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Disclosery

PRLD PRELUDE THERAPEUTICS INC

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CMN (common), issuer CIK 1678660

53 managers (55 13F filers) reported a position in PRLD shares at 2026-03-31, 30,772,416 shares in all. 10 filers opened a position and 5 filers sold out during the quarter.

Managers
53
13F filers
55
New
10
Added
20
Reduced
11
Sold out
5
Shares held by filers
30,772,416

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q1 2026

Filers in the available 13F reports with a share position at 2026-03-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC10,909,256$37.3M0.81%013F-HRTimelineGroup
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP10,123,824$34.6M0.2%013F-HRTimelineGroup
Kynam Capital Management, LP1,592,551$5.45M0.35%+803,68413F-HRTimeline
VANGUARD GROUP INCgroup of 3 filers holding1,392,422$4.76MnewTimeline
EcoR1 Capital, LLC947,049$3.24M0.14%new13F-HRTimeline
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP923,626$3.16M<0.01%+134,93113F-HRTimelineGroup
SPHERA FUNDS MANAGEMENT LTD.in group SPHERA FUNDS MANAGEMENT LTD.558,339$1.91M0.33%+435,58713F-HRTimelineGroup
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC511,519$1.75M<0.01%-24,18413F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC382,737$1.31M<0.01%+231,74013F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP358,906$1.23M<0.01%+85,02313F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY322,161$1.1M<0.01%-12,75513F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.321,886$1.1M<0.01%+55,60613F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC302,458$1.03M<0.01%+29,57213F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC275,200$941K<0.01%+3,90013F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…267,788$916K<0.01%+131,87913F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC236,469$809K<0.01%+118,99213F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC192,963$660K<0.01%+81,92313F-HRTimelineGroup
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC152,825$523K0.03%new13F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP138,231$473K<0.01%+10,93913F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC124,378$425K<0.01%new13F-HRTimelineGroup
Connor, Clark & Lunn Investment Managem…109,085$373K<0.01%+62,99513F-HRTimeline
UBS Group AGin group UBS Group AG64,505$221K<0.01%+62,64813F-HRTimelineGroup
HRT FINANCIAL LP58,699$200K<0.01%new13F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd57,190$196K<0.01%+7,03113F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/56,525$193K<0.01%+46,71713F-HRTimelineGroup
BRIDGEWAY CAPITAL MANAGEMENT, LLC53,500$183K<0.01%013F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP50,120$171K<0.01%013F-HRTimelineGroup
Focus Partners Wealthin group Focus Partners Wealth50,007$171K<0.01%013F-HRTimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP35,210$120K<0.01%new13F-HRTimelineGroup
Cerity Partners LLCin group Cerity Partners LLC32,875$112K<0.01%-7813F-HRTimelineGroup
OMERS ADMINISTRATION Corp32,700$112K<0.01%-40,30013F-HRTimeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC17,420$59.6K<0.01%+1,90013F-HRTimelineGroup
Qube Research & Technologies Ltd16,417$56.1K<0.01%-5,13413F-HRTimeline
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.16,329$55.8K<0.01%-42,83913F-HRTimelineGroup
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC13,652$47.9K<0.01%013F-HRTimelineGroup
Diametric Capital, LP11,980$41K0.01%new13F-HRTimeline
NINE MASTS CAPITAL Ltd11,699$40K0.01%new13F-HRTimeline
Graham Capital Management, L.P.11,343$38.8K<0.01%new13F-HRTimeline
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC10,294$35.2K<0.01%new13F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC8,600$29.4K<0.01%-213F-HRTimelineGroup
FMR LLCin group FMR LLC6,009$20.6K<0.01%-14313F-HRTimelineGroup
GROUP ONE TRADING LLC3,907$13.4K<0.01%+3,40713F-HRTimeline
SBI Securities Co., Ltd.2,641$9.03K<0.01%-10013F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA2,331$8K<0.01%+58913F-HRTimelineGroup
NISA INVESTMENT ADVISORS, LLC1,634$5.59K<0.01%013F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…1,171$4K<0.01%013F-HRTimelineGroup
CALDWELL SUTTER CAPITAL, INC.1,000$3.42K<0.01%-1,00013F-HRTimeline
CWM, LLCin group CWM, LLC573$1.96K<0.01%-11913F-HRTimelineGroup
Fortitude Family Office, LLC230$787<0.01%new13F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS95$325<0.01%013F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO62$190<0.01%013F-HR/ATimelineGroup
Optiver Holding B.V.in group Optiver Holding B.V.20$68<0.01%013F-HR/ATimelineGroup
CITIGROUP INCin group CITIGROUP INC5$17<0.01%+413F-HRTimelineGroup