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Rock Springs Capital Management LP

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13F filer, CIK 1595725, Baltimore, MD

Rock Springs Capital Management LP reported $1,604,789,362 across 93 holdings for the quarter ended 2025-06-30, in a 13F-HR filed 2025-08-14. Its ten largest share positions make up 36.09% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001172661-25-003273

Period
2025-06-30
Reported value
$1.6B
Holdings
93
Top 10 weight
36.09%
New
9
Sold out
12

Largest buys vs the previous quarter

SecurityShares changeApprox. value
AGIOadded+647,565$21.5M
CAInew+793,651$21.2M
OMDAnew+919,951$16.8M
XBInew+151,750$12.6M
ACLXnew+186,314$12.3M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
BLUEPRINT MEDICINES CORPreduced-822,069-$105M
NUVLreduced-334,204-$25.5M
NBIXreduced-190,200-$23.9M
LEGNexited-512,932-$17.4M
UNHreduced-50,000-$15.6M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q2 2025

Share positions as resolved from 13F-HR 0001172661-25-003273, largest first. % of portfolio is the value over $1,604,789,362, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
ARGXARGENX SEQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 233,500 shares; 2024Q4: 229,600 shares; 2025Q1: 175,750 shares; 2025Q2: 175,750 shares 175,750$96.9M6.04%0Timeline
LLYELI LILLY & COQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 142,000 shares; 2024Q4: 144,500 shares; 2025Q1: 113,500 shares; 2025Q2: 116,500 shares 116,500$90.8M5.66%+3,000Timeline
MERUS N VMERUS N VQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 892,549 shares; 2024Q4: 892,549 shares; 2025Q1: 980,751 shares; 2025Q2: 1,063,608 shares 1,063,608$55.9M3.49%+82,857
RYTMRHYTHM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,228,093 shares; 2024Q4: 1,162,718 shares; 2025Q1: 834,188 shares; 2025Q2: 861,153 shares 861,153$54.4M3.39%+26,965Timeline
INSMINSMED INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 683,344 shares; 2024Q4: 550,000 shares; 2025Q1: 515,900 shares; 2025Q2: 525,000 shares 525,000$52.8M3.29%+9,100Timeline
RAREULTRAGENYX PHARMACEUTICAL INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,978,272 shares; 2024Q4: 1,739,813 shares; 2025Q1: 1,394,434 shares; 2025Q2: 1,391,072 shares 1,391,072$50.6M3.15%-3,362Timeline
RVMDREVOLUTION MEDICINES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,009,945 shares; 2024Q4: 1,213,257 shares; 2025Q1: 1,281,640 shares; 2025Q2: 1,330,960 shares 1,330,960$49M3.05%+49,320Timeline
ISRGINTUITIVE SURGICAL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 270,000 shares; 2024Q4: 216,000 shares; 2025Q1: 102,000 shares; 2025Q2: 82,000 shares 82,000$44.6M2.78%-20,000Timeline
MDGLMADRIGAL PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 263,062 shares; 2024Q4: 265,212 shares; 2025Q1: 166,698 shares; 2025Q2: 140,296 shares 140,296$42.5M2.65%-26,402Timeline
MIRMMIRUM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,580,488 shares; 2024Q4: 1,471,564 shares; 2025Q1: 951,765 shares; 2025Q2: 818,206 shares 818,206$41.6M2.59%-133,559Timeline
BSXBOSTON SCIENTIFIC CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 460,000 shares; 2024Q4: 460,000 shares; 2025Q1: 277,000 shares; 2025Q2: 355,000 shares 355,000$38.1M2.38%+78,000Timeline
ASNDASCENDIS PHARMA A/SQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 325,000 shares; 2024Q4: 305,000 shares; 2025Q1: 216,000 shares; 2025Q2: 217,000 shares 217,000$37.5M2.33%+1,000Timeline
IRTCIRHYTHM HOLDINGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 397,500 shares; 2024Q4: 397,500 shares; 2025Q1: 254,300 shares; 2025Q2: 242,500 shares 242,500$37.3M2.33%-11,800Timeline
AKROAKERO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 933,399 shares; 2024Q4: 946,499 shares; 2025Q1: 672,759 shares; 2025Q2: 640,526 shares 640,526$34.2M2.13%-32,233Timeline
PENPENUMBRA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 265,000 shares; 2024Q4: 240,000 shares; 2025Q1: 171,000 shares; 2025Q2: 128,500 shares 128,500$33M2.05%-42,500Timeline
AGIOAGIOS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 699,389 shares; 2024Q4: 471,086 shares; 2025Q1: 342,180 shares; 2025Q2: 989,745 shares 989,745$32.9M2.05%+647,565Timeline
ALNYALNYLAM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 250,000 shares; 2024Q4: 256,200 shares; 2025Q1: 143,250 shares; 2025Q2: 100,000 shares 100,000$32.6M2.03%-43,250Timeline
EVHEVOLENT HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,070,000 shares; 2024Q4: 2,060,000 shares; 2025Q1: 2,695,700 shares; 2025Q2: 2,820,700 shares 2,820,700$31.8M1.98%+125,000Timeline
ZLABZAI LAB LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,315,673 shares; 2024Q4: 1,305,337 shares; 2025Q1: 904,592 shares; 2025Q2: 871,392 shares 871,392$30.5M1.9%-33,200Timeline
EXASEXACT SCIENCES CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,147,500 shares; 2024Q4: 450,000 shares; 2025Q1: 480,000 shares; 2025Q2: 572,000 shares 572,000$30.4M1.89%+92,000Timeline
XENEXENON PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,316,477 shares; 2024Q4: 1,251,859 shares; 2025Q1: 931,681 shares; 2025Q2: 931,681 shares 931,681$29.2M1.82%0Timeline
TVTXTRAVERE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,684,476 shares; 2024Q4: 4,973,649 shares; 2025Q1: 2,921,196 shares; 2025Q2: 1,908,208 shares 1,908,208$28.2M1.76%-1,012,988Timeline
SRRKSCHOLAR ROCK HLDG CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 716,782 shares; 2025Q1: 761,541 shares; 2025Q2: 794,133 shares 794,133$28.1M1.75%+32,592Timeline
DXCMDEXCOM INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 524,000 shares; 2024Q4: 353,000 shares; 2025Q1: 397,650 shares; 2025Q2: 286,750 shares 286,750$25M1.56%-110,900Timeline
PHRPHREESIA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,282,500 shares; 2024Q4: 2,040,000 shares; 2025Q1: 1,148,336 shares; 2025Q2: 837,300 shares 837,300$23.8M1.48%-311,036Timeline
BLUEPRINT MEDICINES CORPBLUEPRINT MEDICINES CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 768,776 shares; 2024Q4: 1,096,899 shares; 2025Q1: 1,007,569 shares; 2025Q2: 185,500 shares 185,500$23.8M1.48%-822,069
GPCRSTRUCTURE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,063,910 shares; 2024Q4: 1,080,963 shares; 2025Q1: 1,132,979 shares; 2025Q2: 1,135,879 shares 1,135,879$23.6M1.47%+2,900Timeline
THCTENET HEALTHCARE CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 129,200 shares; 2025Q1: 130,000 shares; 2025Q2: 130,000 shares 130,000$22.9M1.43%0Timeline
CAICARIS LIFE SCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 793,651 shares 793,651$21.2M1.32%newTimeline
KYMRKYMERA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,049,386 shares; 2024Q4: 1,034,137 shares; 2025Q1: 794,437 shares; 2025Q2: 450,374 shares 450,374$19.7M1.22%-344,063Timeline
OMDAOMADA HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 919,951 shares 919,951$16.8M1.05%newTimeline
CLDXCELLDEX THERAPEUTICS INC NEWQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,103,778 shares; 2024Q4: 1,222,182 shares; 2025Q1: 812,653 shares; 2025Q2: 812,653 shares 812,653$16.5M1.03%0Timeline
AZTAAZENTA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 532,500 shares; 2024Q4: 475,000 shares; 2025Q1: 475,000 shares; 2025Q2: 530,400 shares 530,400$16.3M1.02%+55,400Timeline
ACHCACADIA HEALTHCARE COMPANY INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 815,000 shares; 2024Q4: 583,500 shares; 2025Q1: 681,100 shares; 2025Q2: 696,000 shares 696,000$15.8M0.98%+14,900Timeline
UNHUNITEDHEALTH GROUP INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 294,250 shares; 2024Q4: 176,000 shares; 2025Q1: 100,500 shares; 2025Q2: 50,500 shares 50,500$15.8M0.98%-50,000Timeline
TARSTARSUS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 110,889 shares; 2025Q1: 354,376 shares; 2025Q2: 373,750 shares 373,750$15.1M0.94%+19,374Timeline
SMMTSUMMIT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,040,000 shares; 2024Q4: 1,054,000 shares; 2025Q1: 995,000 shares; 2025Q2: 710,000 shares 710,000$15.1M0.94%-285,000Timeline
AGLAGILON HEALTH INC COM (DE)Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 9,096,800 shares; 2024Q4: 7,463,300 shares; 2025Q1: 6,950,000 shares; 2025Q2: 6,550,400 shares 6,550,400$15.1M0.94%-399,600Timeline
OSCROSCAR HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,011,400 shares; 2024Q4: 1,050,000 shares; 2025Q1: 1,050,000 shares; 2025Q2: 700,000 shares 700,000$15M0.94%-350,000Timeline
VERAVERA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 383,492 shares; 2024Q4: 487,863 shares; 2025Q1: 520,796 shares; 2025Q2: 617,396 shares 617,396$14.5M0.91%+96,600Timeline
ELVNENLIVEN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 428,571 shares; 2024Q4: 428,571 shares; 2025Q1: 465,871 shares; 2025Q2: 701,408 shares 701,408$14.1M0.88%+235,537Timeline
INSPINSPIRE MED SYS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 130,000 shares; 2024Q4: 130,000 shares; 2025Q1: 99,250 shares; 2025Q2: 107,500 shares 107,500$14M0.87%+8,250Timeline
SLNOSOLENO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 124,095 shares; 2025Q1: 124,095 shares; 2025Q2: 154,528 shares 154,528$12.9M0.81%+30,433Timeline
CMPXCOMPASS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,629,239 shares; 2024Q4: 5,779,575 shares; 2025Q1: 4,962,955 shares; 2025Q2: 4,962,955 shares 4,962,955$12.9M0.8%0Timeline
XBISPDR SERIES TRUSTQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 151,750 shares 151,750$12.6M0.78%newTimeline
ACLXARCELLX INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 186,314 shares 186,314$12.3M0.76%newTimeline
MREOMEREO BIOPHARMA GROUP PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 9,534,170 shares; 2024Q4: 9,599,170 shares; 2025Q1: 6,684,247 shares; 2025Q2: 4,465,292 shares 4,465,292$12.1M0.75%-2,218,955Timeline
DHRDANAHER CORP DELQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 58,800 shares; 2025Q2: 59,000 shares 59,000$11.7M0.73%+200Timeline
FOLDAMICUS THERAPEUTICQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,250,280 shares; 2024Q4: 2,599,425 shares; 2025Q1: 1,909,362 shares; 2025Q2: 1,960,334 shares 1,960,334$11.2M0.7%+50,972Timeline
WSTWEST PHARMACEUTICAL SVSC INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 167,750 shares; 2024Q4: 168,750 shares; 2025Q1: 60,250 shares; 2025Q2: 51,030 shares 51,030$11.2M0.7%-9,220Timeline
NBIXNEUROCRINE BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 939,000 shares; 2024Q4: 720,500 shares; 2025Q1: 279,000 shares; 2025Q2: 88,800 shares 88,800$11.2M0.7%-190,200Timeline
PHVSPHARVARIS N VQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 756,931 shares; 2024Q4: 775,131 shares; 2025Q1: 623,402 shares; 2025Q2: 623,402 shares 623,402$11M0.68%0Timeline
EWEDWARDS LIFESCIENCES CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 576,900 shares; 2024Q4: 545,000 shares; 2025Q1: 255,000 shares; 2025Q2: 131,000 shares 131,000$10.2M0.64%-124,000Timeline
NAMSNEWAMSTERDAM PHARMA COMPANYQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 353,319 shares; 2024Q4: 767,522 shares; 2025Q1: 536,111 shares; 2025Q2: 536,111 shares 536,111$9.71M0.6%0Timeline
ARDXARDELYX INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 1,463,629 shares; 2025Q1: 1,604,975 shares; 2025Q2: 2,286,273 shares 2,286,273$8.96M0.56%+681,298Timeline
NUVLNUVALENT INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 429,994 shares; 2024Q4: 429,994 shares; 2025Q1: 427,532 shares; 2025Q2: 93,328 shares 93,328$7.12M0.44%-334,204Timeline
ACRSACLARIS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,753,495 shares; 2024Q4: 6,204,309 shares; 2025Q1: 5,046,309 shares; 2025Q2: 4,769,309 shares 4,769,309$6.77M0.42%-277,000Timeline
CDTXCIDARA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 134,133 shares 134,133$6.53M0.41%newTimeline
ZBIOZENAS BIOPHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 878,667 shares; 2024Q4: 878,667 shares; 2025Q1: 878,667 shares; 2025Q2: 640,467 shares 640,467$6.21M0.39%-238,200Timeline
REGNREGENERON PHARMACEUTICALSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 2,800 shares; 2025Q2: 11,300 shares 11,300$5.93M0.37%+8,500Timeline
COGTCOGENT BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 800,199 shares 800,199$5.75M0.36%newTimeline
DYNDYNE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 461,028 shares; 2024Q4: 474,528 shares; 2025Q1: 524,499 shares; 2025Q2: 580,998 shares 580,998$5.53M0.34%+56,499Timeline
CGEMCULLINAN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 736,914 shares; 2024Q4: 742,114 shares; 2025Q1: 644,633 shares; 2025Q2: 668,233 shares 668,233$5.03M0.31%+23,600Timeline
JANXJANUX THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 204,466 shares; 2025Q1: 204,466 shares; 2025Q2: 210,266 shares 210,266$4.86M0.3%+5,800Timeline
MLYSMINERALYS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 320,813 shares; 2025Q2: 324,513 shares 324,513$4.39M0.27%+3,700Timeline
TMOTHERMO FISHER SCIENTIFIC INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 10,000 shares 10,000$4.05M0.25%newTimeline
GOSSGOSSAMER BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,266,960 shares; 2024Q4: 3,266,960 shares; 2025Q1: 3,266,960 shares; 2025Q2: 3,266,960 shares 3,266,960$4.02M0.25%0Timeline
IMVTIMMUNOVANT INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,221,309 shares; 2024Q4: 909,103 shares; 2025Q1: 975,803 shares; 2025Q2: 221,500 shares 221,500$3.54M0.22%-754,303Timeline
AMLXAMYLYX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 343,228 shares; 2025Q2: 499,764 shares 499,764$3.2M0.2%+156,536Timeline
BCAXBICARA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 445,975 shares; 2024Q4: 445,975 shares; 2025Q1: 336,070 shares; 2025Q2: 336,070 shares 336,070$3.12M0.19%0Timeline
JSPRJASPER THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 459,088 shares; 2024Q4: 463,088 shares; 2025Q1: 545,171 shares; 2025Q2: 545,171 shares 545,171$3.03M0.19%0Timeline
PRTAPROTHENA CORP PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 625,048 shares; 2024Q4: 644,601 shares; 2025Q1: 492,601 shares; 2025Q2: 492,601 shares 492,601$2.99M0.19%0Timeline
ATECALPHATEC HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 200,000 shares; 2025Q1: 267,500 shares; 2025Q2: 267,500 shares 267,500$2.97M0.19%0Timeline
LENZLENZ THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 29,305 shares; 2025Q1: 83,082 shares; 2025Q2: 83,982 shares 83,982$2.46M0.15%+900Timeline
FOCLEDAP TMS S AQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,568,000 shares; 2024Q4: 1,591,800 shares; 2025Q1: 1,270,000 shares; 2025Q2: 1,270,000 shares 1,270,000$2.1M0.13%0Timeline
CGENCOMPUGEN LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 989,990 shares; 2024Q4: 989,990 shares; 2025Q1: 989,990 shares; 2025Q2: 989,990 shares 989,990$1.76M0.11%0Timeline
SIONSIONNA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 99,429 shares; 2025Q2: 99,429 shares 99,429$1.73M0.11%0Timeline
LUNGPULMONX CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 691,300 shares; 2024Q4: 772,151 shares; 2025Q1: 503,700 shares; 2025Q2: 651,100 shares 651,100$1.69M0.11%+147,400Timeline
NGNENEUROGENE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 95,407 shares; 2025Q1: 104,339 shares; 2025Q2: 104,339 shares 104,339$1.56M0.1%0Timeline
CATXPERSPECTIVE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 414,396 shares; 2024Q4: 444,383 shares; 2025Q1: 444,383 shares; 2025Q2: 444,383 shares 444,383$1.53M0.1%0Timeline
APLSAPELLIS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 80,000 shares; 2024Q4: 80,000 shares; 2025Q1: 80,000 shares; 2025Q2: 84,300 shares 84,300$1.46M0.09%+4,300Timeline
SRPTSAREPTA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 307,500 shares; 2024Q4: 307,500 shares; 2025Q1: 159,300 shares; 2025Q2: 68,600 shares 68,600$1.17M0.07%-90,700Timeline
Mersana Therapeutics IncMersana Therapeutics IncQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,046,782 shares; 2024Q4: 3,431,684 shares; 2025Q1: 3,814,684 shares; 2025Q2: 3,814,684 shares 3,814,684$1.13M0.07%0
Applied Therapeutics IncApplied Therapeutics IncQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,746,449 shares; 2024Q4: 1,917,191 shares; 2025Q1: 2,074,891 shares; 2025Q2: 2,075,991 shares 2,075,991$646K0.04%+1,100
ADAPYADAPTIMMUNE THERAPEUTICS PLC SQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,425,468 shares; 2024Q4: 2,483,468 shares; 2025Q1: 2,483,468 shares; 2025Q2: 2,483,468 shares 2,483,468$595K0.04%0Timeline
KRROKORRO BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 35,719 shares; 2024Q4: 35,719 shares; 2025Q1: 35,719 shares; 2025Q2: 35,719 shares 35,719$446K0.03%0Timeline
CRLCHARLES RIV LABS INTL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 2,700 shares 2,700$410K0.03%newTimeline
89BIO INC89BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 552,741 shares; 2025Q1: 844,441 shares; 2025Q2: 40,000 shares 40,000$393K0.02%-804,441
PCVXVAXCYTE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 11,100 shares 11,100$361K0.02%newTimeline
NVAXNOVAVAX INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 650,000 shares; 2024Q4: 650,000 shares; 2025Q1: 650,000 shares; 2025Q2: 53,900 shares 53,900$340K0.02%-596,100Timeline
TLPHTALPHERA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 316,460 shares; 2024Q4: 316,460 shares; 2025Q1: 316,460 shares; 2025Q2: 316,460 shares 316,460$146K0.01%0Timeline
NUVATION BIO INCNUVATION BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 134,028 shares; 2024Q4: 134,028 shares; 2025Q1: 134,028 shares; 2025Q2: 134,028 shares 134,028$36.2K<0.01%0

Principal amounts

Notes and convertibles filed as a face amount (PRN). A face amount is never added to a share count (H6).

SecurityTypeAmountValueChange
GOSSAMER BIO INCGOSSAMER BIO INC NOTE 5.000% 6/0principal9,573,000$4.95M0

Sold out in Q2 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
LEGNLEGEND BIOTECH CORP512,932$17.4Mshares
WRBYWARBY PARKER INC835,000$15.2Mshares
NEVRO CORPNEVRO CORP800,494$4.67Mshares
KMTSKESTRA MED TECHNOLOGIES LTD145,000$3.61Mshares
INOZYME PHARMA INCINOZYME PHARMA INC3,445,299$3.14Mshares
BEAMBEAM THERAPEUTICS INC150,020$2.93Mshares
SGMTSAGIMET BIOSCIENCES INC787,808$2.57Mshares
BCRXBIOCRYST PHARMACEUTICALS INC222,011$1.67Mshares
MGNXMACROGENICS INC1,145,214$1.45Mshares
VIGIL NEUROSCIENCE INCVIGIL NEUROSCIENCE INC471,958$840Kshares
PLRXPLIANT THERAPEUTICS INC589,996$796Kshares
SPRUCE BIOSCIENCES INCSPRUCE BIOSCIENCES INC2,609,125$757Kshares

How Q2 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001172661-25-003273 base2025-08-14acceptance time not in the bulk data set