BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 10,885,357 $84.3M 0.61% 0 13F-HR Timeline Group FCPM III SERVICES B.V. in group FCPM III SERVICES B.V. More: the full row for FCPM III SERVICES B.V. 3,452,330 $26.7M 5.34% 0 13F-HR Timeline Group ARMISTICE CAPITAL, LLC More: the full row for ARMISTICE CAPITAL, LLC 2,978,000 $23M 0.72% +178,000 13F-HR Timeline WESTFIELD CAPITAL MANAGEMENT CO LP More: the full row for WESTFIELD CAPITAL MANAGEMENT CO LP 2,952,543 $22.9M 0.1% +172,052 13F-HR Timeline Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 2,012,752 $15.6M 0.61% 0 13F-HR Timeline Group Long Focus Capital Management, LLC More: the full row for Long Focus Capital Management, LLC 1,418,695 $11M 0.63% +101,402 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 1,384,794 $10.7M <0.01% -83,599 13F-HR Timeline ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 1,314,556 $10.2M 0.02% +616,055 13F-HR Timeline Group Candriam S.C.A. More: the full row for Candriam S.C.A. 1,172,387 $9.07M 0.05% 0 13F-HR Timeline PRINCIPAL FINANCIAL GROUP INC group of 2 filers holding More: the full row for PRINCIPAL FINANCIAL GROUP INC 1,148,420 $8.89M +451,135 Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 1,054,746 $8.16M 0.01% -388,873 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 822,705 $6.37M <0.01% -214,448 13F-HR/A Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 591,535 $4.58M <0.01% -239,099 13F-HR/A Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 518,700 $4.01M 0.01% +200,300 13F-HR Timeline SILVERCREST ASSET MANAGEMENT GROUP LLC More: the full row for SILVERCREST ASSET MANAGEMENT GROUP LLC 476,976 $3.69M 0.02% +211,283 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 430,900 $3.34M 0.01% -1,341,700 13F-HR Timeline Group Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 401,926 $3.11M 0.03% -59,174 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 341,237 $2.64M +214,839 Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 282,418 $2.19M <0.01% +18,070 13F-HR Timeline Group Palo Alto Investors LP More: the full row for Palo Alto Investors LP 221,071 $1.71M 0.32% -27,863 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 197,917 $1.53M <0.01% +23,007 13F-HR Timeline Group PINNACLE ASSOCIATES LTD More: the full row for PINNACLE ASSOCIATES LTD 196,618 $1.52M 0.02% +24,665 13F-HR Timeline Eversept Partners, LP More: the full row for Eversept Partners, LP 194,440 $1.5M 0.12% -17,029 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 189,027 $1.46M <0.01% +49,560 13F-HR Timeline Group PLATINUM INVESTMENT MANAGEMENT LTD More: the full row for PLATINUM INVESTMENT MANAGEMENT LTD 184,603 $1.43M 0.09% -100,778 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 178,092 $1.38M <0.01% -15,000 13F-HR Timeline Birchview Capital, LP More: the full row for Birchview Capital, LP 154,000 $1.19M 0.9% new 13F-HR Timeline Handelsbanken Fonder AB More: the full row for Handelsbanken Fonder AB 150,000 $1.16M <0.01% -50,000 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 140,492 $1.09M <0.01% 0 13F-HR Timeline Group Rangeley Capital, LLC More: the full row for Rangeley Capital, LLC 130,000 $1.01M 0.94% +55,000 13F-HR Timeline MOORE CAPITAL MANAGEMENT, LP More: the full row for MOORE CAPITAL MANAGEMENT, LP 125,000 $968K 0.02% +50,000 13F-HR Timeline Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 103,410 $800K 0.01% +15,693 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 102,459 $793K <0.01% +79,852 13F-HR Timeline Group MONIMUS CAPITAL MANAGEMENT, LP More: the full row for MONIMUS CAPITAL MANAGEMENT, LP 85,224 $660K 0.49% 0 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 74,405 $576K <0.01% +8,408 13F-HR Timeline Group Nan Fung Group Holdings Ltd More: the full row for Nan Fung Group Holdings Ltd 68,943 $534K 0.9% 0 13F-HR Timeline DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 64,492 $499K 0.12% 0 13F-HR Timeline SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 49,056 $380K <0.01% +38,419 13F-HR Timeline Group State of Tennessee, Department of Treas… More: the full row for State of Tennessee, Department of Treasury 44,842 $347K <0.01% +30,460 13F-HR Timeline HARBOR CAPITAL ADVISORS, INC. More: the full row for HARBOR CAPITAL ADVISORS, INC. 41,368 $320K 0.02% -97,293 13F-HR Timeline Man Group plc in group Man Group plc More: the full row for Man Group plc 40,891 $316K <0.01% +12,216 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 39,925 $309K <0.01% -487 13F-HR Timeline Group DekaBank Deutsche Girozentrale More: the full row for DekaBank Deutsche Girozentrale 30,000 $220K <0.01% 0 13F-HR Timeline Dynamic Technology Lab Private Ltd More: the full row for Dynamic Technology Lab Private Ltd 27,959 $216K 0.04% -17,991 13F-HR Timeline Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 27,894 $216K <0.01% +10,156 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 26,629 $206K <0.01% +62 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 24,123 $187K <0.01% -1,634 13F-HR Timeline Group WOODSTOCK CORP More: the full row for WOODSTOCK CORP 23,927 $185K 0.02% 0 13F-HR Timeline Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 21,421 $166K <0.01% +4,681 13F-HR/A Timeline Group State of New Jersey Common Pension Fund… in group State of New Jersey Common Pe… More: the full row for State of New Jersey Common Pension Fund D 20,105 $156K <0.01% new 13F-HR Timeline Group PORTLAND INVESTMENT COUNSEL INC. More: the full row for PORTLAND INVESTMENT COUNSEL INC. 15,000 $116K 0.03% 0 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 14,972 $116K <0.01% +2,668 13F-HR Timeline Group HORIZON KINETICS ASSET MANAGEMENT LLC More: the full row for HORIZON KINETICS ASSET MANAGEMENT LLC 14,396 $111K <0.01% +604 13F-HR Timeline Cerity Partners LLC in group Cerity Partners LLC More: the full row for Cerity Partners LLC 14,350 $111K <0.01% 0 13F-HR Timeline Group Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 14,302 $111K <0.01% +4,699 13F-HR Timeline Erste Asset Management GmbH in group Erste Asset Management GmbH More: the full row for Erste Asset Management GmbH 14,000 $107K <0.01% 0 13F-HR Timeline Group Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 13,421 $104K <0.01% -1,981 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 13,259 $103K <0.01% +1,385 13F-HR Timeline Group Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 13,094 $101K 0.03% +2,273 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 13,080 $101K <0.01% 0 13F-HR Timeline Group Vanguard Personalized Indexing Manageme… in group VANGUARD GROUP INC More: the full row for Vanguard Personalized Indexing Management, LLC 12,953 $100K <0.01% new 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 12,733 $99K <0.01% +2,371 13F-HR Timeline Group Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 12,375 $95.8K <0.01% -727 13F-HR Timeline TOCQUEVILLE ASSET MANAGEMENT L.P. in group TOCQUEVILLE ASSET MANAGEMENT … More: the full row for TOCQUEVILLE ASSET MANAGEMENT L.P. 12,300 $95.2K <0.01% -10,600 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 11,648 $90.2K <0.01% new 13F-HR Timeline Group Crossmark Global Holdings, Inc. More: the full row for Crossmark Global Holdings, Inc. 11,390 $88.2K <0.01% +1 13F-HR Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 11,373 $88K -49,302 Timeline FNY Investment Advisers, LLC More: the full row for FNY Investment Advisers, LLC 10,500 $81K 0.03% new 13F-HR Timeline COMMONWEALTH OF PENNSYLVANIA PUBLIC SCH… More: the full row for COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS 10,116 $78.3K <0.01% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 8,127 $62.9K <0.01% +490 13F-HR/A Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 8,104 $62.7K 0.01% -762 13F-HR Timeline ASSETMARK, INC in group ASSETMARK, INC More: the full row for ASSETMARK, INC 3,625 $28.1K <0.01% +1,552 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 3,275 $25.3K <0.01% +270 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 2,601 $20.1K <0.01% +1,688 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 2,272 $17.6K <0.01% -1,204 13F-HR/A Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 2,116 $16.4K <0.01% +628 13F-HR Timeline NATIXIS in group Natixis Investment Managers More: the full row for NATIXIS 1,947 $14.6K <0.01% 0 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. in group Mirae Asset Global Investment… More: the full row for Mirae Asset Global Investments Co., Ltd. 1,787 $13.8K <0.01% +82 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,665 $12.9K <0.01% -2,494 13F-HR Timeline Group Clearstead Advisors, LLC More: the full row for Clearstead Advisors, LLC 1,393 $10.8K <0.01% 0 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 995 $7.7K <0.01% -131 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 811 $6.28K <0.01% +281 13F-HR Timeline Group Walleye Capital LLC group of 2 filers holding More: the full row for Walleye Capital LLC 630 $4.88K +591 Timeline Manchester Capital Management LLC More: the full row for Manchester Capital Management LLC 590 $4.57K <0.01% 0 13F-HR Timeline HighMark Wealth Management LLC More: the full row for HighMark Wealth Management LLC 435 $3.37K <0.01% 0 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 316 $2.45K <0.01% 0 13F-HR Timeline Group JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 250 $1.85K <0.01% 0 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 200 $1.55K <0.01% 0 13F-HR Timeline Group Winch Advisory Services, LLC More: the full row for Winch Advisory Services, LLC 172 $1.33K <0.01% 0 13F-HR Timeline TOTH FINANCIAL ADVISORY CORP More: the full row for TOTH FINANCIAL ADVISORY CORP 150 $1.16K <0.01% 0 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 103 $1K <0.01% 0 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 18 $132 <0.01% 0 13F-HR Timeline Group Blue Trust, Inc. More: the full row for Blue Trust, Inc. 11 $85 <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 7 $54 <0.01% +1 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 6 $46 <0.01% new 13F-HR Timeline Group Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 5 $39 <0.01% new 13F-HR Timeline Group Caitlin John, LLC More: the full row for Caitlin John, LLC 2 $15 <0.01% new 13F-HR Timeline