Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 12,466,489 $120M 4.78% +2,357,210 13F-HR Timeline Medicxi Ventures Management (Jersey) Ltd More: the full row for Medicxi Ventures Management (Jersey) Ltd 7,464,572 $71.6M 16.75% 0 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 4,140,072 $39.7M 0.01% +489,260 13F-HR Timeline Group Carlyle Group Inc. in group Carlyle Group Inc. More: the full row for Carlyle Group Inc. 3,496,808 $33.5M 0.67% 0 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 3,315,348 $31.8M <0.01% -8,255 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 2,787,311 $26.7M <0.01% +8,624 13F-HR Timeline Group Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 2,519,972 $24.2M 0.04% +5,688 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 2,250,497 $21.6M 0.02% +1,727,134 13F-HR Timeline Group 683 Capital Management, LLC in group 683 Capital Management, LLC More: the full row for 683 Capital Management, LLC 2,105,000 $20.2M 2.05% +660,000 13F-HR Timeline Group NEA Management Company, LLC More: the full row for NEA Management Company, LLC 1,960,169 $18.8M 1.42% 0 13F-HR Timeline WASATCH ADVISORS LP More: the full row for WASATCH ADVISORS LP 1,461,895 $14M 0.07% -239,732 13F-HR Timeline Catalys Pacific, LLC More: the full row for Catalys Pacific, LLC 1,167,114 $11.2M 8.5% 0 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,069,927 $10.3M <0.01% +53,504 13F-HR Timeline Group Avidity Partners Management LP More: the full row for Avidity Partners Management LP 1,064,500 $10.2M 2.05% +264,500 13F-HR Timeline GW&K Investment Management, LLC More: the full row for GW&K Investment Management, LLC 1,048,472 $10.1M 0.09% -55,836 13F-HR Timeline Propel Bio Management, LLC More: the full row for Propel Bio Management, LLC 922,927 $8.85M 10.74% -212,000 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 849,424 $8.15M <0.01% -51,930 13F-HR Timeline Group Catalio Capital Management, LP More: the full row for Catalio Capital Management, LP 672,290 $6.45M 1.35% new 13F-HR Timeline MOORE CAPITAL MANAGEMENT, LP More: the full row for MOORE CAPITAL MANAGEMENT, LP 600,000 $5.75M 0.11% new 13F-HR Timeline Simplify Asset Management Inc. More: the full row for Simplify Asset Management Inc. 521,935 $5.01M 0.3% -160,000 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 517,247 $4.96M <0.01% -13,612 13F-HR Timeline Group StepStone Group LP More: the full row for StepStone Group LP 422,085 $4.05M 8.03% 0 13F-HR Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 419,473 $4.02M -387,849 Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 3 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 413,643 $3.97M +241,032 Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 360,160 $3.45M <0.01% +12,125 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 359,324 $3.45M <0.01% -27,299 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 306,399 $2.94M 0.02% new 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 192,526 $1.85M <0.01% +4,652 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 187,291 $1.8M 0.01% -564,401 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 180,851 $1.73M <0.01% new 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 157,941 $1.51M <0.01% +147,759 13F-HR/A Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 154,928 $1.49M <0.01% -976,104 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 138,516 $1.33M <0.01% +1,123 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 121,166 $1.16M <0.01% +6,631 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 110,110 $1.06M <0.01% +8,590 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 96,080 $921K <0.01% -74,201 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 90,781 $871K <0.01% -8,995 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 82,170 $788K <0.01% +27,268 13F-HR/A Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 64,557 $619K <0.01% +7,818 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 63,424 $608K 0.1% +20,624 13F-HR Timeline Group Penn Mutual Asset Management More: the full row for Penn Mutual Asset Management 62,802 $602K 1.06% 0 13F-HR Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 57,264 $549K <0.01% -2,673 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 50,590 $485K <0.01% +5,000 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 49,924 $479K <0.01% -57,475 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 46,678 $448K <0.01% +18,253 13F-HR Timeline Group Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 44,306 $425K 0.14% -658 13F-HR Timeline Group DIADEMA PARTNERS LP More: the full row for DIADEMA PARTNERS LP 40,294 $386K 0.24% new 13F-HR Timeline Nebula Research & Development LLC More: the full row for Nebula Research & Development LLC 37,937 $364K 0.03% +9,116 13F-HR Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 32,206 $309K 0.03% +30,760 13F-HR Timeline COMMONWEALTH EQUITY SERVICES, LLC More: the full row for COMMONWEALTH EQUITY SERVICES, LLC 31,556 $303K <0.01% -20,875 13F-HR Timeline GILDER GAGNON HOWE & CO LLC More: the full row for GILDER GAGNON HOWE & CO LLC 31,358 $301K <0.01% -10,208 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 30,104 $289K <0.01% +3,091 13F-HR Timeline Kera Capital Partners, Inc. More: the full row for Kera Capital Partners, Inc. 30,059 $288K 0.06% +210 13F-HR Timeline Occidental Asset Management, LLC More: the full row for Occidental Asset Management, LLC 29,672 $285K 0.04% 0 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 28,192 $270K <0.01% +6,708 13F-HR Timeline Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 27,834 $267K <0.01% new 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 26,079 $250K <0.01% -1,093 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 26,031 $250K +580 Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 25,845 $248K <0.01% +1,479 13F-HR Timeline Group Birchview Capital, LP More: the full row for Birchview Capital, LP 25,000 $240K 0.24% new 13F-HR Timeline Summit Financial Wealth Advisors, LLC More: the full row for Summit Financial Wealth Advisors, LLC 22,143 $212K 0.04% -9,000 13F-HR Timeline STIFEL FINANCIAL CORP in group STIFEL FINANCIAL CORP More: the full row for STIFEL FINANCIAL CORP 20,467 $196K <0.01% +3,069 13F-HR Timeline Group Allworth Financial LP More: the full row for Allworth Financial LP 20,448 $196K <0.01% -30 13F-HR Timeline INSPIRION WEALTH ADVISORS, LLC More: the full row for INSPIRION WEALTH ADVISORS, LLC 19,814 $190K 0.03% -50 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 15,826 $152K <0.01% +1,364 13F-HR Timeline Group KESTRA PRIVATE WEALTH SERVICES, LLC in group Kestra Advisory Services, LLC More: the full row for KESTRA PRIVATE WEALTH SERVICES, LLC 15,500 $149K <0.01% 0 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 15,146 $145K <0.01% -64,165 13F-HR Timeline Private Advisor Group, LLC More: the full row for Private Advisor Group, LLC 14,580 $140K <0.01% new 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 14,330 $137K 0.01% -75,861 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 14,022 $134K 0.01% +307 13F-HR Timeline AXQ CAPITAL, LP More: the full row for AXQ CAPITAL, LP 13,620 $131K 0.04% new 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 13,182 $126K <0.01% -32,649 13F-HR Timeline Group VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 11,823 $113K <0.01% +753 13F-HR Timeline Group Entropy Technologies, LP More: the full row for Entropy Technologies, LP 11,600 $111K 0.01% new 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 11,265 $108K <0.01% -449 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 11,250 $108K <0.01% 0 13F-HR/A Timeline Group Fiduciary Trust Co in group Fiduciary Trust Co More: the full row for Fiduciary Trust Co 10,905 $105K <0.01% 0 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 10,770 $103K <0.01% 0 13F-HR/A Timeline STALEY CAPITAL ADVISERS INC More: the full row for STALEY CAPITAL ADVISERS INC 10,000 $95.9K <0.01% 0 13F-HR Timeline Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 9,421 $90.3K 0.08% new 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 8,251 $79.1K <0.01% 0 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 5,881 $56.4K <0.01% -503,701 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 5,710 $54.8K <0.01% +2,102 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 5,072 $48.6K <0.01% +2,122 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 4,311 $41.3K <0.01% +1,216 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 4,087 $39.2K <0.01% -32,351 13F-HR Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 3,174 $30.4K <0.01% new 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 2,889 $27.7K <0.01% -32,373 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 2,736 $26.2K <0.01% -39,063 13F-HR Timeline Group Brooklyn Investment Group More: the full row for Brooklyn Investment Group 2,718 $26.1K <0.01% -738 13F-HR/A Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 2,093 $20K <0.01% -5,291 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,751 $16.8K <0.01% 0 13F-HR Timeline HUNTINGTON NATIONAL BANK in group HUNTINGTON NATIONAL BANK More: the full row for HUNTINGTON NATIONAL BANK 1,588 $15.2K <0.01% +202 13F-HR Timeline Group AMALGAMATED BANK More: the full row for AMALGAMATED BANK 1,354 $13K <0.01% 0 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 1,347 $12.9K <0.01% +1,037 13F-HR Timeline Group C M BIDWELL & ASSOCIATES LTD More: the full row for C M BIDWELL & ASSOCIATES LTD 1,122 $10.8K 0.01% new 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 1,058 $10.1K <0.01% +790 13F-HR Timeline Quarry LP More: the full row for Quarry LP 1,024 $9.82K <0.01% new 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 903 $8.66K <0.01% +341 13F-HR/A Timeline Bear Mountain Capital, Inc. More: the full row for Bear Mountain Capital, Inc. 1,000 $7.95K <0.01% 0 13F-HR Timeline Larson Financial Group LLC More: the full row for Larson Financial Group LLC 647 $6.21K <0.01% 0 13F-HR Timeline JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 465 $4.53K <0.01% new 13F-HR Timeline Group Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 342 $3.28K <0.01% -341 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 277 $2.66K <0.01% -23,486 13F-HR Timeline Group Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 260 $2K <0.01% 0 13F-HR Timeline Group Fortitude Family Office, LLC More: the full row for Fortitude Family Office, LLC 208 $2K <0.01% new 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 186 $1.78K <0.01% -143 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 128 $1.23K <0.01% +78 13F-HR Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 88 $844 <0.01% +72 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 79 $758 <0.01% +42 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 24 $230 <0.01% -703 13F-HR Timeline ELEVATION WEALTH PARTNERS, LLC More: the full row for ELEVATION WEALTH PARTNERS, LLC 20 $192 <0.01% 0 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 11 $105 <0.01% +9 13F-HR Timeline Covestor Ltd More: the full row for Covestor Ltd 16 $0 0% +9 13F-HR Timeline Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.