Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 12,466,489 $147M 4.4% 0 13F-HR Timeline Medicxi Ventures Management (Jersey) Ltd More: the full row for Medicxi Ventures Management (Jersey) Ltd 7,464,572 $87.9M 11.8% 0 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 5,081,451 $59.8M 0.05% +2,830,954 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 3,864,971 $45.5M 0.01% -275,101 13F-HR Timeline Group Carlyle Group Inc. in group Carlyle Group Inc. More: the full row for Carlyle Group Inc. 3,496,808 $41.1M 0.95% 0 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 3,402,324 $40M <0.01% +86,976 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 3,215,572 $37.8M <0.01% +428,261 13F-HR Timeline Group Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 2,503,344 $29.5M 0.05% -16,628 13F-HR/A Timeline NEA Management Company, LLC More: the full row for NEA Management Company, LLC 1,960,169 $23.1M 1.27% 0 13F-HR Timeline 683 Capital Management, LLC in group 683 Capital Management, LLC More: the full row for 683 Capital Management, LLC 1,820,380 $21.4M 1.95% -284,620 13F-HR Timeline Group WASATCH ADVISORS LP More: the full row for WASATCH ADVISORS LP 1,537,218 $18.1M 0.1% +75,323 13F-HR Timeline Catalys Pacific, LLC More: the full row for Catalys Pacific, LLC 1,167,114 $13.7M 3.91% 0 13F-HR Timeline GW&K Investment Management, LLC More: the full row for GW&K Investment Management, LLC 1,144,330 $13.5M 0.12% +95,858 13F-HR Timeline Catalio Capital Management, LP More: the full row for Catalio Capital Management, LP 1,128,521 $13.3M 2.46% +456,231 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,088,910 $12.8M <0.01% +18,983 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,053,591 $12.4M <0.01% +204,167 13F-HR Timeline Group MOORE CAPITAL MANAGEMENT, LP More: the full row for MOORE CAPITAL MANAGEMENT, LP 600,000 $7.06M 0.14% 0 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 554,590 $6.53M <0.01% +373,739 13F-HR Timeline Group Propel Bio Management, LLC More: the full row for Propel Bio Management, LLC 552,927 $6.51M 6.51% -370,000 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 508,720 $5.99M <0.01% new 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 3 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 433,712 $5.1M +20,069 Timeline AIGH Capital Management LLC More: the full row for AIGH Capital Management LLC 429,000 $5.05M 1.77% new 13F-HR Timeline StepStone Group LP More: the full row for StepStone Group LP 422,085 $4.97M 2.34% 0 13F-HR Timeline SummitTX Capital, L.P. More: the full row for SummitTX Capital, L.P. 385,968 $4.54M 0.19% new 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 365,904 $4.31M <0.01% +5,744 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 357,578 $4.21M <0.01% -1,746 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 338,360 $3.98M <0.01% -81,113 13F-HR Timeline Group Simplify Asset Management Inc. More: the full row for Simplify Asset Management Inc. 321,935 $3.79M 0.08% -200,000 13F-HR Timeline Avidity Partners Management LP More: the full row for Avidity Partners Management LP 306,000 $3.6M 0.82% -758,500 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 295,161 $3.47M 0.01% +281,979 13F-HR Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 290,467 $3.42M 0.03% new 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 255,573 $3.01M <0.01% +100,645 13F-HR/A Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 249,094 $2.93M <0.01% +153,014 13F-HR/A Timeline Group NewEdge Advisors, LLC More: the full row for NewEdge Advisors, LLC 201,523 $2.23M 0.01% new 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 187,291 $2.2M 0.01% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 162,443 $1.91M <0.01% +4,502 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 152,032 $1.79M <0.01% -40,494 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 146,459 $1.72M <0.01% new 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 136,948 $1.61M <0.01% -1,568 13F-HR/A Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 128,356 $1.51M <0.01% +46,186 13F-HR/A Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 127,382 $1.5M <0.01% +6,216 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 110,110 $1.3M <0.01% 0 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 107,262 $1.26M <0.01% new 13F-HR Timeline Group GILDER GAGNON HOWE & CO LLC More: the full row for GILDER GAGNON HOWE & CO LLC 88,542 $1.04M 0.01% +57,184 13F-HR Timeline Birchview Capital, LP More: the full row for Birchview Capital, LP 85,000 $1M 0.76% +60,000 13F-HR Timeline Trexquant Investment LP More: the full row for Trexquant Investment LP 78,183 $920K 0.01% new 13F-HR Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 78,058 $919K <0.01% +20,794 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 71,275 $839K 0.01% +56,129 13F-HR Timeline GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 70,258 $827K 0.07% new 13F-HR Timeline Penn Mutual Asset Management More: the full row for Penn Mutual Asset Management 62,802 $739K 1.44% 0 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 61,713 $726K <0.01% -2,844 13F-HR Timeline Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 58,097 $684K 0.01% +30,263 13F-HR Timeline Group INSPIRION WEALTH ADVISORS, LLC More: the full row for INSPIRION WEALTH ADVISORS, LLC 36,634 $662K 0.09% +16,820 13F-HR Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 54,594 $643K 0.04% +22,388 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 54,587 $642K 0.03% +40,257 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 53,648 $631K <0.01% +6,970 13F-HR Timeline Group AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 52,629 $619K <0.01% +2,705 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 45,590 $537K <0.01% -5,000 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 44,306 $521K 0.15% 0 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 42,900 $505K 0.05% -20,524 13F-HR Timeline Group CAXTON ASSOCIATES LLP More: the full row for CAXTON ASSOCIATES LLP 38,570 $454K 0.01% new 13F-HR Timeline TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 34,090 $401K <0.01% new 13F-HR/A Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 31,919 $376K <0.01% +1,815 13F-HR Timeline PharVision Advisers, LLC More: the full row for PharVision Advisers, LLC 30,968 $364K 0.21% new 13F-HR Timeline COMMONWEALTH EQUITY SERVICES, LLC More: the full row for COMMONWEALTH EQUITY SERVICES, LLC 30,616 $360K <0.01% -940 13F-HR Timeline Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 30,272 $356K <0.01% new 13F-HR Timeline Group Kera Capital Partners, Inc. More: the full row for Kera Capital Partners, Inc. 30,059 $354K 0.05% 0 13F-HR Timeline Occidental Asset Management, LLC More: the full row for Occidental Asset Management, LLC 29,672 $349K 0.04% 0 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 29,572 $348K <0.01% +3,493 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 25,845 $304K <0.01% 0 13F-HR Timeline Group TOCQUEVILLE ASSET MANAGEMENT L.P. in group TOCQUEVILLE ASSET MANAGEMENT … More: the full row for TOCQUEVILLE ASSET MANAGEMENT L.P. 24,700 $291K <0.01% new 13F-HR Timeline Group Summit Financial Wealth Advisors, LLC More: the full row for Summit Financial Wealth Advisors, LLC 22,143 $272K 0.04% 0 13F-HR Timeline HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 22,521 $265K <0.01% new 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 22,145 $261K -3,886 Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 21,541 $254K <0.01% -6,651 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 20,448 $241K <0.01% 0 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 19,960 $234K 0.01% new 13F-HR Timeline STIFEL FINANCIAL CORP in group STIFEL FINANCIAL CORP More: the full row for STIFEL FINANCIAL CORP 19,867 $234K <0.01% -600 13F-HR Timeline Group AXQ CAPITAL, LP More: the full row for AXQ CAPITAL, LP 19,862 $234K 0.09% +6,242 13F-HR Timeline OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 16,500 $194K <0.01% new 13F-HR Timeline Fiduciary Trust Co in group Fiduciary Trust Co More: the full row for Fiduciary Trust Co 16,115 $190K <0.01% +5,210 13F-HR Timeline Group KESTRA PRIVATE WEALTH SERVICES, LLC in group Kestra Advisory Services, LLC More: the full row for KESTRA PRIVATE WEALTH SERVICES, LLC 15,500 $182K <0.01% 0 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 14,612 $172K <0.01% -1,214 13F-HR Timeline Group Private Advisor Group, LLC More: the full row for Private Advisor Group, LLC 14,580 $172K <0.01% 0 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 13,635 $160K <0.01% -503,612 13F-HR Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 13,394 $158K <0.01% +10,220 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 12,435 $146K 0.01% -1,587 13F-HR Timeline PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 12,170 $143K <0.01% new 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 11,925 $140K <0.01% +3,674 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 10,952 $130K <0.01% -298 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 10,770 $127K <0.01% 0 13F-HR Timeline Pathstone Holdings, LLC in group Pathstone Holdings, LLC More: the full row for Pathstone Holdings, LLC 10,322 $121K <0.01% new 13F-HR Timeline Group Quantbot Technologies LP More: the full row for Quantbot Technologies LP 9,797 $115K <0.01% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 8,828 $104K <0.01% +3,756 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 7,277 $85.7K <0.01% +7,000 13F-HR Timeline Group Quarry LP More: the full row for Quarry LP 7,007 $82.5K 0.02% +5,983 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 6,999 $82.4K <0.01% +1,118 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 6,362 $74.9K <0.01% +3,626 13F-HR Timeline Group Leonteq Securities AG More: the full row for Leonteq Securities AG 4,800 $56.5K <0.01% new 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 4,248 $50K <0.01% new 13F-HR Timeline CANADA PENSION PLAN INVESTMENT BOARD More: the full row for CANADA PENSION PLAN INVESTMENT BOARD 4,100 $48.3K <0.01% new 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 4,087 $48.1K <0.01% 0 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 3,527 $41.5K <0.01% -784 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 2,891 $34K <0.01% +2 13F-HR Timeline JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 2,523 $29.7K <0.01% +2,058 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 2,159 $25.4K <0.01% +1,256 13F-HR Timeline HUNTINGTON NATIONAL BANK in group HUNTINGTON NATIONAL BANK More: the full row for HUNTINGTON NATIONAL BANK 2,022 $23.8K <0.01% +434 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 1,968 $23K <0.01% -125 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,562 $18.4K <0.01% -4,148 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 1,548 $18.2K <0.01% +201 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,526 $18K <0.01% -225 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 1,354 $16K <0.01% 0 13F-HR Timeline Bear Mountain Capital, Inc. More: the full row for Bear Mountain Capital, Inc. 1,000 $14K <0.01% 0 13F-HR Timeline C M BIDWELL & ASSOCIATES LTD More: the full row for C M BIDWELL & ASSOCIATES LTD 1,122 $13.2K 0.01% 0 13F-HR Timeline QUADRANT CAPITAL GROUP LLC More: the full row for QUADRANT CAPITAL GROUP LLC 1,073 $12.6K <0.01% new 13F-HR Timeline Larson Financial Group LLC More: the full row for Larson Financial Group LLC 647 $7.62K <0.01% 0 13F-HR Timeline Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 584 $6.87K <0.01% new 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 360 $4.24K <0.01% +336 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 342 $4.03K <0.01% 0 13F-HR Timeline MassMutual Private Wealth & Trust, FSB More: the full row for MassMutual Private Wealth & Trust, FSB 287 $3.38K <0.01% new 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 260 $3K <0.01% 0 13F-HR Timeline Group Fortitude Family Office, LLC More: the full row for Fortitude Family Office, LLC 208 $2.45K <0.01% 0 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 188 $2.21K <0.01% -870 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 186 $2.19K <0.01% 0 13F-HR Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 88 $1.04K <0.01% 0 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 71 $836 <0.01% -8 13F-HR Timeline Group Arax Advisory Partners More: the full row for Arax Advisory Partners 59 $695 <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 23 $271 <0.01% -105 13F-HR Timeline ELEVATION WEALTH PARTNERS, LLC More: the full row for ELEVATION WEALTH PARTNERS, LLC 20 $236 <0.01% 0 13F-HR/A Timeline Covestor Ltd More: the full row for Covestor Ltd 16 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios.