MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 9,466,992 $39.1M <0.01% +1,258,977 13F-HR Timeline Group Empery Asset Management, LP More: the full row for Empery Asset Management, LP 8,944,118 $36.9M 44.5% -6,987 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 8,103,400 $33.5M <0.01% -395,700 13F-HR Timeline Group Bain Capital Life Sciences Investors, L… in group Bain Capital Life Sciences In… More: the full row for Bain Capital Life Sciences Investors, LLC 7,967,454 $32.9M 2.97% 0 13F-HR Timeline Group PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 6,737,648 $27.8M 0.55% +423,196 13F-HR/A Timeline Group Saturn V Capital Management LP More: the full row for Saturn V Capital Management LP 6,456,646 $26.7M 4.83% +656,116 13F-HR Timeline Deep Track Capital, LP More: the full row for Deep Track Capital, LP 6,339,535 $26.2M 0.54% +1,325,874 13F-HR Timeline VANGUARD GROUP INC group of 4 filers holding More: the full row for VANGUARD GROUP INC 4,022,847 $16.6M new Timeline Kalehua Capital Management LLC More: the full row for Kalehua Capital Management LLC 3,722,840 $15.4M 10.88% 0 13F-HR/A Timeline BRAIDWELL LP More: the full row for BRAIDWELL LP 3,272,954 $13.5M 0.45% -95,950 13F-HR Timeline Rosalind Advisors, Inc. More: the full row for Rosalind Advisors, Inc. 3,214,766 $13.3M 5.44% +608,846 13F-HR Timeline Blackstone Inc. in group Blackstone Inc. More: the full row for Blackstone Inc. 2,681,922 $11.1M 0.04% 0 13F-HR Timeline Group The filing omitted confidential holdings, a later amendment may add them. Trails Edge Capital Partners, LP More: the full row for Trails Edge Capital Partners, LP 2,571,478 $10.6M 2.5% 0 13F-HR Timeline Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 2,449,468 $10.1M 0.63% 0 13F-HR Timeline Group BVF INC/IL in group BVF INC/IL More: the full row for BVF INC/IL 2,233,742 $9.23M 0.29% 0 13F-HR Timeline Group SAMSARA BIOCAPITAL, LLC More: the full row for SAMSARA BIOCAPITAL, LLC 1,832,566 $7.57M 0.74% -127,434 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,211,794 $5M <0.01% -15,014 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 1,210,514 $5M <0.01% +1,154,536 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 1,001,095 $4.13M 0.02% +240 13F-HR/A Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 958,821 $3.96M +893,427 Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 939,726 $3.88M <0.01% -721 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 882,134 $3.64M <0.01% +50,244 13F-HR Timeline Group STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 850,742 $3.51M 0.68% -47,723 13F-HR/A Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 403,534 $1.67M <0.01% +205,300 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 336,834 $1.39M <0.01% +256,378 13F-HR Timeline Group Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 335,309 $1.38M 1.22% -258,264 13F-HR Timeline Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 330,525 $1.37M 0.05% new 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 267,340 $1.1M <0.01% +263,211 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 218,954 $904K <0.01% +151,207 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 178,235 $736K <0.01% 0 13F-HR Timeline Group Pale Fire Capital SE in group Pale Fire Capital More: the full row for Pale Fire Capital SE 167,590 $692K 0.06% 0 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 150,676 $622K <0.01% +114,915 13F-HR Timeline Group Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 145,000 $599K 0.04% 0 13F-HR Timeline Palumbo Wealth Management LLC More: the full row for Palumbo Wealth Management LLC 131,014 $541K 0.13% +17,657 13F-HR Timeline Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 127,321 $526K 0.01% new 13F-HR Timeline Group Dynamic Technology Lab Private Ltd More: the full row for Dynamic Technology Lab Private Ltd 36,221 $385K 0.06% new 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 66,749 $276K <0.01% -39 13F-HR Timeline Group OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 57,300 $237K <0.01% -51,900 13F-HR Timeline Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 50,287 $208K <0.01% +18,048 13F-HR Timeline Group Catalyst Funds Management Pty Ltd More: the full row for Catalyst Funds Management Pty Ltd 47,383 $196K 0.03% new 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 37,143 $153K <0.01% -54,270 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 35,765 $148K <0.01% +3,433 13F-HR Timeline Group Diametric Capital, LP More: the full row for Diametric Capital, LP 28,973 $120K 0.03% new 13F-HR Timeline STIFEL FINANCIAL CORP in group STIFEL FINANCIAL CORP More: the full row for STIFEL FINANCIAL CORP 21,789 $90K <0.01% +1,293 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 19,968 $82.5K <0.01% new 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 19,514 $80.6K <0.01% new 13F-HR Timeline Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 19,474 $80.4K <0.01% -6,644 13F-HR Timeline Group CAXTON CORP More: the full row for CAXTON CORP 15,557 $64.2K 1.6% 0 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 14,703 $60.7K <0.01% -64,369 13F-HR Timeline TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 13,868 $57.3K <0.01% -3,378 13F-HR Timeline Group Creative Planning in group Creative Planning More: the full row for Creative Planning 13,819 $57.1K <0.01% -2,608 13F-HR Timeline Group Virtu Financial LLC in group Virtu Financial LLC More: the full row for Virtu Financial LLC 12,730 $53K <0.01% -9,759 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 12,317 $50.9K <0.01% new 13F-HR Timeline Group SummitTX Capital, L.P. More: the full row for SummitTX Capital, L.P. 11,200 $46.3K <0.01% new 13F-HR Timeline WINTON GROUP Ltd in group WINTON GROUP Ltd More: the full row for WINTON GROUP Ltd 10,600 $43.8K <0.01% new 13F-HR Timeline Group Indivisible Partners More: the full row for Indivisible Partners 10,000 $37K <0.01% 0 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 4,756 $19.6K <0.01% +4,245 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 2,814 $11.6K <0.01% -54,686 13F-HR Timeline Group SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 1,996 $8.24K <0.01% -758 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 1,759 $7.26K <0.01% 0 13F-HR Timeline Group State of Wyoming More: the full row for State of Wyoming 1,065 $4.4K <0.01% new 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 729 $3.01K <0.01% 0 13F-HR Timeline Group ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 802 $3K <0.01% new 13F-HR Timeline Group GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 712 $2.94K <0.01% -3,286 13F-HR Timeline Bleichroeder LP More: the full row for Bleichroeder LP 595 $2.46K <0.01% 0 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 331 $1.44K <0.01% 0 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 310 $1.28K <0.01% -405 13F-HR Timeline Blue Trust, Inc. More: the full row for Blue Trust, Inc. 284 $1.17K <0.01% 0 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 180 $743 <0.01% -10,266 13F-HR Timeline Group QUADRANT CAPITAL GROUP LLC More: the full row for QUADRANT CAPITAL GROUP LLC 128 $529 <0.01% new 13F-HR/A Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 116 $479 <0.01% new 13F-HR/A Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 54 $223 <0.01% +4 13F-HR Timeline JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 38 $154 <0.01% 0 13F-HR Timeline Group Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 33 $136 <0.01% 0 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 33 $132 <0.01% -4,548 13F-HR/A Timeline Group HighMark Wealth Management LLC More: the full row for HighMark Wealth Management LLC 6 $24 <0.01% 0 13F-HR Timeline NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO in group NORTHWESTERN MUTUAL INVESTMEN… More: the full row for NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 5 $21 <0.01% 0 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 115 $0 0% +11 13F-HR Timeline Group Value filed as zero, left out of ratios.