SAMSARA BIOCAPITAL, LLC More: the full row for SAMSARA BIOCAPITAL, LLC 1,717,127 $39.3M 5.39% +449,337 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,516,157 $34.7M <0.01% +144,278 13F-HR Timeline Group RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 1,350,256 $30.9M 0.47% +215,000 13F-HR Timeline Redmile Group, LLC in group Redmile Group, LLC More: the full row for Redmile Group, LLC 1,319,763 $30.2M 2.1% +355,416 13F-HR Timeline Group Casdin Capital, LLC More: the full row for Casdin Capital, LLC 1,295,361 $29.6M 1.98% +770,745 13F-HR Timeline EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 1,271,342 $29.1M 1.16% 0 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 860,333 $19.7M <0.01% +128,532 13F-HR Timeline Group Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 800,000 $18.3M 1.34% +600,000 13F-HR Timeline Group BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 674,450 $15.4M 0.16% +218,435 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 568,016 $13M <0.01% -8,144 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 481,001 $11M <0.01% +476,418 13F-HR Timeline Group ArrowMark Colorado Holdings LLC More: the full row for ArrowMark Colorado Holdings LLC 448,601 $10.3M 0.14% +62,136 13F-HR Timeline DEERFIELD MANAGEMENT COMPANY, L.P. in group DEERFIELD MANAGEMENT COMPANY,… More: the full row for DEERFIELD MANAGEMENT COMPANY, L.P. 448,145 $10.2M 0.19% new 13F-HR Timeline Group GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 442,761 $10.1M 4.77% -561,530 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 347,201 $7.94M <0.01% +342,077 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 329,863 $7.54M <0.01% -26,562 13F-HR/A Timeline Group Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 303,000 $6.93M 1.18% +288,000 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 234,625 $5.36M <0.01% +14,026 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 225,373 $5.15M <0.01% -21,167 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 152,371 $3.48M <0.01% -181,997 13F-HR/A Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 123,291 $2.82M <0.01% new 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 100,566 $2.3M <0.01% +5,845 13F-HR Timeline Group Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 95,407 $2.18M 0.08% new 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 83,340 $1.91M 0.01% +252 13F-HR Timeline Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 80,000 $1.83M 0.11% new 13F-HR Timeline Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 74,836 $1.71M 0.02% +30,336 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 74,778 $1.71M <0.01% +34,538 13F-HR Timeline Group JENNISON ASSOCIATES LLC More: the full row for JENNISON ASSOCIATES LLC 72,596 $1.66M <0.01% -6,054 13F-HR Timeline BLAIR WILLIAM & CO/IL More: the full row for BLAIR WILLIAM & CO/IL 62,640 $1.43M <0.01% new 13F-HR Timeline DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 51,500 $1.18M 0.3% +43,725 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 38,058 $870K <0.01% -3,107 13F-HR Timeline Group Driehaus Capital Management LLC More: the full row for Driehaus Capital Management LLC 32,765 $749K 0.01% -69,422 13F-HR Timeline OCONNOR, A Distinct Business Unit of UB… More: the full row for OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 32,734 $748K 0.02% +23,907 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 30,317 $693K <0.01% 0 13F-HR Timeline Group Nuveen Asset Management, LLC in group TIAA More: the full row for Nuveen Asset Management, LLC 27,482 $628K <0.01% 0 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 26,507 $606K <0.01% -14,071 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 22,601 $517K <0.01% -69 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 21,717 $496K <0.01% +3,427 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 20,629 $472K <0.01% new 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 17,533 $401K <0.01% +2,674 13F-HR/A Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 17,431 $398K <0.01% +12,451 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 15,800 $361K <0.01% new 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 15,704 $359K <0.01% +1,326 13F-HR/A Timeline Raiffeisen Bank International AG in group Raiffeisen Bank International… More: the full row for Raiffeisen Bank International AG 16,000 $356K 0.01% 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 15,256 $349K 0.03% new 13F-HR Timeline Group M&T Bank Corp in group M&T Bank Corp More: the full row for M&T Bank Corp 14,138 $323K <0.01% new 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 14,079 $322K <0.01% new 13F-HR Timeline Group GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 10,936 $250K 0.02% new 13F-HR Timeline Mariner, LLC in group Mariner, LLC More: the full row for Mariner, LLC 10,475 $239K <0.01% new 13F-HR Timeline Group Mitsubishi UFJ Asset Management Co., Lt… in group Mitsubishi UFJ Trust & Bankin… More: the full row for Mitsubishi UFJ Asset Management Co., Ltd. 10,290 $239K <0.01% +4,334 13F-HR Timeline Group HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 9,933 $227K <0.01% new 13F-HR Timeline Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 9,189 $210K <0.01% -23,477 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 8,100 $185K <0.01% +638 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 6,419 $147K +723 Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 6,054 $138K <0.01% 0 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 5,444 $124K <0.01% +1,397 13F-HR Timeline Group Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 5,121 $117K <0.01% -386 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 4,200 $96K <0.01% 0 13F-HR/A Timeline VIRTUS ADVISERS, LLC in group Virtus Investment Advisers, L… More: the full row for VIRTUS ADVISERS, LLC 3,183 $72.8K 0.03% +989 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 3,150 $72K 0.01% new 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 3,126 $71.5K <0.01% new 13F-HR Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 2,071 $47.3K <0.01% 13F-HR Timeline Leonteq Securities AG More: the full row for Leonteq Securities AG 2,000 $45.7K <0.01% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 1,380 $31.5K <0.01% -790 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 1,088 $25K <0.01% -403 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 1,022 $23.4K <0.01% 0 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 1,009 $23.1K <0.01% 0 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 746 $17.1K <0.01% 0 13F-HR/A Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 629 $14.4K <0.01% -7,767 13F-HR Timeline Group ATTICUS WEALTH MANAGEMENT, LLC More: the full row for ATTICUS WEALTH MANAGEMENT, LLC 437 $9.99K <0.01% 0 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 356 $8K <0.01% 0 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 312 $7.13K <0.01% 13F-HR Timeline R Squared Ltd More: the full row for R Squared Ltd 290 $6.63K 0.01% 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 171 $3.91K <0.01% +149 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 137 $3.13K <0.01% +107 13F-HR/A Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 134 $3.06K <0.01% new 13F-HR Timeline Wilmington Savings Fund Society, FSB More: the full row for Wilmington Savings Fund Society, FSB 132 $3.02K <0.01% new 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 95 $2.17K <0.01% 13F-HR/A Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 50 $1.14K <0.01% 0 13F-HR Timeline Truvestments Capital LLC More: the full row for Truvestments Capital LLC 46 $1.05K <0.01% 0 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 43 $983 <0.01% -69 13F-HR Timeline Group Creative Planning in group Creative Planning More: the full row for Creative Planning 41 $937 <0.01% new 13F-HR Timeline Group SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 35 $800 <0.01% 13F-HR Timeline Physician Wealth Advisors, Inc. More: the full row for Physician Wealth Advisors, Inc. 29 $663 <0.01% new 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 22 $503 <0.01% 0 13F-HR Timeline CoreCap Advisors, LLC More: the full row for CoreCap Advisors, LLC 11 $251 <0.01% new 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 0 $114 <0.01% new 13F-HR Timeline Amount filed as zero, left out of ratios. CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 2 $0 0% -2 13F-HR Timeline Group Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.