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Disclosery

CBIO CRESCENT BIOPHARMA INC.

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COMMON STOCK (common), issuer CIK 1253689

55 managers (56 13F filers) reported a position in CBIO shares at 2025-12-31, 23,741,858 shares in all. 20 filers opened a position and 6 filers sold out during the quarter.

Managers
55
13F filers
56
New
20
Added
17
Reduced
9
Sold out
6
Shares held by filers
23,741,858

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC4,133,514$49M<0.01%+2,718,83413F-HRTimelineGroup
BVF INC/ILin group BVF INC/IL2,748,763$32.6M1.1%+1,360,90013F-HRTimelineGroup
Fairmount Funds Management LLCin group Fairmount Funds Management LLC2,747,866$32.6M2.48%+1,360,00013F-HRTimelineGroup
Venrock Adviser, LLC2,133,576$25.3M1.25%+745,71213F-HRTimeline
FCPM III SERVICES B.V.in group FCPM III SERVICES B.V.1,677,852$19.9M2.61%new13F-HRTimelineGroup
Vestal Point Capital, LP1,500,000$17.8M0.65%new13F-HRTimeline
Opaleye Management Inc.1,178,300$14M1.84%new13F-HR/ATimeline
TANG CAPITAL MANAGEMENT LLCin group TANG CAPITAL MANAGEMENT LLC872,398$10.3M0.51%+192,57413F-HRTimelineGroup
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC606,000$7.19M0.54%new13F-HR/ATimelineGroup
Logos Global Management LP600,000$7.12M0.47%013F-HRTimeline
VANGUARD GROUP INCin group VANGUARD GROUP INC557,506$6.61M<0.01%-100,39413F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC453,686$5.38M0.1%013F-HRTimelineGroup
Deep Track Capital, LP453,686$5.38M0.12%013F-HRTimeline
Boxer Capital Management, LLCin group Boxer Capital Management, LLC453,686$5.38M1.18%013F-HRTimelineGroup
RTW INVESTMENTS, LP372,856$4.42M0.04%new13F-HRTimeline
NEXTBio Capital Management LP372,856$4.42M2.59%13F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/338,125$4.01M<0.01%-45,47013F-HRTimeline
Driehaus Capital Management LLC302,457$3.59M0.02%013F-HRTimeline
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.300,000$3.56M0.01%new13F-HRTimelineGroup
HEIGHTS CAPITAL MANAGEMENT, INCin group HEIGHTS CAPITAL MANAGEMENT, I…264,000$3.13M1.18%new13F-HRTimelineGroup
Alyeska Investment Group, L.P.in group Alyeska Investment Group, L.P.264,000$3.11M0.01%new13F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding157,724$1.87M+129,406Timeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…143,412$1.63M<0.01%+125,71413F-HRTimelineGroup
Balyasny Asset Management L.P.in group Balyasny Asset Management111,715$1.32M<0.01%new13F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.109,230$1.3M<0.01%+11513F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC91,079$1.08M<0.01%+21,94513F-HRTimelineGroup
Stonepine Capital Management, LLC87,682$1.04M0.82%new13F-HRTimeline
Blackstone Inc.in group Blackstone Inc.75,614$897K<0.01%013F-HRTimelineGroupThe filing omitted confidential holdings, a later amendment may add them.
Woodline Partners LP74,000$878K<0.01%new13F-HRTimeline
Burkehill Global Management, LP74,000$844K0.06%new13F-HRTimeline
Jefferies Financial Group Inc.in group Jefferies Financial Group Inc.64,244$762K0.01%-38,47013F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC61,882$734K<0.01%new13F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…57,048$677K<0.01%new13F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC46,700$554K<0.01%+19,80013F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY27,521$326K<0.01%+27,37613F-HR/ATimelineGroup
STATE STREET CORPin group STATE STREET CORP26,217$311K<0.01%+7,60013F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC25,245$299K<0.01%-11,73013F-HR/ATimelineGroup
MOORE CAPITAL MANAGEMENT, LP25,000$296K0.01%new13F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …24,903$289K<0.01%-2013F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO23,339$277K<0.01%+23,32213F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC22,965$272K<0.01%new13F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP21,826$259K<0.01%-21,86813F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP17,229$204K<0.01%+41313F-HRTimelineGroup
HRT FINANCIAL LP13,083$155K<0.01%new13F-HRTimeline
OMERS ADMINISTRATION Corp11,600$138K<0.01%new13F-HRTimeline
UBS Group AGin group UBS Group AG7,125$84.5K<0.01%-5,53613F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/5,573$66.1K<0.01%+1,71013F-HRTimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS3,585$42.5K<0.01%+3,58113F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC623$7.39K<0.01%-17513F-HRTimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…409$4.85K<0.01%+20913F-HRTimelineGroup
SBI Securities Co., Ltd.68$806<0.01%013F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.26$308<0.01%013F-HRTimelineGroup
GROUP ONE TRADING LLC4$47<0.01%-7813F-HRTimeline
Avion Wealth40$00%new13F-HRTimelineValue filed as zero, left out of ratios.
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA20$00%013F-HRTimelineGroupValue filed as zero, left out of ratios.