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Disclosery

PRLD PRELUDE THERAPEUTICS INC

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CMN (common), issuer CIK 1678660

47 managers (48 13F filers) reported a position in PRLD shares at 2025-12-31, 28,472,315 shares in all. 10 filers opened a position and 9 filers sold out during the quarter.

Managers
47
13F filers
48
New
10
Added
14
Reduced
15
Sold out
9
Shares held by filers
28,472,315

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC10,909,256$31.6M0.65%013F-HRTimelineGroup
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP10,123,824$29.4M0.17%013F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC1,413,986$4.1M<0.01%+421,13213F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding1,025,995$2.98M+651,062Timeline
Kynam Capital Management, LP788,867$2.29M0.15%new13F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/755,956$2.19M<0.01%-120,38213F-HRTimeline
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC535,703$1.55M<0.01%-4,86213F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY334,916$971K<0.01%+50,71313F-HR/ATimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP273,883$794K<0.01%new13F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC272,886$792K<0.01%+55,31813F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC271,300$787K<0.01%-272,70013F-HRTimeline
BlackRock, Inc.in group BlackRock, Inc.266,280$772K<0.01%+1,30713F-HRTimelineGroup
TD Asset Management Inc160,652$466K<0.01%013F-HRTimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC150,997$438K<0.01%-996,04713F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…135,909$394K<0.01%new13F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP127,292$369K<0.01%+29,70013F-HRTimelineGroup
SPHERA FUNDS MANAGEMENT LTD.in group SPHERA FUNDS MANAGEMENT LTD.122,752$356K0.07%new13F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC117,477$341K<0.01%+38,15013F-HR/ATimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC111,040$322K<0.01%+76,21813F-HRTimelineGroup
OMERS ADMINISTRATION Corp73,000$212K<0.01%new13F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …70,546$200K<0.01%+1,29413F-HRTimelineGroup
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.59,168$172K<0.01%new13F-HRTimelineGroup
BRIDGEWAY CAPITAL MANAGEMENT, LLC53,500$155K<0.01%013F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd50,159$145K<0.01%+34,58113F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP50,120$145K<0.01%+13,69913F-HRTimelineGroup
Focus Partners Wealthin group Focus Partners Wealth50,007$145K<0.01%new13F-HRTimelineGroup
Connor, Clark & Lunn Investment Managem…46,090$134K<0.01%new13F-HRTimeline
Cerity Partners LLCin group Cerity Partners LLC32,953$95.6K<0.01%-1,38013F-HRTimelineGroup
Qube Research & Technologies Ltd21,551$62.5K<0.01%new13F-HRTimeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC15,520$45K<0.01%-10,32013F-HRTimelineGroup
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC13,652$39.5K<0.01%-9513F-HR/ATimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/9,808$28.4K<0.01%+96013F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC8,602$24.9K<0.01%-11013F-HRTimelineGroup
FMR LLCin group FMR LLC6,152$17.8K<0.01%-2,94713F-HRTimelineGroup
SBI Securities Co., Ltd.2,741$7.95K<0.01%013F-HRTimeline
CALDWELL SUTTER CAPITAL, INC.2,000$5.8K<0.01%new13F-HRTimeline
UBS Group AGin group UBS Group AG1,857$5.38K<0.01%-2,31413F-HRTimelineGroup
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA1,742$5K<0.01%-5,97013F-HRTimelineGroup
NISA INVESTMENT ADVISORS, LLC1,634$4.74K<0.01%013F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…1,171$3.4K<0.01%013F-HRTimelineGroup
CWM, LLCin group CWM, LLC692$2K<0.01%-52713F-HRTimelineGroup
GROUP ONE TRADING LLC500$1.45K<0.01%013F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS95$276<0.01%+4313F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO62$180<0.01%-3,81713F-HRTimelineGroup
Optiver Holding B.V.in group Optiver Holding B.V.20$58<0.01%013F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC1$3<0.01%-5,97413F-HRTimelineGroup
IFP Advisors, Inc1$3<0.01%-1713F-HRTimeline