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Tetragon Partners GP Ltd

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13F filer, CIK 1515070, GRAND CAYMAN, Cayman Islands

Tetragon Partners GP Ltd reported $515,114,933 across 36 holdings for the quarter ended 2026-03-31, in a 13F-HR filed 2026-05-15. Its ten largest share positions make up 83.02% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0000919574-26-003297

Period
2026-03-31
Reported value
$515M
Holdings
36
Top 10 weight
83.02%
New
12
Sold out
4

Part of the filer group Tetragon Partners GP Ltd

How groups are built

Largest buys vs the previous quarter

SecurityShares changeApprox. value
PATHadded+7,757,628$86.1M
WBDnew+923,725$25.4M
WKadded+100,000$5.96M
DFTXnew+199,994$3.78M
SLNOnew+102,125$3.42M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
RAPTexited-131,770-$4.46M
ANNXreduced-740,000-$4.1M
FOLDexited-260,771-$3.71M
PRAXreduced-7,000-$2.26M
ZVRAexited-192,518-$1.72M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q1 2026

Share positions as resolved from 13F-HR 0000919574-26-003297, largest first. % of portfolio is the value over $508,920,733, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
PATHUIPATH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 6,950,000 shares; 2024Q4: 6,950,000 shares; 2025Q1: 8,950,000 shares; 2025Q2: 13,722,244 shares; 2025Q3: 16,950,000 shares; 2025Q4: 17,450,000 shares; 2026Q1: 25,207,628 shares 25,207,628$280M54.98%+7,757,628Timeline
KGEIKOLIBRI GLOBAL ENERGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 7,070,568 shares; 2024Q4: 7,070,568 shares; 2025Q1: 7,070,568 shares; 2025Q2: 7,068,857 shares; 2025Q3: 7,070,568 shares; 2025Q4: 6,934,504 shares; 2026Q1: 6,834,504 shares 6,834,504$37.5M7.37%-100,000Timeline
WBDWARNER BROS DISCOVERY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 923,725 shares 923,725$25.4M4.98%newTimeline
WKWORKIVA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 150,000 shares; 2025Q3: 150,000 shares; 2025Q4: 150,000 shares; 2026Q1: 250,000 shares 250,000$14.9M2.93%+100,000Timeline
LYFTLYFT INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,000,000 shares; 2024Q4: 1,000,000 shares; 2025Q1: 1,000,000 shares; 2025Q2: 1,000,000 shares; 2025Q3: 1,000,000 shares; 2025Q4: 1,000,000 shares; 2026Q1: 1,000,000 shares 1,000,000$13.3M2.61%0Timeline
CXMSPRINKLR INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 2,200,000 shares; 2024Q4: 2,200,000 shares; 2025Q1: 2,200,000 shares; 2025Q2: 2,200,000 shares; 2025Q3: 2,200,000 shares; 2025Q4: 2,200,000 shares; 2026Q1: 2,200,000 shares 2,200,000$13.2M2.59%0Timeline
AUTLAUTOLUS THERAPEUTICS LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 8,000,000 shares; 2024Q4: 8,250,000 shares; 2025Q1: 8,600,000 shares; 2025Q2: 9,500,000 shares; 2025Q3: 9,500,000 shares; 2025Q4: 9,500,000 shares; 2026Q1: 9,500,000 shares 9,500,000$13.1M2.58%0Timeline
CLDXCELLDEX THERAPEUTICS INC NEWQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 192,000 shares; 2025Q1: 261,000 shares; 2025Q2: 316,150 shares; 2025Q3: 303,600 shares; 2025Q4: 243,800 shares; 2026Q1: 312,316 shares 312,316$9.91M1.95%+68,516Timeline
ARWRARROWHEAD PHARMACEUTICALS INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 81,841 shares; 2025Q4: 96,935 shares; 2026Q1: 127,198 shares 127,198$7.98M1.57%+30,263Timeline
NKTRNEKTAR THERAPEUTICSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 69,287 shares; 2026Q1: 103,037 shares 103,037$7.41M1.46%+33,750Timeline
ANNXANNEXON INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 784,355 shares; 2024Q4: 1,400,000 shares; 2025Q1: 2,650,000 shares; 2025Q2: 2,810,000 shares; 2025Q3: 2,112,455 shares; 2025Q4: 2,032,455 shares; 2026Q1: 1,292,455 shares 1,292,455$7.16M1.41%-740,000Timeline
PHVSPHARVARIS N VQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 126,995 shares; 2025Q2: 188,100 shares; 2025Q3: 194,612 shares; 2025Q4: 194,612 shares; 2026Q1: 221,611 shares 221,611$6.26M1.23%+26,999Timeline
ALKSALKERMES PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 15,632 shares; 2025Q3: 89,612 shares; 2025Q4: 141,172 shares; 2026Q1: 159,791 shares 159,791$5.65M1.11%+18,619Timeline
AGIOAGIOS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 162,018 shares; 2026Q1: 164,839 shares 164,839$5.58M1.1%+2,821Timeline
IMVTIMMUNOVANT INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 131,167 shares; 2025Q2: 147,817 shares; 2025Q3: 188,379 shares; 2025Q4: 166,187 shares; 2026Q1: 218,507 shares 218,507$5.43M1.07%+52,320Timeline
PRAXPRAXIS PRECISION MEDICINES IQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 22,952 shares; 2026Q1: 15,952 shares 15,952$5.14M1.01%-7,000Timeline
KRYSKRYSTAL BIOTECH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 4,870 shares; 2025Q4: 11,814 shares; 2026Q1: 19,668 shares 19,668$5.08M1%+7,854Timeline
DYNDYNE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 138,375 shares; 2025Q3: 223,181 shares; 2025Q4: 247,997 shares; 2026Q1: 258,132 shares 258,132$4.68M0.92%+10,135Timeline
AMLXAMYLYX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 218,750 shares; 2025Q3: 258,242 shares; 2025Q4: 272,828 shares; 2026Q1: 317,877 shares 317,877$4.42M0.87%+45,049Timeline
MBXMBX BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 177,840 shares; 2025Q4: 143,327 shares; 2026Q1: 145,480 shares 145,480$4.34M0.85%+2,153Timeline
DFTXDEFINIUM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 199,994 shares 199,994$3.78M0.74%newTimeline
SLNOSOLENO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 102,125 shares 102,125$3.42M0.67%newTimeline
AXSMAXSOME THERAPEUTICS INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 41,250 shares; 2025Q1: 33,806 shares; 2025Q2: 41,531 shares; 2025Q3: 46,456 shares; 2025Q4: 26,934 shares; 2026Q1: 20,059 shares 20,059$3.39M0.67%-6,875Timeline
HRMYHARMONY BIOSCIENCES HLDGS INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 82,824 shares; 2026Q1: 119,340 shares 119,340$3.34M0.66%+36,516Timeline
SLNSILENCE THERAPEUTICS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 365,369 shares; 2026Q1: 630,161 shares 630,161$3.32M0.65%+264,792Timeline
ACADACADIA PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 107,000 shares; 2025Q2: 161,396 shares; 2025Q3: 86,071 shares; 2025Q4: not reported; 2026Q1: 144,620 shares 144,620$3.22M0.63%newTimeline
IONSIONIS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 41,764 shares 41,764$3.14M0.62%newTimeline
MPLTMAPLIGHT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 164,525 shares; 2026Q1: 112,115 shares 112,115$2.28M0.45%-52,410Timeline
RLAYRELAY THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 619,000 shares; 2025Q2: 699,000 shares; 2025Q3: 223,123 shares; 2025Q4: not reported; 2026Q1: 181,543 shares 181,543$1.81M0.35%newTimeline
SNOWSNOWFLAKE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 10,000 shares; 2024Q4: 10,000 shares; 2025Q1: 10,000 shares; 2025Q2: 10,000 shares; 2025Q3: 10,000 shares; 2025Q4: 10,000 shares; 2026Q1: 10,000 shares 10,000$1.51M0.3%0Timeline
AARDAARDVARK THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 316,621 shares 316,621$1.19M0.23%newTimeline
TECXTECTONIC THERAPEUTIC INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 187,500 shares; 2025Q2: 228,832 shares; 2025Q3: 243,728 shares; 2025Q4: not reported; 2026Q1: 37,588 shares 37,588$1.16M0.23%newTimeline
RAREULTRAGENYX PHARMACEUTICAL INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 17,718 shares; 2025Q4: not reported; 2026Q1: 39,473 shares 39,473$827K0.16%newTimeline
KPTIKARYOPHARM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 52,984 shares 52,984$295K0.06%newTimeline

Options

Puts and calls, as filed. The amount and value describe the underlying shares, not the option premium, so they stay out of % of portfolio (H5).

SecurityTypeAmountValueChange
AXSMAXSOME THERAPEUTICS INC. Stockcall35,000$5.92Mnew
KPTIKARYOPHARM THERAPEUTICS INC COMMON STOCKcall50,000$278Knew

Sold out in Q1 2026

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
RAPTRAPT THERAPEUTICS INC131,770$4.46Mshares
FOLDAMICUS THERAPEUTIC260,771$3.71Mshares
ZVRAZEVRA THERAPEUTICS INC192,518$1.72Mshares
AVADEL PHARMACEUTICALSAVADEL PHARMACEUTICALS43,763$943Kshares

How Q1 2026 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0000919574-26-003297 base2026-05-15acceptance time not in the bulk data set