PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 2,951,116 $47.2M 0.01% new 13F-HR Timeline JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 1,815,474 $29.1M 0.01% +1,648,808 13F-HR/A Timeline Group Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 1,675,262 $26.8M 1% new 13F-HR Timeline PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 1,447,782 $23.2M 0.46% +1,008,640 13F-HR/A Timeline Group Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 1,017,600 $16.3M 2.33% +50,000 13F-HR Timeline Group Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 975,200 $15.6M 13.72% +963,316 13F-HR Timeline Logos Global Management LP More: the full row for Logos Global Management LP 625,000 $9.99M 0.51% new 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 596,564 $9.54M <0.01% +188 13F-HR Timeline Group Velan Capital Investment Management LP More: the full row for Velan Capital Investment Management LP 583,333 $9.33M 5.84% +500,000 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 540,126 $8.64M 0.01% +456,793 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 533,965 $8.54M 0.01% +110,550 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 533,889 $8.54M 0.01% +231,416 13F-HR Timeline Group ARMISTICE CAPITAL, LLC More: the full row for ARMISTICE CAPITAL, LLC 478,827 $7.66M 0.25% new 13F-HR Timeline Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 427,141 $6.83M 0.19% 0 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 399,184 $6.38M 0.01% new 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 381,419 $6.1M <0.01% +380,743 13F-HR Timeline Group RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 370,246 $5.92M 0.06% -8,100 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 366,791 $5.86M 0.14% +14,585 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 352,572 $5.64M 0.01% +54,419 13F-HR Timeline Group BVF INC/IL in group BVF INC/IL More: the full row for BVF INC/IL 339,549 $5.43M 0.17% 0 13F-HR Timeline Group GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 327,307 $5.23M 1.28% new 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 323,911 $5.18M 0.02% +180,430 13F-HR/A Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 322,600 $5.16M <0.01% +181,500 13F-HR Timeline Group VANGUARD GROUP INC group of 3 filers holding More: the full row for VANGUARD GROUP INC 300,150 $4.8M new Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 279,537 $4.47M <0.01% new 13F-HR/A Timeline Group Avidity Partners Management LP More: the full row for Avidity Partners Management LP 215,934 $3.45M 0.7% new 13F-HR/A Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 213,462 $3.41M 0.21% +149,789 13F-HR Timeline Group Vivo Capital, LLC More: the full row for Vivo Capital, LLC 208,333 $3.33M 0.28% 0 13F-HR/A Timeline BOONE CAPITAL MANAGEMENT LLC More: the full row for BOONE CAPITAL MANAGEMENT LLC 200,000 $3.2M 0.98% new 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 194,616 $3.11M 0.01% new 13F-HR Timeline Group STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 188,700 $3.02M 0.58% new 13F-HR/A Timeline DIADEMA PARTNERS LP More: the full row for DIADEMA PARTNERS LP 179,738 $2.87M 1.19% -63,432 13F-HR Timeline Integral Health Asset Management, LLC More: the full row for Integral Health Asset Management, LLC 167,000 $2.67M 0.14% 0 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 152,600 $2.44M <0.01% +27,021 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 152,516 $2.44M <0.01% +22,988 13F-HR Timeline Group SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 136,015 $2.17M 0.37% -54,096 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 120,529 $1.93M 0.02% new 13F-HR Timeline Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 104,400 $1.67M 0.08% new 13F-HR Timeline Deeter Investments LLP More: the full row for Deeter Investments LLP 100,000 $1.6M 0.28% 0 13F-HR Timeline Verdad Advisers, LP More: the full row for Verdad Advisers, LP 95,330 $1.52M 1.72% new 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 69,160 $1.11M <0.01% +13,461 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 68,588 $1.1M <0.01% +35,118 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 62,786 $1M <0.01% new 13F-HR Timeline Group Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 58,182 $930K 0.36% -7,090 13F-HR Timeline Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 53,439 $854K 0.02% 0 13F-HR Timeline Trexquant Investment LP More: the full row for Trexquant Investment LP 50,712 $811K 0.01% new 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 47,851 $765K 0.01% new 13F-HR Timeline Group Creek Drive Management Group LLC More: the full row for Creek Drive Management Group LLC 45,000 $720K 0.45% new 13F-HR Timeline BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 44,900 $718K 0.01% 0 13F-HR Timeline Artia Global Partners LP More: the full row for Artia Global Partners LP 42,080 $673K 0.15% 0 13F-HR Timeline HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 41,819 $668K <0.01% new 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 33,628 $538K <0.01% new 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 31,854 $509K <0.01% +9,445 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 31,336 $501K <0.01% new 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 30,647 $490K <0.01% +15,351 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 28,990 $464K <0.01% new 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 28,977 $463K <0.01% new 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 28,285 $452K <0.01% new 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 18,569 $297K <0.01% +14,789 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 16,977 $271K <0.01% +263 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 16,698 $267K <0.01% new 13F-HR Timeline Group Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 15,472 $247K <0.01% -5,176 13F-HR Timeline Group Verition Fund Management LLC More: the full row for Verition Fund Management LLC 13,589 $217K <0.01% new 13F-HR Timeline Corient Private Wealth LP in group Corient Private Wealth LP More: the full row for Corient Private Wealth LP 12,388 $198K <0.01% 0 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 12,049 $193K <0.01% new 13F-HR Timeline Group LETKO, BROSSEAU & ASSOCIATES INC More: the full row for LETKO, BROSSEAU & ASSOCIATES INC 10,650 $170K <0.01% 0 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 9,418 $132K <0.01% +8,516 13F-HR/A Timeline Group ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 4,502 $71K <0.01% new 13F-HR Timeline Group Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 2,501 $40K <0.01% +2,500 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,100 $17.6K <0.01% +901 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 57 $911 <0.01% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 1 $16 <0.01% 0 13F-HR Timeline Group MAI Capital Management More: the full row for MAI Capital Management 1 $16 <0.01% new 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 1 $16 <0.01% 0 13F-HR Timeline Physician Wealth Advisors, Inc. More: the full row for Physician Wealth Advisors, Inc. 1 $16 <0.01% 0 13F-HR Timeline Titiun Yejiel More: the full row for Titiun Yejiel 1 $16 <0.01% 0 13F-HR Timeline JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 1 $15 <0.01% 0 13F-HR Timeline Group Union Bancaire Privee, UBP SA More: the full row for Union Bancaire Privee, UBP SA 1 $11 <0.01% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 4 $0 0% new 13F-HR Timeline Group Value filed as zero, left out of ratios.