RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 6,955,993 $110M 1.35% 0 13F-HR Timeline Group Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 5,216,969 $82.4M 3.22% 0 13F-HR Timeline Group Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 5,100,000 $80.5M 3.65% +100,000 13F-HR Timeline RED TREE MANAGEMENT, LLC More: the full row for RED TREE MANAGEMENT, LLC 3,170,509 $50.1M 60.39% 0 13F-HR Timeline TPG GP A, LLC in group TPG GP A, LLC More: the full row for TPG GP A, LLC 3,010,425 $47.5M 2.59% 0 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 2,698,361 $42.6M <0.01% +159,957 13F-HR Timeline Group Deep Track Capital, LP More: the full row for Deep Track Capital, LP 2,426,657 $38.3M 1.07% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 2,311,789 $36.5M <0.01% +200,469 13F-HR Timeline Group Omega Fund Management, LLC More: the full row for Omega Fund Management, LLC 2,204,650 $34.8M 15.66% 0 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 2,200,925 $34.8M <0.01% +195,667 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 1,755,411 $27.7M <0.01% -394,899 13F-HR Timeline Blackstone Inc. in group Blackstone Inc. More: the full row for Blackstone Inc. 1,224,336 $19.3M 0.08% 0 13F-HR Timeline Group The filing omitted confidential holdings, a later amendment may add them. MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 1,014,892 $16M 0.01% +273,873 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 831,208 $13.1M <0.01% +158,723 13F-HR Timeline Group FIL Ltd in group FIL Ltd More: the full row for FIL Ltd 803,753 $12.7M 0.01% -210,100 13F-HR Timeline Group ACORN CAPITAL ADVISORS, LLC More: the full row for ACORN CAPITAL ADVISORS, LLC 643,382 $10.2M 5.16% 0 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 590,277 $9.32M <0.01% +49,210 13F-HR Timeline Group Aisling Capital Management LP More: the full row for Aisling Capital Management LP 568,919 $8.98M 1.97% 0 13F-HR Timeline Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 504,085 $7.96M 0.06% +241,334 13F-HR Timeline T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 464,727 $7.34M <0.01% new 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 456,621 $7.21M <0.01% +5,393 13F-HR/A Timeline Group NAN FUNG TRINITY (HK) LTD More: the full row for NAN FUNG TRINITY (HK) LTD 384,885 $6.08M 0.61% +42,000 13F-HR Timeline Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 370,666 $5.85M 0.34% +34,596 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 348,690 $5.51M 0.03% 0 13F-HR Timeline Clearbridge Investments, LLC in group Franklin Resources More: the full row for Clearbridge Investments, LLC 324,321 $5.12M <0.01% new 13F-HR Timeline Group DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 317,001 $5.01M 1.24% 0 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 280,876 $4.44M <0.01% +87,823 13F-HR Timeline Group Napean Trading & Investment Co (Singapo… More: the full row for Napean Trading & Investment Co (Singapore) PTE Ltd 275,942 $4.36M 0.85% 0 13F-HR Timeline SECTORAL ASSET MANAGEMENT INC More: the full row for SECTORAL ASSET MANAGEMENT INC 266,495 $4.21M 2.6% +65,100 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 260,866 $4.12M <0.01% +29,253 13F-HR Timeline Group SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 250,606 $3.96M 0.57% new 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 232,761 $3.68M <0.01% +80,904 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 184,982 $2.92M <0.01% -39,556 13F-HR Timeline SUPERSTRING CAPITAL MANAGEMENT LP More: the full row for SUPERSTRING CAPITAL MANAGEMENT LP 175,902 $2.78M 2.74% -13,797 13F-HR Timeline SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 173,651 $2.41M <0.01% -251,690 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 127,455 $2.01M <0.01% +3,370 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 126,802 $2M <0.01% +1,019 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 112,086 $1.77M <0.01% +60,277 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 100,028 $1.58M <0.01% -104,432 13F-HR/A Timeline Group CANTOR FITZGERALD, L. P. in group CANTOR FITZGERALD, L. P. More: the full row for CANTOR FITZGERALD, L. P. 100,000 $1.58M 0.03% new 13F-HR/A Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 97,362 $1.54M <0.01% +9,756 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 95,238 $1.5M <0.01% -39,219 13F-HR Timeline Group SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 85,747 $1.35M 0.32% +20,068 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 84,534 $1.33M <0.01% +4,106 13F-HR Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 67,701 $1.07M <0.01% 0 13F-HR Timeline Group Mariner, LLC in group Mariner, LLC More: the full row for Mariner, LLC 62,660 $989K <0.01% +50,223 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 53,882 $851K 0.01% new 13F-HR Timeline SCS Capital Management LLC More: the full row for SCS Capital Management LLC 53,430 $844K 0.01% 0 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 48,148 $760K <0.01% -9,186 13F-HR/A Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 45,619 $720K <0.01% -1,292 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 44,437 $702K <0.01% 0 13F-HR Timeline Group Cinctive Capital Management LP More: the full row for Cinctive Capital Management LP 41,849 $661K 0.03% new 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 40,770 $644K <0.01% -4,790 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 39,126 $618K <0.01% +11,654 13F-HR Timeline Group Trexquant Investment LP More: the full row for Trexquant Investment LP 38,013 $600K 0.01% -12,483 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 37,774 $596K 0.03% +5,360 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 36,516 $577K <0.01% +33,348 13F-HR Timeline Group Bleakley Financial Group, LLC More: the full row for Bleakley Financial Group, LLC 30,478 $481K 0.01% new 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 30,138 $476K <0.01% -186,698 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 26,378 $417K <0.01% -3,045 13F-HR Timeline Group Jain Global LLC More: the full row for Jain Global LLC 26,179 $413K 0.01% -91,731 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 25,924 $409K <0.01% +4,223 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 24,935 $394K <0.01% -2,523 13F-HR/A Timeline Group Atle Fund Management AB More: the full row for Atle Fund Management AB 203,755 $342K 1.27% +56,375 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 21,519 $340K <0.01% new 13F-HR Timeline Group TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 18,730 $296K <0.01% new 13F-HR/A Timeline ALGERT GLOBAL LLC More: the full row for ALGERT GLOBAL LLC 17,590 $278K <0.01% new 13F-HR/A Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 17,411 $275K <0.01% +534 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 16,110 $254K <0.01% -2,619 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 15,982 $252K <0.01% -108 13F-HR Timeline Group LPL Financial LLC More: the full row for LPL Financial LLC 14,297 $226K <0.01% new 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 14,038 $222K <0.01% -13,635 13F-HR Timeline Ascent Group, LLC in group Ascent Group, LLC More: the full row for Ascent Group, LLC 13,930 $220K 0.01% new 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 13,705 $216K 0.02% -9,170 13F-HR Timeline Group Orion Porfolio Solutions, LLC More: the full row for Orion Porfolio Solutions, LLC 11,303 $178K <0.01% new 13F-HR Timeline CAXTON CORP More: the full row for CAXTON CORP 10,941 $173K 0.76% 0 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 10,677 $169K <0.01% -419 13F-HR Timeline Group Quantinno Capital Management LP More: the full row for Quantinno Capital Management LP 10,577 $167K <0.01% new 13F-HR Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 10,044 $159K <0.01% new 13F-HR Timeline Group VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 9,910 $156K <0.01% 0 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 9,836 $155K <0.01% +1,727 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 9,835 $155K 0.04% +1,708 13F-HR Timeline Group Avanza Fonder AB More: the full row for Avanza Fonder AB 9,371 $148K <0.01% +2,804 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 4,407 $69.6K <0.01% +3,974 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 4,000 $63.2K <0.01% -22,094 13F-HR Timeline Larson Financial Group LLC More: the full row for Larson Financial Group LLC 3,949 $62.4K <0.01% +3,595 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 3,493 $55.2K <0.01% 0 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 3,156 $49.8K <0.01% 0 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 2,226 $35.1K <0.01% +1,352 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 2,141 $33.8K <0.01% +6 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,801 $28.4K <0.01% -2,987 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 1,355 $21K <0.01% +1,184 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 1,190 $18.8K 0.01% new 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 1,136 $17.9K <0.01% +459 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 1,008 $15K <0.01% new 13F-HR Timeline FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 667 $10.5K <0.01% +382 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 656 $10.4K <0.01% -10,864 13F-HR Timeline Group AMALGAMATED BANK More: the full row for AMALGAMATED BANK 658 $10K <0.01% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 411 $7K <0.01% -6,669 13F-HR Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 369 $5.83K <0.01% +291 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 319 $5.04K <0.01% new 13F-HR Timeline Group Point72 Europe (London) LLP More: the full row for Point72 Europe (London) LLP 292 $4.61K <0.01% new 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 235 $3.71K <0.01% -175 13F-HR Timeline Group PRIVATE TRUST CO NA More: the full row for PRIVATE TRUST CO NA 225 $3.55K <0.01% new 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 161 $2.54K <0.01% new 13F-HR Timeline Global Retirement Partners, LLC More: the full row for Global Retirement Partners, LLC 105 $1.66K <0.01% new 13F-HR Timeline Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 95 $1.5K <0.01% 0 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 70 $1.1K <0.01% +11 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 42 $664 <0.01% -252 13F-HR Timeline CoreCap Advisors, LLC More: the full row for CoreCap Advisors, LLC 32 $505 <0.01% new 13F-HR Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 23 $364 <0.01% 0 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 15 $237 <0.01% new 13F-HR Timeline Essential Partners LLC More: the full row for Essential Partners LLC 9 $142 <0.01% +5 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 1 $16 <0.01% new 13F-HR Timeline