Capital Investments, LLC More: the full row for MRP Capital Investments, LLC 40 $1.15K <0.01% new 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 39 $1.12K <0.01% new 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 35 $1K <0.01% new 13F-HR/A Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 52 $1K <0.01% +18 13F-HR Timeline Group ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 25 $717 <0.01% 0 13F-HR Timeline Quantbot Technologies LP More: the full row for Quantbot Technologies LP 7 $201 <0.01% new 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 6 $172 <0.01% new 13F-HR Timeline Group Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 3 $86 <0.01% -14 13F-HR Timeline AdvisorNet Financial, Inc More: the full row for AdvisorNet Financial, Inc 2 $57 <0.01% 0 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 1 $29 <0.01% new 13F-HR Timeline Covestor Ltd More: the full row for Covestor Ltd 4 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios. NOMURA ASSET MANAGEMENT CO LTD in group NOMURA ASSET MANAGEMENT CO LTD More: the full row for NOMURA ASSET MANAGEMENT CO LTD 0 $0 0% new 13F-HR Timeline Group Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.