Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 10,109,279 $82.1M 3.41% 0 13F-HR Timeline Medicxi Ventures Management (Jersey) Ltd More: the full row for Medicxi Ventures Management (Jersey) Ltd 7,464,572 $60.6M 11.46% 0 13F-HR Timeline JENNISON ASSOCIATES LLC More: the full row for JENNISON ASSOCIATES LLC 7,062,507 $57.3M 0.03% +1,196,118 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 3,671,386 $29.8M 0.01% -425,376 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 3,502,375 $28.4M <0.01% +379,805 13F-HR Timeline Group Carlyle Group Inc. in group Carlyle Group Inc. More: the full row for Carlyle Group Inc. 3,496,808 $28.4M 0.68% 0 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 2,779,561 $22.6M <0.01% +83,238 13F-HR Timeline Group Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 2,527,054 $20.5M 0.04% -54,334 13F-HR Timeline Checkpoint Capital L.P. More: the full row for Checkpoint Capital L.P. 2,274,157 $18.5M 9.4% +769,850 13F-HR Timeline NEA Management Company, LLC More: the full row for NEA Management Company, LLC 1,960,169 $15.9M 0.9% 0 13F-HR Timeline WASATCH ADVISORS LP More: the full row for WASATCH ADVISORS LP 1,558,928 $12.7M 0.06% +1,311,986 13F-HR Timeline Avidity Partners Management LP More: the full row for Avidity Partners Management LP 1,390,100 $11.3M 1.13% -414,393 13F-HR Timeline Catalys Pacific, LLC More: the full row for Catalys Pacific, LLC 1,167,114 $9.48M 8.18% +44,542 13F-HR Timeline GW&K Investment Management, LLC More: the full row for GW&K Investment Management, LLC 1,102,805 $8.96M 0.08% -23,278 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,039,936 $8.44M <0.01% +117,148 13F-HR Timeline Group 683 Capital Management, LLC in group 683 Capital Management, LLC More: the full row for 683 Capital Management, LLC 1,025,000 $8.32M 0.82% +15,000 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,018,495 $8.27M <0.01% +155,577 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 1,001,692 $8.13M 0.06% -1,571,720 13F-HR Timeline Propel Bio Management, LLC More: the full row for Propel Bio Management, LLC 989,927 $8.04M 7.98% +120,000 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 966,400 $7.85M <0.01% +526,910 13F-HR/A Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 801,401 $6.51M <0.01% -502,713 13F-HR Timeline Group Decheng Capital LLC More: the full row for Decheng Capital LLC 694,254 $5.64M 1.21% -555,746 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 619,490 $5.03M +465,460 Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 583,419 $4.74M +413,453 Timeline Simplify Asset Management Inc. More: the full row for Simplify Asset Management Inc. 581,935 $4.73M 0.33% +60,000 13F-HR Timeline TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 500,000 $4.06M 0.27% new 13F-HR Timeline Group PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 463,340 $3.76M 0.01% +48,000 13F-HR Timeline Group Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 460,753 $3.74M 0.17% 0 13F-HR Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 455,837 $3.7M <0.01% 13F-HR/A Timeline Group StepStone Group LP More: the full row for StepStone Group LP 422,085 $3.43M 3% 0 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 412,262 $3.35M <0.01% -21,959 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 397,964 $3.23M <0.01% +77,189 13F-HR Timeline Group Trexquant Investment LP More: the full row for Trexquant Investment LP 378,637 $3.07M 0.04% new 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 353,038 $2.87M <0.01% +60,178 13F-HR Timeline Group Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 282,553 $2.29M 0.04% new 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 235,404 $1.91M <0.01% +56,734 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 166,505 $1.35M <0.01% +62,726 13F-HR Timeline Group Nuveen Asset Management, LLC in group TIAA More: the full row for Nuveen Asset Management, LLC 147,523 $1.2M <0.01% -6,851 13F-HR Timeline Group ORACLE INVESTMENT MANAGEMENT INC More: the full row for ORACLE INVESTMENT MANAGEMENT INC 145,064 $1.18M 0.79% -604,423 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 136,907 $1.11M <0.01% +1,476 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 135,995 $1.1M <0.01% -37,388 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 132,269 $1.07M <0.01% +50,499 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 102,748 $834K <0.01% +4,557 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 98,068 $796K <0.01% new 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 77,869 $632K <0.01% +50,027 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 76,463 $621K <0.01% +18,656 13F-HR/A Timeline Group Swiss National Bank More: the full row for Swiss National Bank 73,300 $595K <0.01% 0 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 72,007 $585K <0.01% -148,396 13F-HR Timeline Group Penn Mutual Asset Management More: the full row for Penn Mutual Asset Management 62,802 $510K 0.92% 0 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 59,991 $487K <0.01% +27,063 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 55,973 $455K <0.01% new 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 55,968 $454K <0.01% +5,110 13F-HR/A Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 55,400 $450K 0.09% +55,200 13F-HR Timeline Group COMMONWEALTH EQUITY SERVICES, LLC More: the full row for COMMONWEALTH EQUITY SERVICES, LLC 50,772 $412K <0.01% +40,362 13F-HR Timeline Summit Financial Wealth Advisors, LLC More: the full row for Summit Financial Wealth Advisors, LLC 68,125 $384K 0.08% +39,093 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 45,590 $370K <0.01% -4,520 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 44,577 $362K <0.01% +13,056 13F-HR Timeline Group VIRTUS ADVISERS, LLC in group Virtus Investment Advisers, L… More: the full row for VIRTUS ADVISERS, LLC 43,789 $356K 0.15% +13,711 13F-HR Timeline Group GILDER GAGNON HOWE & CO LLC More: the full row for GILDER GAGNON HOWE & CO LLC 41,610 $338K <0.01% -1,581,273 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 39,532 $321K <0.01% new 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 36,438 $296K <0.01% +2,060 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 35,262 $286K <0.01% +1 13F-HR/A Timeline TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 34,049 $276K <0.01% -2,334 13F-HR Timeline Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 32,500 $264K <0.01% new 13F-HR Timeline DARK FOREST CAPITAL MANAGEMENT LP More: the full row for DARK FOREST CAPITAL MANAGEMENT LP 32,029 $260K 0.04% new 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 30,213 $245K <0.01% +9,986 13F-HR/A Timeline Group Occidental Asset Management, LLC More: the full row for Occidental Asset Management, LLC 29,672 $241K 0.04% 0 13F-HR Timeline Kera Capital Partners, Inc. More: the full row for Kera Capital Partners, Inc. 26,849 $218K 0.06% 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 25,641 $209K <0.01% +4,592 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 25,516 $207K <0.01% +7,462 13F-HR Timeline Group KEYBANK NATIONAL ASSOCIATION/OH in group KEYBANK NATIONAL ASSOCIATION/… More: the full row for KEYBANK NATIONAL ASSOCIATION/OH 25,512 $207K <0.01% +7,469 13F-HR Timeline Group Aristides Capital LLC More: the full row for Aristides Capital LLC 25,200 $205K 0.06% new 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 24,428 $198K +3,217 Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 24,366 $198K <0.01% +5,337 13F-HR Timeline Group Creative Planning in group Creative Planning More: the full row for Creative Planning 23,243 $189K <0.01% -10,641 13F-HR Timeline Group Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 22,845 $186K <0.01% new 13F-HR Timeline Group LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 21,070 $171K <0.01% new 13F-HR Timeline Nebula Research & Development LLC More: the full row for Nebula Research & Development LLC 20,963 $170K 0.02% new 13F-HR Timeline Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 19,508 $158K <0.01% +1,263 13F-HR Timeline Group INSPIRION WEALTH ADVISORS, LLC More: the full row for INSPIRION WEALTH ADVISORS, LLC 19,964 $144K 0.02% -16,670 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 17,658 $143K <0.01% new 13F-HR Timeline Group Allworth Financial LP More: the full row for Allworth Financial LP 20,448 $143K <0.01% -2,146 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 17,424 $141K <0.01% +5,981 13F-HR Timeline Capula Management Ltd in group Capula Management Ltd More: the full row for Capula Management Ltd 16,083 $131K <0.01% new 13F-HR Timeline Group The filing omitted confidential holdings, a later amendment may add them. Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 15,710 $128K <0.01% +5,639 13F-HR Timeline KESTRA PRIVATE WEALTH SERVICES, LLC in group Kestra Advisory Services, LLC More: the full row for KESTRA PRIVATE WEALTH SERVICES, LLC 15,500 $126K <0.01% +5,500 13F-HR Timeline Group CANADA PENSION PLAN INVESTMENT BOARD More: the full row for CANADA PENSION PLAN INVESTMENT BOARD 15,400 $125K <0.01% new 13F-HR Timeline Numerai GP LLC More: the full row for Numerai GP LLC 15,264 $124K 0.03% -34,063 13F-HR Timeline GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 15,173 $123K 0.01% +90 13F-HR Timeline Bayesian Capital Management, LP More: the full row for Bayesian Capital Management, LP 14,900 $121K 0.01% new 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 14,499 $118K 0.01% +1,365 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 14,289 $116K <0.01% +3,804 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 13,990 $114K <0.01% +396 13F-HR Timeline Group Stratos Wealth Advisors, LLC in group Stratos Wealth Partners, LTD. More: the full row for Stratos Wealth Advisors, LLC 13,438 $109K 0.01% 0 13F-HR Timeline Group Virtu Financial LLC in group Virtu Financial LLC More: the full row for Virtu Financial LLC 13,424 $109K 0.01% new 13F-HR Timeline Group PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 13,310 $108K <0.01% new 13F-HR Timeline Versor Investments LP More: the full row for Versor Investments LP 12,400 $101K 0.02% new 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 11,689 $94.9K <0.01% +325 13F-HR/A Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 11,587 $94K <0.01% +4,581 13F-HR Timeline Group Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 11,113 $90.2K <0.01% new 13F-HR Timeline TEACHER RETIREMENT SYSTEM OF TEXAS More: the full row for TEACHER RETIREMENT SYSTEM OF TEXAS 11,065 $90K <0.01% new 13F-HR Timeline ARIZONA STATE RETIREMENT SYSTEM More: the full row for ARIZONA STATE RETIREMENT SYSTEM 10,900 $88.5K <0.01% +86 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 10,770 $87.5K <0.01% 0 13F-HR/A Timeline Klingman & Associates, LLC More: the full row for Klingman & Associates, LLC 10,517 $85.4K 0.01% +141 13F-HR Timeline STALEY CAPITAL ADVISERS INC More: the full row for STALEY CAPITAL ADVISERS INC 10,000 $81.2K <0.01% 0 13F-HR Timeline KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 9,100 $73.9K <0.01% 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 8,251 $67K <0.01% 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 6,826 $55.4K <0.01% +1,578 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 5,395 $43K <0.01% -10,303 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 4,414 $35.8K <0.01% +27 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 3,292 $26.7K <0.01% +2,277 13F-HR/A Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 3,095 $25.1K <0.01% 0 13F-HR Timeline Group CANADA LIFE ASSURANCE Co in group CANADA LIFE ASSURANCE Co More: the full row for CANADA LIFE ASSURANCE Co 2,839 $23K <0.01% 0 13F-HR Timeline Group Point72 (DIFC) Ltd More: the full row for Point72 (DIFC) Ltd 1,951 $15.8K <0.01% new 13F-HR Timeline HUNTINGTON NATIONAL BANK in group HUNTINGTON NATIONAL BANK More: the full row for HUNTINGTON NATIONAL BANK 1,497 $12.2K <0.01% +26 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,436 $11.7K <0.01% 13F-HR Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 1,334 $10.8K <0.01% -9,584 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 1,090 $9K <0.01% 0 13F-HR Timeline R Squared Ltd More: the full row for R Squared Ltd 1,061 $8.62K 0.01% 13F-HR Timeline Bear Mountain Capital, Inc. More: the full row for Bear Mountain Capital, Inc. 1,000 $7.17K <0.01% 0 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 867 $7.04K <0.01% +761 13F-HR Timeline PUBLIC EMPLOYEES RETIREMENT ASSOCIATION… More: the full row for PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO 840 $7K <0.01% 0 13F-HR Timeline Larson Financial Group LLC More: the full row for Larson Financial Group LLC 797 $6.47K <0.01% +150 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 508 $4.12K <0.01% +354 13F-HR Timeline Greenline Partners, LLC More: the full row for Greenline Partners, LLC 500 $4.06K <0.01% new 13F-HR Timeline BFSG, LLC More: the full row for BFSG, LLC 300 $2.44K <0.01% 0 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 273 $2.22K <0.01% 0 13F-HR Timeline Group Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 260 $2K <0.01% 0 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 179 $1.45K <0.01% 13F-HR/A Timeline Lindbrook Capital, LLC More: the full row for Lindbrook Capital, LLC 155 $1.26K <0.01% new 13F-HR Timeline Riggs Asset Managment Co. Inc. More: the full row for Riggs Asset Managment Co. Inc. 69 $552 <0.01% 0 13F-HR Timeline Amundi in group Amundi More: the full row for Amundi 42 $292 <0.01% new 13F-HR Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 21 $171 <0.01% new 13F-HR Timeline Group ELEVATION WEALTH PARTNERS, LLC More: the full row for ELEVATION WEALTH PARTNERS, LLC 20 $163 <0.01% 0 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 19 $154 <0.01% -93 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 17 $138 <0.01% -10 13F-HR Timeline Aster Capital Management (DIFC) Ltd More: the full row for Aster Capital Management (DIFC) Ltd 15 $122 <0.01% -30 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 10 $81 <0.01% -55 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 2 $16 <0.01% new 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 35 $0 0% +3 13F-HR Timeline Group Value filed as zero, left out of ratios. Covestor Ltd More: the full row for Covestor Ltd 7 $0 0% new 13F-HR Timeline Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.