Skorpios Trust More: the full row for Skorpios Trust 6,906,181 $45.9M 99.7% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 5,862,436 $39M <0.01% -25,075 13F-HR Timeline Group Lynx1 Capital Management LP in group Lynx1 Capital Management LP More: the full row for Lynx1 Capital Management LP 5,291,929 $35.2M 12.6% +104,738 13F-HR Timeline Group RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 5,123,525 $34.1M 0.52% 0 13F-HR Timeline BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 4,633,838 $30.8M 0.34% 0 13F-HR Timeline Group Redmile Group, LLC in group Redmile Group, LLC More: the full row for Redmile Group, LLC 4,485,981 $29.8M 2.82% -107,648 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 3,590,825 $23.9M <0.01% +153,581 13F-HR Timeline Group TORONTO DOMINION BANK in group TORONTO DOMINION BANK More: the full row for TORONTO DOMINION BANK 3,173,258 $21.1M 0.05% 0 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 2,784,202 $18.5M <0.01% +53,004 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 2,541,937 $16.9M <0.01% +2,376,741 13F-HR Timeline Group Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 2,247,347 $14.9M 0.84% +247,347 13F-HR/A Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 2,131,783 $14.2M 0.02% +1,180,351 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 1,662,039 $11.1M <0.01% +293,072 13F-HR/A Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,575,283 $10.5M <0.01% -12,380 13F-HR Timeline Group Assenagon Asset Management S.A. More: the full row for Assenagon Asset Management S.A. 959,603 $6.38M 0.01% -391,322 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 901,986 $6M <0.01% +24,891 13F-HR Timeline Group Checkpoint Capital L.P. More: the full row for Checkpoint Capital L.P. 730,717 $4.86M 2.67% +425,330 13F-HR Timeline MPM BIOIMPACT LLC More: the full row for MPM BIOIMPACT LLC 693,988 $4.62M 0.79% +8,162 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 664,735 $4.42M <0.01% +125,835 13F-HR Timeline Group Granahan Investment Management, LLC More: the full row for Granahan Investment Management, LLC 660,430 $4.39M 0.22% +92,741 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 532,884 $3.54M <0.01% +523,793 13F-HR Timeline Group TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 500,000 $3.33M 0.18% +200,000 13F-HR Timeline Group DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 443,998 $2.95M 0.84% +272,901 13F-HR Timeline Erste Asset Management GmbH in group Erste Asset Management GmbH More: the full row for Erste Asset Management GmbH 396,000 $2.67M 0.03% new 13F-HR Timeline Group JACOBS LEVY EQUITY MANAGEMENT, INC More: the full row for JACOBS LEVY EQUITY MANAGEMENT, INC 357,248 $2.38M 0.01% new 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 346,664 $2.31M <0.01% -4,124 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 335,360 $2.23M 0.01% +43,565 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 310,307 $2.06M <0.01% -31,822 13F-HR/A Timeline Group Opaleye Management Inc. More: the full row for Opaleye Management Inc. 300,000 $2M 0.44% +275,000 13F-HR Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 254,633 $1.69M -18,716 Timeline Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 254,161 $1.69M 0.13% 0 13F-HR Timeline Birchview Capital, LP More: the full row for Birchview Capital, LP 210,005 $1.4M 1.21% +5 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 178,300 $1.19M <0.01% +49,257 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 135,960 $904K <0.01% +1,148 13F-HR Timeline Group Palo Alto Investors LP More: the full row for Palo Alto Investors LP 125,861 $837K 0.16% 0 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 118,529 $788K -69,379 Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 108,087 $719K <0.01% 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 107,562 $715K <0.01% +14,982 13F-HR Timeline Group GILDER GAGNON HOWE & CO LLC More: the full row for GILDER GAGNON HOWE & CO LLC 105,817 $704K 0.01% +13,271 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 95,120 $633K <0.01% +217 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 89,985 $598K <0.01% -3,210 13F-HR Timeline Group Trexquant Investment LP More: the full row for Trexquant Investment LP 86,140 $573K 0.01% -16,891 13F-HR Timeline Fort Point Capital Partners LLC More: the full row for Fort Point Capital Partners LLC 75,429 $502K 0.06% 0 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 74,620 $496K <0.01% +16,487 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 68,361 $455K <0.01% -11,751 13F-HR/A Timeline Group Swiss National Bank More: the full row for Swiss National Bank 67,300 $448K <0.01% 0 13F-HR Timeline Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 61,706 $410K <0.01% -5,521 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 49,599 $330K <0.01% +225 13F-HR/A Timeline Kennondale Capital Management LLC More: the full row for Kennondale Capital Management LLC 42,100 $280K 0.31% new 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 40,630 $270K <0.01% 0 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 40,181 $267K 0.01% new 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 39,890 $265K <0.01% -2,940 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 39,098 $261K <0.01% +1,643 13F-HR Timeline STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 37,606 $250K <0.01% +5,890 13F-HR Timeline Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 36,087 $240K 0.01% +17,453 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 35,347 $235K <0.01% 0 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 32,068 $213K <0.01% 0 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 30,085 $200K 0.04% new 13F-HR Timeline Group Dauntless Investment Group, LLC More: the full row for Dauntless Investment Group, LLC 28,600 $190K 0.7% new 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 26,978 $179K <0.01% +15,001 13F-HR/A Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 25,954 $175K +1,171 Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 26,183 $174K <0.01% +14,118 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 25,566 $170K <0.01% -325,048 13F-HR Timeline Group Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 23,643 $157K <0.01% new 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 22,334 $149K <0.01% +5,918 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 22,314 $148K <0.01% 0 13F-HR Timeline Group Net Worth Advisory Group More: the full row for Net Worth Advisory Group 20,741 $138K 0.04% new 13F-HR Timeline JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 18,900 $136K <0.01% 0 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 20,257 $135K <0.01% +293 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 20,254 $135K <0.01% -551 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 19,620 $130K <0.01% -57,209 13F-HR Timeline Group Mesirow Financial Investment Management… More: the full row for Mesirow Financial Investment Management, Inc. 15,779 $119K <0.01% 0 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 17,680 $118K <0.01% +894 13F-HR Timeline Group Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 17,600 $117K <0.01% -261 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 16,119 $107K <0.01% new 13F-HR Timeline Group Freestone Grove Partners LP More: the full row for Freestone Grove Partners LP 14,776 $98.3K <0.01% -3,273 13F-HR Timeline AXQ CAPITAL, LP More: the full row for AXQ CAPITAL, LP 14,600 $97.1K 0.04% new 13F-HR Timeline FOX RUN MANAGEMENT, L.L.C. More: the full row for FOX RUN MANAGEMENT, L.L.C. 13,780 $91.6K 0.01% new 13F-HR Timeline Virtus Investment Advisers, LLC group of 2 filers holding More: the full row for Virtus Investment Advisers, LLC 13,323 $88.6K +7,553 Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 13,237 $88K <0.01% -67 13F-HR Timeline Group PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 12,882 $85.7K <0.01% -266 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 12,847 $85.4K <0.01% -10,772 13F-HR Timeline Group Creative Planning in group Creative Planning More: the full row for Creative Planning 12,598 $83.8K <0.01% new 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 11,222 $74.6K <0.01% +11,108 13F-HR Timeline Group CANADA LIFE ASSURANCE Co in group CANADA LIFE ASSURANCE Co More: the full row for CANADA LIFE ASSURANCE Co 10,889 $73K <0.01% +1,173 13F-HR Timeline Group AlphaQuest LLC More: the full row for AlphaQuest LLC 10,832 $72K 0.01% new 13F-HR Timeline Dorsey & Whitney Trust CO LLC More: the full row for Dorsey & Whitney Trust CO LLC 10,815 $71.9K <0.01% 0 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 10,635 $70.7K <0.01% 0 13F-HR/A Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 10,624 $70.7K 0.01% -607 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 10,164 $67.6K <0.01% -2,462 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 9,129 $60.7K <0.01% 0 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 7,174 $47.7K <0.01% 0 13F-HR Timeline KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 5,700 $37.9K <0.01% 0 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 3,484 $23.2K <0.01% 0 13F-HR Timeline Group JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 2,950 $21.3K <0.01% +1,900 13F-HR/A Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 2,760 $18.4K <0.01% +56 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 2,518 $16.7K <0.01% -1,904 13F-HR Timeline Group Covestor Ltd More: the full row for Covestor Ltd 2,417 $16K 0.01% new 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 2,257 $15K <0.01% +776 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 2,061 $13.7K <0.01% +2,000 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,355 $9.01K <0.01% +243 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 1,240 $8K <0.01% +261 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 806 $5.36K <0.01% +530 13F-HR/A Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 779 $5.18K <0.01% -11,151 13F-HR Timeline Group VALLEY NATIONAL ADVISERS INC More: the full row for VALLEY NATIONAL ADVISERS INC 750 $4K <0.01% 0 13F-HR Timeline Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 560 $3.72K <0.01% 0 13F-HR Timeline Stone House Investment Management, LLC More: the full row for Stone House Investment Management, LLC 500 $3.33K <0.01% new 13F-HR Timeline MONTAG A & ASSOCIATES INC More: the full row for MONTAG A & ASSOCIATES INC 440 $2.93K <0.01% new 13F-HR Timeline Wilmington Savings Fund Society, FSB More: the full row for Wilmington Savings Fund Society, FSB 400 $2.66K <0.01% 0 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 175 $1K <0.01% 0 13F-HR Timeline Group COLDSTREAM CAPITAL MANAGEMENT INC More: the full row for COLDSTREAM CAPITAL MANAGEMENT INC 55 $366 <0.01% new 13F-HR Timeline HARBOUR INVESTMENTS, INC. More: the full row for HARBOUR INVESTMENTS, INC. 50 $333 <0.01% 0 13F-HR Timeline Parkside Financial Bank & Trust More: the full row for Parkside Financial Bank & Trust 50 $332 <0.01% new 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 44 $293 <0.01% +34 13F-HR Timeline Group Larson Financial Group LLC More: the full row for Larson Financial Group LLC 38 $253 <0.01% new 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 37 $246 <0.01% 0 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 25 $166 <0.01% -25 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 24 $160 <0.01% new 13F-HR Timeline Brooklyn Investment Group More: the full row for Brooklyn Investment Group 7 $47 <0.01% new 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 7 $44 <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 4 $27 <0.01% -5 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 48 $0 0% -689 13F-HR/A Timeline Group Value filed as zero, left out of ratios. CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 45 $0 0% -796 13F-HR Timeline Group Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.