RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 7,255,993 $144M 1.53% +300,000 13F-HR Timeline Group T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 6,605,780 $131M 0.09% +3,369,185 13F-HR Timeline Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 5,802,970 $115M 3.2% +586,001 13F-HR Timeline Group Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 5,425,000 $108M 3.02% +1,850,000 13F-HR Timeline Deep Track Capital, LP More: the full row for Deep Track Capital, LP 4,062,500 $80.8M 1.67% +1,448,496 13F-HR Timeline JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 3,339,218 $66.4M 0.03% +692,933 13F-HR/A Timeline Group RED TREE MANAGEMENT, LLC More: the full row for RED TREE MANAGEMENT, LLC 3,170,509 $63.1M 56.39% 0 13F-HR Timeline TPG GP A, LLC in group TPG GP A, LLC More: the full row for TPG GP A, LLC 3,010,425 $59.9M 1.63% 0 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 2,843,707 $56.6M <0.01% +315,256 13F-HR Timeline Group Omega Fund Management, LLC More: the full row for Omega Fund Management, LLC 2,392,150 $47.6M 29.16% +187,500 13F-HR Timeline VANGUARD GROUP INC group of 6 filers holding More: the full row for VANGUARD GROUP INC 2,326,018 $46.3M new Timeline VANGUARD CAPITAL MANAGEMENT LLC : 1,774,220 (<0.01%) 13F-HR/A VANGUARD PORTFOLIO MANAGEMENT LLC : 290,939 (<0.01%) 13F-HR VANGUARD FIDUCIARY TRUST CO : 216,753 (<0.01%) 13F-HR VANGUARD ASSET MANAGEMENT, Ltd : 23,943 (<0.01%) 13F-HR Vanguard Global Advisers, LLC : 12,736 (<0.01%) 13F-HR Vanguard Investments Australia, L… : 7,427 (<0.01%) 13F-HR FMR LLC in group FMR LLC More: the full row for FMR LLC 2,100,929 $41.8M <0.01% -1,246,294 13F-HR Timeline Group Franklin Resources group of 2 filers holding More: the full row for Franklin Resources 1,910,864 $38M -7,923 Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,659,342 $33M 0.02% +887,084 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,419,388 $28.2M <0.01% -230,149 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 1,376,198 $27.4M <0.01% -183,337 13F-HR Timeline Jones Hill Capital LP More: the full row for Jones Hill Capital LP 1,260,136 $25.1M 5.37% 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 830,906 $16.5M <0.01% +19,506 13F-HR Timeline Group FIL Ltd in group FIL Ltd More: the full row for FIL Ltd 679,904 $13.5M 0.01% -78,589 13F-HR Timeline Group ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 667,300 $13.3M 0.29% +458,200 13F-HR Timeline Group ACORN CAPITAL ADVISORS, LLC More: the full row for ACORN CAPITAL ADVISORS, LLC 643,382 $12.8M 3.64% 0 13F-HR Timeline Aisling Capital Management LP More: the full row for Aisling Capital Management LP 568,919 $11.3M 2.38% 0 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 558,964 $11.1M <0.01% +6,633 13F-HR Timeline Group Palo Alto Investors LP More: the full row for Palo Alto Investors LP 550,408 $10.9M 1.67% +251,833 13F-HR Timeline Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 489,095 $9.73M 0.57% +60,000 13F-HR Timeline NAN FUNG TRINITY (HK) LTD More: the full row for NAN FUNG TRINITY (HK) LTD 427,885 $8.51M 0.93% +55,500 13F-HR Timeline DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 421,733 $8.39M 1.91% +160,150 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 421,219 $8.38M <0.01% +311,763 13F-HR Timeline Group Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 401,444 $7.98M 0.01% 0 13F-HR/A Timeline ALGERT GLOBAL LLC More: the full row for ALGERT GLOBAL LLC 330,833 $6.58M 0.1% +12,564 13F-HR/A Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 327,989 $6.52M <0.01% -7,693 13F-HR Timeline Group D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 276,943 $5.51M <0.01% +140,421 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 269,718 $5.36M <0.01% +25,092 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 263,985 $5.25M <0.01% -8,160 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 255,571 $5.08M <0.01% +18,464 13F-HR Timeline Group Candriam S.C.A. More: the full row for Candriam S.C.A. 238,822 $4.75M 0.02% new 13F-HR Timeline Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 233,703 $4.65M 0.03% +83,703 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 232,690 $4.63M 0.02% 0 13F-HR/A Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 180,101 $3.58M -12,166 Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 177,408 $3.38M <0.01% +160,561 13F-HR/A Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 156,702 $3.12M <0.01% -277,997 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 131,656 $2.62M <0.01% +3,030 13F-HR Timeline Group Atle Fund Management AB More: the full row for Atle Fund Management AB 1,169,634 $2.32M 0.75% +1,058,271 13F-HR Timeline Napean Trading & Investment Co (Singapo… More: the full row for Napean Trading & Investment Co (Singapore) PTE Ltd 113,780 $2.26M 0.97% 0 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 109,261 $2.17M <0.01% +68,327 13F-HR Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 108,008 $2.15M 0.01% new 13F-HR/A Timeline Group Burkehill Global Management, LP More: the full row for Burkehill Global Management, LP 100,000 $1.99M 0.1% new 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 90,285 $1.8M <0.01% -8,633 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 89,881 $1.79M <0.01% -8,600 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 83,264 $1.66M <0.01% -5,413 13F-HR Timeline Group Shay Capital LLC More: the full row for Shay Capital LLC 63,500 $1.26M 0.18% -800 13F-HR Timeline SEVEN GRAND MANAGERS, LLC More: the full row for SEVEN GRAND MANAGERS, LLC 62,500 $1.24M 0.08% new 13F-HR Timeline MARTINGALE ASSET MANAGEMENT L P More: the full row for MARTINGALE ASSET MANAGEMENT L P 57,538 $1.14M 0.03% new 13F-HR Timeline Mariner, LLC in group Mariner, LLC More: the full row for Mariner, LLC 55,037 $1.09M <0.01% -9,525 13F-HR Timeline Group Swiss National Bank More: the full row for Swiss National Bank 55,000 $1.09M <0.01% +22,700 13F-HR Timeline SCS Capital Management LLC More: the full row for SCS Capital Management LLC 53,430 $1.06M 0.01% 0 13F-HR Timeline ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 51,580 $1.03M <0.01% +6,602 13F-HR Timeline Group AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 51,553 $1.03M <0.01% +27,060 13F-HR Timeline Group Swiss Life Asset Management Ltd in group Swiss Life Asset Management L… More: the full row for Swiss Life Asset Management Ltd 8,651 $979K <0.01% new 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 43,984 $875K <0.01% +5,143 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 40,747 $810K <0.01% +164 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 40,396 $803K <0.01% -55,505 13F-HR Timeline Group HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 40,209 $799K <0.01% -9,938 13F-HR Timeline Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 38,003 $756K <0.01% -21,816 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 31,650 $630K <0.01% +10,644 13F-HR Timeline Group Bleakley Financial Group, LLC More: the full row for Bleakley Financial Group, LLC 29,331 $583K 0.01% +149 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 28,823 $573K <0.01% -74,418 13F-HR Timeline Group PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 27,330 $544K <0.01% new 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 31,830 $536K <0.01% +2,720 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 24,961 $496K -5,732 Timeline OPTIMIZE FINANCIAL INC. More: the full row for OPTIMIZE FINANCIAL INC. 23,996 $477K 0.23% new 13F-HR Timeline Caption Management, LLC More: the full row for Caption Management, LLC 23,000 $457K 0.02% 0 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 22,227 $442K <0.01% +6,269 13F-HR Timeline Group Creative Planning in group Creative Planning More: the full row for Creative Planning 21,816 $434K <0.01% -18 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 21,797 $434K <0.01% new 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 20,971 $415K +169 Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 19,893 $396K <0.01% -36,705 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 18,360 $365K <0.01% -3,159 13F-HR Timeline Group VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 18,008 $358K <0.01% -187 13F-HR Timeline Group Quantinno Capital Management LP More: the full row for Quantinno Capital Management LP 17,612 $350K <0.01% +2,447 13F-HR Timeline PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 17,128 $341K 0.01% -5,049 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 16,923 $337K <0.01% -235 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 15,818 $315K <0.01% -214 13F-HR/A Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 14,977 $298K <0.01% -20,266 13F-HR/A Timeline Group Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 14,755 $293K 0.08% +360 13F-HR Timeline Group Ascent Group, LLC in group Ascent Group, LLC More: the full row for Ascent Group, LLC 14,152 $281K 0.01% +1 13F-HR Timeline Group LPL Financial LLC More: the full row for LPL Financial LLC 14,106 $281K <0.01% -177 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 13,705 $273K 0.02% 0 13F-HR Timeline Group VARCOV Co. More: the full row for VARCOV Co. 13,292 $264K 0.1% -2,361 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 13,186 $262K <0.01% new 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 11,244 $224K 0.02% +2,317 13F-HR Timeline LETKO, BROSSEAU & ASSOCIATES INC More: the full row for LETKO, BROSSEAU & ASSOCIATES INC 11,175 $222K <0.01% 0 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 10,771 $214K <0.01% new 13F-HR Timeline Group Thrive Wealth Management, LLC More: the full row for Thrive Wealth Management, LLC 10,344 $206K 0.03% new 13F-HR Timeline VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 10,070 $200K <0.01% 0 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 9,836 $196K <0.01% 0 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 9,585 $191K <0.01% -57,112 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 7,500 $149K <0.01% 0 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 6,400 $127K <0.01% new 13F-HR Timeline KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 6,100 $121K <0.01% +2,600 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 4,489 $89.3K <0.01% -5 13F-HR Timeline Group Larson Financial Group LLC More: the full row for Larson Financial Group LLC 3,495 $69.5K <0.01% -64 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 2,893 $57.5K <0.01% 0 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 2,544 $50.6K 0.01% -3,231 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 2,464 $49K <0.01% +1,780 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 1,400 $27.8K <0.01% +275 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 1,306 $26K <0.01% -15,608 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,220 $24.3K <0.01% +144 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 1,138 $22.6K <0.01% -20 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 1,000 $19.9K <0.01% -720 13F-HR Timeline Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 601 $12K <0.01% +480 13F-HR Timeline Group Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 434 $8.63K <0.01% +326 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 383 $7.62K <0.01% +64 13F-HR Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 315 $6.27K <0.01% +6 13F-HR/A Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 251 $4.99K <0.01% +17 13F-HR Timeline Group Smartleaf Asset Management LLC More: the full row for Smartleaf Asset Management LLC 248 $4.72K <0.01% -26 13F-HR Timeline PRIVATE TRUST CO NA More: the full row for PRIVATE TRUST CO NA 225 $4.47K <0.01% 0 13F-HR Timeline JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 229 $4.21K <0.01% new 13F-HR Timeline Group FIFTH THIRD BANCORP in group FIFTH THIRD BANK, NATIONAL AS… More: the full row for FIFTH THIRD BANCORP 170 $3.38K <0.01% new 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 161 $3.2K <0.01% -409 13F-HR Timeline NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO in group NORTHWESTERN MUTUAL INVESTMEN… More: the full row for NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 157 $3.12K <0.01% new 13F-HR Timeline Group Rossby Financial, LCC More: the full row for Rossby Financial, LCC 111 $2.28K <0.01% new 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 80 $2K <0.01% -1,002 13F-HR Timeline Group Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 80 $1.64K <0.01% +13 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 74 $1.47K <0.01% +21 13F-HR Timeline MAI Capital Management More: the full row for MAI Capital Management 57 $1.13K <0.01% +12 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 36 $716 <0.01% new 13F-HR/A Timeline CoreCap Advisors, LLC More: the full row for CoreCap Advisors, LLC 32 $636 <0.01% 0 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 30 $597 <0.01% new 13F-HR Timeline Root Financial Partners, LLC More: the full row for Root Financial Partners, LLC 29 $577 <0.01% new 13F-HR Timeline WPG Advisers, LLC More: the full row for WPG Advisers, LLC 28 $557 <0.01% +2 13F-HR Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 23 $458 <0.01% 0 13F-HR Timeline QUADRANT CAPITAL GROUP LLC More: the full row for QUADRANT CAPITAL GROUP LLC 13 $259 <0.01% new 13F-HR/A Timeline Stone House Investment Management, LLC More: the full row for Stone House Investment Management, LLC 11 $219 <0.01% +1 13F-HR Timeline Essential Partners LLC More: the full row for Essential Partners LLC 9 $179 <0.01% 0 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 8 $159 <0.01% +5 13F-HR Timeline