RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 6,955,993 $64.6M 1.09% 0 13F-HR Timeline Group Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 5,216,969 $48.5M 2.51% +1,949,886 13F-HR Timeline Group Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 5,000,000 $46.5M 2.45% +2,231,025 13F-HR Timeline RED TREE MANAGEMENT, LLC More: the full row for RED TREE MANAGEMENT, LLC 3,170,509 $29.5M 40.18% 0 13F-HR Timeline TPG GP A, LLC in group TPG GP A, LLC More: the full row for TPG GP A, LLC 3,010,425 $28M 1.49% 0 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 2,538,404 $23.6M <0.01% -1,073,169 13F-HR Timeline Group Deep Track Capital, LP More: the full row for Deep Track Capital, LP 2,426,657 $22.5M 0.72% +426,657 13F-HR Timeline Omega Fund Management, LLC More: the full row for Omega Fund Management, LLC 2,204,650 $20.5M 13.26% 0 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 2,150,310 $20M <0.01% +352,289 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 2,111,320 $19.6M <0.01% +769,388 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 2,005,258 $18.6M <0.01% +914,140 13F-HR Timeline Group Blackstone Inc. in group Blackstone Inc. More: the full row for Blackstone Inc. 1,224,336 $11.4M 0.05% +196,042 13F-HR Timeline Group FIL Ltd in group FIL Ltd More: the full row for FIL Ltd 1,013,853 $9.42M 0.01% 0 13F-HR Timeline Group Foresite Capital Management VI LLC in group Foresite Capital Management V… More: the full row for Foresite Capital Management VI LLC 949,260 $8.82M 4.96% -740 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 741,019 $6.88M 0.01% +715,371 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 672,485 $6.25M <0.01% +180,833 13F-HR Timeline Group ACORN CAPITAL ADVISORS, LLC More: the full row for ACORN CAPITAL ADVISORS, LLC 643,382 $5.98M 3.91% 0 13F-HR Timeline Aisling Capital Management LP More: the full row for Aisling Capital Management LP 568,919 $5.29M 1.47% 0 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 541,067 $5.03M <0.01% +170,936 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 451,228 $4.19M <0.01% +432,818 13F-HR Timeline Group SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 425,341 $3.95M <0.01% +383,681 13F-HR Timeline Artisan Partners Limited Partnership More: the full row for Artisan Partners Limited Partnership 402,765 $3.74M 0.01% new 13F-HR Timeline Logos Global Management LP More: the full row for Logos Global Management LP 400,000 $3.72M 0.5% new 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 348,690 $3.24M 0.02% 0 13F-HR Timeline NAN FUNG TRINITY (HK) LTD More: the full row for NAN FUNG TRINITY (HK) LTD 342,885 $3.19M 0.38% new 13F-HR Timeline Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 336,070 $3.12M 0.19% 0 13F-HR Timeline DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 317,001 $2.94M 0.81% +105,000 13F-HR Timeline Napean Trading & Investment Co (Singapo… More: the full row for Napean Trading & Investment Co (Singapore) PTE Ltd 275,942 $2.56M 0.68% 0 13F-HR Timeline READYSTATE ASSET MANAGEMENT LP More: the full row for READYSTATE ASSET MANAGEMENT LP 270,200 $2.51M 0.1% new 13F-HR Timeline Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 262,751 $2.44M 0.02% -103,213 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 231,613 $2.15M <0.01% +77,401 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 224,538 $2.09M <0.01% +93,600 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 221,516 $2.06M <0.01% new 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 216,836 $2.01M <0.01% new 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 204,460 $1.9M <0.01% -947,671 13F-HR Timeline Group SECTORAL ASSET MANAGEMENT INC More: the full row for SECTORAL ASSET MANAGEMENT INC 201,395 $1.87M 1.24% new 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 193,053 $1.79M <0.01% +40,049 13F-HR Timeline Group SUPERSTRING CAPITAL MANAGEMENT LP More: the full row for SUPERSTRING CAPITAL MANAGEMENT LP 189,699 $1.76M 2.2% new 13F-HR Timeline Verition Fund Management LLC More: the full row for Verition Fund Management LLC 170,962 $1.59M 0.01% new 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 151,857 $1.41M <0.01% +26,162 13F-HR Timeline Group Atle Fund Management AB More: the full row for Atle Fund Management AB 147,380 $1.37M 0.59% +27,547 13F-HR Timeline TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 134,457 $1.25M <0.01% +121,687 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 125,783 $1.17M <0.01% +57,222 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 124,085 $1.15M <0.01% +12,702 13F-HR Timeline Group Jain Global LLC More: the full row for Jain Global LLC 117,910 $1.1M 0.02% new 13F-HR Timeline Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 102,525 $952K 0.01% new 13F-HR Timeline Skandinaviska Enskilda Banken AB (publ) More: the full row for Skandinaviska Enskilda Banken AB (publ) 99,236 $922K <0.01% +61,201 13F-HR Timeline Catalio Capital Management, LP More: the full row for Catalio Capital Management, LP 97,800 $909K 0.19% new 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 87,606 $814K <0.01% +21,752 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 80,428 $747K <0.01% +38,236 13F-HR Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 67,701 $629K <0.01% new 13F-HR Timeline Group SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 65,679 $610K 0.16% new 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 57,334 $533K <0.01% +37,063 13F-HR/A Timeline Group Atom Investors LP More: the full row for Atom Investors LP 55,141 $512K 0.05% new 13F-HR Timeline SCS Capital Management LLC More: the full row for SCS Capital Management LLC 53,430 $496K 0.01% new 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 51,809 $481K <0.01% new 13F-HR Timeline Group Trexquant Investment LP More: the full row for Trexquant Investment LP 50,496 $469K 0.01% new 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 46,911 $436K <0.01% +23,893 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 45,560 $423K <0.01% new 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 44,437 $413K <0.01% +19,409 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 43,248 $402K <0.01% +18,346 13F-HR Timeline Group NORGES BANK More: the full row for NORGES BANK 42,889 $398K <0.01% 0 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 32,414 $301K 0.01% +3,961 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 29,423 $273K <0.01% new 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 28,604 $266K <0.01% new 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 27,673 $257K <0.01% +10,927 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 27,472 $255K <0.01% new 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 27,458 $255K <0.01% +5,664 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 26,094 $242K <0.01% +22,094 13F-HR/A Timeline Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 24,308 $226K <0.01% new 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 22,875 $213K 0.03% new 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 21,701 $202K <0.01% +11,448 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 18,729 $174K <0.01% +7,354 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 16,877 $157K <0.01% +1,962 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 16,090 $149K <0.01% new 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 13,363 $124K <0.01% new 13F-HR/A Timeline Group Mariner, LLC in group Mariner, LLC More: the full row for Mariner, LLC 12,437 $116K <0.01% new 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 11,520 $107K <0.01% -5,938 13F-HR Timeline Group AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 11,096 $103K <0.01% new 13F-HR Timeline Group CAXTON CORP More: the full row for CAXTON CORP 10,941 $102K 1.03% 0 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 9,910 $92.1K <0.01% -24,520 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 8,127 $75.5K 0.03% -970 13F-HR Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 8,109 $75.3K <0.01% +4,417 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 7,080 $65K <0.01% +6,215 13F-HR/A Timeline Group Avanza Fonder AB More: the full row for Avanza Fonder AB 6,567 $61K <0.01% -86 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 4,788 $44.5K <0.01% +3,866 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 3,493 $32.5K <0.01% +1,474 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 3,168 $29.4K <0.01% -18,349 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 3,156 $29.3K <0.01% +1,233 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 2,135 $19.8K <0.01% +709 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 874 $8.12K <0.01% +712 13F-HR/A Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 677 $6.29K <0.01% +82 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 658 $6K <0.01% 0 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 433 $4.02K <0.01% new 13F-HR/A Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 410 $3.81K <0.01% -157 13F-HR Timeline Group Larson Financial Group LLC More: the full row for Larson Financial Group LLC 354 $3.29K <0.01% -716 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 294 $2.73K <0.01% -31 13F-HR Timeline FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 285 $2.65K <0.01% -11,715 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 171 $2K <0.01% -2,027 13F-HR Timeline Group Kessler Investment Group, LLC More: the full row for Kessler Investment Group, LLC 200 $1.86K <0.01% 0 13F-HR Timeline Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 95 $883 <0.01% new 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 78 $724 <0.01% -24 13F-HR Timeline Group Arax Advisory Partners More: the full row for Arax Advisory Partners 59 $549 <0.01% new 13F-HR Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 23 $214 <0.01% -10 13F-HR Timeline Essential Partners LLC More: the full row for Essential Partners LLC 4 $37 <0.01% 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 2 $19 <0.01% new 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.