BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 10,885,357 $75.7M 0.73% 0 13F-HR Timeline Group FCPM III SERVICES B.V. in group FCPM III SERVICES B.V. More: the full row for FCPM III SERVICES B.V. 3,452,330 $24M 6.5% 0 13F-HR Timeline Group ARMISTICE CAPITAL, LLC More: the full row for ARMISTICE CAPITAL, LLC 2,800,000 $19.5M 0.74% +128,000 13F-HR Timeline WESTFIELD CAPITAL MANAGEMENT CO LP More: the full row for WESTFIELD CAPITAL MANAGEMENT CO LP 2,780,491 $19.3M 0.08% +123,186 13F-HR Timeline Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 2,012,752 $14M 0.72% +200,000 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 1,772,600 $12.3M 0.03% -1,919,469 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 1,468,393 $10.2M <0.01% -68,191 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 1,443,619 $10M 0.01% +990,191 13F-HR Timeline Group Long Focus Capital Management, LLC More: the full row for Long Focus Capital Management, LLC 1,317,293 $9.16M 0.59% +23,540 13F-HR Timeline Deep Track Capital, LP More: the full row for Deep Track Capital, LP 1,203,244 $8.36M 0.27% +436,228 13F-HR Timeline Candriam S.C.A. More: the full row for Candriam S.C.A. 1,172,387 $8.15M 0.05% -32,820 13F-HR Timeline BNP PARIBAS ASSET MANAGEMENT Holding S.… in group BNP PARIBAS ASSET MANAGEMENT … More: the full row for BNP PARIBAS ASSET MANAGEMENT Holding S.A. 1,041,456 $7.24M 0.02% -178,232 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 1,037,153 $7.21M <0.01% +37,316 13F-HR Timeline Group TYBOURNE CAPITAL MANAGEMENT (HK) LTD More: the full row for TYBOURNE CAPITAL MANAGEMENT (HK) LTD 993,743 $6.91M 20% +417,400 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 830,634 $5.77M <0.01% +267,075 13F-HR Timeline Group PRINCIPAL FINANCIAL GROUP INC group of 2 filers holding More: the full row for PRINCIPAL FINANCIAL GROUP INC 697,285 $4.85M +66,025 Timeline ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 698,501 $4.84M 0.01% +572,439 13F-HR Timeline Group Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 461,100 $3.2M 0.05% +52,211 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 362,325 $2.52M 0.01% -1,426 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 318,400 $2.21M <0.01% +16,900 13F-HR Timeline PLATINUM INVESTMENT MANAGEMENT LTD More: the full row for PLATINUM INVESTMENT MANAGEMENT LTD 285,381 $1.98M 0.13% -2,218 13F-HR Timeline AXA S.A. in group AXA S.A. More: the full row for AXA S.A. 280,152 $1.95M 0.01% -273,530 13F-HR Timeline Group SILVERCREST ASSET MANAGEMENT GROUP LLC More: the full row for SILVERCREST ASSET MANAGEMENT GROUP LLC 265,693 $1.85M 0.01% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 264,348 $1.84M <0.01% -58,528 13F-HR Timeline Group Palo Alto Investors LP More: the full row for Palo Alto Investors LP 248,934 $1.73M 0.37% 0 13F-HR Timeline Eversept Partners, LP More: the full row for Eversept Partners, LP 211,469 $1.47M 0.15% new 13F-HR Timeline Handelsbanken Fonder AB More: the full row for Handelsbanken Fonder AB 200,000 $1.39M <0.01% -15,900 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 193,092 $1.34M <0.01% 0 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 174,910 $1.21M <0.01% +39,252 13F-HR Timeline Group PINNACLE ASSOCIATES LTD More: the full row for PINNACLE ASSOCIATES LTD 171,953 $1.2M 0.02% -42,325 13F-HR Timeline OCONNOR, A Distinct Business Unit of UB… More: the full row for OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 143,800 $999K 0.03% -4,922 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 140,492 $976K <0.01% +2,243 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 139,467 $969K <0.01% +9,397 13F-HR Timeline Group HARBOR CAPITAL ADVISORS, INC. More: the full row for HARBOR CAPITAL ADVISORS, INC. 138,661 $964K 0.04% -9,468 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 126,398 $878K new Timeline Janney Montgomery Scott LLC More: the full row for Janney Montgomery Scott LLC 100,291 $697K <0.01% new 13F-HR Timeline Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 100,000 $695K 0.05% new 13F-HR Timeline Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 87,717 $610K 0.01% +40,468 13F-HR Timeline MONIMUS CAPITAL MANAGEMENT, LP More: the full row for MONIMUS CAPITAL MANAGEMENT, LP 85,224 $592K 0.48% new 13F-HR Timeline MOORE CAPITAL MANAGEMENT, LP More: the full row for MOORE CAPITAL MANAGEMENT, LP 75,000 $521K 0.01% +25,000 13F-HR Timeline Rangeley Capital, LLC More: the full row for Rangeley Capital, LLC 75,000 $521K 0.65% new 13F-HR Timeline Nan Fung Group Holdings Ltd More: the full row for Nan Fung Group Holdings Ltd 68,943 $479K 0.76% 0 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 65,997 $459K <0.01% -19,656 13F-HR Timeline Group DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 64,492 $448K 0.12% -16,307 13F-HR Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 60,675 $422K -17,127 Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 52,265 $363K <0.01% +27,073 13F-HR Timeline Group Dynamic Technology Lab Private Ltd More: the full row for Dynamic Technology Lab Private Ltd 45,950 $320K 0.04% new 13F-HR Timeline Skandinaviska Enskilda Banken AB (publ) More: the full row for Skandinaviska Enskilda Banken AB (publ) 42,729 $297K <0.01% 0 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 40,412 $281K <0.01% +19,035 13F-HR Timeline Group Paloma Partners Management Co in group Paloma Partners Management Co More: the full row for Paloma Partners Management Co 39,250 $273K 0.06% new 13F-HR Timeline Group DekaBank Deutsche Girozentrale More: the full row for DekaBank Deutsche Girozentrale 30,000 $211K <0.01% 0 13F-HR Timeline Man Group plc in group Man Group plc More: the full row for Man Group plc 28,675 $199K <0.01% new 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 26,567 $185K <0.01% new 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 25,757 $179K <0.01% new 13F-HR Timeline Group WOODSTOCK CORP More: the full row for WOODSTOCK CORP 23,927 $166K 0.02% -1,054 13F-HR Timeline TOCQUEVILLE ASSET MANAGEMENT L.P. in group TOCQUEVILLE ASSET MANAGEMENT … More: the full row for TOCQUEVILLE ASSET MANAGEMENT L.P. 22,900 $159K <0.01% +4,600 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 22,607 $157K <0.01% new 13F-HR Timeline Group Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 17,738 $123K <0.01% new 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 16,740 $116K <0.01% new 13F-HR/A Timeline Group PORTLAND INVESTMENT COUNSEL INC. More: the full row for PORTLAND INVESTMENT COUNSEL INC. 15,000 $109K 0.03% 0 13F-HR Timeline Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 15,402 $107K <0.01% new 13F-HR Timeline Erste Asset Management GmbH in group Erste Asset Management GmbH More: the full row for Erste Asset Management GmbH 14,000 $101K <0.01% 0 13F-HR Timeline Group State of Tennessee, Department of Treas… More: the full row for State of Tennessee, Department of Treasury 14,382 $100K <0.01% new 13F-HR Timeline Cerity Partners LLC in group Cerity Partners LLC More: the full row for Cerity Partners LLC 14,350 $99.7K <0.01% +1,000 13F-HR Timeline Group HORIZON KINETICS ASSET MANAGEMENT LLC More: the full row for HORIZON KINETICS ASSET MANAGEMENT LLC 13,792 $95.9K <0.01% -604 13F-HR Timeline Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 13,102 $91.1K <0.01% new 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 13,080 $90.9K <0.01% 0 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 12,304 $85.5K <0.01% new 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 11,874 $82.5K <0.01% new 13F-HR/A Timeline Group Crossmark Global Holdings, Inc. More: the full row for Crossmark Global Holdings, Inc. 11,389 $79.2K <0.01% -11 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 10,821 $75.2K 0.03% +2,659 13F-HR Timeline Group SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 10,637 $73.9K <0.01% 0 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 10,362 $72K <0.01% -7,578 13F-HR/A Timeline Group Ausdal Financial Partners, Inc. More: the full row for Ausdal Financial Partners, Inc. 10,000 $69.5K <0.01% new 13F-HR Timeline Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 9,603 $66.8K <0.01% +9,542 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 8,866 $61.6K 0.01% +33 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 7,637 $53.1K <0.01% +593 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 4,159 $28.9K <0.01% +3,078 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 3,476 $24.2K <0.01% +168 13F-HR/A Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 3,005 $20.9K <0.01% +1,701 13F-HR Timeline ASSETMARK, INC in group ASSETMARK, INC More: the full row for ASSETMARK, INC 2,073 $14.4K <0.01% +791 13F-HR Timeline Group NATIXIS in group Natixis Investment Managers More: the full row for NATIXIS 1,947 $13.9K <0.01% -179 13F-HR Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 1,933 $13.4K <0.01% new 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. in group Mirae Asset Global Investment… More: the full row for Mirae Asset Global Investments Co., Ltd. 1,705 $11.8K <0.01% +241 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 1,517 $10.5K 0.01% +1,515 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 1,488 $10.3K <0.01% +430 13F-HR Timeline Clearstead Advisors, LLC More: the full row for Clearstead Advisors, LLC 1,393 $9.68K <0.01% new 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 1,294 $8.99K <0.01% +1,128 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 1,241 $8K <0.01% +670 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,126 $7.83K <0.01% 0 13F-HR Timeline Brooklyn Investment Group More: the full row for Brooklyn Investment Group 923 $6.42K <0.01% new 13F-HR/A Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 913 $6.34K <0.01% +224 13F-HR Timeline Group Manchester Capital Management LLC More: the full row for Manchester Capital Management LLC 590 $4.1K <0.01% 0 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 530 $3.68K <0.01% -681 13F-HR Timeline Group HighMark Wealth Management LLC More: the full row for HighMark Wealth Management LLC 435 $3.02K <0.01% 0 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 316 $2.2K <0.01% 0 13F-HR Timeline Group JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 250 $1.81K <0.01% 0 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 200 $1.39K <0.01% new 13F-HR Timeline Group Winch Advisory Services, LLC More: the full row for Winch Advisory Services, LLC 172 $1.2K <0.01% 0 13F-HR Timeline TOTH FINANCIAL ADVISORY CORP More: the full row for TOTH FINANCIAL ADVISORY CORP 150 $1.04K <0.01% new 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 103 $1K <0.01% 0 13F-HR Timeline Group TD Waterhouse Canada Inc. More: the full row for TD Waterhouse Canada Inc. 100 $699 <0.01% 0 13F-HR Timeline Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 39 $271 <0.01% new 13F-HR Timeline Group CIBC Private Wealth Group LLC in group CIBC Bancorp USA Inc. More: the full row for CIBC Private Wealth Group LLC 23 $160 <0.01% new 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 18 $125 <0.01% 0 13F-HR/A Timeline Group Blue Trust, Inc. More: the full row for Blue Trust, Inc. 11 $76 <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 6 $42 <0.01% 0 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.