FMR LLC in group FMR LLC More: the full row for FMR LLC 4,133,514 $75.9M <0.01% 0 13F-HR Timeline Group BVF INC/IL in group BVF INC/IL More: the full row for BVF INC/IL 2,748,763 $50.5M 1.61% 0 13F-HR Timeline Group Fairmount Funds Management LLC in group Fairmount Funds Management LLC More: the full row for Fairmount Funds Management LLC 2,747,866 $50.5M 3.65% 0 13F-HR Timeline Group Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 2,133,576 $39.2M 1.46% 0 13F-HR Timeline FCPM III SERVICES B.V. in group FCPM III SERVICES B.V. More: the full row for FCPM III SERVICES B.V. 1,677,852 $30.8M 4.27% 0 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 1,510,033 $27.7M 0.05% +1,398,318 13F-HR Timeline Group Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 1,500,000 $27.6M 0.77% 0 13F-HR Timeline Opaleye Management Inc. More: the full row for Opaleye Management Inc. 1,312,615 $24.1M 3.18% +134,315 13F-HR Timeline TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 1,160,000 $21.3M 1.08% +287,602 13F-HR Timeline Group VANGUARD GROUP INC group of 3 filers holding More: the full row for VANGUARD GROUP INC 854,287 $15.7M new Timeline Logos Global Management LP More: the full row for Logos Global Management LP 482,500 $8.86M 0.46% -117,500 13F-HR Timeline Deep Track Capital, LP More: the full row for Deep Track Capital, LP 453,686 $8.33M 0.17% 0 13F-HR Timeline RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 372,856 $6.85M 0.07% 0 13F-HR Timeline NEXTBio Capital Management LP More: the full row for NEXTBio Capital Management LP 372,856 $6.85M 3.18% 0 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 323,553 $5.94M <0.01% +261,671 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 303,551 $5.58M <0.01% -34,574 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 300,000 $5.51M 0.01% 0 13F-HR Timeline Group Alyeska Investment Group, L.P. in group Alyeska Investment Group, L.P. More: the full row for Alyeska Investment Group, L.P. 264,000 $4.85M 0.01% 0 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 228,475 $4.2M <0.01% +203,230 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 213,635 $3.92M 0.01% +156,587 13F-HR Timeline Group PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 206,942 $3.8M 0.08% -246,744 13F-HR/A Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 200,780 $3.69M <0.01% +178,954 13F-HR Timeline Group Exome Asset Management LLC More: the full row for Exome Asset Management LLC 153,191 $2.81M 1.66% new 13F-HR Timeline JENNISON ASSOCIATES LLC More: the full row for JENNISON ASSOCIATES LLC 152,974 $2.81M <0.01% new 13F-HR Timeline SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 130,500 $2.4M 0.28% new 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 115,828 $2.13M <0.01% -9,396 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 115,725 $2.13M <0.01% +6,495 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 104,221 $1.92M <0.01% +13,142 13F-HR Timeline Group Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 88,867 $1.63M 0.01% new 13F-HR Timeline Group Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 85,000 $1.56M 1.37% -2,682 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 82,706 $1.52M <0.01% +75,581 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 74,000 $1.36M 0.01% 0 13F-HR/A Timeline Burkehill Global Management, LP More: the full row for Burkehill Global Management, LP 74,000 $1.36M 0.07% 0 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 50,273 $924K 0.06% -555,727 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 39,067 $718K <0.01% +12,850 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 41,004 $681K <0.01% +17,665 13F-HR/A Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 30,189 $555K <0.01% new 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 29,277 $538K <0.01% +23,704 13F-HR Timeline Group MOORE CAPITAL MANAGEMENT, LP More: the full row for MOORE CAPITAL MANAGEMENT, LP 25,000 $459K 0.02% 0 13F-HR Timeline Lighthouse Investment Partners, LLC in group Lighthouse Investment Partner… More: the full row for Lighthouse Investment Partners, LLC 25,000 $459K 0.02% new 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 24,903 $457K <0.01% 0 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 24,262 $446K <0.01% -22,438 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 20,169 $371K <0.01% +19,546 13F-HR Timeline Group Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 19,530 $359K <0.01% new 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 18,577 $341K <0.01% -8,944 13F-HR Timeline Group OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 17,800 $327K <0.01% +6,200 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 17,229 $316K <0.01% 0 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 15,694 $288K <0.01% +12,109 13F-HR Timeline Group ALGERT GLOBAL LLC More: the full row for ALGERT GLOBAL LLC 13,806 $254K <0.01% new 13F-HR/A Timeline Verdad Advisers, LP More: the full row for Verdad Advisers, LP 12,748 $234K 0.26% new 13F-HR Timeline Cannon Global Investment Management, LLC More: the full row for Cannon Global Investment Management, LLC 10,200 $187K 0.45% new 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 264 $4.85K <0.01% new 13F-HR/A Timeline Allworth Financial LP More: the full row for Allworth Financial LP 161 $2.96K <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 68 $1.25K <0.01% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 51 $1K <0.01% +31 13F-HR Timeline Group Fortitude Family Office, LLC More: the full row for Fortitude Family Office, LLC 40 $735 <0.01% new 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 26 $477 <0.01% 0 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 4 $73 <0.01% new 13F-HR Timeline