BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 10,885,357 $152M 1.63% +1,485,397 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 4,554,900 $63.8M 0.17% +3,655,101 13F-HR Timeline Group FCPM III SERVICES B.V. in group FCPM III SERVICES B.V. More: the full row for FCPM III SERVICES B.V. 3,452,330 $48.3M 8.16% +1,112,369 13F-HR Timeline Group WESTFIELD CAPITAL MANAGEMENT CO LP More: the full row for WESTFIELD CAPITAL MANAGEMENT CO LP 2,610,337 $36.5M 0.16% +759,392 13F-HR Timeline ARMISTICE CAPITAL, LLC More: the full row for ARMISTICE CAPITAL, LLC 2,196,000 $30.7M 0.71% +240,000 13F-HR Timeline Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 1,839,398 $25.8M 1.14% new 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 1,585,127 $22.2M <0.01% -136,913 13F-HR Timeline Deep Track Capital, LP More: the full row for Deep Track Capital, LP 1,276,081 $17.9M 0.67% -2,271,920 13F-HR Timeline TYBOURNE CAPITAL MANAGEMENT (HK) LTD More: the full row for TYBOURNE CAPITAL MANAGEMENT (HK) LTD 1,269,535 $17.8M 4.46% -125,000 13F-HR Timeline BNP PARIBAS ASSET MANAGEMENT Holding S.… in group BNP PARIBAS ASSET MANAGEMENT … More: the full row for BNP PARIBAS ASSET MANAGEMENT Holding S.A. 1,155,651 $16.2M 0.04% +395,764 13F-HR Timeline Group RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 1,093,477 $15.3M 0.2% -1,159,523 13F-HR Timeline Group Candriam S.C.A. More: the full row for Candriam S.C.A. 1,087,876 $15.2M 0.09% +37,278 13F-HR Timeline EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 910,000 $12.7M 0.51% 0 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 862,137 $12.1M <0.01% -487,757 13F-HR/A Timeline Group AXA S.A. in group AXA S.A. More: the full row for AXA S.A. 553,959 $7.76M 0.02% -440 13F-HR Timeline Group Long Focus Capital Management, LLC More: the full row for Long Focus Capital Management, LLC 543,092 $7.6M 0.58% new 13F-HR Timeline PRINCIPAL FINANCIAL GROUP INC in group PRINCIPAL FINANCIAL GROUP INC More: the full row for PRINCIPAL FINANCIAL GROUP INC 406,470 $5.69M <0.01% -36,671 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 392,859 $5.5M <0.01% +7,994 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 365,408 $5.12M <0.01% -54,355 13F-HR Timeline Group Parkman Healthcare Partners LLC More: the full row for Parkman Healthcare Partners LLC 352,481 $4.93M 0.66% -92,915 13F-HR Timeline PLATINUM INVESTMENT MANAGEMENT LTD More: the full row for PLATINUM INVESTMENT MANAGEMENT LTD 309,059 $4.33M 0.25% +36,910 13F-HR Timeline Verition Fund Management LLC More: the full row for Verition Fund Management LLC 280,327 $3.92M 0.02% +68,176 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 269,500 $3.77M 0.01% -3,100 13F-HR Timeline Palo Alto Investors LP More: the full row for Palo Alto Investors LP 248,934 $3.49M 0.54% +189,352 13F-HR Timeline PINNACLE ASSOCIATES LTD More: the full row for PINNACLE ASSOCIATES LTD 226,742 $3.17M 0.04% new 13F-HR Timeline Aquilo Capital Management, LLC More: the full row for Aquilo Capital Management, LLC 221,911 $3.11M 5.32% +40,000 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 216,016 $3.02M <0.01% -5,400 13F-HR Timeline Handelsbanken Fonder AB More: the full row for Handelsbanken Fonder AB 215,900 $3.02M 0.01% -2,800 13F-HR Timeline PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 197,108 $2.76M 0.08% -58,886 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 176,757 $2.47M <0.01% new 13F-HR Timeline Group Caption Management, LLC More: the full row for Caption Management, LLC 163,076 $2.28M 0.09% new 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 144,230 $2.02M <0.01% +41,481 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 139,075 $1.95M <0.01% -99,741 13F-HR Timeline Group SILVERCREST ASSET MANAGEMENT GROUP LLC More: the full row for SILVERCREST ASSET MANAGEMENT GROUP LLC 137,740 $1.93M 0.01% -1,353 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 132,361 $1.85M <0.01% +120,295 13F-HR Timeline Group HARBOR CAPITAL ADVISORS, INC. More: the full row for HARBOR CAPITAL ADVISORS, INC. 131,505 $1.84M 0.08% -2,202 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 124,497 $1.74M <0.01% -5,208 13F-HR Timeline Group HighVista Strategies LLC More: the full row for HighVista Strategies LLC 124,430 $1.74M 0.65% -15,114 13F-HR Timeline DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 120,799 $1.69M 0.43% -1,401 13F-HR Timeline Springhill Fund Asset Management (HK) C… More: the full row for Springhill Fund Asset Management (HK) Co Ltd 116,400 $1.63M 2.65% 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 87,765 $1.23M <0.01% +1,494 13F-HR Timeline Group OCONNOR, A Distinct Business Unit of UB… More: the full row for OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 80,236 $1.12M 0.03% +44,260 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Nan Fung Group Holdings Ltd More: the full row for Nan Fung Group Holdings Ltd 68,943 $965K 0.83% +37,358 13F-HR Timeline Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 49,899 $699K 0.01% -28,721 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 48,420 $678K <0.01% -56,870 13F-HR/A Timeline Group EntryPoint Capital, LLC More: the full row for EntryPoint Capital, LLC 43,873 $614K 0.26% new 13F-HR Timeline Skandinaviska Enskilda Banken AB (publ) More: the full row for Skandinaviska Enskilda Banken AB (publ) 42,729 $603K <0.01% 0 13F-HR Timeline Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 42,500 $595K <0.01% -380,500 13F-HR Timeline Altium Capital Management LLC More: the full row for Altium Capital Management LLC 40,352 $565K 0.18% -44,648 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 38,815 $543K <0.01% +480 13F-HR Timeline Group DekaBank Deutsche Girozentrale More: the full row for DekaBank Deutsche Girozentrale 30,000 $414K <0.01% 0 13F-HR Timeline WOODSTOCK CORP More: the full row for WOODSTOCK CORP 24,981 $350K 0.03% 0 13F-HR Timeline Allianz Asset Management GmbH in group Allianz SE More: the full row for Allianz Asset Management GmbH 24,600 $344K <0.01% 0 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 23,991 $336K <0.01% +3,811 13F-HR Timeline Group WEXFORD CAPITAL LP More: the full row for WEXFORD CAPITAL LP 17,879 $250K 0.06% -17,000 13F-HR Timeline TOCQUEVILLE ASSET MANAGEMENT L.P. in group TOCQUEVILLE ASSET MANAGEMENT … More: the full row for TOCQUEVILLE ASSET MANAGEMENT L.P. 14,700 $206K <0.01% -700 13F-HR Timeline Group Erste Asset Management GmbH in group Erste Asset Management GmbH More: the full row for Erste Asset Management GmbH 14,000 $204K <0.01% 0 13F-HR Timeline Group HORIZON KINETICS ASSET MANAGEMENT LLC More: the full row for HORIZON KINETICS ASSET MANAGEMENT LLC 14,396 $202K <0.01% +604 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 12,900 $181K <0.01% 0 13F-HR Timeline Group Crossmark Global Holdings, Inc. More: the full row for Crossmark Global Holdings, Inc. 11,378 $159K <0.01% +11 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 9,773 $137K <0.01% +9,310 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 9,329 $131K 0.01% +2,191 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 7,707 $108K <0.01% -717 13F-HR Timeline Group EXCHANGE TRADED CONCEPTS, LLC More: the full row for EXCHANGE TRADED CONCEPTS, LLC 6,707 $93.9K <0.01% 0 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 6,417 $89.8K <0.01% -1,653 13F-HR/A Timeline Group HighMark Wealth Management LLC More: the full row for HighMark Wealth Management LLC 4,435 $62.1K 0.04% 0 13F-HR Timeline Avior Wealth Management, LLC More: the full row for Avior Wealth Management, LLC 4,043 $56.6K <0.01% new 13F-HR Timeline VIRTUS ADVISERS, LLC in group Virtus Investment Advisers, L… More: the full row for VIRTUS ADVISERS, LLC 3,535 $49.5K 0.02% -254 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 2,612 $36.6K <0.01% +2,345 13F-HR/A Timeline Group NATIXIS in group Natixis Investment Managers More: the full row for NATIXIS 2,298 $33.2K <0.01% -437 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. in group Mirae Asset Global Investment… More: the full row for Mirae Asset Global Investments Co., Ltd. 1,466 $21.3K <0.01% +124 13F-HR Timeline Group ASSETMARK, INC in group ASSETMARK, INC More: the full row for ASSETMARK, INC 1,260 $17.6K <0.01% -259 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 1,157 $16.2K <0.01% +57 13F-HR/A Timeline Coppell Advisory Solutions LLC More: the full row for Coppell Advisory Solutions LLC 1,076 $15K <0.01% 0 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 925 $12.9K <0.01% +296 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 924 $12.9K <0.01% 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 917 $12.8K <0.01% -1,109 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 760 $10.6K <0.01% -282 13F-HR/A Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 680 $9.52K <0.01% -118 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 630 $8.82K <0.01% -38 13F-HR Timeline Group Manchester Capital Management LLC More: the full row for Manchester Capital Management LLC 590 $8.26K <0.01% 0 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 466 $6.52K <0.01% new 13F-HR/A Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 316 $4.42K <0.01% -150,200 13F-HR Timeline Group R Squared Ltd More: the full row for R Squared Ltd 180 $2.52K <0.01% 13F-HR Timeline Winch Advisory Services, LLC More: the full row for Winch Advisory Services, LLC 172 $2.41K <0.01% 0 13F-HR Timeline JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 150 $2.1K <0.01% +50 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 148 $2.07K <0.01% 13F-HR/A Timeline AdvisorNet Financial, Inc More: the full row for AdvisorNet Financial, Inc 100 $1.4K <0.01% new 13F-HR Timeline TD Waterhouse Canada Inc. More: the full row for TD Waterhouse Canada Inc. 100 $1.4K <0.01% new 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 103 $1K <0.01% 0 13F-HR Timeline Group Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 61 $854 <0.01% 0 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 24 $336 <0.01% +4 13F-HR Timeline Group Bell Investment Advisors, Inc More: the full row for Bell Investment Advisors, Inc 22 $308 <0.01% 0 13F-HR Timeline Caitlin John, LLC More: the full row for Caitlin John, LLC 14 $196 <0.01% 0 13F-HR Timeline Blue Trust, Inc. More: the full row for Blue Trust, Inc. 11 $154 <0.01% -524 13F-HR/A Timeline Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 10 $140 <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 7 $98 <0.01% 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.