BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 10,885,357 $92.4M 1.02% 0 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 3,692,069 $31.3M 0.09% -862,831 13F-HR/A Timeline Group FCPM III SERVICES B.V. in group FCPM III SERVICES B.V. More: the full row for FCPM III SERVICES B.V. 3,452,330 $29.3M 7.08% 0 13F-HR Timeline Group ARMISTICE CAPITAL, LLC More: the full row for ARMISTICE CAPITAL, LLC 2,672,000 $22.7M 0.61% +476,000 13F-HR Timeline WESTFIELD CAPITAL MANAGEMENT CO LP More: the full row for WESTFIELD CAPITAL MANAGEMENT CO LP 2,657,305 $22.6M 0.11% +46,968 13F-HR Timeline Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 1,812,752 $15.4M 0.87% -26,646 13F-HR/A Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 1,536,584 $13M <0.01% -48,543 13F-HR Timeline Long Focus Capital Management, LLC More: the full row for Long Focus Capital Management, LLC 1,293,753 $11M 0.75% +750,661 13F-HR Timeline BNP PARIBAS ASSET MANAGEMENT Holding S.… in group BNP PARIBAS ASSET MANAGEMENT … More: the full row for BNP PARIBAS ASSET MANAGEMENT Holding S.A. 1,219,688 $10.4M 0.03% +64,037 13F-HR Timeline Group Candriam S.C.A. More: the full row for Candriam S.C.A. 1,205,207 $10.2M 0.06% +117,331 13F-HR Timeline RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 1,093,477 $9.28M 0.16% 0 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 999,837 $8.49M <0.01% +137,700 13F-HR Timeline Group EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 910,000 $7.73M 0.46% 0 13F-HR Timeline Deep Track Capital, LP More: the full row for Deep Track Capital, LP 767,016 $6.51M 0.21% -509,065 13F-HR Timeline PRINCIPAL FINANCIAL GROUP INC in group PRINCIPAL FINANCIAL GROUP INC More: the full row for PRINCIPAL FINANCIAL GROUP INC 631,260 $5.36M <0.01% +224,790 13F-HR Timeline Group TYBOURNE CAPITAL MANAGEMENT (HK) LTD More: the full row for TYBOURNE CAPITAL MANAGEMENT (HK) LTD 576,343 $4.89M 20.77% -693,192 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 563,559 $4.78M <0.01% +170,700 13F-HR Timeline Group AXA S.A. in group AXA S.A. More: the full row for AXA S.A. 553,682 $4.7M 0.02% -277 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 453,428 $3.85M <0.01% +276,671 13F-HR Timeline Group Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 408,889 $3.47M 0.06% new 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 363,751 $3.09M 0.02% new 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 322,876 $2.74M <0.01% -42,532 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 301,500 $2.56M <0.01% +32,000 13F-HR Timeline PLATINUM INVESTMENT MANAGEMENT LTD More: the full row for PLATINUM INVESTMENT MANAGEMENT LTD 287,599 $2.44M 0.14% -21,460 13F-HR Timeline SILVERCREST ASSET MANAGEMENT GROUP LLC More: the full row for SILVERCREST ASSET MANAGEMENT GROUP LLC 265,693 $2.26M 0.02% +127,953 13F-HR Timeline Palo Alto Investors LP More: the full row for Palo Alto Investors LP 248,934 $2.11M 0.4% 0 13F-HR Timeline Handelsbanken Fonder AB More: the full row for Handelsbanken Fonder AB 215,900 $1.83M 0.01% 0 13F-HR Timeline PINNACLE ASSOCIATES LTD More: the full row for PINNACLE ASSOCIATES LTD 214,278 $1.82M 0.03% -12,464 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 193,092 $1.64M <0.01% -22,924 13F-HR Timeline Aquilo Capital Management, LLC More: the full row for Aquilo Capital Management, LLC 171,695 $1.46M 3.93% -50,216 13F-HR Timeline OCONNOR, A Distinct Business Unit of UB… More: the full row for OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 148,722 $1.26M 0.03% +68,486 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. HARBOR CAPITAL ADVISORS, INC. More: the full row for HARBOR CAPITAL ADVISORS, INC. 148,129 $1.26M 0.06% +16,624 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 138,249 $1.17M <0.01% +13,752 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 135,658 $1.17M <0.01% -3,417 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 130,070 $1.1M <0.01% -14,160 13F-HR Timeline Group ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 126,062 $1.06M <0.01% new 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 85,653 $727K <0.01% -2,112 13F-HR Timeline Group Caption Management, LLC More: the full row for Caption Management, LLC 81,559 $692K 0.03% -81,517 13F-HR Timeline DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 80,799 $686K 0.19% -40,000 13F-HR Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 77,802 $661K -54,559 Timeline Nan Fung Group Holdings Ltd More: the full row for Nan Fung Group Holdings Ltd 68,943 $585K 0.48% 0 13F-HR Timeline Shay Capital LLC More: the full row for Shay Capital LLC 60,000 $509K 0.15% new 13F-HR Timeline MOORE CAPITAL MANAGEMENT, LP More: the full row for MOORE CAPITAL MANAGEMENT, LP 50,000 $424K 0.01% new 13F-HR/A Timeline Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 47,249 $401K 0.01% -2,650 13F-HR Timeline Skandinaviska Enskilda Banken AB (publ) More: the full row for Skandinaviska Enskilda Banken AB (publ) 42,729 $363K <0.01% 0 13F-HR Timeline DekaBank Deutsche Girozentrale More: the full row for DekaBank Deutsche Girozentrale 30,000 $256K <0.01% 0 13F-HR Timeline EntryPoint Capital, LLC More: the full row for EntryPoint Capital, LLC 28,857 $245K 0.11% -15,016 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 25,192 $214K <0.01% new 13F-HR/A Timeline Group WOODSTOCK CORP More: the full row for WOODSTOCK CORP 24,981 $212K 0.02% 0 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 21,377 $181K <0.01% -17,438 13F-HR Timeline Group TOCQUEVILLE ASSET MANAGEMENT L.P. in group TOCQUEVILLE ASSET MANAGEMENT … More: the full row for TOCQUEVILLE ASSET MANAGEMENT L.P. 18,300 $155K <0.01% +3,600 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 17,940 $152K <0.01% +8,167 13F-HR/A Timeline Group PORTLAND INVESTMENT COUNSEL INC. More: the full row for PORTLAND INVESTMENT COUNSEL INC. 15,000 $127K 0.04% new 13F-HR Timeline Erste Asset Management GmbH in group Erste Asset Management GmbH More: the full row for Erste Asset Management GmbH 14,000 $126K <0.01% 0 13F-HR Timeline Group HORIZON KINETICS ASSET MANAGEMENT LLC More: the full row for HORIZON KINETICS ASSET MANAGEMENT LLC 14,396 $122K <0.01% 0 13F-HR Timeline Cerity Partners LLC in group Cerity Partners LLC More: the full row for Cerity Partners LLC 13,350 $113K <0.01% new 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 13,080 $111K <0.01% +180 13F-HR Timeline Group EXCHANGE TRADED CONCEPTS, LLC More: the full row for EXCHANGE TRADED CONCEPTS, LLC 12,764 $108K <0.01% +6,057 13F-HR Timeline ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 12,420 $105K <0.01% new 13F-HR Timeline Group GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 11,952 $101K 0.01% new 13F-HR Timeline Crossmark Global Holdings, Inc. More: the full row for Crossmark Global Holdings, Inc. 11,400 $96.8K <0.01% +22 13F-HR Timeline SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 10,637 $90.3K <0.01% new 13F-HR/A Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 8,833 $75K 0.01% -496 13F-HR Timeline Virtus Investment Advisers, LLC group of 2 filers holding More: the full row for Virtus Investment Advisers, LLC 8,162 $69.3K +4,627 Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 7,044 $59.8K <0.01% -663 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 6,417 $54.5K <0.01% 0 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 3,308 $28.1K <0.01% +696 13F-HR/A Timeline Group NATIXIS in group Natixis Investment Managers More: the full row for NATIXIS 2,126 $17.9K <0.01% -172 13F-HR/A Timeline Group Mirae Asset Global Investments Co., Ltd. in group Mirae Asset Global Investment… More: the full row for Mirae Asset Global Investments Co., Ltd. 1,464 $13.1K <0.01% -2 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 1,304 $11.1K <0.01% +147 13F-HR/A Timeline ASSETMARK, INC in group ASSETMARK, INC More: the full row for ASSETMARK, INC 1,282 $10.9K <0.01% +22 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 1,211 $10.3K <0.01% +531 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,126 $9.56K <0.01% +202 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,081 $9.18K <0.01% +156 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 1,058 $8.98K <0.01% +141 13F-HR/A Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 689 $5.85K <0.01% +59 13F-HR Timeline Group Manchester Capital Management LLC More: the full row for Manchester Capital Management LLC 590 $5.01K <0.01% 0 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 571 $4K <0.01% new 13F-HR Timeline HighMark Wealth Management LLC More: the full row for HighMark Wealth Management LLC 435 $3.69K <0.01% -4,000 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 316 $2.68K <0.01% 0 13F-HR Timeline Group JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 250 $2.24K <0.01% +100 13F-HR/A Timeline Group SVB WEALTH LLC More: the full row for SVB WEALTH LLC 210 $1.78K <0.01% new 13F-HR Timeline Winch Advisory Services, LLC More: the full row for Winch Advisory Services, LLC 172 $1.46K <0.01% 0 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 166 $1.41K <0.01% -300 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 103 $1K <0.01% 0 13F-HR Timeline Group TD Waterhouse Canada Inc. More: the full row for TD Waterhouse Canada Inc. 100 $785 <0.01% 0 13F-HR Timeline Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 61 $518 <0.01% 0 13F-HR Timeline Bell Investment Advisors, Inc More: the full row for Bell Investment Advisors, Inc 22 $187 <0.01% 0 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 18 $152 <0.01% -742 13F-HR Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 13 $110 <0.01% -11 13F-HR Timeline Group Blue Trust, Inc. More: the full row for Blue Trust, Inc. 11 $93 <0.01% 0 13F-HR Timeline Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 10 $85 <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 6 $51 <0.01% -1 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 2 $17 <0.01% -146 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.